메뉴 건너뛰기




Volumn 64, Issue 17, 2007, Pages 2306-2322

Molecular genetics of RecQ helicase disorders

Author keywords

Cancer pre disposition; Chromosomal instability; DNA repair; Homologous recombination; Premature aging; RecQ helicases; Telomeres

Indexed keywords

RECQ HELICASE;

EID: 34548321123     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-007-7121-z     Document Type: Review
Times cited : (119)

References (155)
  • 1
    • 0021792806 scopus 로고
    • The recQ gene of Escherichia coli K12: Molecular cloning and isolation of insertion mutants
    • Nakayama, K., Irino, N. and Nakayama, H. (1985) The recQ gene of Escherichia coli K12: molecular cloning and isolation of insertion mutants. Mol. Gen. Genet. 200, 266-271.
    • (1985) Mol. Gen. Genet , vol.200 , pp. 266-271
    • Nakayama, K.1    Irino, N.2    Nakayama, H.3
  • 3
    • 0030888233 scopus 로고    scopus 로고
    • RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli
    • Hanada, K., Ukita, T., Kohno, Y., Saito, K., Kato, J. and Ikeda, H. (1997) RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli. Proc. Natl. Acad. Sci. USA 94, 3860-3865.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 3860-3865
    • Hanada, K.1    Ukita, T.2    Kohno, Y.3    Saito, K.4    Kato, J.5    Ikeda, H.6
  • 4
    • 0028033989 scopus 로고
    • The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: A potential eukaryotic reverse gyrase
    • Gangloff, S., McDonald, J. P., Bendixen, C., Arthur, L. and Rothstein, R. (1994) The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase. Mol. Cell. Biol. 14, 8391-8398.
    • (1994) Mol. Cell. Biol , vol.14 , pp. 8391-8398
    • Gangloff, S.1    McDonald, J.P.2    Bendixen, C.3    Arthur, L.4    Rothstein, R.5
  • 5
    • 0027331383 scopus 로고
    • Bloom syndrome: A mendelian prototype of somatic mutation disease
    • German, J. (1993) Bloom syndrome: a mendelian prototype of somatic mutation disease. Medicine 72, 393-406.
    • (1993) Medicine , vol.72 , pp. 393-406
    • German, J.1
  • 6
    • 0024465870 scopus 로고
    • Mutator phenotype of Werner syndrome is characterized by extensive deletions
    • Fukuchi, K., Martin, G. M. and Monnat, R. J. Jr. (1989) Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc. Natl. Acad. Sci. USA 86, 5893-5897.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 5893-5897
    • Fukuchi, K.1    Martin, G.M.2    Monnat Jr., R.J.3
  • 7
    • 0034737004 scopus 로고    scopus 로고
    • Rothmund-Thomson syndrome due to RECQ4helicase mutations: Report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome
    • Lindor, N. M., Furuichi, Y., Kitao, S., Shimamoto, A., Arndt, C. and Jalal, S. (2000) Rothmund-Thomson syndrome due to RECQ4helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome. Am. J. Med. Genet. 90, 223-228.
    • (2000) Am. J. Med. Genet , vol.90 , pp. 223-228
    • Lindor, N.M.1    Furuichi, Y.2    Kitao, S.3    Shimamoto, A.4    Arndt, C.5    Jalal, S.6
  • 8
    • 0037115947 scopus 로고    scopus 로고
    • RecQ family helicases: Roles as tumor suppressor proteins
    • Nakayama, H. (2002) RecQ family helicases: roles as tumor suppressor proteins. Oncogene 21, 9008-9021.
    • (2002) Oncogene , vol.21 , pp. 9008-9021
    • Nakayama, H.1
  • 9
    • 0033046015 scopus 로고    scopus 로고
    • Evolution of the RECQ family of helicases: A Drosophila homolog, Dmblm, is similar to the human bloom syndrome gene
    • Kusano, K., Berres, M. E. and Engels, W. R. (1999) Evolution of the RECQ family of helicases: A Drosophila homolog, Dmblm, is similar to the human bloom syndrome gene. Genetics 151, 1027-1039.
    • (1999) Genetics , vol.151 , pp. 1027-1039
    • Kusano, K.1    Berres, M.E.2    Engels, W.R.3
  • 11
    • 0027942415 scopus 로고
    • Cloning and characterization of RECQL, a potential human homologue of the Escherichia coli DNA helicase RecQ
    • Puranam, K. L. and Blackshear, P. J. (1994) Cloning and characterization of RECQL, a potential human homologue of the Escherichia coli DNA helicase RecQ. J. Biol. Chem. 269, 29838-29845.
    • (1994) J. Biol. Chem , vol.269 , pp. 29838-29845
    • Puranam, K.L.1    Blackshear, P.J.2
  • 14
    • 0032535661 scopus 로고    scopus 로고
    • Cloning of two new human helicase genes of the RecQ family: Biological significance of multiple species in higher eukaryotes
    • Kitao, S., Ohsugi, I., Ichikawa, K., Goto, M., Furuichi, Y. and Shimamoto, A. (1998) Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes. Genomics 54, 443-452.
    • (1998) Genomics , vol.54 , pp. 443-452
    • Kitao, S.1    Ohsugi, I.2    Ichikawa, K.3    Goto, M.4    Furuichi, Y.5    Shimamoto, A.6
  • 15
    • 0032736140 scopus 로고    scopus 로고
    • Rothmund-Thomson syndrome responsible gene, RECQL4: Genomic structure and products
    • Kitao, S., Lindor, N. M., Shiratori, M., Furuichi, Y. and Shimamoto, A. (1999) Rothmund-Thomson syndrome responsible gene, RECQL4: genomic structure and products. Genomics 61, 268-276.
    • (1999) Genomics , vol.61 , pp. 268-276
    • Kitao, S.1    Lindor, N.M.2    Shiratori, M.3    Furuichi, Y.4    Shimamoto, A.5
  • 18
    • 0001542940 scopus 로고
    • Chromosomal breakage in a rare and probably genetically determined syndrome of man
    • German, J., Archibald, R. and Bloom, D. (1965) Chromosomal breakage in a rare and probably genetically determined syndrome of man. Science 148, 506-507.
    • (1965) Science , vol.148 , pp. 506-507
    • German, J.1    Archibald, R.2    Bloom, D.3
  • 19
    • 4444312648 scopus 로고    scopus 로고
    • The function of RecQ helicase gene family (especially BLM) in DNA recombination and joining
    • Kaneko, H., Fukao, T. and Kondo, N. (2004) The function of RecQ helicase gene family (especially BLM) in DNA recombination and joining. Adv. Biophys. 38, 45-64.
    • (2004) Adv. Biophys , vol.38 , pp. 45-64
    • Kaneko, H.1    Fukao, T.2    Kondo, N.3
  • 20
    • 0035425563 scopus 로고    scopus 로고
    • Successful pregnancy in a woman with Bloom syndrome
    • Chisholm, C. A., Bray, M. J. and Karns, L. B. (2001) Successful pregnancy in a woman with Bloom syndrome. Am. J. Med. Genet. 102, 136-138.
