-
1
-
-
0021792806
-
The recQ gene of Escherichia coli K12: Molecular cloning and isolation of insertion mutants
-
Nakayama, K., Irino, N. and Nakayama, H. (1985) The recQ gene of Escherichia coli K12: molecular cloning and isolation of insertion mutants. Mol. Gen. Genet. 200, 266-271.
-
(1985)
Mol. Gen. Genet
, vol.200
, pp. 266-271
-
-
Nakayama, K.1
Irino, N.2
Nakayama, H.3
-
2
-
-
0024991930
-
Escherichia coli RecQ protein is a DNA helicase
-
Umezu, K., Nakayama, K. and Nakayama, H. (1990) Escherichia coli RecQ protein is a DNA helicase. Proc. Natl. Acad. Sci. USA 87, 5363-5367.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 5363-5367
-
-
Umezu, K.1
Nakayama, K.2
Nakayama, H.3
-
3
-
-
0030888233
-
RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli
-
Hanada, K., Ukita, T., Kohno, Y., Saito, K., Kato, J. and Ikeda, H. (1997) RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli. Proc. Natl. Acad. Sci. USA 94, 3860-3865.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 3860-3865
-
-
Hanada, K.1
Ukita, T.2
Kohno, Y.3
Saito, K.4
Kato, J.5
Ikeda, H.6
-
4
-
-
0028033989
-
The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: A potential eukaryotic reverse gyrase
-
Gangloff, S., McDonald, J. P., Bendixen, C., Arthur, L. and Rothstein, R. (1994) The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase. Mol. Cell. Biol. 14, 8391-8398.
-
(1994)
Mol. Cell. Biol
, vol.14
, pp. 8391-8398
-
-
Gangloff, S.1
McDonald, J.P.2
Bendixen, C.3
Arthur, L.4
Rothstein, R.5
-
5
-
-
0027331383
-
Bloom syndrome: A mendelian prototype of somatic mutation disease
-
German, J. (1993) Bloom syndrome: a mendelian prototype of somatic mutation disease. Medicine 72, 393-406.
-
(1993)
Medicine
, vol.72
, pp. 393-406
-
-
German, J.1
-
6
-
-
0024465870
-
Mutator phenotype of Werner syndrome is characterized by extensive deletions
-
Fukuchi, K., Martin, G. M. and Monnat, R. J. Jr. (1989) Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc. Natl. Acad. Sci. USA 86, 5893-5897.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 5893-5897
-
-
Fukuchi, K.1
Martin, G.M.2
Monnat Jr., R.J.3
-
7
-
-
0034737004
-
Rothmund-Thomson syndrome due to RECQ4helicase mutations: Report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome
-
Lindor, N. M., Furuichi, Y., Kitao, S., Shimamoto, A., Arndt, C. and Jalal, S. (2000) Rothmund-Thomson syndrome due to RECQ4helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome. Am. J. Med. Genet. 90, 223-228.
-
(2000)
Am. J. Med. Genet
, vol.90
, pp. 223-228
-
-
Lindor, N.M.1
Furuichi, Y.2
Kitao, S.3
Shimamoto, A.4
Arndt, C.5
Jalal, S.6
-
8
-
-
0037115947
-
RecQ family helicases: Roles as tumor suppressor proteins
-
Nakayama, H. (2002) RecQ family helicases: roles as tumor suppressor proteins. Oncogene 21, 9008-9021.
-
(2002)
Oncogene
, vol.21
, pp. 9008-9021
-
-
Nakayama, H.1
-
9
-
-
0033046015
-
Evolution of the RECQ family of helicases: A Drosophila homolog, Dmblm, is similar to the human bloom syndrome gene
-
Kusano, K., Berres, M. E. and Engels, W. R. (1999) Evolution of the RECQ family of helicases: A Drosophila homolog, Dmblm, is similar to the human bloom syndrome gene. Genetics 151, 1027-1039.
-
(1999)
Genetics
, vol.151
, pp. 1027-1039
-
-
Kusano, K.1
Berres, M.E.2
Engels, W.R.3
-
10
-
-
0028061993
-
Molecular cloning of cDNA encoding human DNA helicase Q1 which has homology to Escherichia coli Rec Q helicase and localization of the gene at chromosome 12p12
-
Seki, M., Miyazawa, H., Tada, S., Yanagisawa, J., Yamaoka, T., Hoshino, S., Ozawa, K., Eki, T., Nogami, M., Okumura, K., Taguchi, H., Hanaoka, F. and Enomoto, T. (1994) Molecular cloning of cDNA encoding human DNA helicase Q1 which has homology to Escherichia coli Rec Q helicase and localization of the gene at chromosome 12p12. Nucleic Acids Res. 22, 4566-4573.
-
(1994)
Nucleic Acids Res
, vol.22
, pp. 4566-4573
-
-
Seki, M.1
Miyazawa, H.2
Tada, S.3
Yanagisawa, J.4
Yamaoka, T.5
Hoshino, S.6
Ozawa, K.7
Eki, T.8
Nogami, M.9
Okumura, K.10
Taguchi, H.11
Hanaoka, F.12
Enomoto, T.13
-
11
-
-
0027942415
-
Cloning and characterization of RECQL, a potential human homologue of the Escherichia coli DNA helicase RecQ
-
Puranam, K. L. and Blackshear, P. J. (1994) Cloning and characterization of RECQL, a potential human homologue of the Escherichia coli DNA helicase RecQ. J. Biol. Chem. 269, 29838-29845.
-
(1994)
J. Biol. Chem
, vol.269
, pp. 29838-29845
-
-
Puranam, K.L.1
Blackshear, P.J.2
-
12
-
-
0028785586
-
The Bloom's syndrome gene product is homologous toRecQ helicases
-
Ellis, N. A., Groden, J., Ye, T. Z., Straughen, J., Lennon, D. J., Ciocci, S., Proytcheva, M. and German, J. (1995) The Bloom's syndrome gene product is homologous toRecQ helicases. Cell 83, 655-666.
