Cancer, aging and cellular senescence

In Vivo

Volumn 14, Issue 1, 2000, Pages 183-188

  Campisi, Judith ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Cellular immortalization; DNA damage; Oncogenes; Replicative senescene; Telomerase; Telomeres; Tumor suppressor genes

Indexed keywords

APOPTOSIS; CANCER INHIBITION; CELL AGING; CELL DIFFERENTIATION; CELL IMMORTALIZATION; CELL PROLIFERATION; DNA DAMAGE; GENE ACTIVITY; GENE MUTATION; HUMAN; NONHUMAN; ONCOGENE; PHENOTYPE; REVIEW; SENESCENCE; TELOMERE; TUMOR SUPPRESSOR GENE;

EID: 0034069237     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (60)

1. Hayflick L and Moorhead PS: The serial cultivation of human diploid cell strains. Exp Cell Res 25: 585-621, 1961.
2. Haytlick L: The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37: 614-636, 1965.
3. Ponten J: The relationship between in vitro transformation and tumor formation in vivo. Biochim Biophys Acta 458: 397-422, 1976.
4. Sager R: Senescence as a mode of tumor suppression. Environ Health Persp 93:59-62, 1991.
5. Ruley HE: Adenovirus early region IA enables viral and cellular transforming genes to transform plimary cells in culture. Nature 304: 602-606, 1983.
6. Weinberg RA: The action of oncogenes in the cytoplasm and nucleus. Science 230: 770-774, 1985.
7. Weinberg RA:Tumor suppressor genes. Science 254: 1138-1146, 1991.
8. Galloway DA and McDougall JK: Human papillomaviruses and carcinomas. Adv Virus Res 37: 125-171, 1989.
9. Shay JW, and Wright WR: Defining the molecular mechanisms of human cell immortalization. Biochim Biophys Acta 1071: 1-7, 1991.
10. Hinds P, Finlay C and Levine AJ: Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation. J Virol 63: 739-746, 1989.
11. Hara E, Tsuli H, Shinozaki S and Oda K: Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of lifespan in human diploid libroblasts, TIG-1. Biochem Biophys Res Comm 179: 528-534, 1991.
12. Dimri GP and Campisi J: Molecular and cell biology of replicative senescence. Cold Spring Harbor Symposia on Quantitative Biology, Molec Gen Canc 54: 67-73, 1994.
13. Bookstein R, and Lee WH: Molecular genetics of the retinoblastoma tumor suppressor gene. Crit Rev Oncol 2: 211-227, 1991.
14. Hollstein M, Sidransky D, Vogelstein B, and Harris CC: p53 mutation in human cancer. Science 253: 49-53, 1991.
15. Alcorta DA, Xiong Y, Phelps D, Hannon G, Beach D and BalTett JC: Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci USA 93: 13742-13747, 1996.
16. Hara E, Smith R, PalTy D, Tahara H, and Peters G: Regulation of p16 (CdkN2) expression and its implications for cell immortalization and senescence. Mol Cell Biol 16: 859-867, 1996.
17. Donehower LA, Harvey M, Slagke BL, McArthur MJ, Montgomery CA Jr, Butel JS and Bradley A: Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 356: 215-21, 1992.
18. Harvey M, Sands AT, Weiss RS, Hegi ME, Wiseman RW, Pantazis P, Giovanella BC, Tainsky MA, Bradley A and Donehower LA: In vitro growth characteristics of embryo fibroblasts isolated fiom p53-deficient mice. Oncogene 8: 2457-67, 1993.
19. Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT and Weinberg RA: Tumor spectrum analysis in p53-mutant mice. Curr Bio 4: 1-7, 1994.
20. Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D and DePinho RA: Role of the INK4A locus in tumor suppression and cell mortality. Cell 85: 27-37, 1996.
21. Campisi J: Replicative senescence: An old lives tale? Cell 84: 497-500, 1996.
22. Campisi J, Dimri GP and E, Hara: Control of replicative senescence. In: Handbook of the Biology of Aging. (Schneider E and Rowe J, eds) 4th edition, New York, Academic Press, 1996, pp 121-149.
23. Campisi J: Aging and cancer: The double-edged sword of replicative senescence. J. Am. Geriatrics Soc. 45: 1-6, 1997.
24. Goldstein S: Replicative senescence: The human fibroblast comes of age. Science 249: 1129-1133, 1990.
25. Cristofalo VJ and Pignolo RJ: Replicative senescence of human fibroblast-like cells in culture. Physiol Rev 73: 617-638, 1993.
26. McColmick A and Campisi J: Cellular aging and senescence. Curr Op Cell Bio 3: 230-234, 1990.
27. Campisi J. The biology of replicative senescence. Europ J Canc 33: 703-709, 1997.
28. ∼ mmed cell death. J Cell Biochem 54: 432-439, 1994.
29. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith OM, Peacocke M and Campisi J: A novel biomarker identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92: 9363-9367, 1995.
30. Mishima K, Handa JT, Aotaki-Keen A, Lutty GA, Morse LS and Hjelmeland LM: Senescence-associated beta-galactosidase histochemistry for the primate eye. Invest Ophthalmol Vis Sci 40: 1590-1593, 1999