    • (2001) Am. J. Med. Genet , vol.102 , pp. 136-138
    • Chisholm, C.A.1    Bray, M.J.2    Karns, L.B.3
  • 21
    • 0020619254 scopus 로고    scopus 로고
    • Vijayalaxmi, Evans, H. J., Ray, J. H. and German, J. (1983) Bloom's syndrome: evidence for an increased mutation frequency in vivo. Science 221, 851-853.
    • Vijayalaxmi, Evans, H. J., Ray, J. H. and German, J. (1983) Bloom's syndrome: evidence for an increased mutation frequency in vivo. Science 221, 851-853.
  • 22
    • 3142544243 scopus 로고
    • Evidence for increased in vivo mutation and somatic recombination in Bloom's syndrome
    • Langlois, R. G., Bigbee, W. L., Jensen, R. H. and German, J. (1989) Evidence for increased in vivo mutation and somatic recombination in Bloom's syndrome. Proc. Natl. Acad. Sci. USA 86, 670-674.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 670-674
    • Langlois, R.G.1    Bigbee, W.L.2    Jensen, R.H.3    German, J.4
  • 23
    • 0022364961 scopus 로고
    • Evidence for chromosome instability in vivo in Bloom syndrome: Increased numbers of micronuclei in exfoliated cells
    • Rosin, M. P. and German, J. (1985) Evidence for chromosome instability in vivo in Bloom syndrome: increased numbers of micronuclei in exfoliated cells. Hum. Genet . 71, 187-191.
    • (1985) Hum. Genet , vol.71 , pp. 187-191
    • Rosin, M.P.1    German, J.2
  • 25
    • 0346351375 scopus 로고
    • A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes
    • Chaganti, R. S., Schonberg, S. and German, J. (1974) A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes. Proc. Natl. Acad. Sci. USA 71, 4508-4512.
    • (1974) Proc. Natl. Acad. Sci. USA , vol.71 , pp. 4508-4512
    • Chaganti, R.S.1    Schonberg, S.2    German, J.3
  • 26
    • 0021741404 scopus 로고
    • Bloom's syndrome and EM9 cells in BrdU-containing medium exhibit similarly elevated frequencies of sister chromatid exchange but dissimilar amounts of cellular proliferation and chromosome disruption
    • Ray, J. H. and German, J. (1984) Bloom's syndrome and EM9 cells in BrdU-containing medium exhibit similarly elevated frequencies of sister chromatid exchange but dissimilar amounts of cellular proliferation and chromosome disruption. Chromosoma 90, 383-388.
    • (1984) Chromosoma , vol.90 , pp. 383-388
    • Ray, J.H.1    German, J.2
  • 28
    • 3042575122 scopus 로고    scopus 로고
    • Genome-wide phenotype analysis in ES cells by regulated disruption of Bloom's syndrome gene
    • Yusa, K., Horie, K., Kondoh, G., Kouno, M., Maeda, Y., Kinoshita, T. and Takeda, J. (2004) Genome-wide phenotype analysis in ES cells by regulated disruption of Bloom's syndrome gene. Nature 429, 896-899.
    • (2004) Nature , vol.429 , pp. 896-899
    • Yusa, K.1    Horie, K.2    Kondoh, G.3    Kouno, M.4    Maeda, Y.5    Kinoshita, T.6    Takeda, J.7
  • 30
    • 0034182744 scopus 로고    scopus 로고
    • Characterization of the nuclear localization signal in the DNA helicase responsible for Bloom syndrome
    • Hayakawa, S., Kaneko, H., Fukao, T., Kasahara, K., Matsumoto, T., Furuichi, Y. and Kondo, N. (2000) Characterization of the nuclear localization signal in the DNA helicase responsible for Bloom syndrome. Int. J. Mol. Med. 5, 477-484.
    • (2000) Int. J. Mol. Med , vol.5 , pp. 477-484
    • Hayakawa, S.1    Kaneko, H.2    Fukao, T.3    Kasahara, K.4    Matsumoto, T.5    Furuichi, Y.6    Kondo, N.7
  • 32
    • 19844372703 scopus 로고    scopus 로고
    • Structural and functional characterizations reveal the importance of a zinc binding domain in Bloom's syndrome helicase
    • Guo, R. B., Rigolet, P., Zargarian, L., Fermandjian, S. and Xi, X. G. (2005) Structural and functional characterizations reveal the importance of a zinc binding domain in Bloom's syndrome helicase. Nucleic Acids Res. 33, 3109-3124.
    • (2005) Nucleic Acids Res , vol.33 , pp. 3109-3124
    • Guo, R.B.1    Rigolet, P.2    Zargarian, L.3    Fermandjian, S.4    Xi, X.G.5
  • 33
    • 0031678636 scopus 로고    scopus 로고
    • Carrier frequency of the Bloom syndrome blmAsh mutation in the Ashkenazi Jewish population
    • Li, L., Eng, C., Desnick, R. J., German, J. and Ellis, N. A. (1998) Carrier frequency of the Bloom syndrome blmAsh mutation in the Ashkenazi Jewish population. Mol. Genet. Metab. 64, 286-290.
    • (1998) Mol. Genet. Metab , vol.64 , pp. 286-290
    • Li, L.1    Eng, C.2    Desnick, R.J.3    German, J.4    Ellis, N.A.5
  • 34
    • 0032471419 scopus 로고    scopus 로고
    • The Ashkenazic Jewish Bloom syndrome mutation blmAsh is present in non-Jewish Americans of Spanish ancestry
    • Ellis, N. A., Ciocci, S., Proytcheva, M., Lennon, D., Groden, J. and German, J. (1998) The Ashkenazic Jewish Bloom syndrome mutation blmAsh is present in non-Jewish Americans of Spanish ancestry. Am. J. Hum. Genet. 63, 1685-1693.
    • (1998) Am. J. Hum. Genet , vol.63 , pp. 1685-1693
    • Ellis, N.A.1    Ciocci, S.2    Proytcheva, M.3    Lennon, D.4    Groden, J.5    German, J.6
  • 35
    • 0030686496 scopus 로고    scopus 로고
    • The Bloom's syndrome gene product is a 3′-5′ DNA helicase
    • Karow, J. K., Chakraverty, R. K. and Hickson, I. D. (1997) The Bloom's syndrome gene product is a 3′-5′ DNA helicase. J. Biol. Chem. 272, 30611-30614.
    • (1997) J. Biol. Chem , vol.272 , pp. 30611-30614
    • Karow, J.K.1    Chakraverty, R.K.2    Hickson, I.D.3
  • 36
    • 0035393720 scopus 로고    scopus 로고
    • The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases
    • Mohaghegh, P., Karow, J. K., Brosh R. M. Jr., Bohr, V. A. and Hickson, I. D. (2001) The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases. Nucleic Acids Res. 29, 2843-2849.