-
(1995)
Cell
, vol.83
, pp. 655-666
-
-
Ellis, N.A.1
Groden, J.2
Ye, T.Z.3
Straughen, J.4
Lennon, D.J.5
Ciocci, S.6
Proytcheva, M.7
German, J.8
-
13
-
-
15844409553
-
Positional cloning of the Werner's syndrome gene
-
Yu, C. E., Oshima, J., Fu, Y. H., Wijsman, E. M., Hisama, F., Alisch, R., Matthews, S., Nakura, J., Miki, T., Ouais, S., Martin, G. M., Mulligan, J. and Schellenberg, G. D. (1996) Positional cloning of the Werner's syndrome gene. Science 272, 258-262.
-
(1996)
Science
, vol.272
, pp. 258-262
-
-
Yu, C.E.1
Oshima, J.2
Fu, Y.H.3
Wijsman, E.M.4
Hisama, F.5
Alisch, R.6
Matthews, S.7
Nakura, J.8
Miki, T.9
Ouais, S.10
Martin, G.M.11
Mulligan, J.12
Schellenberg, G.D.13
-
14
-
-
0032535661
-
Cloning of two new human helicase genes of the RecQ family: Biological significance of multiple species in higher eukaryotes
-
Kitao, S., Ohsugi, I., Ichikawa, K., Goto, M., Furuichi, Y. and Shimamoto, A. (1998) Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes. Genomics 54, 443-452.
-
(1998)
Genomics
, vol.54
, pp. 443-452
-
-
Kitao, S.1
Ohsugi, I.2
Ichikawa, K.3
Goto, M.4
Furuichi, Y.5
Shimamoto, A.6
-
15
-
-
0032736140
-
Rothmund-Thomson syndrome responsible gene, RECQL4: Genomic structure and products
-
Kitao, S., Lindor, N. M., Shiratori, M., Furuichi, Y. and Shimamoto, A. (1999) Rothmund-Thomson syndrome responsible gene, RECQL4: genomic structure and products. Genomics 61, 268-276.
-
(1999)
Genomics
, vol.61
, pp. 268-276
-
-
Kitao, S.1
Lindor, N.M.2
Shiratori, M.3
Furuichi, Y.4
Shimamoto, A.5
-
16
-
-
0242609126
-
Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases
-
Siitonen, H. A., Kopra, O., Kaariainen, H., Haravuori, H., Winter, R. M., Saamanen, A. M., Peltonen, L. and Kestila, M. (2003) Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases. Hum. Mol. Genet. 12, 2837-2844.
-
(2003)
Hum. Mol. Genet
, vol.12
, pp. 2837-2844
-
-
Siitonen, H.A.1
Kopra, O.2
Kaariainen, H.3
Haravuori, H.4
Winter, R.M.5
Saamanen, A.M.6
Peltonen, L.7
Kestila, M.8
-
17
-
-
32944476196
-
Revisiting the craniosynostosis-radial ray hypoplasia association: Baller-Gerold syndrome caused by mutations in the RECQL4 gene
-
Van Maldergem, L., Siitonen, H. A., Jalkh, N., Chouery, E., De Roy, M., Delague, V., Muenke, M., Jabs, E. W., Cai, J., Wang, L. L., Plon, S. E., Fourneau, C., Kestila, M., Gillerot, Y., Megarbane, A. and Verloes, A. (2006) Revisiting the craniosynostosis-radial ray hypoplasia association: Baller-Gerold syndrome caused by mutations in the RECQL4 gene. J. Med. Genet. 43, 148-152.
-
(2006)
J. Med. Genet
, vol.43
, pp. 148-152
-
-
Van Maldergem, L.1
Siitonen, H.A.2
Jalkh, N.3
Chouery, E.4
De Roy, M.5
Delague, V.6
Muenke, M.7
Jabs, E.W.8
Cai, J.9
Wang, L.L.10
Plon, S.E.11
Fourneau, C.12
Kestila, M.13
Gillerot, Y.14
Megarbane, A.15
Verloes, A.16
-
18
-
-
0001542940
-
Chromosomal breakage in a rare and probably genetically determined syndrome of man
-
German, J., Archibald, R. and Bloom, D. (1965) Chromosomal breakage in a rare and probably genetically determined syndrome of man. Science 148, 506-507.
-
(1965)
Science
, vol.148
, pp. 506-507
-
-
German, J.1
Archibald, R.2
Bloom, D.3
-
19
-
-
4444312648
-
The function of RecQ helicase gene family (especially BLM) in DNA recombination and joining
-
Kaneko, H., Fukao, T. and Kondo, N. (2004) The function of RecQ helicase gene family (especially BLM) in DNA recombination and joining. Adv. Biophys. 38, 45-64.
-
(2004)
Adv. Biophys
, vol.38
, pp. 45-64
-
-
Kaneko, H.1
Fukao, T.2
Kondo, N.3
-
20
-
-
0035425563
-
Successful pregnancy in a woman with Bloom syndrome
-
Chisholm, C. A., Bray, M. J. and Karns, L. B. (2001) Successful pregnancy in a woman with Bloom syndrome. Am. J. Med. Genet. 102, 136-138.
-
(2001)
Am. J. Med. Genet
, vol.102
, pp. 136-138
-
-
Chisholm, C.A.1
Bray, M.J.2
Karns, L.B.3
-
21
-
-
0020619254
-
-
Vijayalaxmi, Evans, H. J., Ray, J. H. and German, J. (1983) Bloom's syndrome: evidence for an increased mutation frequency in vivo. Science 221, 851-853.
-
Vijayalaxmi, Evans, H. J., Ray, J. H. and German, J. (1983) Bloom's syndrome: evidence for an increased mutation frequency in vivo. Science 221, 851-853.
-
-
-
-
22
-
-
3142544243
-
Evidence for increased in vivo mutation and somatic recombination in Bloom's syndrome
-
Langlois, R. G., Bigbee, W. L., Jensen, R. H. and German, J. (1989) Evidence for increased in vivo mutation and somatic recombination in Bloom's syndrome. Proc. Natl. Acad. Sci. USA 86, 670-674.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 670-674
-
-
Langlois, R.G.1
Bigbee, W.L.2
Jensen, R.H.3
German, J.4
-
23
-
-
0022364961
-
Evidence for chromosome instability in vivo in Bloom syndrome: Increased numbers of micronuclei in exfoliated cells
-
Rosin, M. P. and German, J. (1985) Evidence for chromosome instability in vivo in Bloom syndrome: increased numbers of micronuclei in exfoliated cells. Hum. Genet . 71, 187-191.
-
(1985)
Hum. Genet
, vol.71
, pp. 187-191
-
-
Rosin, M.P.1
German, J.2
-
24
-
-
0347320803
-
Hyperrecombination and genetic instability in BLM-deficient epithelial cells
-
Traverso, G., Bettegowda, C., Kraus, J., Speicher, M. R., Kinzler, K. W., Vogelstein, B. and Lengauer, C. (2003) Hyperrecombination and genetic instability in BLM-deficient epithelial cells. Cancer Res. 63, 8578-8581.
-
(2003)
Cancer Res
, vol.63
, pp. 8578-8581
-
-
Traverso, G.1
Bettegowda, C.2
Kraus, J.3
Speicher, M.R.4
Kinzler, K.W.5
Vogelstein, B.6
Lengauer, C.7
-
25
-
-
0346351375
-
A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes
-
Chaganti, R. S., Schonberg, S. and German, J. (1974) A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes. Proc. Natl. Acad. Sci. USA 71, 4508-4512.
-
(1974)
Proc. Natl. Acad. Sci. USA
, vol.71
, pp. 4508-4512
-
-
Chaganti, R.S.1
Schonberg, S.2
German, J.3
-
26
-
-
0021741404
-
Bloom's syndrome and EM9 cells in BrdU-containing medium exhibit similarly elevated frequencies of sister chromatid exchange but dissimilar amounts of cellular proliferation and chromosome disruption
-
Ray, J. H. and German, J. (1984) Bloom's syndrome and EM9 cells in BrdU-containing medium exhibit similarly elevated frequencies of sister chromatid exchange but dissimilar amounts of cellular proliferation and chromosome disruption. Chromosoma 90, 383-388.
-
(1984)
Chromosoma
, vol.90
, pp. 383-388
-
-
Ray, J.H.1
German, J.2
-
27
-
-
0033667704
-
Cancer predisposition caused by elevated mitotic recombination in Bloom mice
-
Luo, G., Santoro, I. M., McDaniel, L. D., Nishijima, I., Mills, M., Youssoufian, H., Vogel, H., Schultz, R. A. and Bradley, A. (2000) Cancer predisposition caused by elevated mitotic recombination in Bloom mice. Nat. Genet. 26, 424-429.
-
(2000)
Nat. Genet
, vol.26
, pp. 424-429
-
-
Luo, G.1
Santoro, I.M.2
McDaniel, L.D.3
Nishijima, I.4
Mills, M.5
Youssoufian, H.6
Vogel, H.7
Schultz, R.A.8
Bradley, A.9
-
28
-
-
3042575122
-
Genome-wide phenotype analysis in ES cells by regulated disruption of Bloom's syndrome gene
-
Yusa, K., Horie, K., Kondoh, G., Kouno, M., Maeda, Y., Kinoshita, T. and Takeda, J. (2004) Genome-wide phenotype analysis in ES cells by regulated disruption of Bloom's syndrome gene. Nature 429, 896-899.
-
(2004)
Nature
, vol.429
, pp. 896-899
-
-
Yusa, K.1
Horie, K.2
Kondoh, G.3
Kouno, M.4
Maeda, Y.5
Kinoshita, T.6
Takeda, J.7
-
29
-
-
0017705228
-
Bloom's syndrome. VI. The disorder in Israel and an estimation of the gene frequency in the Ashkenazim
-
German, J., Bloom, D., Passarge, E., Fried, K., Goodman, R. M., Katzenellenbogen, I., Laron, Z., Legum, C., Levin, S. and Wahrman (1977) Bloom's syndrome. VI. The disorder in Israel and an estimation of the gene frequency in the Ashkenazim. Am. J. Hum. Genet. 29, 553-562.
-
(1977)
Am. J. Hum. Genet
, vol.29
, pp. 553-562
-
-
German, J.1
Bloom, D.2
Passarge, E.3
Fried, K.4
Goodman, R.M.5
Katzenellenbogen, I.6
Laron, Z.7
Legum, C.8
Levin, S.9
Wahrman10
-
30
-
-
0034182744
-
Characterization of the nuclear localization signal in the DNA helicase responsible for Bloom syndrome
-
Hayakawa, S., Kaneko, H., Fukao, T., Kasahara, K., Matsumoto, T., Furuichi, Y. and Kondo, N. (2000) Characterization of the nuclear localization signal in the DNA helicase responsible for Bloom syndrome. Int. J. Mol. Med. 5, 477-484.
-
(2000)
Int. J. Mol. Med
, vol.5
, pp. 477-484
-
-
Hayakawa, S.1
Kaneko, H.2
Fukao, T.3
Kasahara, K.4
Matsumoto, T.5
Furuichi, Y.6
Kondo, N.7
-
31
-
-
0034203273
-
Identification of a novel BLM missense mutation (2706T>C) in a Moroccan patient with Bloom's syndrome
-
Barakat, A., Ababou, M., Onclercq, R., Dutertre, S., Chadli, E., Hda, N., Benslimane, A. and Amor-Gueret, M. (2000) Identification of a novel BLM missense mutation (2706T>C) in a Moroccan patient with Bloom's syndrome. Hum. Mutat. 15, 584-585.
-
(2000)
Hum. Mutat
, vol.15
, pp. 584-585
-
-
Barakat, A.1
Ababou, M.2
Onclercq, R.3
Dutertre, S.4
Chadli, E.5
Hda, N.6
Benslimane, A.7
Amor-Gueret, M.8
-
32
-
-
19844372703
-
Structural and functional characterizations reveal the importance of a zinc binding domain in Bloom's syndrome helicase
-
Guo, R. B., Rigolet, P., Zargarian, L., Fermandjian, S. and Xi, X. G. (2005) Structural and functional characterizations reveal the importance of a zinc binding domain in Bloom's syndrome helicase. Nucleic Acids Res. 33, 3109-3124.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 3109-3124
-
-
Guo, R.B.1
Rigolet, P.2
Zargarian, L.3
Fermandjian, S.4
Xi, X.G.5
-
33
-
-
0031678636
-
Carrier frequency of the Bloom syndrome blmAsh mutation in the Ashkenazi Jewish population
-
Li, L., Eng, C., Desnick, R. J., German, J. and Ellis, N. A. (1998) Carrier frequency of the Bloom syndrome blmAsh mutation in the Ashkenazi Jewish population. Mol. Genet. Metab. 64, 286-290.
-
(1998)
Mol. Genet. Metab
, vol.64
, pp. 286-290
-
-
Li, L.1
Eng, C.2
Desnick, R.J.3
German, J.4
Ellis, N.A.5
-
34
-
-
0032471419
-
The Ashkenazic Jewish Bloom syndrome mutation blmAsh is present in non-Jewish Americans of Spanish ancestry
-
Ellis, N. A., Ciocci, S., Proytcheva, M., Lennon, D., Groden, J. and German, J. (1998) The Ashkenazic Jewish Bloom syndrome mutation blmAsh is present in non-Jewish Americans of Spanish ancestry. Am. J. Hum. Genet. 63, 1685-1693.
-
(1998)
Am. J. Hum. Genet
, vol.63
, pp. 1685-1693
-
-
Ellis, N.A.1
Ciocci, S.2
Proytcheva, M.3
Lennon, D.4
Groden, J.5
German, J.6
-
35
-
-
0030686496
-
The Bloom's syndrome gene product is a 3′-5′ DNA helicase
-
Karow, J. K., Chakraverty, R. K. and Hickson, I. D. (1997) The Bloom's syndrome gene product is a 3′-5′ DNA helicase. J. Biol. Chem. 272, 30611-30614.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 30611-30614
-
-
Karow, J.K.1
Chakraverty, R.K.2
Hickson, I.D.3
-
36
-
-
0035393720
-
The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases
-
Mohaghegh, P., Karow, J. K., Brosh R. M. Jr., Bohr, V. A. and Hickson, I. D. (2001) The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases. Nucleic Acids Res. 29, 2843-2849.
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 2843-2849
-
-
Mohaghegh, P.1
Karow, J.K.2
Brosh Jr., R.M.3
Bohr, V.A.4
Hickson, I.D.5
-
37
-
-
0035909817
-
Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands
-
Li, J. L., Harrison, R. J., Reszka, A. P., Brosh, R. M. Jr., Bohr, V. A., Neidle, S. and Hickson, I. D. (2001) Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands. Biochemistry 40, 15194-15202.
-
(2001)
Biochemistry
, vol.40
, pp. 15194-15202
-
-
Li, J.L.1
Harrison, R.J.2
Reszka, A.P.3
Brosh Jr., R.M.4
Bohr, V.A.5
Neidle, S.6
Hickson, I.D.7
-
38
-
-
33646843592
-
Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase
-
Bachrati, C. Z., Borts, R. H. and Hickson, I. D. (2006) Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase. Nucleic Acids Res. 34, 2269-2279.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 2269-2279
-
-
Bachrati, C.Z.1
Borts, R.H.2
Hickson, I.D.3
-
39
-
-
0032538453
-
The Bloom's syndrome helicase unwinds G4 DNA
-
Sun, H., Karow, J. K., Hickson, I. D. and Maizels, N. (1998) The Bloom's syndrome helicase unwinds G4 DNA. J. Biol. Chem. 273, 27587-27592.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 27587-27592
-
-
Sun, H.1
Karow, J.K.2
Hickson, I.D.3
Maizels, N.4
-
40
-
-
0034612333
-
The Bloom's syndrome gene product promotes branch migration of holliday junctions
-
Karow, J. K., Constantinou, A., Li, J. L., West, S. C. and Hickson, I. D. (2000) The Bloom's syndrome gene product promotes branch migration of holliday junctions. Proc. Natl. Acad. Sci. USA 97, 6504-6508.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 6504-6508
-
-
Karow, J.K.1
Constantinou, A.2
Li, J.L.3
West, S.C.4
Hickson, I.D.5
-
41
-
-
0034604545
-
Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity
-
Brosh, R. M. Jr., Li, J. L., Kenny, M. K., Karow, J. K., Cooper, M. P., Kureekattil, R. P., Hickson, I. D. and Bohr, V. A. (2000) Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity. J. Biol. Chem. 275, 23500-23508.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 23500-23508
-
-
Brosh Jr., R.M.1
Li, J.L.2
Kenny, M.K.3
Karow, J.K.4
Cooper, M.P.5
Kureekattil, R.P.6
Hickson, I.D.7
Bohr, V.A.8
-
42
-
-
22444447945
-
The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA
-
Cheok, C. F., Wu, L., Garcia, P. L., Janscak, P. and Hickson, I. D. (2005) The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA. Nucleic Acids Res. 33, 3932-3941.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 3932-3941
-
-
Cheok, C.F.1
Wu, L.2
Garcia, P.L.3
Janscak, P.4
Hickson, I.D.5
-
43
-
-
20744437108
-
RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange
-
Machwe, A., Xiao, L., Groden, J., Matson, S. W. and Orren, D. K. (2005) RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange. J. Biol. Chem. 280, 23397-23407.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 23397-23407
-
-
Machwe, A.1
Xiao, L.2
Groden, J.3
Matson, S.W.4
Orren, D.K.5
-
44
-
-
0034737641
-
The Bloom's syndrome gene product interacts with topoisomerase III
-
Wu, L., Davies, S. L., North, P. S., Goulaouic, H., Riou, J. F., Turley, H., Gatter, K. C. and Hickson, I. D. (2000) The Bloom's syndrome gene product interacts with topoisomerase III. J. Biol. Chem. 275, 9636-9644.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 9636-9644
-
-
Wu, L.1
Davies, S.L.2
North, P.S.3
Goulaouic, H.4
Riou, J.F.5
Turley, H.6
Gatter, K.C.7
Hickson, I.D.8
-
45
-
-
0037112611
-
The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha
-
Wu, L. and Hickson, I. D. (2002) The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha. Nucleic Acids Res. 30, 4823-4829.
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 4823-4829
-
-
Wu, L.1
Hickson, I.D.2
-
46
-
-
0029986401
-
Human TOP3: A single-copy gene encoding DNA topoisomerase III
-
Hanai, R., Caron, P. R. and Wang, J. C. (1996) Human TOP3: a single-copy gene encoding DNA topoisomerase III. Proc. Natl. Acad. Sci. USA 93, 3653-3657.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 3653-3657
-
-
Hanai, R.1
Caron, P.R.2
Wang, J.C.3
-
47
-
-
0038642027
-
A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome
-
Meetei, A. R., Sechi, S., Wallisch, M., Yang, D., Young, M. K., Joenje, H., Hoatlin, M. E. and Wang, W. (2003) A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. Mol. Cell. Biol. 23, 3417-3426.
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 3417-3426
-
-
Meetei, A.R.1
Sechi, S.2
Wallisch, M.3
Yang, D.4
Young, M.K.5
Joenje, H.6
Hoatlin, M.E.7
Wang, W.8
-
48
-
-
17844386117
-
BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity
-
Yin, J., Sobeck, A., Xu, C., Meetei, A. R., Hoatlin, M., Li, L. and Wang, W. (2005) BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity. EMBO J. 24, 1465-1476.
-
(2005)
EMBO J
, vol.24
, pp. 1465-1476
-
-
Yin, J.1
Sobeck, A.2
Xu, C.3
Meetei, A.R.4
Hoatlin, M.5
Li, L.6
Wang, W.7
-
49
-
-
18944395928
-
Yeast Rmi1/Nce4 controls genome stability as a subunit of the Sgs1-Top3 complex
-
Mullen, J. R., Nallaseth, F. S., Lan, Y. Q., Slagle, C. E. and Brill, S. J. (2005) Yeast Rmi1/Nce4 controls genome stability as a subunit of the Sgs1-Top3 complex. Mol. Cell. Biol. 25, 4476-4487.
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 4476-4487
-
-
Mullen, J.R.1
Nallaseth, F.S.2
Lan, Y.Q.3
Slagle, C.E.4
Brill, S.J.5
-
50
-
-
21244434850
-
RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/ Topo III complex
-
Chang, M., Bellaoui, M., Zhang, C., Desai, R., Morozov, P., Delgado-Cruzata, L., Rothstein, R., Freyer, G. A., Boone, C. and Brown, G. W. (2005) RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/ Topo III complex. EMBO J. 24, 2024-2033.
-
(2005)
EMBO J
, vol.24
, pp. 2024-2033
-
-
Chang, M.1
Bellaoui, M.2
Zhang, C.3
Desai, R.4
Morozov, P.5
Delgado-Cruzata, L.6
Rothstein, R.7
Freyer, G.A.8
Boone, C.9
Brown, G.W.10
-
51
-
-
0032999346
-
Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells
-
Sonoda, E., Sasaki, M. S., Morrison, C., Yamaguchi-Iwai, Y., Takata, M. and Takeda, S. (1999) Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells. Mol. Cell. Biol. 19, 5166-5169.
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 5166-5169
-
-
Sonoda, E.1
Sasaki, M.S.2
Morrison, C.3
Yamaguchi-Iwai, Y.4
Takata, M.5
Takeda, S.6
-
52
-
-
0034600976
-
Possible association of BLM in decreasing DNA double strand breaks during DNA replication
-
Wang, W., Seki, M., Narita, Y., Sonoda, E., Takeda, S., Yamada, K., Masuko, T., Katada, T. and Enomoto, T. (2000) Possible association of BLM in decreasing DNA double strand breaks during DNA replication. EMBO J. 19, 3428-3435.
-
(2000)
EMBO J
, vol.19
, pp. 3428-3435
-
-
Wang, W.1
Seki, M.2
Narita, Y.3
Sonoda, E.4
Takeda, S.5
Yamada, K.6
Masuko, T.7
Katada, T.8
Enomoto, T.9
-
53
-
-
0034727684
-
Binding and melting of D-loops by the Bloom syndrome helicase
-
van Brabant, A. J., Ye, T., Sanz, M., German, I. J., Ellis, N. A. and Holloman, W. K. (2000) Binding and melting of D-loops by the Bloom syndrome helicase. Biochemistry 39, 14617-14625.
-
(2000)
Biochemistry
, vol.39
, pp. 14617-14625
-
-
van Brabant, A.J.1
Ye, T.2
Sanz, M.3
German, I.J.4
Ellis, N.A.5
Holloman, W.K.6
-
54
-
-
0037428069
-
Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing
-
Adams, M. D., McVey, M. and Sekelsky, J. J. (2003) Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing. Science 299, 265-267.
-
(2003)
Science
, vol.299
, pp. 265-267
-
-
Adams, M.D.1
McVey, M.2
Sekelsky, J.J.3
-
55
-
-
33750946794
-
Template disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants
-
Johnson-Schlitz, D. and Engels, W. R. (2006) Template disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants. Proc. Natl. Acad. Sci. USA 103, 16840-16845.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 16840-16845
-
-
Johnson-Schlitz, D.1
Engels, W.R.2
-
56
-
-
0347987856
-
The Bloom's syndrome helicase suppresses crossing over during homologous recombination
-
Wu, L. and Hickson, I. D. (2003) The Bloom's syndrome helicase suppresses crossing over during homologous recombination. Nature 426, 870-874.
-
(2003)
Nature
, vol.426
, pp. 870-874
-
-
Wu, L.1
Hickson, I.D.2
-
57
-
-
33645242115
-
BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates
-
Wu, L., Bachrati, C. Z., Ou, J., Xu, C., Yin, J., Chang, M., Wang, W., Li, L., Brown, G. W. and Hickson, I. D. (2006) BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates. Proc. Natl. Acad. Sci. USA 103, 4068-4073.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 4068-4073
-
-
Wu, L.1
Bachrati, C.Z.2
Ou, J.3
Xu, C.4
Yin, J.5
Chang, M.6
Wang, W.7
Li, L.8
Brown, G.W.9
Hickson, I.D.10
-
58
-
-
33744927719
-
A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75
-
Raynard, S., Bussen, W. and Sung, P. (2006) A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75. J. Biol. Chem. 281, 13861-13864.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 13861-13864
-
-
Raynard, S.1
Bussen, W.2
Sung, P.3
-
59
-
-
23044449199
-
The HRDC domain of BLM is required for the dissolution of double Holliday junctions
-
Wu, L., Chan, K. L., Ralf, C., Bernstein, D. A., Garcia, P. L., Bohr, V. A.,Vindigni, A., Janscak, P., Keck, J. L. and Hickson, I. D. (2005) The HRDC domain of BLM is required for the dissolution of double Holliday junctions. EMBO J. 24, 2679-2687.
-
(2005)
EMBO J
, vol.24
, pp. 2679-2687
-
-
Wu, L.1
Chan, K.L.2
Ralf, C.3
Bernstein, D.A.4
Garcia, P.L.5
Bohr, V.A.6
Vindigni, A.7
Janscak, P.8
Keck, J.L.9
Hickson, I.D.10
-
60
-
-
33746600628
-
Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration
-
Plank, J. L., Wu, J. and Hsieh, T. S. (2006) Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration. Proc. Natl. Acad. Sci. USA 103, 11118-11123.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 11118-11123
-
-
Plank, J.L.1
Wu, J.2
Hsieh, T.S.3
-
61
-
-
0032721540
-
PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1
-
Ishov, A. M., Sotnikov, A. G., Negorev, D., Vladimirova, O. V., Neff, N., Kamitani, T., Yeh, E. T., Strauss, J. F. 3rd and Maul, G. G. (1999) PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1. J. Cell Biol. 147, 221-234.
-
(1999)
J. Cell Biol
, vol.147
, pp. 221-234
-
-
Ishov, A.M.1
Sotnikov, A.G.2
Negorev, D.3
Vladimirova, O.V.4
Neff, N.5
Kamitani, T.6
Yeh, E.T.7
Strauss 3rd, J.F.8
Maul, G.G.9
-
62
-
-
2342661679
-
The C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stability
-
Yankiwski, V., Noonan, J. P. and Neff, N. F. (2001) The C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stability. BMC Cell Biol. 2, 11.
-
(2001)
BMC Cell Biol
, vol.2
, pp. 11
-
-
Yankiwski, V.1
Noonan, J.P.2
Neff, N.F.3
-
63
-
-
0035897415
-
Regulation and localization of the Bloom syndrome protein in response to DNA damage
-
Bischof, O., Kim, S. H., Irving, J., Beresten, S., Ellis, N. A. and Campisi, J. (2001) Regulation and localization of the Bloom syndrome protein in response to DNA damage. J. Cell Biol. 153, 367-380.
-
(2001)
J. Cell Biol
, vol.153
, pp. 367-380
-
-
Bischof, O.1
Kim, S.H.2
Irving, J.3
Beresten, S.4
Ellis, N.A.5
Campisi, J.6
-
64
-
-
0033848907
-
The puzzling multiple lives of PML and its role in the genesis of cancer
-
Ruggero, D., Wang, Z. G. and Pandolfi, P. P. (2000) The puzzling multiple lives of PML and its role in the genesis of cancer. Bioessays 22, 827-835.
-
(2000)
Bioessays
, vol.22
, pp. 827-835
-
-
Ruggero, D.1
Wang, Z.G.2
Pandolfi, P.P.3
-
65
-
-
0036798404
-
Finding a role for PML in APL pathogenesis: A critical assessment of potential PML activities
-
Strudwick, S. and Borden, K. L. (2002) Finding a role for PML in APL pathogenesis: a critical assessment of potential PML activities. Leukemia 16, 1906-1917.
-
(2002)
Leukemia
, vol.16
, pp. 1906-1917
-
-
Strudwick, S.1
Borden, K.L.2
-
66
-
-
4644351274
-
PML nuclear bodies: Dynamic sensors of DNA damage and cellular stress
-
Dellaire, G. and Bazett-Jones, D. P. (2004) PML nuclear bodies: dynamic sensors of DNA damage and cellular stress. Bioessays 26, 963-977.
-
(2004)
Bioessays
, vol.26
, pp. 963-977
-
-
Dellaire, G.1
Bazett-Jones, D.P.2
-
67
-
-
0033545879
-
Bloom's syndrome protein, BLM, colocalizes with replication protein A in meiotic prophase nuclei of mammalian spermatocytes
-
Walpita, D., Plug, A. W., Neff, N. F., German, J. and Ashley, T. (1999) Bloom's syndrome protein, BLM, colocalizes with replication protein A in meiotic prophase nuclei of mammalian spermatocytes. Proc. Natl. Acad. Sci. USA 96, 5622-5627.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 5622-5627
-
-
Walpita, D.1
Plug, A.W.2
Neff, N.F.3
German, J.4
Ashley, T.5
-
68
-
-
1642458364
-
Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest
-
Davies, S. L., North, P. S., Dart, A., Lakin, N. D. and Hickson, I. D. (2004) Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest. Mol. Cell. Biol. 24, 1279-1291.
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 1279-1291
-
-
Davies, S.L.1
North, P.S.2
Dart, A.3
Lakin, N.D.4
Hickson, I.D.5
-
69
-
-
26444467122
-
Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage
-
Rao, V. A., Fan, A. M., Meng, L., Doe, C. F., North, P. S., Hickson, I. D. and Pommier, Y. (2005) Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage. Mol. Cell. Biol. 25, 8925-8937.
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 8925-8937
-
-
Rao, V.A.1
Fan, A.M.2
Meng, L.3
Doe, C.F.4
North, P.S.5
Hickson, I.D.6
Pommier, Y.7
-
70
-
-
0035377356
-
Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51
-
Wu, L., Davies, S. L., Levitt, N. C. and Hickson, I. D. (2001) Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51. J. Biol. Chem. 276, 19375-19381.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 19375-19381
-
-
Wu, L.1
Davies, S.L.2
Levitt, N.C.3
Hickson, I.D.4
-
71
-
-
0346993508
-
Constitutive DNA damage is linked to DNA replication abnormalities in Bloom's syndrome cells
-
Rassool, F. V., North, P. S., Mufti, G. J. and Hickson, I. D. (2003) Constitutive DNA damage is linked to DNA replication abnormalities in Bloom's syndrome cells. Oncogene 22, 8749-8757.
-
(2003)
Oncogene
, vol.22
, pp. 8749-8757
-
-
Rassool, F.V.1
North, P.S.2
Mufti, G.J.3
Hickson, I.D.4
-
72
-
-
0141864666
-
Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks
-
Davalos, A. R. and Campisi, J. (2003) Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks. J. Cell Biol. 162, 1197-1209.
-
(2003)
J. Cell Biol
, vol.162
, pp. 1197-1209
-
-
Davalos, A.R.1
Campisi, J.2
-
73
-
-
17144395509
-
ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation
-
Davalos, A. R., Kaminker, P., Hansen, R. K. and Campisi, J. (2004) ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation. Cell Cycle 3, 1579-1586.
-
(2004)
Cell Cycle
, vol.3
, pp. 1579-1586
-
-
Davalos, A.R.1
Kaminker, P.2
Hansen, R.K.3
Campisi, J.4
-
74
-
-
18544372261
-
Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM
-
Beamish, H., Kedar, P., Kaneko, H., Chen, P., Fukao, T., Peng, C., Beresten, S., Gueven, N., Purdie, D., Lees-Miller, S., Ellis, N., Kondo, N. and Lavin, M. F. (2002) Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM. J. Biol. Chem. 277, 30515-30523.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 30515-30523
-
-
Beamish, H.1
Kedar, P.2
Kaneko, H.3
Chen, P.4
Fukao, T.5
Peng, C.6
Beresten, S.7
Gueven, N.8
Purdie, D.9
Lees-Miller, S.10
Ellis, N.11
Kondo, N.12
Lavin, M.F.13
-
75
-
-
33746778751
-
BLM is an early responder to DNA double-strand breaks
-
Karmakar, P., Seki, M., Kanamori, M., Hashiguchi, K., Ohtsuki, M., Murata, E., Inoue, E., Tada, S., Lan, L., Yasui, A. and Enomoto, T. (2006) BLM is an early responder to DNA double-strand breaks. Biochem. Biophys. Res. Commun. 348, 62-69.
-
(2006)
Biochem. Biophys. Res. Commun
, vol.348
, pp. 62-69
-
-
Karmakar, P.1
Seki, M.2
Kanamori, M.3
Hashiguchi, K.4
Ohtsuki, M.5
Murata, E.6
Inoue, E.7
Tada, S.8
Lan, L.9
Yasui, A.10
Enomoto, T.11
-
76
-
-
33747352774
-
The Bloom's syndrome helicase can promote the regression of a model replication fork
-
Ralf, C., Hickson, I. D. and Wu, L. (2006) The Bloom's syndrome helicase can promote the regression of a model replication fork. J. Biol. Chem. 281, 22839-22846.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 22839-22846
-
-
Ralf, C.1
Hickson, I.D.2
Wu, L.3
-
77
-
-
0036544565
-
Bloom's syndrome protein is required for correct relocalization of RAD50/ MRE11/NBS1 complex after replication fork arrest
-
Franchitto, A. and Pichierri, P. (2002) Bloom's syndrome protein is required for correct relocalization of RAD50/ MRE11/NBS1 complex after replication fork arrest. J. Cell. Biol. 157, 19-30.
-
(2002)
J. Cell. Biol
, vol.157
, pp. 19-30
-
-
Franchitto, A.1
Pichierri, P.2
-
78
-
-
33746841515
-
MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability
-
Leng, M., Chan, D. W., Luo, H., Zhu, C., Qin, J. and Wang, Y. (2006) MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability. Proc. Natl. Acad. Sci. USA 103, 11485-11490.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 11485-11490
-
-
Leng, M.1
Chan, D.W.2
Luo, H.3
Zhu, C.4
Qin, J.5
Wang, Y.6
-
79
-
-
1342306874
-
The absence of a functional relationship between ATM and BLM, the components of BASC, in DT40 cells
-
Wang, W., Seki, M., Otsuki, M., Tada, S., Takao, N., Yamamoto, K., Hayashi, M., Honma, M. and Enomoto, T. (2004) The absence of a functional relationship between ATM and BLM, the components of BASC, in DT40 cells. Biochim. Biophys. Acta 1688, 137-144.
-
(2004)
Biochim. Biophys. Acta
, vol.1688
, pp. 137-144
-
-
Wang, W.1
Seki, M.2
Otsuki, M.3
Tada, S.4
Takao, N.5
Yamamoto, K.6
Hayashi, M.7
Honma, M.8
Enomoto, T.9
-
80
-
-
0032213939
-
Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene
-
Chester, N., Kuo, F., Kozak, C., O'Hara, C. D. and Leder, P. (1998) Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene. Genes Dev. 12, 3382-3393.
-
(1998)
Genes Dev
, vol.12
, pp. 3382-3393
-
-
Chester, N.1
Kuo, F.2
Kozak, C.3
O'Hara, C.D.4
Leder, P.5
-
81
-
-
0026537477
-
Long-term study of the immunodeficiency of Bloom's syndrome
-
Kondo, N., Motoyoshi, F., Mori, S., Kuwabara, N., Orii, T. and German, J. (1992) Long-term study of the immunodeficiency of Bloom's syndrome. Acta Paediatr. 81, 86-90.
-
(1992)
Acta Paediatr
, vol.81
, pp. 86-90
-
-
Kondo, N.1
Motoyoshi, F.2
Mori, S.3
Kuwabara, N.4
Orii, T.5
German, J.6
-
82
-
-
0037144601
-
Enhanced tumor formation in mice heterozygous for Blm mutation
-
Goss, K. H., Risinger, M. A., Kordich, J. J., Sanz, M. M., Straughen, J. E., Slovek, L. E., Capobianco, A. J., German, J., Boivin, G. P. and Groden, J. (2002) Enhanced tumor formation in mice heterozygous for Blm mutation. Science 297, 2051-2053.
-
(2002)
Science
, vol.297
, pp. 2051-2053
-
-
Goss, K.H.1
Risinger, M.A.2
Kordich, J.J.3
Sanz, M.M.4
Straughen, J.E.5
Slovek, L.E.6
Capobianco, A.J.7
German, J.8
Boivin, G.P.9
Groden, J.10
-
83
-
-
33747751867
-
Mutation of the murine Bloom's syndrome gene produces global genome destabilization
-
Chester, N., Babbe, H., Pinkas, J., Manning, C. and Leder, P. (2006) Mutation of the murine Bloom's syndrome gene produces global genome destabilization. Mol. Cell. Biol. 26, 6713-6726.
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 6713-6726
-
-
Chester, N.1
Babbe, H.2
Pinkas, J.3
Manning, C.4
Leder, P.5
-
84
-
-
28544450724
-
Induction of renal tumorigenesis with elevated levels of somatic loss of heterozygosity in Tsc1+/- mice on a Blm-deficient background
-
Wilson, C., Idziaszczyk, S., Colley, J., Humphreys, V., Guy, C., Maynard, J., Sampson, J. R. and Cheadle, J. P. (2005) Induction of renal tumorigenesis with elevated levels of somatic loss of heterozygosity in Tsc1+/- mice on a Blm-deficient background. Cancer Res. 65, 10179-10182.
-
(2005)
Cancer Res
, vol.65
, pp. 10179-10182
-
-
Wilson, C.1
Idziaszczyk, S.2
Colley, J.3
Humphreys, V.4
Guy, C.5
Maynard, J.6
Sampson, J.R.7
Cheadle, J.P.8
-
85
-
-
33748060509
-
Tsc1 haploinsufficiency without mammalian target of rapamycin activation is sufficient for renal cyst formation in Tsc1+/- mice
-
Wilson, C., Bonnet, C., Guy, C., Idziaszczyk, S., Colley, J., Humphreys, V., Maynard, J., Sampson, J. R. and Cheadle, J. P. (2006) Tsc1 haploinsufficiency without mammalian target of rapamycin activation is sufficient for renal cyst formation in Tsc1+/- mice. Cancer Res. 66, 7934-7938.
-
(2006)
Cancer Res
, vol.66
, pp. 7934-7938
-
-
Wilson, C.1
Bonnet, C.2
Guy, C.3
Idziaszczyk, S.4
Colley, J.5
Humphreys, V.6
Maynard, J.7
Sampson, J.R.8
Cheadle, J.P.9
-
86
-
-
3042531072
-
Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells
-
Guo, G., Wang, W. and Bradley, A. (2004) Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells. Nature 429, 891-895.
-
(2004)
Nature
, vol.429
, pp. 891-895
-
-
Guo, G.1
Wang, W.2
Bradley, A.3
-
87
-
-
33746569501
-
Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice
-
Suzuki, T., Minehata, K., Akagi, K., Jenkins, N. A. and Copeland, N. G. (2006) Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice. EMBO J. 25, 3422-3431.
-
(2006)
EMBO J
, vol.25
, pp. 3422-3431
-
-
Suzuki, T.1
Minehata, K.2
Akagi, K.3
Jenkins, N.A.4
Copeland, N.G.5
-
88
-
-
0013907774
-
Werner syndrome. A review of its symptomatology, natural history, pathlogic features, genetics and relationship to the natural aging process
-
Epstein, C. J., Martin, G. M., Schultz, A. L. and Motulsky, A. G. (1966) Werner syndrome. A review of its symptomatology, natural history, pathlogic features, genetics and relationship to the natural aging process. Medicine 45, 177-221.
-
(1966)
Medicine
, vol.45
, pp. 177-221
-
-
Epstein, C.J.1
Martin, G.M.2
Schultz, A.L.3
Motulsky, A.G.4
-
89
-
-
0030691121
-
Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing
-
Goto, M. (1997) Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing. Mech. Ageing Dev. 98, 239-254.
-
(1997)
Mech. Ageing Dev
, vol.98
, pp. 239-254
-
-
Goto, M.1
-
90
-
-
10544231878
-
Homozygous and compound heterozygous mutations at the Werner syndrome locus
-
Oshima, J., Yu, C. E., Piussan, C., Klein, G., Jabkowski, J., Balci, S., Miki, T., Nakura, J., Ogihara, T., Ells, J., Smith, M., Melaragno, M. I., Fraccaro, M., Scappaticci, S., Matthews, J., Ouais, S., Jarzebowicz, A., Schellenberg, G. D. and Martin, G. M. (1996) Homozygous and compound heterozygous mutations at the Werner syndrome locus. Hum. Mol. Genet. 5, 1909-1913.
-
(1996)
Hum. Mol. Genet
, vol.5
, pp. 1909-1913
-
-
Oshima, J.1
Yu, C.E.2
Piussan, C.3
Klein, G.4
Jabkowski, J.5
Balci, S.6
Miki, T.7
Nakura, J.8
Ogihara, T.9
Ells, J.10
Smith, M.11
Melaragno, M.I.12
Fraccaro, M.13
Scappaticci, S.14
Matthews, J.15
Ouais, S.16
Jarzebowicz, A.17
Schellenberg, G.D.18
Martin, G.M.19
-
91
-
-
16944366241
-
Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group
-
Yu, C. E., Oshima, J., Wijsman, E. M., Nakura, J., Miki, T., Piussan, C., