메뉴 건너뛰기




Volumn 17, Issue 3, 2002, Pages 167-189

Genetic Polymorphism of Human Cytochrome P450 Involved in Drug Metabolism

Author keywords

cytochrome P450; drug metabolizing enzymes; genotype; individual difference; polymorphism

Indexed keywords


EID: 85013917085     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.17.167     Document Type: Review
Times cited : (34)

References (153)
  • 1
    • 0024236331 scopus 로고
    • The molecular biology of cytochrome P450s
    • Gonzalez, F. J.: The molecular biology of cytochrome P450s. Pharmacol. Rev., 40: 243-288 (1989).
    • (1989) Pharmacol. Rev. , vol.40 , pp. 243-288
    • Gonzalez, F.J.1
  • 4
    • 0028799758 scopus 로고
    • Reproducing abnormal cholesterol biosynthesis as seen in the Smith-Lemli-Opitz syndrome by inhibiting the conversion of 7-dehydrocholesterol to cholesterol in rats
    • Xu, G., Salen, G., Shefer, S., Ness, G. C., Chen, T. S., Zhao, Z. and Tint, G. S.: Reproducing abnormal cholesterol biosynthesis as seen in the Smith-Lemli-Opitz syndrome by inhibiting the conversion of 7-dehydrocholesterol to cholesterol in rats. J. Clin. Invest, 95: 76-81 (1995).
    • (1995) J. Clin. Invest , vol.95 , pp. 76-81
    • Xu, G.1    Salen, G.2    Shefer, S.3    Ness, G.C.4    Chen, T.S.5    Zhao, Z.6    Tint, G.S.7
  • 5
    • 0035028517 scopus 로고    scopus 로고
    • Steroid 11 ε-hydroxylase deficiency and related disorders
    • White, P. C.: Steroid 11 ε-hydroxylase deficiency and related disorders. Endocrinol Metab Clin. North Am, 30: 61-79 (2001).
    • (2001) Endocrinol Metab Clin. North Am , vol.30 , pp. 61-79
    • White, P.C.1
  • 6
    • 0035022439 scopus 로고    scopus 로고
    • CYP21 mutations and congenital adrenal hyperplasia
    • Lee, H.: CYP21 mutations and congenital adrenal hyperplasia. Clin. Genet., 59: 293-301 (2001).
    • (2001) Clin. Genet. , vol.59 , pp. 293-301
    • Lee, H.1
  • 11
    • 0025639014 scopus 로고
    • Genetic polymorphisms of drug metabolism
    • Meyer, U. A.: Genetic polymorphisms of drug metabolism. pundam Clin. Pharmacol., 4: 595-615 (1990).
    • (1990) pundam Clin. Pharmacol. , vol.4 , pp. 595-615
    • Meyer, U.A.1
  • 13
    • 0030834058 scopus 로고    scopus 로고
    • Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors
    • Rendic, S. and Di Carlo, F. J.: Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab. Rev., 29: 413-580 (1997).
    • (1997) Drug Metab. Rev. , vol.29 , pp. 413-580
    • Rendic, S.1    Di Carlo, F.J.2
  • 14
    • 0022432242 scopus 로고
    • Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism
    • Jaiswal, A. K., Gonzalez, F. J. and Nebert, D. W.: Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism. Nucleic Acids. Res., 13: 4503-4520 (1985).
    • (1985) Nucleic Acids. Res. , vol.13 , pp. 4503-4520
    • Jaiswal, A.K.1    Gonzalez, F.J.2    Nebert, D.W.3
  • 15
    • 0034054613 scopus 로고    scopus 로고
    • Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms
    • Smart, J. and Daly, A. K.: Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. Pharmacogenetics, 10: 11-24 (2000).
    • (2000) Pharmacogenetics , vol.10 , pp. 11-24
    • Smart, J.1    Daly, A.K.2
  • 16
    • 0025737529 scopus 로고
    • PCR detection of an A/G polymorphism within exon 7 of the CYP1A1 gene
    • Hayashi, S. I., Watanabe, J., Nakachi, K. and Kawajiri, K.: PCR detection of an A/G polymorphism within exon 7 of the CYP1A1 gene. Nucleic Acids. Res., 19: 4797 (1991).
    • (1991) Nucleic Acids. Res. , vol.19 , pp. 4797
    • Hayashi, S.I.1    Watanabe, J.2    Nakachi, K.3    Kawajiri, K.4
  • 17
    • 0031550543 scopus 로고    scopus 로고
    • In vitro kinetics of two human CYP1A1 variant enzymes suggested to be associated with interindividual differences in cancer susceptibility
    • Persson, I., Johansson, I., and Ingelman-Sundberg, M.: In vitro kinetics of two human CYP1A1 variant enzymes suggested to be associated with interindividual differences in cancer susceptibility. Biochem. Biophys. Res. Commun., 231: 227-230 (1997).
    • (1997) Biochem. Biophys. Res. Commun. , vol.231 , pp. 227-230
    • Persson, I.1    Johansson, I.2    Ingelman-Sundberg, M.3
  • 19
    • 0029854529 scopus 로고    scopus 로고
    • A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility
    • Cascorbi, I., Brockmoller, J. and Roots, I.: A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility. Cancer Res., 56: 4965-4969 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 4965-4969
    • Cascorbi, I.1    Brockmoller, J.2    Roots, I.3
  • 20
    • 0035320769 scopus 로고    scopus 로고
    • Detection of known and two novel (M331I and R464S) missense mutations in the human CYP1A1 gene in a French Caucasian population
    • Chevalier, D., Allorge, D., Lo-Guidice, J. M., Cauffiez, C., Lhermitte, M., Lafitte, J. J. and Broly, F.: Detection of known and two novel (M331I and R464S) missense mutations in the human CYP1A1 gene in a French Caucasian population. Hum. Mutat., 17: 355 (2001).
    • (2001) Hum. Mutat. , vol.17 , pp. 355
    • Chevalier, D.1    Allorge, D.2    Lo-Guidice, J.M.3    Cauffiez, C.4    Lhermitte, M.5    Lafitte, J.J.6    Broly, F.7
  • 21
    • 0024362285 scopus 로고
    • The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene
    • Quattrochi, L. C. and Tukey, R. H.: The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene. Mol. Pharmacol., 36: 66-71 (1989).
    • (1989) Mol. Pharmacol. , vol.36 , pp. 66-71
    • Quattrochi, L.C.1    Tukey, R.H.2
  • 22
    • 0024445437 scopus 로고
    • Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression
    • Ikeya, K., Jaiswal, A. K., Owens, R. A., Jones, J. E., Nebert, D. W. and Kimura, S.: Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression. Mol. Endocrinol., 3: 1399-1408 (1989).
    • (1989) Mol. Endocrinol. , vol.3 , pp. 1399-1408
    • Ikeya, K.1    Jaiswal, A.K.2    Owens, R.A.3    Jones, J.E.4    Nebert, D.W.5    Kimura, S.6
  • 23
    • 0028336794 scopus 로고
    • Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: absence of mutation prescribing the phenotype in the CYP1A2 gene
    • Nakajima, M., Yokoi, T., Mizutani, M., Shin, S., Kadlubar, F. F. and Kamataki, T.: Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: absence of mutation prescribing the phenotype in the CYP1A2 gene. Cancer Epidemiol Biomarkers Prev., 3: 413-421 (1994).
    • (1994) Cancer Epidemiol Biomarkers Prev. , vol.3 , pp. 413-421
    • Nakajima, M.1    Yokoi, T.2    Mizutani, M.3    Shin, S.4    Kadlubar, F.F.5    Kamataki, T.6
  • 24
    • 0032929010 scopus 로고    scopus 로고
    • Genetic polymorphism in the 5'-flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans
    • Nakajima, M., Yokoi, T., Mizutani, M., Kinoshita, M., Funayama, M. and Kamataki, T.: Genetic polymorphism in the 5'-flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans. J. Biochem., 125: 803-808 (1999).
    • (1999) J. Biochem. , vol.125 , pp. 803-808
    • Nakajima, M.1    Yokoi, T.2    Mizutani, M.3    Kinoshita, M.4    Funayama, M.5    Kamataki, T.6
  • 25
    • 0032751791 scopus 로고    scopus 로고
    • Detection of three genetic polymorphisms in the 5'-flanking region and intron 1 of human CYP1A2 in the Japanese population
    • Chida, M., Yokoi, T., Fukui, T., Kinoshita, M., Yokota, J. and Kamataki, T.: Detection of three genetic polymorphisms in the 5'-flanking region and intron 1 of human CYP1A2 in the Japanese population. Jpn. J. Cancer Res., 90: 899-902 (1999).
    • (1999) Jpn. J. Cancer Res. , vol.90 , pp. 899-902
    • Chida, M.1    Yokoi, T.2    Fukui, T.3    Kinoshita, M.4    Yokota, J.5    Kamataki, T.6
  • 26
    • 0032908778 scopus 로고    scopus 로고
    • Functional significance of a C-A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine
    • Sachse, C., Brockmoller, J., Bauer, S., and Roots, I.: Functional significance of a C-A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Br. J. Clin. Pharmacol., 47: 445-449 (1999).
    • (1999) Br. J. Clin. Pharmacol. , vol.47 , pp. 445-449
    • Sachse, C.1    Brockmoller, J.2    Bauer, S.3    Roots, I.4
  • 27
    • 0035316570 scopus 로고    scopus 로고
    • Five novel natural allelic variants-951A>C, 1042G>A (D348N), 1156A>T (I386F), 1217G>A (C406Y) and 1291C>T (C431Y)-of the human CYP1A2 gene in a French Caucasian population
    • Chevalier, D., Cauffiez, C., Allorge, D., Lo-Guidice, J. M., Lhermitte, M., Lafitte, J. J. and Broly, F.: Five novel natural allelic variants-951A>C, 1042G>A (D348N), 1156A>T (I386F), 1217G>A (C406Y) and 1291C>T (C431Y)-of the human CYP1A2 gene in a French Caucasian population. Hum. Mutat., 17: 355356 (2001).
    • (2001) Hum. Mutat. , vol.17 , pp. 355356
    • Chevalier, D.1    Cauffiez, C.2    Allorge, D.3    Lo-Guidice, J.M.4    Lhermitte, M.5    Lafitte, J.J.6    Broly, F.7
  • 28
    • 0032969730 scopus 로고    scopus 로고
    • Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese
    • Huang, J. D., Guo, W. C., Lai, M. D., Guo, Y. L. and Lambert, G. H.: Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese. Drug Metab. Dispos., 27: 98-101 (1999).
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 98-101
    • Huang, J.D.1    Guo, W.C.2    Lai, M.D.3    Guo, Y.L.4    Lambert, G.H.5
  • 29
    • 0032810704 scopus 로고    scopus 로고
    • Detailed modelling of caffeine metabolism and examination of the CYP1A2 gene: lack of a polymorphism in CYP1A2 in Caucasians
    • Welfare, M., Aitkin, M., Bassendine, M. and Daly, A.: Detailed modelling of caffeine metabolism and examination of the CYP1A2 gene: lack of a polymorphism in CYP1A2 in Caucasians. Pharmacogenetics, 9: 367-375 (1999).
    • (1999) Pharmacogenetics , vol.9 , pp. 367-375
    • Welfare, M.1    Aitkin, M.2    Bassendine, M.3    Daly, A.4
  • 31
    • 0030942553 scopus 로고    scopus 로고
    • Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21
    • Stoilov, I., Akarsu, A. N. and Sarfarazi, M.: Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21. Hum. Mol. Genet., 6: 641-647 (1997).
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 641-647
    • Stoilov, I.1    Akarsu, A.N.2    Sarfarazi, M.3
  • 32
    • 0036178055 scopus 로고    scopus 로고
    • Functional analysis of six different polymorphic CYP1B1 enzyme variants found in an Ethiopian population
    • Aklillu, E., Oscarson, M., Hidestrand, M., Leidvik, B., Otter, C. and Ingelman-Sundberg, M.: Functional analysis of six different polymorphic CYP1B1 enzyme variants found in an Ethiopian population. Mol. Pharmacol., 61: 586-594 (2002).
    • (2002) Mol. Pharmacol. , vol.61 , pp. 586-594
    • Aklillu, E.1    Oscarson, M.2    Hidestrand, M.3    Leidvik, B.4    Otter, C.5    Ingelman-Sundberg, M.6
  • 34
  • 37
    • 0030977819 scopus 로고    scopus 로고
    • Human Ah receptor (AHR) gene: localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility
    • Micka, J., Milatovich, A., Menon, A., Grabowski, G. A., Puga, A. and Nebert, D. W.: Human Ah receptor (AHR) gene: localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility. Pharmacogenetics, 7: 95-101 (1997).
    • (1997) Pharmacogenetics , vol.7 , pp. 95-101
    • Micka, J.1    Milatovich, A.2    Menon, A.3    Grabowski, G.A.4    Puga, A.5    Nebert, D.W.6
  • 38
    • 0032437084 scopus 로고    scopus 로고
    • Recent advances in understanding the molecular basis of polymorphisms in genes encoding cytochrome P450 enzymes
    • Daly, A. K., Fairbrother, K. S. and Smart, J.: Recent advances in understanding the molecular basis of polymorphisms in genes encoding cytochrome P450 enzymes. Toxicol. Lett., 102-103: 143-147 (1998).
    • (1998) Toxicol. Lett. , vol.102-103 , pp. 143-147
    • Daly, A.K.1    Fairbrother, K.S.2    Smart, J.3
  • 39
    • 0032611186 scopus 로고    scopus 로고
    • Chapter 14. Ah receptor gene polymorphisms and human cancer susceptibility
    • Garte, S. and Sogawa, K.: Chapter 14. Ah receptor gene polymorphisms and human cancer susceptibility. IARCSci. Publ., 148: 149-157 (1999).
    • (1999) IARCSci. Publ. , vol.148 , pp. 149-157
    • Garte, S.1    Sogawa, K.2
  • 40
    • 0032899367 scopus 로고    scopus 로고
    • Identification of a novel mechanism of regulation of Ah (dioxin) receptor function
    • Mimura, J., Ema, M., Sogawa, K. and Fujii-Kuriyama, Y.: Identification of a novel mechanism of regulation of Ah (dioxin) receptor function. Genes. Dev., 13: 20-25 (1999).
    • (1999) Genes. Dev. , vol.13 , pp. 20-25
    • Mimura, J.1    Ema, M.2    Sogawa, K.3    Fujii-Kuriyama, Y.4
  • 41
    • 0036136055 scopus 로고    scopus 로고
    • Characterization of the aryl hydrocarbon receptor repressor gene and association of its Pro185Ala polymorphism with micropenis
    • Fujita, H., Kosaki, R., Yoshihashi, H., Ogata, T., Tomita, M., Hasegawa, T., Takahashi, T., Matsuo, N. and Kosaki, K.: Characterization of the aryl hydrocarbon receptor repressor gene and association of its Pro185Ala polymorphism with micropenis. Teratology, 65: 10-18 (2002).
    • (2002) Teratology , vol.65 , pp. 10-18
    • Fujita, H.1    Kosaki, R.2    Yoshihashi, H.3    Ogata, T.4    Tomita, M.5    Hasegawa, T.6    Takahashi, T.7    Matsuo, N.8    Kosaki, K.9
  • 43
    • 0035154274 scopus 로고    scopus 로고
    • Genetic polymorphisms in the cytochrome P450 2A6 (CYP2A6) gene: implications for interindividual differences in nicotine metabolism
    • Oscarson, M.: Genetic polymorphisms in the cytochrome P450 2A6 (CYP2A6) gene: implications for interindividual differences in nicotine metabolism. Drug Metab. Dispos., 29: 91-95 (2001).
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 91-95
    • Oscarson, M.1
  • 44
    • 0025022689 scopus 로고
    • The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes
    • Yamano, S., Tatsuno, J. and Gonzalez, F. J.: The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. Biochemistry, 29: 1322-1329 (1990).
    • (1990) Biochemistry , vol.29 , pp. 1322-1329
    • Yamano, S.1    Tatsuno, J.2    Gonzalez, F.J.3
  • 47
    • 0032945691 scopus 로고    scopus 로고
    • A new CYP2A6 gene deletion responsible for the in vivo polymorphic metabolism of (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride in humans
    • Nunoya, K. I., Yokoi, T., Kimura, K., Kainuma, T., Satoh, K., Kinoshita, M. and Kamataki, T.: A new CYP2A6 gene deletion responsible for the in vivo polymorphic metabolism of (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride in humans. J. Pharmacol. Exp. Ther., 289: 437-442 (1999).
    • (1999) J. Pharmacol. Exp. Ther. , vol.289 , pp. 437-442
    • Nunoya, K.I.1    Yokoi, T.2    Kimura, K.3    Kainuma, T.4    Satoh, K.5    Kinoshita, M.6    Kamataki, T.7
  • 49
    • 0033807421 scopus 로고    scopus 로고
    • Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking
    • Rao, Y., Hoffmann, E., Zia, M., Bodin, L., Zeman, M., Sellers, E. M. and Tyndale, R. F.: Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking. Mol. Pharmacol., S8: 747-755 (2000).
    • (2000) Mol. Pharmacol. , vol.S8 , pp. 747-755
    • Rao, Y.1    Hoffmann, E.2    Zia, M.3    Bodin, L.4    Zeman, M.5    Sellers, E.M.6    Tyndale, R.F.7
  • 51
    • 0034816629 scopus 로고    scopus 로고
    • Identification of a single nucleotide polymorphism in the TATA box of the CYP2A6 gene: impairment of its promoter activity
    • Pitarque, M., von Richter, O., Oke, B., Berkkan, H., Oscarson, M. and Ingelman-Sundberg, M.: Identification of a single nucleotide polymorphism in the TATA box of the CYP2A6 gene: impairment of its promoter activity. Biochem. Biophys. Res. Commun., 284: 455-460 (2001).
    • (2001) Biochem. Biophys. Res. Commun. , vol.284 , pp. 455-460
    • Pitarque, M.1    von Richter, O.2    Oke, B.3    Berkkan, H.4    Oscarson, M.5    Ingelman-Sundberg, M.6
  • 52
    • 0035947589 scopus 로고    scopus 로고
    • CYP2A6*6, a novel polymorphism in cytochrome P450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity
    • Kitagawa, K., Kunugita, N., Kitagawa, M. and Kawamoto, T.: CYP2A6*6, a novel polymorphism in cytochrome P450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity. J. Biol. Chem., 276: 17830-17835 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 17830-17835
    • Kitagawa, K.1    Kunugita, N.2    Kitagawa, M.3    Kawamoto, T.4
  • 54
    • 0030697098 scopus 로고    scopus 로고
    • A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin
    • Hadidi, H., Zahlsen, K., Idle, J. R. and Cholerton, S.: A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin. Pood Chem. Toxicol., 35: 903-907 (1997).
    • (1997) Pood Chem. Toxicol. , vol.35 , pp. 903-907
    • Hadidi, H.1    Zahlsen, K.2    Idle, J.R.3    Cholerton, S.4
  • 55
    • 0034805710 scopus 로고    scopus 로고
    • A novel single nucleotide polymorphism altering stability and activity of CYP2A6
    • Ariyoshi, N., Sawamura, Y. and Kamataki, T.: A novel single nucleotide polymorphism altering stability and activity of CYP2A6. Biochem. Biophys. Res. Commun., 281: 810-814 (2001).
    • (2001) Biochem. Biophys. Res. Commun. , vol.281 , pp. 810-814
    • Ariyoshi, N.1    Sawamura, Y.2    Kamataki, T.3
  • 57
    • 0028802138 scopus 로고
    • Isoflurane-chlorodifluoroethene interaction in human liver microsomes. Role of cytochrome P4502B6 in potentiation of haloethene metabolism
    • Baker, M. T., Olson, M. J., Wang, Y., Ronnenberg, W. C., Jr., Johnson, J. T. and Brady, A. N.: Isoflurane-chlorodifluoroethene interaction in human liver microsomes. Role of cytochrome P4502B6 in potentiation of haloethene metabolism. Drug Metab. Dispos., 23: 60-64 (1995).
    • (1995) Drug Metab. Dispos. , vol.23 , pp. 60-64
    • Baker, M.T.1    Olson, M.J.2    Wang, Y.3    Ronnenberg, W.C.4    Johnson, J.T.5    Brady, A.N.6
  • 58
    • 0032414615 scopus 로고    scopus 로고
    • Molecular genetics of the human cytochrome P450 monooxygenase superfamily
    • Smith, G., Stubbins, M. J., Harries, L. W. and Wolf, C. R.: Molecular genetics of the human cytochrome P450 monooxygenase superfamily. Xenobiotica, 28: 1129-1165 (1998).
    • (1998) Xenobiotica , vol.28 , pp. 1129-1165
    • Smith, G.1    Stubbins, M.J.2    Harries, L.W.3    Wolf, C.R.4
  • 60
    • 0024464027 scopus 로고
    • cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver
    • Yamano, S., Nhamburo, P., Aoyama, T., Meyer, U., Inaba, T., Kalow, W., Gelboin, H., McBride, O. and Gonzalez, F.: cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver. Biochemistry, 28: 7340-7348, (1989).
    • (1989) Biochemistry , vol.28 , pp. 7340-7348
    • Yamano, S.1    Nhamburo, P.2    Aoyama, T.3    Meyer, U.4    Inaba, T.5    Kalow, W.6    Gelboin, H.7    McBride, O.8    Gonzalez, F.9
  • 62
    • 0032937343 scopus 로고    scopus 로고
    • The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor fluvastatin: effect on human cytochrome P-450 and implications for metabolic drug interactions
    • Fischer, V., Johanson, L., Heitz, F., Tullman, R., Graham, E., Baldeck, J. P. and Robinson, W. T.: The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor fluvastatin: effect on human cytochrome P-450 and implications for metabolic drug interactions. Drug Metab. Dispos., 27: 410-416 (1999).
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 410-416
    • Fischer, V.1    Johanson, L.2    Heitz, F.3    Tullman, R.4    Graham, E.5    Baldeck, J.P.6    Robinson, W.T.7
  • 63
  • 64
    • 0032604625 scopus 로고    scopus 로고
    • Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs
    • Klose, T. S., Blaisdell, J. A. and Goldstein, J. A.: Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs. J. Biochem. Mol. Toxicol., 13: 289-295 (1999).
    • (1999) J. Biochem. Mol. Toxicol. , vol.13 , pp. 289-295
    • Klose, T.S.1    Blaisdell, J.A.2    Goldstein, J.A.3
  • 65
  • 66
    • 0023443243 scopus 로고
    • Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form
    • Yasumori, T., Kawano, S., Nagata, K., Shimada, M., Yamazoe, Y. and Kato, R.: Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form. J. Biochem., 102: 1075-1082 (1987).
    • (1987) J. Biochem. , vol.102 , pp. 1075-1082
    • Yasumori, T.1    Kawano, S.2    Nagata, K.3    Shimada, M.4    Yamazoe, Y.5    Kato, R.6
  • 67
    • 0025763625 scopus 로고
    • Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily
    • Romkes, M., Faletto, M., Blaisdell, J., Raucy, J. and Goldstein, J.: Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. Biochemistry, 30: 3247-3255 (1991).
    • (1991) Biochemistry , vol.30 , pp. 3247-3255
    • Romkes, M.1    Faletto, M.2    Blaisdell, J.3    Raucy, J.4    Goldstein, J.5
  • 72
    • 0035217171 scopus 로고    scopus 로고
    • Identification of a null allele of CYP2C9 in an African-American exhibiting toxicity to phenytoin
    • Kidd, R. S., Curry, T. B., Gallagher, S., Edeki, T., Blaisdell, J. and Goldstein, J. A.: Identification of a null allele of CYP2C9 in an African-American exhibiting toxicity to phenytoin. Pharmacogenetics, 11: 803-808 (2001).
    • (2001) Pharmacogenetics , vol.11 , pp. 803-808
    • Kidd, R.S.1    Curry, T.B.2    Gallagher, S.3    Edeki, T.4    Blaisdell, J.5    Goldstein, J.A.6
  • 73
    • 0031840217 scopus 로고    scopus 로고
    • Genetic polymorphism of cytochrome P450s, CYP2C19, and CYP2C9 in a Japanese population
    • Kimura, M., Ieiri, I., Mamiya, K., Urae, A. and Higuchi, S.: Genetic polymorphism of cytochrome P450s, CYP2C19, and CYP2C9 in a Japanese population. Ther. Drug Monit., 20: 243-247 (1998).
    • (1998) Ther. Drug Monit. , vol.20 , pp. 243-247
    • Kimura, M.1    Ieiri, I.2    Mamiya, K.3    Urae, A.4    Higuchi, S.5
  • 75
    • 0034892729 scopus 로고    scopus 로고
    • Genetic polymorphisms and functional characterization of the 5'-flanking region of the human CYP2C9 gene: in vitro and in vivo studies
    • Shintani, M., Ieiri, I., Inoue, K., Mamiya, K., Ninomiya, H., Tashiro, N., Higuchi, S. and Otsubo, K.: Genetic polymorphisms and functional characterization of the 5'-flanking region of the human CYP2C9 gene: in vitro and in vivo studies. Clin. Pharmacol. Ther., 70: 175-182 (2001).
    • (2001) Clin. Pharmacol. Ther. , vol.70 , pp. 175-182
    • Shintani, M.1    Ieiri, I.2    Inoue, K.3    Mamiya, K.4    Ninomiya, H.5    Tashiro, N.6    Higuchi, S.7    Otsubo, K.8
  • 76
    • 0031957174 scopus 로고    scopus 로고
    • Fluconazole but not itraconazole decreases the metabolism of losartan to E-3174
    • Kaukonen, K. M., Olkkola, K. T. and Neuvonen, P. J.: Fluconazole but not itraconazole decreases the metabolism of losartan to E-3174. Eur. J. Clin. Pharmacol., 53: 445-449 (1998).
    • (1998) Eur. J. Clin. Pharmacol. , vol.53 , pp. 445-449
    • Kaukonen, K.M.1    Olkkola, K.T.2    Neuvonen, P.J.3
  • 77
    • 0028260641 scopus 로고
    • The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans
    • de Morais, S. M., Wilkinson, G. R., Blaisdell, J., Nakamura, K., Meyer, U. A. and Goldstein, J. A.: The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J. Biol. Chem., 269: 15419-15422 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 15419-15422
    • de Morais, S.M.1    Wilkinson, G.R.2    Blaisdell, J.3    Nakamura, K.4    Meyer, U.A.5    Goldstein, J.A.6
  • 78
    • 0028044085 scopus 로고
    • Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese
    • de Morais, S. M., Wilkinson, G. R., Blaisdell, J., Meyer, U. A., Nakamura, K. and Goldstein, J. A.: Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Mol. Pharmacol., 46: 594-598 (1994).
    • (1994) Mol. Pharmacol. , vol.46 , pp. 594-598
    • de Morais, S.M.1    Wilkinson, G.R.2    Blaisdell, J.3    Meyer, U.A.4    Nakamura, K.5    Goldstein, J.A.6
  • 79
    • 8244249473 scopus 로고    scopus 로고
    • Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele
    • Xiao, Z. S., Goldstein, J. A., Xie, H. G., Blaisdell, J., Wang, W., Jiang, C. H., Yan, F. X., He, N., Huang, S. L., Xu, Z. H. and Zhou, H. H.: Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele. J. Pharmacol. Exp. Ther., 281: 604-609 (1997).
    • (1997) J. Pharmacol. Exp. Ther. , vol.281 , pp. 604-609
    • Xiao, Z.S.1    Goldstein, J.A.2    Xie, H.G.3    Blaisdell, J.4    Wang, W.5    Jiang, C.H.6    Yan, F.X.7    He, N.8    Huang, S.L.9    Xu, Z.H.10    Zhou, H.H.11
  • 81
    • 0032797302 scopus 로고    scopus 로고
    • A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin
    • Ibeanu, G. C., Blaisdell, J., Ferguson, R. J., Ghanayem, B. I., Brosen, K., Benhamou, S., Bouchardy, C., Wilkinson, G. R., Dayer, P. and Goldstein, J. A.: A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin. J. Pharmacol. Exp. Ther., 290: 635-640 (1999).
    • (1999) J. Pharmacol. Exp. Ther. , vol.290 , pp. 635-640
    • Ibeanu, G.C.1    Blaisdell, J.2    Ferguson, R.J.3    Ghanayem, B.I.4    Brosen, K.5    Benhamou, S.6    Bouchardy, C.7    Wilkinson, G.R.8    Dayer, P.9    Goldstein, J.A.10
  • 83
    • 0034792584 scopus 로고    scopus 로고
    • Clinical relevance of genetic polymorphisms in the human CYP2C subfamily
    • Goldstein, J. A.: Clinical relevance of genetic polymorphisms in the human CYP2C subfamily. Br. J. Clin. Pharmacol., 52: 349-355 (2001).
    • (2001) Br. J. Clin. Pharmacol. , vol.52 , pp. 349-355
    • Goldstein, J.A.1
  • 85
    • 0025948746 scopus 로고
    • Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA
    • Furuya, H., Meyer, U. A., Gelboin, H. V. and Gonzalez, F. J.: Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA. Mol. Pharmacol., 40: 375-382 (1991).
    • (1991) Mol. Pharmacol. , vol.40 , pp. 375-382
    • Furuya, H.1    Meyer, U.A.2    Gelboin, H.V.3    Gonzalez, F.J.4
  • 86
    • 0029868939 scopus 로고    scopus 로고
    • Identification of a new nonfunctional CYP2C18 allele in Japanese: substitution of T204 to A in exon2 generates a premature stop codon
    • Komai, K., Sumida, K., Kaneko, H. and Nakatsuka, I.: Identification of a new nonfunctional CYP2C18 allele in Japanese: substitution of T204 to A in exon2 generates a premature stop codon. Pharmacogenetics, 6: 117-119 (1996).
    • (1996) Pharmacogenetics , vol.6 , pp. 117-119
    • Komai, K.1    Sumida, K.2    Kaneko, H.3    Nakatsuka, I.4
  • 91
    • 0024796958 scopus 로고
    • The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene
    • Kimura, S., Umeno, M., Skoda, R. C., Meyer, U. A. and Gonzalez, F. J.: The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. Am. J. Hum. Genet., 4S: 889-904 (1989).
    • (1989) Am. J. Hum. Genet. , vol.4S , pp. 889-904
    • Kimura, S.1    Umeno, M.2    Skoda, R.C.3    Meyer, U.A.4    Gonzalez, F.J.5
  • 92
    • 0025243460 scopus 로고
    • The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934-A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site. Am. J. Hum
    • Hanioka, N., Kimura, S., Meyer, U. and Gonzalez, F.: The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934-A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site. Am. J. Hum. Genet., 47: 994-1001 (1990).
    • (1990) Genet. , vol.47 , pp. 994-1001
    • Hanioka, N.1    Kimura, S.2    Meyer, U.3    Gonzalez, F.4
  • 93
    • 0025036544 scopus 로고
    • Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes. J
    • Kagimoto, M., Heim, M., Kagimoto, K., Zeugin, T. and Meyer, U. A.: Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes. J. Biol. Chem., 26S: 17209-17214 (1990).
    • (1990) Biol. Chem. , vol.26S , pp. 17209-17214
    • Kagimoto, M.1    Heim, M.2    Kagimoto, K.3    Zeugin, T.4    Meyer, U.A.5
  • 94
    • 0026240145 scopus 로고
    • Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype
    • Tyndale, R., Aoyama, T., Broly, F., Matsunaga, T., Inaba, T., Kalow, W., Gelboin, H. V., Meyer, U. A. and Gonzalez, F. J.: Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype. Pharmacogenetics, I: 26-32 (1991).
    • (1991) Pharmacogenetics , vol.I , pp. 26-32
    • Tyndale, R.1    Aoyama, T.2    Broly, F.3    Matsunaga, T.4    Inaba, T.5    Kalow, W.6    Gelboin, H.V.7    Meyer, U.A.8    Gonzalez, F.J.9
  • 95
    • 0025805934 scopus 로고
    • Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism
    • Gaedigk, A., Blum, M., Gaedigk, R., Eichelbaum, M. and Meyer, U. A.: Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism. Am. J. Hum. Genet., 48: 943-950 (1991).
    • (1991) Am. J. Hum. Genet. , vol.48 , pp. 943-950
    • Gaedigk, A.1    Blum, M.2    Gaedigk, R.3    Eichelbaum, M.4    Meyer, U.A.5
  • 96
    • 0027527966 scopus 로고
    • Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism
    • Yokota, H., Tamura, S., Furuya, H., Kimura, S., Watanabe, M., Kanazawa, I., Kondo, I. and Gonzalez, F. J.: Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism. Pharmacogenetics, 3: 256-263 (1993).
    • (1993) Pharmacogenetics , vol.3 , pp. 256-263
    • Yokota, H.1    Tamura, S.2    Furuya, H.3    Kimura, S.4    Watanabe, M.5    Kanazawa, I.6    Kondo, I.7    Gonzalez, F.J.8
  • 97
    • 0027136288 scopus 로고
    • Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
    • Johansson, I., Lundqvist, E., Bertilsson, L., Dahl, M. L., Sjoqvist, F. and Ingelman-Sundberg, M.: Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc. Natl. Acad. Sci. U.S.A., 90: 11825-11829 (1993).
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 11825-11829
    • Johansson, I.1    Lundqvist, E.2    Bertilsson, L.3    Dahl, M.L.4    Sjoqvist, F.5    Ingelman-Sundberg, M.6
  • 98
    • 0027968799 scopus 로고
    • DNA haplotype-dependent differences in the amino acid sequence of debrisoquine 4-hydroxylase (CYP2D6): evidence for two major allozymes in extensive metabolisers
    • Panserat, S., Mura, C., Gerard, N., Vincent-Viry, M., Galteau, M. M., Jacqz-Aigrain, E. and Krishnamoorthy, R.: DNA haplotype-dependent differences in the amino acid sequence of debrisoquine 4-hydroxylase (CYP2D6): evidence for two major allozymes in extensive metabolisers. Hum. Genet., 94: 401-406 (1994).
    • (1994) Hum. Genet. , vol.94 , pp. 401-406
    • Panserat, S.1    Mura, C.2    Gerard, N.3    Vincent-Viry, M.4    Galteau, M.M.5    Jacqz-Aigrain, E.6    Krishnamoorthy, R.7
  • 99
    • 0028109283 scopus 로고
    • A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine
    • Evert, B., Griese, E. U. and Eichelbaum, M.: A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine. Naunyn Schmiedebergs Arch. Pharmacol., 350: 434-439 (1994).
    • (1994) Naunyn Schmiedebergs Arch. Pharmacol. , vol.350 , pp. 434-439
    • Evert, B.1    Griese, E.U.2    Eichelbaum, M.3
  • 100
    • 0027965620 scopus 로고
    • Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation
    • Johansson, I., Oscarson, M., Yue, Q. Y., Bertilsson, L., Sjoqvist, F. and Ingelman-Sundberg, M.: Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation. Mol. Pharmacol., 46 : 452-459 (1994).
    • (1994) Mol. Pharmacol. , vol.46 , pp. 452-459
    • Johansson, I.1    Oscarson, M.2    Yue, Q.Y.3    Bertilsson, L.4    Sjoqvist, F.5    Ingelman-Sundberg, M.6
  • 101
    • 0028305240 scopus 로고
    • Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype
    • Saxena, R., Shaw, G. L., Relling, M. V., Frame, J. N., Moir, D. T., Evans, W. E., Caporaso, N. and Weiffen-bach, B.: Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype. Hum. Mol. Genet., 3: 923-926 (1994).
    • (1994) Hum. Mol. Genet. , vol.3 , pp. 923-926
    • Saxena, R.1    Shaw, G.L.2    Relling, M.V.3    Frame, J.N.4    Moir, D.T.5    Evans, W.E.6    Caporaso, N.7    Weiffen-bach, B.8
  • 102
    • 0029622336 scopus 로고
    • An efficient strategy for detection of known and new mutations of the CYP2D6 gene using single strand conformation polymorphism analysis
    • Broly, F., Marez, D., Sabbagh, N., Legrand, M., Millecamps, S., Lo Guidice, J. M., Boone, P. and Meyer, U. A.: An efficient strategy for detection of known and new mutations of the CYP2D6 gene using single strand conformation polymorphism analysis. Pharmacogenetics, 5: 373-384 (1995).
    • (1995) Pharmacogenetics , vol.5 , pp. 373-384
    • Broly, F.1    Marez, D.2    Sabbagh, N.3    Legrand, M.4    Millecamps, S.5    Lo Guidice, J.M.6    Boone, P.7    Meyer, U.A.8
  • 103
    • 0028846090 scopus 로고
    • An unequal crossover event within the CYP2D gene cluster generates a chimeric CYP2D7 /CYP2D6 gene which is associated with the poor metabolizer phenotype
    • Panserat, S., Mura, C., Gerard, N., Vincent-Viry, M., Galteau, M. M., Jacoz-Aigrain, E., and Krishnamoorthy, R.: An unequal crossover event within the CYP2D gene cluster generates a chimeric CYP2D7 /CYP2D6 gene which is associated with the poor metabolizer phenotype. Br. J. Clin. Pharmacol., 40: 361-367 (1995).
    • (1995) Br. J. Clin. Pharmacol. , vol.40 , pp. 361-367
    • Panserat, S.1    Mura, C.2    Gerard, N.3    Vincent-Viry, M.4    Galteau, M.M.5    Jacoz-Aigrain, E.6    Krishnamoorthy, R.7
  • 104
    • 0029064096 scopus 로고
    • Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis
    • Dahl, M. L., Johansson, I., Bertilsson, L., Ingelman-Sundberg, M. and Sjoqvist, F.: Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis. J. Pharmacol. Exp. Ther., 274: 516-520 (1995).
    • (1995) J. Pharmacol. Exp. Ther. , vol.274 , pp. 516-520
    • Dahl, M.L.1    Johansson, I.2    Bertilsson, L.3    Ingelman-Sundberg, M.4    Sjoqvist, F.5
  • 105
    • 0028826569 scopus 로고
    • A novel CYP2D 6 allele with an abolished splice recognition site associated with the poor metabolizer phenotype
    • Marez, D., Sabbagh, N., Legrand, M., Lo-Guidice, J. M., Boone, P. and Broly, F.: A novel CYP2D 6 allele with an abolished splice recognition site associated with the poor metabolizer phenotype. Pharmacogenetics, S: 305-311 (1995).
    • (1995) Pharmacogenetics , vol.S , pp. 305-311
    • Marez, D.1    Sabbagh, N.2    Legrand, M.3    Lo-Guidice, J.M.4    Boone, P.5    Broly, F.6
  • 106
    • 0030432585 scopus 로고    scopus 로고
    • Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles
    • Aklillu, E., Persson, I., Bertilsson, L., Johansson, I., Rodrigues, F. and Ingelman-Sundberg, M.: Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles. J. Pharmacol. Exp. Ther., 278: 441-446 (1996).
    • (1996) J. Pharmacol. Exp. Ther. , vol.278 , pp. 441-446
    • Aklillu, E.1    Persson, I.2    Bertilsson, L.3    Johansson, I.4    Rodrigues, F.5    Ingelman-Sundberg, M.6
  • 107
    • 0029736710 scopus 로고    scopus 로고
    • Characterization and PCR-based detection of two different hybrid CYP2D7P/CYP2D6 alleles associated with the poor metabolizer phenotype
    • Daly, A. K., Fairbrother, K. S., Andreassen, O. A., London, S. J., Idle, J. R. and Steen, V. M.: Characterization and PCR-based detection of two different hybrid CYP2D7P/CYP2D6 alleles associated with the poor metabolizer phenotype. Pharmacogenetics, 6: 319-328 (1996).
    • (1996) Pharmacogenetics , vol.6 , pp. 319-328
    • Daly, A.K.1    Fairbrother, K.S.2    Andreassen, O.A.3    London, S.J.4    Idle, J.R.5    Steen, V.M.6
  • 108
    • 0029853664 scopus 로고    scopus 로고
    • A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity
    • Masimirembwa, C., Persson, I., Bertilsson, L., Hasler, J. and Ingelman-Sundberg, M.: A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity. Br. J. Clin. Pharmacol., 42: 713-719 (1996).
    • (1996) Br. J. Clin. Pharmacol. , vol.42 , pp. 713-719
    • Masimirembwa, C.1    Persson, I.2    Bertilsson, L.3    Hasler, J.4    Ingelman-Sundberg, M.5
  • 109
    • 0029661560 scopus 로고    scopus 로고
    • A rare insertion of T226 in exon 1 of CYP2D6 causes a frameshift and is associated with the poor metabolizer phenotype: CYP2D6*15
    • Sachse, C., Brockmoller, J., Bauer, S., Reum, T. and Roots, I.: A rare insertion of T226 in exon 1 of CYP2D6 causes a frameshift and is associated with the poor metabolizer phenotype: CYP2D6*15. Pharmacogenetics, 6: 269-272 (1996).
    • (1996) Pharmacogenetics , vol.6 , pp. 269-272
    • Sachse, C.1    Brockmoller, J.2    Bauer, S.3    Reum, T.4    Roots, I.5
  • 111
    • 0030938177 scopus 로고    scopus 로고
    • Characterization of the 16 + 9 kb and 30 + 9 kb CYP2D6 XbaI haplotypes
    • Lovlie, R., Daly, A. K., Idle, J. R. and Steen, V. M.: Characterization of the 16 + 9 kb and 30 + 9 kb CYP2D6 XbaI haplotypes. Pharmacogenetics, 7: 149-1S2 (1997).
    • (1997) Pharmacogenetics , vol.7 , pp. 149-1S2
    • Lovlie, R.1    Daly, A.K.2    Idle, J.R.3    Steen, V.M.4
  • 112
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P4S0 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences
    • Sachse, C., Brockmoller, J., Bauer, S. and Roots, I.: Cytochrome P4S0 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am. J. Hum. Genet., 60: 284-29S (1997).
    • (1997) Am. J. Hum. Genet. , vol.60 , pp. 284-29S
    • Sachse, C.1    Brockmoller, J.2    Bauer, S.3    Roots, I.4
  • 113
    • 0030860004 scopus 로고    scopus 로고
    • Polymorphism of the cytochrome P4S0 CYP2D6 gene in a European population: characterization of 48 mutations and S3 alleles, their frequencies and evolution
    • Marez, D., Legrand, M., Sabbagh, N., Guidice, J. M., Spire, C., Lafitte, J. J., Meyer, U. A. and Broly, F.: Polymorphism of the cytochrome P4S0 CYP2D6 gene in a European population: characterization of 48 mutations and S3 alleles, their frequencies and evolution. Pharmacogenetics, 7: 193-202 (1997).
    • (1997) Pharmacogenetics , vol.7 , pp. 193-202
    • Marez, D.1    Legrand, M.2    Sabbagh, N.3    Guidice, J.M.4    Spire, C.5    Lafitte, J.J.6    Meyer, U.A.7    Broly, F.8
  • 115
    • 0032421471 scopus 로고    scopus 로고
    • CYP2D6 phenotype-genotype relationships in African-Americans and Caucasians in Los Angeles
    • Leathart, J. B., London, S. J., Steward, A., Adams, J. D., Idle, J. R. and Daly, A. K.: CYP2D6 phenotype-genotype relationships in African-Americans and Caucasians in Los Angeles. Pharmacogenetics, 8: S29-S41 (1998).
    • (1998) Pharmacogenetics , vol.8 , pp. S29-S41
    • Leathart, J.B.1    London, S.J.2    Steward, A.3    Adams, J.D.4    Idle, J.R.5    Daly, A.K.6
  • 116
    • 0032963135 scopus 로고    scopus 로고
    • G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese
    • Wang, S. L., Lai, M. D. and Huang, J. D.: G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese. Drug Metab. Dispos., 27: 38S-388 (1999).
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 38S-388
    • Wang, S.L.1    Lai, M.D.2    Huang, J.D.3
  • 117
    • 0033141361 scopus 로고    scopus 로고
    • A rare G2061 insertion affecting the open reading frame of CYP2D6 and responsible for the poor metabolizer phenotype
    • Marez-Allorge, D., Ellis, S. W., Lo Guidice, J. M., Tucker, G. T. and Broly, F.: A rare G2061 insertion affecting the open reading frame of CYP2D6 and responsible for the poor metabolizer phenotype. Pharmacogenetics, 9: 393-396 (1999).
    • (1999) Pharmacogenetics , vol.9 , pp. 393-396
    • Marez-Allorge, D.1    Ellis, S.W.2    Lo Guidice, J.M.3    Tucker, G.T.4    Broly, F.5
  • 118
    • 0033790979 scopus 로고    scopus 로고
    • Elucidation of the genetic basis of the common ‘intermediate metabolizer' phenotype for drug oxidation by CYP2D6
    • Raimundo, S., Fischer, J., Eichelbaum, M., Griese, E. U., Schwab, M. and Zanger, U. M.: Elucidation of the genetic basis of the common ‘intermediate metabolizer' phenotype for drug oxidation by CYP2D6. Pharmacogenetics, 10: S77-S81 (2000).
    • (2000) Pharmacogenetics , vol.10 , pp. S77-S81
    • Raimundo, S.1    Fischer, J.2    Eichelbaum, M.3    Griese, E.U.4    Schwab, M.5    Zanger, U.M.6
  • 119
    • 0034745465 scopus 로고    scopus 로고
    • Characterization of (+ / -)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6
    • Shimada, T., Tsumura, F., Yamazaki, H., Guengerich, F. P. and Inoue, K.: Characterization of (+ / -)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6. Pharmacogenetics, 11: 143-1S6 (2001).
    • (2001) Pharmacogenetics , vol.11 , pp. 143-1S6
    • Shimada, T.1    Tsumura, F.2    Yamazaki, H.3    Guengerich, F.P.4    Inoue, K.5
  • 120
    • 0031438162 scopus 로고    scopus 로고
    • A combination of mutations in the CYP2D6*17 (CYP2D6Z) allele causes alterations in enzyme function
    • Oscarson, M., Hidestrand, M., Johansson, I. and Ingelman-Sundberg, M.: A combination of mutations in the CYP2D6*17 (CYP2D6Z) allele causes alterations in enzyme function. Mol. Pharmacol., 52: 1034-1040 (1997).
    • (1997) Mol. Pharmacol. , vol.52 , pp. 1034-1040
    • Oscarson, M.1    Hidestrand, M.2    Johansson, I.3    Ingelman-Sundberg, M.4
  • 121
    • 0026031652 scopus 로고
    • Interethnic variation of drug metabolism
    • Kalow, W.: Interethnic variation of drug metabolism. Trends Pharmacol. Sci., 12: 102-107 (1991).
    • (1991) Trends Pharmacol. Sci. , vol.12 , pp. 102-107
    • Kalow, W.1
  • 122
    • 0036204756 scopus 로고    scopus 로고
    • Molecular genetics of CYP2D 6: clinical relevance with focus on psychotropic drugs
    • Bertilsson, L., Dahl, M. L., Dalen, P. and Al-Shurbaji, A.: Molecular genetics of CYP2D 6: clinical relevance with focus on psychotropic drugs. Br. J. Clin. Pharmacol., 53: 111-122 (2002).
    • (2002) Br. J. Clin. Pharmacol. , vol.53 , pp. 111-122
    • Bertilsson, L.1    Dahl, M.L.2    Dalen, P.3    Al-Shurbaji, A.4
  • 123
    • 0032586732 scopus 로고    scopus 로고
    • Analysis of the CYP2D6 gene in relation to dextromethorphan O-demethylation capacity in a Japanese population
    • Tateishi, T., Chida, M., Ariyoshi, N., Mizorogi, Y., Kamataki, T. and Kobayashi, S.: Analysis of the CYP2D6 gene in relation to dextromethorphan O-demethylation capacity in a Japanese population. Clin. Pharmacol. Ther., 65: S70-S7S (1999).
    • (1999) Clin. Pharmacol. Ther. , vol.65 , pp. S70-S7S
    • Tateishi, T.1    Chida, M.2    Ariyoshi, N.3    Mizorogi, Y.4    Kamataki, T.5    Kobayashi, S.6
  • 124
    • 0030826785 scopus 로고    scopus 로고
    • Effects of the CYP2D6 genotype on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese schizophrenic patients
    • Suzuki, A., Otani, K., Mihara, K., Yasui, N., Kaneko, S., Inoue, Y. and Hayashi, K.: Effects of the CYP2D6 genotype on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese schizophrenic patients. Pharmacogenetics, 7: 41S-418 (1997).
    • (1997) Pharmacogenetics , vol.7 , pp. 41S-418
    • Suzuki, A.1    Otani, K.2    Mihara, K.3    Yasui, N.4    Kaneko, S.5    Inoue, Y.6    Hayashi, K.7
  • 125
    • 0032793249 scopus 로고    scopus 로고
    • Polymorphic human cytochrome P4S0 enzymes: an opportunity for individualized drug treatment
    • Ingelman-Sundberg, M., Oscarson, M. and McLellan, R. A.: Polymorphic human cytochrome P4S0 enzymes: an opportunity for individualized drug treatment. Trends Pharmacol. Sci., 20: 342-349 (1999).
    • (1999) Trends Pharmacol. Sci. , vol.20 , pp. 342-349
    • Ingelman-Sundberg, M.1    Oscarson, M.2    McLellan, R.A.3
  • 126
    • 0025992864 scopus 로고
    • Oxidation of toxic and carcinogenic chemicals by human cytochrome P-4S0 enzymes
    • Guengerich, F. P. and Shimada, T.: Oxidation of toxic and carcinogenic chemicals by human cytochrome P-4S0 enzymes. Chem. Res. Toxicol., 4: 391-407 (1991).
    • (1991) Chem. Res. Toxicol. , vol.4 , pp. 391-407
    • Guengerich, F.P.1    Shimada, T.2
  • 127
    • 0024244103 scopus 로고
    • Human ethanol-inducible P4S0IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression
    • Umeno, M., McBride, O., Yang, C., Gelboin, H. and Gonzalez, F.: Human ethanol-inducible P4S0IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression. Biochemistry, 27: 9006-9013 (1988).
    • (1988) Biochemistry , vol.27 , pp. 9006-9013
    • Umeno, M.1    McBride, O.2    Yang, C.3    Gelboin, H.4    Gonzalez, F.5
  • 128
    • 0026062622 scopus 로고
    • Genetic polymorphisms in the S'-flanking region change transcriptional regulation of the human cytochrome P4S0IIE1 gene
    • Hayashi, S., Watanabe, J. and Kawajiri, K.: Genetic polymorphisms in the S'-flanking region change transcriptional regulation of the human cytochrome P4S0IIE1 gene. J. Biochem., 110: SS9-S6S (1991).
    • (1991) J. Biochem. , vol.110 , pp. SS9-S6S
    • Hayashi, S.1    Watanabe, J.2    Kawajiri, K.3
  • 132
    • 0033600711 scopus 로고    scopus 로고
    • Structural and functional characterization of the S' -flanking region of the rat and human cytochrome P4S0 2E1 genes: identification of a polymorphic repeat in the human gene
    • Hu, Y., Hakkola, J., Oscarson, M. and Ingelman-Sun-dberg, M.: Structural and functional characterization of the S' -flanking region of the rat and human cytochrome P4S0 2E1 genes: identification of a polymorphic repeat in the human gene. Biochem. Biophys. Res. Commun., 263: 286-293 (1999).
    • (1999) Biochem. Biophys. Res. Commun. , vol.263 , pp. 286-293
    • Hu, Y.1    Hakkola, J.2    Oscarson, M.3    Ingelman-Sun-dberg, M.4
  • 133
    • 0344938358 scopus 로고    scopus 로고
    • Inhibition and induction of human cytochrome P4S0 (CYP) enzymes
    • Pelkonen, O., Maenpaa, J., Taavitsainen, P., Rautio, A. and Raunio, H.: Inhibition and induction of human cytochrome P4S0 (CYP) enzymes. Xenobiotica, 28: 1203-12S3 (1998).
    • (1998) Xenobiotica , vol.28 , pp. 1203-12S3
    • Pelkonen, O.1    Maenpaa, J.2    Taavitsainen, P.3    Rautio, A.4    Raunio, H.5
  • 136
    • 0028175687 scopus 로고
    • Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver
    • Schuetz, J. D., Beach, D. L. and Guzelian, P. S.: Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver. Pharmacogenetics, 4: 11-20 (1994).
    • (1994) Pharmacogenetics , vol.4 , pp. 11-20
    • Schuetz, J.D.1    Beach, D.L.2    Guzelian, P.S.3
  • 137
    • 0028270821 scopus 로고
    • Cytochrome P450 in human fetal liver: significance and fetal-specific expression
    • Kitada, M. and Kamataki, T.: Cytochrome P450 in human fetal liver: significance and fetal-specific expression. Drug Metab. Rev., 26: 305-323 (1994).
    • (1994) Drug Metab. Rev. , vol.26 , pp. 305-323
    • Kitada, M.1    Kamataki, T.2
  • 138
    • 0034736577 scopus 로고    scopus 로고
    • The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons
    • Finta, C. and Zaphiropoulos, P. G.: The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons. Gene, 260: 13-23 (2000).
    • (2000) Gene , vol.260 , pp. 13-23
    • Finta, C.1    Zaphiropoulos, P.G.2
  • 139
    • 0023858226 scopus 로고
    • Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase
    • Gonzalez, F., Schmid, B., Umeno, M., Mcbride, O., Hardwick, J., Meyer, U., Gelboin, H. and Idle, J.: Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase. DNA, 7: 79-86 (1988).
    • (1988) DNA , vol.7 , pp. 79-86
    • Gonzalez, F.1    Schmid, B.2    Umeno, M.3    Mcbride, O.4    Hardwick, J.5    Meyer, U.6    Gelboin, H.7    Idle, J.8
  • 140
    • 0345643389 scopus 로고    scopus 로고
    • Interindividual differences in hepatic expression of CYP3A: relationship to genetic polymorphism in the 5'-upstream regulatory region
    • Westlind, A., Lofberg, L., Tindberg, N., Andersson, T. B. and Ingelman-Sundberg, M.: Interindividual differences in hepatic expression of CYP3A: relationship to genetic polymorphism in the 5'-upstream regulatory region. Biochem. Biophys. Res. Commun., 259: 201-205 (1999).
    • (1999) Biochem. Biophys. Res. Commun. , vol.259 , pp. 201-205
    • Westlind, A.1    Lofberg, L.2    Tindberg, N.3    Andersson, T.B.4    Ingelman-Sundberg, M.5
  • 141
    • 0033632228 scopus 로고    scopus 로고
    • CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12 evidence for an allelic variant with altered catalytic activity
    • Sata, F., Sapone, A., Elizondo, G., Stocker, P., Miller, V. P., Zheng, W., Raunio, H., Crespi, C. L. and Gonzalez, F. J.: CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity. Clin. Pharmacol. Ther., 67: 48-56 (2000).
    • (2000) Clin. Pharmacol. Ther. , vol.67 , pp. 48-56
    • Sata, F.1    Sapone, A.2    Elizondo, G.3    Stocker, P.4    Miller, V.P.5    Zheng, W.6    Raunio, H.7    Crespi, C.L.8    Gonzalez, F.J.9
  • 143
    • 0035197548 scopus 로고    scopus 로고
    • Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos
    • Dai, D., Tang, J., Rose, R., Hodgson, E., Bienstock, R. J., Mohrenweiser, H. W. and Goldstein, J. A.: Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos. J. Pharmacol. Exp. Ther., 299: 825-831 (2001).
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , pp. 825-831
    • Dai, D.1    Tang, J.2    Rose, R.3    Hodgson, E.4    Bienstock, R.J.5    Mohrenweiser, H.W.6    Goldstein, J.A.7
  • 145
    • 0037139169 scopus 로고    scopus 로고
    • Mutation analysis of the human CYP3A4 gene 5' regulatory region: population screening using non-radioactive SSCP
    • Hamzeiy, H., Vahdati-Mashhadian, N., Edwards, H. J. and Goldfarb, P. S.: Mutation analysis of the human CYP3A4 gene 5' regulatory region: population screening using non-radioactive SSCP. Mutat. Res., 500: 103-110 (2002).
    • (2002) Mutat. Res. , vol.500 , pp. 103-110
    • Hamzeiy, H.1    Vahdati-Mashhadian, N.2    Edwards, H.J.3    Goldfarb, P.S.4
  • 147
    • 0024412071 scopus 로고
    • Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine
    • Aoyama, T., Yamano, S., Waxman, D., Lapenson, D., Meyer, U., Fischer, V., Tyndale, R., Inaba, T., Kalow, W. and Gelboin, H.: Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. J. Biol. Chem., 264: 10388-10395 (1989).
    • (1989) J. Biol. Chem. , vol.264 , pp. 10388-10395
    • Aoyama, T.1    Yamano, S.2    Waxman, D.3    Lapenson, D.4    Meyer, U.5    Fischer, V.6    Tyndale, R.7    Inaba, T.8    Kalow, W.9    Gelboin, H.10
  • 148
    • 0342468270 scopus 로고    scopus 로고
    • Detection of CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein?
    • Jounaidi, Y., Hyrailles, V., Gervot, L. and Maurel, P.: Detection of CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein? Biochem. Biophys. Res. Commun., 221: 466-470 (1996).
    • (1996) Biochem. Biophys. Res. Commun. , vol.221 , pp. 466-470
    • Jounaidi, Y.1    Hyrailles, V.2    Gervot, L.3    Maurel, P.4
  • 149
    • 0034874776 scopus 로고    scopus 로고
    • Genetic polymorphism of cytochrome P450 3A5 in Chinese
    • Chou, F. C., Tzeng, S. J. and Huang, J. D.: Genetic polymorphism of cytochrome P450 3A5 in Chinese. Drug Metab. Dispos., 29: 1205-1209 (2001).
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 1205-1209
    • Chou, F.C.1    Tzeng, S.J.2    Huang, J.D.3
  • 151


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.