    • (2001) Nucleic Acids Res , vol.29 , pp. 2843-2849
    • Mohaghegh, P.1    Karow, J.K.2    Brosh Jr., R.M.3    Bohr, V.A.4    Hickson, I.D.5
  • 37
    • 0035909817 scopus 로고    scopus 로고
    • Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands
    • Li, J. L., Harrison, R. J., Reszka, A. P., Brosh, R. M. Jr., Bohr, V. A., Neidle, S. and Hickson, I. D. (2001) Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands. Biochemistry 40, 15194-15202.
    • (2001) Biochemistry , vol.40 , pp. 15194-15202
    • Li, J.L.1    Harrison, R.J.2    Reszka, A.P.3    Brosh Jr., R.M.4    Bohr, V.A.5    Neidle, S.6    Hickson, I.D.7
  • 38
    • 33646843592 scopus 로고    scopus 로고
    • Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase
    • Bachrati, C. Z., Borts, R. H. and Hickson, I. D. (2006) Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase. Nucleic Acids Res. 34, 2269-2279.
    • (2006) Nucleic Acids Res , vol.34 , pp. 2269-2279
    • Bachrati, C.Z.1    Borts, R.H.2    Hickson, I.D.3
  • 39
    • 0032538453 scopus 로고    scopus 로고
    • The Bloom's syndrome helicase unwinds G4 DNA
    • Sun, H., Karow, J. K., Hickson, I. D. and Maizels, N. (1998) The Bloom's syndrome helicase unwinds G4 DNA. J. Biol. Chem. 273, 27587-27592.
    • (1998) J. Biol. Chem , vol.273 , pp. 27587-27592
    • Sun, H.1    Karow, J.K.2    Hickson, I.D.3    Maizels, N.4
  • 40
  • 41
    • 0034604545 scopus 로고    scopus 로고
    • Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity
    • Brosh, R. M. Jr., Li, J. L., Kenny, M. K., Karow, J. K., Cooper, M. P., Kureekattil, R. P., Hickson, I. D. and Bohr, V. A. (2000) Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity. J. Biol. Chem. 275, 23500-23508.
    • (2000) J. Biol. Chem , vol.275 , pp. 23500-23508
    • Brosh Jr., R.M.1    Li, J.L.2    Kenny, M.K.3    Karow, J.K.4    Cooper, M.P.5    Kureekattil, R.P.6    Hickson, I.D.7    Bohr, V.A.8
  • 42
    • 22444447945 scopus 로고    scopus 로고
    • The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA
    • Cheok, C. F., Wu, L., Garcia, P. L., Janscak, P. and Hickson, I. D. (2005) The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA. Nucleic Acids Res. 33, 3932-3941.
    • (2005) Nucleic Acids Res , vol.33 , pp. 3932-3941
    • Cheok, C.F.1    Wu, L.2    Garcia, P.L.3    Janscak, P.4    Hickson, I.D.5
  • 43
    • 20744437108 scopus 로고    scopus 로고
    • RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange
    • Machwe, A., Xiao, L., Groden, J., Matson, S. W. and Orren, D. K. (2005) RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange. J. Biol. Chem. 280, 23397-23407.
    • (2005) J. Biol. Chem , vol.280 , pp. 23397-23407
    • Machwe, A.1    Xiao, L.2    Groden, J.3    Matson, S.W.4    Orren, D.K.5
  • 45
    • 0037112611 scopus 로고    scopus 로고
    • The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha
    • Wu, L. and Hickson, I. D. (2002) The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha. Nucleic Acids Res. 30, 4823-4829.
    • (2002) Nucleic Acids Res , vol.30 , pp. 4823-4829
    • Wu, L.1    Hickson, I.D.2
  • 46
    • 0029986401 scopus 로고    scopus 로고
    • Human TOP3: A single-copy gene encoding DNA topoisomerase III
    • Hanai, R., Caron, P. R. and Wang, J. C. (1996) Human TOP3: a single-copy gene encoding DNA topoisomerase III. Proc. Natl. Acad. Sci. USA 93, 3653-3657.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3653-3657
    • Hanai, R.1    Caron, P.R.2    Wang, J.C.3
  • 48
    • 17844386117 scopus 로고    scopus 로고
    • BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity
    • Yin, J., Sobeck, A., Xu, C., Meetei, A. R., Hoatlin, M., Li, L. and Wang, W. (2005) BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity. EMBO J. 24, 1465-1476.
    • (2005) EMBO J , vol.24 , pp. 1465-1476
    • Yin, J.1    Sobeck, A.2    Xu, C.3    Meetei, A.R.4    Hoatlin, M.5    Li, L.6    Wang, W.7
  • 49
    • 18944395928 scopus 로고    scopus 로고
    • Yeast Rmi1/Nce4 controls genome stability as a subunit of the Sgs1-Top3 complex
    • Mullen, J. R., Nallaseth, F. S., Lan, Y. Q., Slagle, C. E. and Brill, S. J. (2005) Yeast Rmi1/Nce4 controls genome stability as a subunit of the Sgs1-Top3 complex. Mol. Cell. Biol. 25, 4476-4487.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 4476-4487
    • Mullen, J.R.1    Nallaseth, F.S.2    Lan, Y.Q.3    Slagle, C.E.4    Brill, S.J.5
  • 51
    • 0032999346 scopus 로고    scopus 로고
    • Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells
    • Sonoda, E., Sasaki, M. S., Morrison, C., Yamaguchi-Iwai, Y., Takata, M. and Takeda, S. (1999) Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells. Mol. Cell. Biol. 19, 5166-5169.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 5166-5169
    • Sonoda, E.1    Sasaki, M.S.2    Morrison, C.3    Yamaguchi-Iwai, Y.4    Takata, M.5    Takeda, S.6
  • 52
    • 0034600976 scopus 로고    scopus 로고
    • Possible association of BLM in decreasing DNA double strand breaks during DNA replication
    • Wang, W., Seki, M., Narita, Y., Sonoda, E., Takeda, S., Yamada, K., Masuko, T., Katada, T. and Enomoto, T. (2000) Possible association of BLM in decreasing DNA double strand breaks during DNA replication. EMBO J. 19, 3428-3435.
    • (2000) EMBO J , vol.19 , pp. 3428-3435
    • Wang, W.1    Seki, M.2    Narita, Y.3    Sonoda, E.4    Takeda, S.5    Yamada, K.6    Masuko, T.7    Katada, T.8    Enomoto, T.9
  • 54
    • 0037428069 scopus 로고    scopus 로고
    • Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing
    • Adams, M. D., McVey, M. and Sekelsky, J. J. (2003) Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing. Science 299, 265-267.
    • (2003) Science , vol.299 , pp. 265-267
    • Adams, M.D.1    McVey, M.2    Sekelsky, J.J.3
  • 55
    • 33750946794 scopus 로고    scopus 로고
    • Template disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants
    • Johnson-Schlitz, D. and Engels, W. R. (2006) Template disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants. Proc. Natl. Acad. Sci. USA 103, 16840-16845.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 16840-16845
    • Johnson-Schlitz, D.1    Engels, W.R.2
  • 56
    • 0347987856 scopus 로고    scopus 로고
    • The Bloom's syndrome helicase suppresses crossing over during homologous recombination
    • Wu, L. and Hickson, I. D. (2003) The Bloom's syndrome helicase suppresses crossing over during homologous recombination. Nature 426, 870-874.
    • (2003) Nature , vol.426 , pp. 870-874
    • Wu, L.1    Hickson, I.D.2
  • 58
    • 33744927719 scopus 로고    scopus 로고
    • A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75
    • Raynard, S., Bussen, W. and Sung, P. (2006) A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75. J. Biol. Chem. 281, 13861-13864.
    • (2006) J. Biol. Chem , vol.281 , pp. 13861-13864
    • Raynard, S.1    Bussen, W.2    Sung, P.3
  • 60
    • 33746600628 scopus 로고    scopus 로고
    • Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration
    • Plank, J. L., Wu, J. and Hsieh, T. S. (2006) Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration. Proc. Natl. Acad. Sci. USA 103, 11118-11123.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 11118-11123
    • Plank, J.L.1    Wu, J.2    Hsieh, T.S.3
  • 61
    • 0032721540 scopus 로고    scopus 로고
    • PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1
    • Ishov, A. M., Sotnikov, A. G., Negorev, D., Vladimirova, O. V., Neff, N., Kamitani, T., Yeh, E. T., Strauss, J. F. 3rd and Maul, G. G. (1999) PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1. J. Cell Biol. 147, 221-234.
    • (1999) J. Cell Biol , vol.147 , pp. 221-234
    • Ishov, A.M.1    Sotnikov, A.G.2    Negorev, D.3    Vladimirova, O.V.4    Neff, N.5    Kamitani, T.6    Yeh, E.T.7    Strauss 3rd, J.F.8    Maul, G.G.9
  • 62
    • 2342661679 scopus 로고    scopus 로고
    • The C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stability
    • Yankiwski, V., Noonan, J. P. and Neff, N. F. (2001) The C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stability. BMC Cell Biol. 2, 11.
    • (2001) BMC Cell Biol , vol.2 , pp. 11
    • Yankiwski, V.1    Noonan, J.P.2    Neff, N.F.3
  • 63
    • 0035897415 scopus 로고    scopus 로고
    • Regulation and localization of the Bloom syndrome protein in response to DNA damage
    • Bischof, O., Kim, S. H., Irving, J., Beresten, S., Ellis, N. A. and Campisi, J. (2001) Regulation and localization of the Bloom syndrome protein in response to DNA damage. J. Cell Biol. 153, 367-380.
    • (2001) J. Cell Biol , vol.153 , pp. 367-380
    • Bischof, O.1    Kim, S.H.2    Irving, J.3    Beresten, S.4    Ellis, N.A.5    Campisi, J.6
  • 64
    • 0033848907 scopus 로고    scopus 로고
    • The puzzling multiple lives of PML and its role in the genesis of cancer
    • Ruggero, D., Wang, Z. G. and Pandolfi, P. P. (2000) The puzzling multiple lives of PML and its role in the genesis of cancer. Bioessays 22, 827-835.
    • (2000) Bioessays , vol.22 , pp. 827-835
    • Ruggero, D.1    Wang, Z.G.2    Pandolfi, P.P.3
  • 65
    • 0036798404 scopus 로고    scopus 로고
    • Finding a role for PML in APL pathogenesis: A critical assessment of potential PML activities
    • Strudwick, S. and Borden, K. L. (2002) Finding a role for PML in APL pathogenesis: a critical assessment of potential PML activities. Leukemia 16, 1906-1917.
    • (2002) Leukemia , vol.16 , pp. 1906-1917
    • Strudwick, S.1    Borden, K.L.2
  • 66
    • 4644351274 scopus 로고    scopus 로고
    • PML nuclear bodies: Dynamic sensors of DNA damage and cellular stress
    • Dellaire, G. and Bazett-Jones, D. P. (2004) PML nuclear bodies: dynamic sensors of DNA damage and cellular stress. Bioessays 26, 963-977.
    • (2004) Bioessays , vol.26 , pp. 963-977
    • Dellaire, G.1    Bazett-Jones, D.P.2
  • 67
    • 0033545879 scopus 로고    scopus 로고
    • Bloom's syndrome protein, BLM, colocalizes with replication protein A in meiotic prophase nuclei of mammalian spermatocytes
    • Walpita, D., Plug, A. W., Neff, N. F., German, J. and Ashley, T. (1999) Bloom's syndrome protein, BLM, colocalizes with replication protein A in meiotic prophase nuclei of mammalian spermatocytes. Proc. Natl. Acad. Sci. USA 96, 5622-5627.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 5622-5627
    • Walpita, D.1    Plug, A.W.2    Neff, N.F.3    German, J.4    Ashley, T.5
  • 68
    • 1642458364 scopus 로고    scopus 로고
    • Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest
    • Davies, S. L., North, P. S., Dart, A., Lakin, N. D. and Hickson, I. D. (2004) Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest. Mol. Cell. Biol. 24, 1279-1291.
    • (2004) Mol. Cell. Biol , vol.24 , pp. 1279-1291
    • Davies, S.L.1    North, P.S.2    Dart, A.3    Lakin, N.D.4    Hickson, I.D.5
  • 69
    • 26444467122 scopus 로고    scopus 로고
    • Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage
    • Rao, V. A., Fan, A. M., Meng, L., Doe, C. F., North, P. S., Hickson, I. D. and Pommier, Y. (2005) Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage. Mol. Cell. Biol. 25, 8925-8937.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 8925-8937
    • Rao, V.A.1    Fan, A.M.2    Meng, L.3    Doe, C.F.4    North, P.S.5    Hickson, I.D.6    Pommier, Y.7
  • 70
    • 0035377356 scopus 로고    scopus 로고
    • Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51
    • Wu, L., Davies, S. L., Levitt, N. C. and Hickson, I. D. (2001) Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51. J. Biol. Chem. 276, 19375-19381.
    • (2001) J. Biol. Chem , vol.276 , pp. 19375-19381
    • Wu, L.1    Davies, S.L.2    Levitt, N.C.3    Hickson, I.D.4
  • 71
    • 0346993508 scopus 로고    scopus 로고
    • Constitutive DNA damage is linked to DNA replication abnormalities in Bloom's syndrome cells
    • Rassool, F. V., North, P. S., Mufti, G. J. and Hickson, I. D. (2003) Constitutive DNA damage is linked to DNA replication abnormalities in Bloom's syndrome cells. Oncogene 22, 8749-8757.
    • (2003) Oncogene , vol.22 , pp. 8749-8757
    • Rassool, F.V.1    North, P.S.2    Mufti, G.J.3    Hickson, I.D.4
  • 72
    • 0141864666 scopus 로고    scopus 로고
    • Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks
    • Davalos, A. R. and Campisi, J. (2003) Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks. J. Cell Biol. 162, 1197-1209.
    • (2003) J. Cell Biol , vol.162 , pp. 1197-1209
    • Davalos, A.R.1    Campisi, J.2
  • 73
    • 17144395509 scopus 로고    scopus 로고
    • ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation
    • Davalos, A. R., Kaminker, P., Hansen, R. K. and Campisi, J. (2004) ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation. Cell Cycle 3, 1579-1586.
    • (2004) Cell Cycle , vol.3 , pp. 1579-1586
    • Davalos, A.R.1    Kaminker, P.2    Hansen, R.K.3    Campisi, J.4
  • 76
    • 33747352774 scopus 로고    scopus 로고
    • The Bloom's syndrome helicase can promote the regression of a model replication fork
    • Ralf, C., Hickson, I. D. and Wu, L. (2006) The Bloom's syndrome helicase can promote the regression of a model replication fork. J. Biol. Chem. 281, 22839-22846.
    • (2006) J. Biol. Chem , vol.281 , pp. 22839-22846
    • Ralf, C.1    Hickson, I.D.2    Wu, L.3
  • 77
    • 0036544565 scopus 로고    scopus 로고
    • Bloom's syndrome protein is required for correct relocalization of RAD50/ MRE11/NBS1 complex after replication fork arrest
    • Franchitto, A. and Pichierri, P. (2002) Bloom's syndrome protein is required for correct relocalization of RAD50/ MRE11/NBS1 complex after replication fork arrest. J. Cell. Biol. 157, 19-30.
    • (2002) J. Cell. Biol , vol.157 , pp. 19-30
    • Franchitto, A.1    Pichierri, P.2
  • 78
    • 33746841515 scopus 로고    scopus 로고
    • MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability
    • Leng, M., Chan, D. W., Luo, H., Zhu, C., Qin, J. and Wang, Y. (2006) MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability. Proc. Natl. Acad. Sci. USA 103, 11485-11490.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 11485-11490
    • Leng, M.1    Chan, D.W.2    Luo, H.3    Zhu, C.4    Qin, J.5    Wang, Y.6
  • 80
    • 0032213939 scopus 로고    scopus 로고
    • Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene
    • Chester, N., Kuo, F., Kozak, C., O'Hara, C. D. and Leder, P. (1998) Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene. Genes Dev. 12, 3382-3393.
    • (1998) Genes Dev , vol.12 , pp. 3382-3393
    • Chester, N.1    Kuo, F.2    Kozak, C.3    O'Hara, C.D.4    Leder, P.5
  • 83
    • 33747751867 scopus 로고    scopus 로고
    • Mutation of the murine Bloom's syndrome gene produces global genome destabilization
    • Chester, N., Babbe, H., Pinkas, J., Manning, C. and Leder, P. (2006) Mutation of the murine Bloom's syndrome gene produces global genome destabilization. Mol. Cell. Biol. 26, 6713-6726.
    • (2006) Mol. Cell. Biol , vol.26 , pp. 6713-6726
    • Chester, N.1    Babbe, H.2    Pinkas, J.3    Manning, C.4    Leder, P.5
  • 84
    • 28544450724 scopus 로고    scopus 로고
    • Induction of renal tumorigenesis with elevated levels of somatic loss of heterozygosity in Tsc1+/- mice on a Blm-deficient background
    • Wilson, C., Idziaszczyk, S., Colley, J., Humphreys, V., Guy, C., Maynard, J., Sampson, J. R. and Cheadle, J. P. (2005) Induction of renal tumorigenesis with elevated levels of somatic loss of heterozygosity in Tsc1+/- mice on a Blm-deficient background. Cancer Res. 65, 10179-10182.
    • (2005) Cancer Res , vol.65 , pp. 10179-10182
    • Wilson, C.1    Idziaszczyk, S.2    Colley, J.3    Humphreys, V.4    Guy, C.5    Maynard, J.6    Sampson, J.R.7    Cheadle, J.P.8
  • 85
    • 33748060509 scopus 로고    scopus 로고
    • Tsc1 haploinsufficiency without mammalian target of rapamycin activation is sufficient for renal cyst formation in Tsc1+/- mice
    • Wilson, C., Bonnet, C., Guy, C., Idziaszczyk, S., Colley, J., Humphreys, V., Maynard, J., Sampson, J. R. and Cheadle, J. P. (2006) Tsc1 haploinsufficiency without mammalian target of rapamycin activation is sufficient for renal cyst formation in Tsc1+/- mice. Cancer Res. 66, 7934-7938.
    • (2006) Cancer Res , vol.66 , pp. 7934-7938
    • Wilson, C.1    Bonnet, C.2    Guy, C.3    Idziaszczyk, S.4    Colley, J.5    Humphreys, V.6    Maynard, J.7    Sampson, J.R.8    Cheadle, J.P.9
  • 86
    • 3042531072 scopus 로고    scopus 로고
    • Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells
    • Guo, G., Wang, W. and Bradley, A. (2004) Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells. Nature 429, 891-895.
    • (2004) Nature , vol.429 , pp. 891-895
    • Guo, G.1    Wang, W.2    Bradley, A.3
  • 87
    • 33746569501 scopus 로고    scopus 로고
    • Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice
    • Suzuki, T., Minehata, K., Akagi, K., Jenkins, N. A. and Copeland, N. G. (2006) Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice. EMBO J. 25, 3422-3431.
    • (2006) EMBO J , vol.25 , pp. 3422-3431
    • Suzuki, T.1    Minehata, K.2    Akagi, K.3    Jenkins, N.A.4    Copeland, N.G.5
  • 88
    • 0013907774 scopus 로고
    • Werner syndrome. A review of its symptomatology, natural history, pathlogic features, genetics and relationship to the natural aging process
    • Epstein, C. J., Martin, G. M., Schultz, A. L. and Motulsky, A. G. (1966) Werner syndrome. A review of its symptomatology, natural history, pathlogic features, genetics and relationship to the natural aging process. Medicine 45, 177-221.
    • (1966) Medicine , vol.45 , pp. 177-221
    • Epstein, C.J.1    Martin, G.M.2    Schultz, A.L.3    Motulsky, A.G.4
  • 89
    • 0030691121 scopus 로고    scopus 로고
    • Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing
    • Goto, M. (1997) Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing. Mech. Ageing Dev. 98, 239-254.
    • (1997) Mech. Ageing Dev , vol.98 , pp. 239-254
    • Goto, M.1
  • 93
  • 94
    • 0035799620 scopus 로고    scopus 로고
    • Diverged nuclear localization of Werner helicase in human and mouse cells
    • Suzuki, T., Shiratori, M., Furuichi, Y. and Matsumoto, T. (2001) Diverged nuclear localization of Werner helicase in human and mouse cells. Oncogene 20, 2551-2558.
    • (2001) Oncogene , vol.20 , pp. 2551-2558
    • Suzuki, T.1    Shiratori, M.2    Furuichi, Y.3    Matsumoto, T.4
  • 96
    • 0032526583 scopus 로고    scopus 로고
    • Characterization of Werner syndrome protein DNA helicase activity: Directionality, substrate dependence and stimulation by replication protein A
    • Shen, J. C., Gray, M. D., Oshima, J. and Loeb, L. A. (1998) Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A. Nucleic Acids Res. 26, 2879-2885.
    • (1998) Nucleic Acids Res , vol.26 , pp. 2879-2885
    • Shen, J.C.1    Gray, M.D.2    Oshima, J.3    Loeb, L.A.4
  • 97
    • 0032545423 scopus 로고    scopus 로고
    • Werner syndrome protein. II. Characterization of the integral 3′ -> 5′ DNA exonuclease
    • Kamath-Loeb, A. S., Shen, J. C., Loeb, L. A. and Fry, M. (1998) Werner syndrome protein. II. Characterization of the integral 3′ -> 5′ DNA exonuclease. J. Biol. Chem. 273, 34145-34150.
    • (1998) J. Biol. Chem , vol.273 , pp. 34145-34150
    • Kamath-Loeb, A.S.1    Shen, J.C.2    Loeb, L.A.3    Fry, M.4
  • 98
    • 0031686571 scopus 로고    scopus 로고
    • The premature ageing syndrome protein, WRN, is a 3′ -> 5′ exonuclease
    • Huang, S., Li, B., Gray, M. D., Oshima, J., Mian, I. S. and Campisi, J. (1998) The premature ageing syndrome protein, WRN, is a 3′ -> 5′ exonuclease. Nat. Genet. 20, 114-116.
    • (1998) Nat. Genet , vol.20 , pp. 114-116
    • Huang, S.1    Li, B.2    Gray, M.D.3    Oshima, J.4    Mian, I.S.5    Campisi, J.6
  • 99
  • 100
    • 0037189485 scopus 로고    scopus 로고
    • Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase
    • Brosh, R. M., Jr., Waheed, J. and Sommers, J. A. (2002) Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase. J. Biol. Chem. 277, 23236-23245.
    • (2002) J. Biol. Chem , vol.277 , pp. 23236-23245
    • Brosh Jr., R.M.1    Waheed, J.2    Sommers, J.A.3
  • 101
    • 0347362703 scopus 로고    scopus 로고
    • Werner syndrome protein contains three structure-specific DNA binding domains
    • von Kobbe, C., Thoma, N. H., Czyzewski, B. K., Pavletich, N. P. and Bohr, V. A. (2003) Werner syndrome protein contains three structure-specific DNA binding domains. J. Biol. Chem. 278, 52997-53006.
    • (2003) J. Biol. Chem , vol.278 , pp. 52997-53006
    • von Kobbe, C.1    Thoma, N.H.2    Czyzewski, B.K.3    Pavletich, N.P.4    Bohr, V.A.5
  • 102
    • 0034231844 scopus 로고    scopus 로고
    • Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPAupon replication arrest
    • 1, 80-84
    • Constantinou, A., Tarsounas, M., Karow, J. K., Brosh, R. M., Bohr, V. A., Hickson, I. D. and West, S. C. (2000) Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPAupon replication arrest. EMBO Rep. 1, 80-84.
    • (2000) EMBO Rep
    • Constantinou, A.1    Tarsounas, M.2    Karow, J.K.3    Brosh, R.M.4    Bohr, V.A.5    Hickson, I.D.6    West, S.C.7
  • 104
    • 0036714151 scopus 로고    scopus 로고
    • Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein
    • Li, B. and Comai, L. (2002) Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein. Nucleic Acids Res. 30, 3653-3661.
    • (2002) Nucleic Acids Res , vol.30 , pp. 3653-3661
    • Li, B.1    Comai, L.2
  • 106
    • 0034283889 scopus 로고    scopus 로고
    • Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA
    • Shen, J. C. and Loeb, L. A. (2000) Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA. Nucleic Acids Res. 28, 3260-3268.
    • (2000) Nucleic Acids Res , vol.28 , pp. 3260-3268
    • Shen, J.C.1    Loeb, L.A.2
  • 107
    • 0141567744 scopus 로고    scopus 로고
    • RecQ helicases: Suppressors of tumorigenesis and premature aging
    • Bachrati, C. Z. and Hickson, I. D. (2003) RecQ helicases: suppressors of tumorigenesis and premature aging. Biochem. J. 374, 577-606.
    • (2003) Biochem. J , vol.374 , pp. 577-606
    • Bachrati, C.Z.1    Hickson, I.D.2
  • 109
    • 10944225939 scopus 로고    scopus 로고
    • Pathways and functions of the Werner syndrome protein
    • Lee, J. W., Harrigan, J., Opresko, P. L. and Bohr, V. A. (2005) Pathways and functions of the Werner syndrome protein. Mech. Ageing Dev. 126, 79-86.
    • (2005) Mech. Ageing Dev , vol.126 , pp. 79-86
    • Lee, J.W.1    Harrigan, J.2    Opresko, P.L.3    Bohr, V.A.4
  • 110
    • 3543130605 scopus 로고    scopus 로고
    • Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells
    • Baird, D. M., Davis, T., Rowson, J., Jones, C. J. and Kipling, D. (2004) Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells. Hum. Mol. Genet. 13, 1515-1524.
    • (2004) Hum. Mol. Genet , vol.13 , pp. 1515-1524
    • Baird, D.M.1    Davis, T.2    Rowson, J.3    Jones, C.J.4    Kipling, D.5
  • 111
    • 0033545238 scopus 로고    scopus 로고
    • Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization
    • Shiratori, M., Sakamoto, S., Suzuki, N., Tokutake, Y., Kawabe, Y., Enomoto, T., Sugimoto, M., Goto, M., Matsumoto, T. and Furuichi, Y. (1999) Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization. J. Cell Biol. 144, 1-9.
    • (1999) J. Cell Biol , vol.144 , pp. 1-9
    • Shiratori, M.1    Sakamoto, S.2    Suzuki, N.3    Tokutake, Y.4    Kawabe, Y.5    Enomoto, T.6    Sugimoto, M.7    Goto, M.8    Matsumoto, T.9    Furuichi, Y.10
  • 112
    • 0035339672 scopus 로고    scopus 로고
    • A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA
    • Orren, D. K., Machwe, A., Karmakar, P., Piotrowski, J., Cooper, M. P. and Bohr, V. A. (2001) A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA. Nucleic Acids Res. 29, 1926-1934.
    • (2001) Nucleic Acids Res , vol.29 , pp. 1926-1934
    • Orren, D.K.1    Machwe, A.2    Karmakar, P.3    Piotrowski, J.4    Cooper, M.P.5    Bohr, V.A.6
  • 113
    • 0037102588 scopus 로고    scopus 로고
    • Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus
    • Karmakar, P., Snowden, C. M., Ramsden, D. A. and Bohr, V. A. (2002) Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus. Nucleic Acids Res. 30, 3583-3591.
    • (2002) Nucleic Acids Res , vol.30 , pp. 3583-3591
    • Karmakar, P.1    Snowden, C.M.2    Ramsden, D.A.3    Bohr, V.A.4
  • 114
    • 0037175018 scopus 로고    scopus 로고
    • Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases
    • Opresko, P. L., von Kobbe, C., Laine, J. P., Harrigan, J., Hickson, I. D. and Bohr, V. A. (2002) Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases. J. Biol. Chem. 277, 41110-41119.
    • (2002) J. Biol. Chem , vol.277 , pp. 41110-41119
    • Opresko, P.L.1    von Kobbe, C.2    Laine, J.P.3    Harrigan, J.4    Hickson, I.D.5    Bohr, V.A.6
  • 115
    • 2942637828 scopus 로고    scopus 로고
    • The Werner syndrome helicase and exonuclease cooperate to resolve telomeric Dloops in a manner regulated by TRF1 and TRF2
    • Opresko, P. L., Otterlei, M., Graakjaer, J., Bruheim, P., Dawut, L., Kolvraa, S., May, A., Seidman, M. M. and Bohr, V. A. (2004) The Werner syndrome helicase and exonuclease cooperate to resolve telomeric Dloops in a manner regulated by TRF1 and TRF2. Mol. Cell 14, 763-774.
    • (2004) Mol. Cell , vol.14 , pp. 763-774
    • Opresko, P.L.1    Otterlei, M.2    Graakjaer, J.3    Bruheim, P.4    Dawut, L.5    Kolvraa, S.6    May, A.7    Seidman, M.M.8    Bohr, V.A.9
  • 116
    • 0942290416 scopus 로고    scopus 로고
    • TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA
    • Machwe, A., Xiao, L. and Orren, D. K. (2004) TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA. Oncogene 23, 149-156.
    • (2004) Oncogene , vol.23 , pp. 149-156
    • Machwe, A.1    Xiao, L.2    Orren, D.K.3
  • 119
    • 0035865143 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase
    • Johnson, F. B., Marciniak, R. A., McVey, M., Stewart, S. A., Hahn, W. C. and Guarente, L. (2001) The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase. EMBO J. 20, 905-913.
    • (2001) EMBO J , vol.20 , pp. 905-913
    • Johnson, F.B.1    Marciniak, R.A.2    McVey, M.3    Stewart, S.A.4    Hahn, W.C.5    Guarente, L.6
  • 120
    • 0035853104 scopus 로고    scopus 로고
    • Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase
    • Cohen, H. and Sinclair, D. A. (2001) Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase. Proc. Natl. Acad. Sci. USA 98, 3174-3179.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 3174-3179
    • Cohen, H.1    Sinclair, D.A.2
  • 121
    • 32644444037 scopus 로고    scopus 로고
    • Evidence that the S. cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence
    • Azam, M., Lee, J. Y., Abraham, V., Chanoux, R., Schoenly, K. A. and Johnson, F. B. (2006) Evidence that the S. cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence. Nucleic Acids Res. 34, 506-516.
    • (2006) Nucleic Acids Res , vol.34 , pp. 506-516
    • Azam, M.1    Lee, J.Y.2    Abraham, V.3    Chanoux, R.4    Schoenly, K.A.5    Johnson, F.B.6
  • 122
    • 27644443332 scopus 로고    scopus 로고
    • Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway
    • Laud, P. R., Multani, A. S., Bailey, S. M., Wu, L., Ma, J., Kingsley, C., Lebel, M., Pathak, S., DePinho, R. A. and Chang, S. (2005) Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway. Genes Dev. 19, 2560-2570.
    • (2005) Genes Dev , vol.19 , pp. 2560-2570
    • Laud, P.R.1    Multani, A.S.2    Bailey, S.M.3    Wu, L.4    Ma, J.5    Kingsley, C.6    Lebel, M.7    Pathak, S.8    DePinho, R.A.9    Chang, S.10
  • 123
    • 10344256183 scopus 로고    scopus 로고
    • Defective telomere lagging strand synthesis in cells lacking WRN helicase activity
    • Crabbe, L., Verdun, R. E., Haggblom, C. I. and Karlseder, J. (2004) Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science 306, 1951-1953.
    • (2004) Science , vol.306 , pp. 1951-1953
    • Crabbe, L.1    Verdun, R.E.2    Haggblom, C.I.3    Karlseder, J.4
  • 124
    • 0036537074 scopus 로고    scopus 로고
    • Designer skin: Lineage commitment in postnatal epidermis
    • Niemann, C. and Watt, F. M. (2002) Designer skin: lineage commitment in postnatal epidermis. Trends Cell Biol. 12, 185-192.
    • (2002) Trends Cell Biol , vol.12 , pp. 185-192
    • Niemann, C.1    Watt, F.M.2
  • 125
    • 0036683057 scopus 로고    scopus 로고
    • Role of integrins in regulating epidermal adhesion, growth and differentiation
    • Watt, F. M. (2002) Role of integrins in regulating epidermal adhesion, growth and differentiation. EMBO J. 21, 3919-3926.
    • (2002) EMBO J , vol.21 , pp. 3919-3926
    • Watt, F.M.1
  • 126
    • 0030778620 scopus 로고    scopus 로고
    • c-Myc promotes differentiation of human epidermal stem cells
    • Gandarillas, A. and Watt, F. M. (1997) c-Myc promotes differentiation of human epidermal stem cells. Genes Dev. 11, 2869-2882.
    • (1997) Genes Dev , vol.11 , pp. 2869-2882
    • Gandarillas, A.1    Watt, F.M.2
  • 127
    • 0035901594 scopus 로고    scopus 로고
    • c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny
    • Arnold, I. and Watt, F. M. (2001) c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny. Curr. Biol. 11, 558-568.
    • (2001) Curr. Biol , vol.11 , pp. 558-568
    • Arnold, I.1    Watt, F.M.2
  • 129
    • 0032573157 scopus 로고    scopus 로고
    • A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
    • Lebel, M. and Leder, P. (1998) A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc. Natl. Acad. Sci. USA 95, 13097-13102.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 13097-13102
    • Lebel, M.1    Leder, P.2
  • 130
    • 0036200960 scopus 로고    scopus 로고
    • Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue
    • Lebel, M. (2002) Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue. Carcinogenesis 23, 213-216.
    • (2002) Carcinogenesis , vol.23 , pp. 213-216
    • Lebel, M.1
  • 131
    • 0242585417 scopus 로고    scopus 로고
    • Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice
    • Lebel, M., Lavoie, J., Gaudreault, I., Bronsard, M. and Drouin, R. (2003) Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice. Am. J. Pathol. 162, 1559-1569.
    • (2003) Am. J. Pathol , vol.162 , pp. 1559-1569
    • Lebel, M.1    Lavoie, J.2    Gaudreault, I.3    Bronsard, M.4    Drouin, R.5
  • 132
    • 0033978881 scopus 로고    scopus 로고
    • Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene
    • Wang, L., Ogburn, C. E., Ware, C. B., Ladiges, W. C., Youssoufian, H., Martin, G. M. and Oshima, J. (2000) Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene. Genetics 154, 357-362.
    • (2000) Genetics , vol.154 , pp. 357-362
    • Wang, L.1    Ogburn, C.E.2    Ware, C.B.3    Ladiges, W.C.4    Youssoufian, H.5    Martin, G.M.6    Oshima, J.7
  • 134
    • 0036233108 scopus 로고    scopus 로고
    • Preparation of the gene targeted knockout mice for human premature aging diseases, Werner syndrome, and Rothmund-Thomson syndrome caused by the mutation of DNA helicases
    • Ichikawa, K., Noda, T. and Furuichi, Y. (2002) Preparation of the gene targeted knockout mice for human premature aging diseases, Werner syndrome, and Rothmund-Thomson syndrome caused by the mutation of DNA helicases. Nippon Yakurigaku Zasshi 119, 219-226.
    • (2002) Nippon Yakurigaku Zasshi , vol.119 , pp. 219-226
    • Ichikawa, K.1    Noda, T.2    Furuichi, Y.3
  • 139
    • 0030820485 scopus 로고    scopus 로고
    • Human cancer and DNA repair-deficient diseases
    • Sarasin, A. and Stary, A. (1997) Human cancer and DNA repair-deficient diseases. Cancer Detect. Prev. 21, 406-411.
    • (1997) Cancer Detect. Prev , vol.21 , pp. 406-411
    • Sarasin, A.1    Stary, A.2
  • 140
    • 0034054019 scopus 로고    scopus 로고
    • Nucleotide excision repair and human syndromes
    • de Boer, J. and Hoeijmakers, J. H. (2000) Nucleotide excision repair and human syndromes. Carcinogenesis 21, 453-460.
    • (2000) Carcinogenesis , vol.21 , pp. 453-460
    • de Boer, J.1    Hoeijmakers, J.H.2
  • 141
    • 0035827305 scopus 로고    scopus 로고
    • The 14th Datta Lecture. TFIIH: From transcription to clinic
    • Egly, J. M. (2001) The 14th Datta Lecture. TFIIH: from transcription to clinic. FEBS Lett. 498, 124-128.
    • (2001) FEBS Lett , vol.498 , pp. 124-128
    • Egly, J.M.1
  • 142
    • 0942268166 scopus 로고    scopus 로고
    • DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy
    • Lehmann, A. R. (2003) DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy. Biochimie 85, 1101-1111.
    • (2003) Biochimie , vol.85 , pp. 1101-1111
    • Lehmann, A.R.1
  • 143
    • 30344477373 scopus 로고    scopus 로고
    • Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome
    • Macris, M. A., Krejci, L., Bussen, W., Shimamoto, A. and Sung, P. (2006) Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome. DNA Repair (Amst) 5, 172-180.
    • (2006) DNA Repair (Amst) , vol.5 , pp. 172-180
    • Macris, M.A.1    Krejci, L.2    Bussen, W.3    Shimamoto, A.4    Sung, P.5
  • 144
    • 3543007196 scopus 로고    scopus 로고
    • Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide
    • Garcia, P. L., Liu, Y., Jiricny, J., West, S. C. and Janscak, P. (2004) Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide. EMBO J. 23, 2882-2891.
    • (2004) EMBO J , vol.23 , pp. 2882-2891
    • Garcia, P.L.1    Liu, Y.2    Jiricny, J.3    West, S.C.4    Janscak, P.5
  • 146
    • 27144460601 scopus 로고    scopus 로고
    • The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability
    • Petkovic, M., Dietschy, T., Freire, R., Jiao, R. and Stagljar, I. (2005) The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability. J. Cell Sci. 118, 4261-4269.
    • (2005) J. Cell Sci , vol.118 , pp. 4261-4269
    • Petkovic, M.1    Dietschy, T.2    Freire, R.3    Jiao, R.4    Stagljar, I.5
  • 148
    • 33646048761 scopus 로고    scopus 로고
    • Recql4 haploinsufficiency in mice leads to defects in osteoblast progenitors: Implications for low bone mass phenotype
    • Yang, J., Murthy, S., Winata, T., Werner, S., Abe, M., Prahalad, A. K. and Hock, J. M. (2006) Recql4 haploinsufficiency in mice leads to defects in osteoblast progenitors: Implications for low bone mass phenotype. Biochem. Biophys. Res. Commun. 344, 346-352.
    • (2006) Biochem. Biophys. Res. Commun , vol.344 , pp. 346-352
    • Yang, J.1    Murthy, S.2    Winata, T.3    Werner, S.4    Abe, M.5    Prahalad, A.K.6    Hock, J.M.7
  • 149
    • 15544389502 scopus 로고    scopus 로고
    • Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome
    • Mann, M. B., Hodges, C. A., Barnes, E., Vogel, H., Hassold, T. J. and Luo, G. (2005) Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome. Hum. Mol. Genet. 14, 813-825.
    • (2005) Hum. Mol. Genet , vol.14 , pp. 813-825
    • Mann, M.B.1    Hodges, C.A.2    Barnes, E.3    Vogel, H.4    Hassold, T.J.5    Luo, G.6
  • 150
    • 33748744378 scopus 로고    scopus 로고
    • Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability
    • Sharma, S., Doherty, K. M. and Brosh, R. M. Jr. (2006) Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem. J. 398, 319-337.
    • (2006) Biochem. J , vol.398 , pp. 319-337
    • Sharma, S.1    Doherty, K.M.2    Brosh Jr., R.M.3
  • 153
    • 0034164070 scopus 로고    scopus 로고
    • Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta
    • Shimamoto, A., Nishikawa, K., Kitao, S. and Furuichi, Y. (2000) Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta. Nucleic Acids Res. 28, 1647-1655.
    • (2000) Nucleic Acids Res , vol.28 , pp. 1647-1655
    • Shimamoto, A.1    Nishikawa, K.2    Kitao, S.3    Furuichi, Y.4
  • 154
    • 33750980979 scopus 로고    scopus 로고
    • Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork
    • Kanagaraj, R., Saydam, N., Garcia, P. L., Zheng, L. and Janscak, P. (2006) Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork. Nucleic Acids Res. 34, 5217-5231.
    • (2006) Nucleic Acids Res , vol.34 , pp. 5217-5231
    • Kanagaraj, R.1    Saydam, N.2    Garcia, P.L.3    Zheng, L.4    Janscak, P.5
  • 155
    • 17644410077 scopus 로고    scopus 로고
    • Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers
    • Hu, Y., Lu, X., Barnes, E., Yan, M., Lou, H. and Luo, G. (2005) Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers. Mol. Cell. Biol. 25, 3431-3442.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 3431-3442
    • Hu, Y.1    Lu, X.2    Barnes, E.3    Yan, M.4    Lou, H.5    Luo, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.