Investigation of the coordinated functional activities of cytochrome P450 3A4 and P-glycoprotein in limiting the absorption of xenobiotics in Caco-2 cells

Journal of Pharmaceutical Sciences

Volumn 91, Issue 1, 2002, Pages 117-128

  Tran, Christine D H ^a   Timmins, Peter ^a   Conway, Barbara R ^a   Irwin, William J ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

1 ,25 Dihydroxyvitamin D3; Efflux; Intestinal cytochrome P450 3A4 (CYP3A4); Intestinal P glycoprotein (P gp); Midazolam metabolism

Indexed keywords

CALCITRIOL; CYTOCHROME P450 3A4; DOXORUBICIN; GLYCOPROTEIN P; MIDAZOLAM; VINCRISTINE SULFATE; XENOBIOTIC AGENT;

ARTICLE; CELL GROWTH; CELL STRAIN CACO 2; CELL SURVIVAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG METABOLISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE CELL; MULTIDRUG RESISTANCE; PROTEIN EXPRESSION; WESTERN BLOTTING;

EID: 0036144831     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.1173     Document Type: Article

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