31. Pendergrass WR, Lane MA, Bodkin NL, Hansen BC, Ingram DK, Roth GS, Yi L, Bin H and Wolf NS: Cellular proliferation potential during aging and caloric restriction in rhesus monkeys (Macaca mulatta). J Cell Physiol 180: 123-30, 1999.
32. Linskens M, Harley CB, West MD, Campisi J and Haytlick L: Replicative senescence and cell death. Science 267: 17, 1995.
33. Stanulis-Praeger B: Cellular senescence revisited: A review. Mech Aging & Dev 38: 1-48, 1987.
34. Levy MZ, Allsopp RC, Futcher AB, Greider CW and Harley CB: Telomere end- replication problem and cell aging. J Molec Bio 225: 951-960, 1992.
35. Harley CB, Futcher AB and Greider CW: Telomeres shorten during ageing of human fibroblasts. Nature 345: 458-460, 1990.
36. Allsopp RC, Vazili H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW and Harley CB: Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 89: 10114-10118, 1992.
37. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S and Wright WE: Extension of life span by introduction of telomerase into normal human cells. Science 279: 349-352, 1998.
38. Vaziri, H, and Benchimol S: Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span, Curr Biol 8: 279-282, 1998.
39. Weinrich SL, Pruzan R, Ma L, Ouellette M, Tesmer VM, Holt SE, Bodnar AG, Lichsteiner S, Kim NW, Trager JR, Taylor RD, Carlos R, Andrews WH, Wright WE, Shay JW, Harley CB, Mori, GB: Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nature Genet 17: 498-502, 1997.
40. Kim NW, Platyszek M, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL and Shay JW: Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015, 1994.
41. Buchkovich KJ and Greider CW: Telomerase regulation during entry into the cell cycle in normal human T cells. Molec Cell Bio 7: 1443-1454, 1996.
42. Weng NP, Levine BL, June CH and Hodes RJ: Regulated expression of telomerase activity in human T lymphocyte development and activation. J Exp Med 183: 2471-2479, 1996.
43. Kiyono T, Foster SA, Koop JI McDougall JK, Galloway DA and Klingelhutz AJ: Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 396: 84-88, 1998.
44. Bryan TM, Englezo, A, Dalla-Pozza L, Dunha, MA and Reddel R: Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor- derived cell lines. Nature Med 3: 1271-1274, 1997.
45. Robles SJ and Adami GR: Agents that cause DNA double strand breaks lead to p16INK4a emichment and the premature senescence of normal tibmhlasts. Oncogene 16: 1113-1123, 1998.
46. DiLeonardo A, Linke SP, Clarkin K and Wahl GM: DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes & Dev. 8: 2540-2551, 1994.
47. Chen Q, Bartholomew JC, Campisi J, Acosta M, Reagen JD and Ames B: Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rh control G(1) arrest but not cell replication. Biochem J 332: 43-50, 1998.
48. Serrano M, Lin AW, McCurrach ME, Beach D and Lowe SW: Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88: 593-602, 1997.
49. Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M and Lowe SW: Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes & Dev 12: 3008-3019, 1998.
50. Zhu J, Woods D, McMahon M and Bishop JM: Senescence of human fibroblasts induced by oncogenic raf. Genes & Dev 12: 2997-3007, 1998.
51. Dimri GP, Itahana K, Acosta M and Campisi J: Regulation of a senescence checkpoint response by the H2F1 transcription factor and p14ARF tumor suppressor. Mol Cell Bio, in press, 2000.
52. Finch CR: Longevity, Senescence, and the Genome, University of Chicago Press, 1991.
53. Rose MR: The Evolutionary Biology of Aging. Oxford University Press, 1991.
54. Miller RA: Gerontology as oncology: Research on aging as a key to the understanding of cancer. Cancer 68: 2490-2501, 1991.
55. Campisi J: The role of cellular senescence in skin aging. J Invest Dermatol 3: 1-5, 1998.
56. Roskelley CD and Bissell MJ: Dynamic reciprocity revisited: a continuous, bidirectional flow of information between cells and the extracellular matrix regulates mammary epithelial cell function. Biochem Cell Bio 73: 391-397, 1995.
57. Adams JC and Watt FM: Regulation of development and differentiation by the extracellular matrix. Development 117: 1183-1198, 1993.
58. Bissell MJ, Hall HG, and Parry G: How does the extracellular matrix direct gene expression? J Theor Biol 99, 31-68, 1982.
59. Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C, and Bissell J: Reversion of the malignant phenotype of human breast cell in three dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol 137: 231-45, 1997.
60. Boudreau M, Reddy ST, Stoker AW, Fairman C, and Bissell MJ: The embryonic environment and extracellular matrix suppress oncogenic transformation by Rous sarcoma virus in chick embryos. Mol Cell Diff 3: 261-274, 1995.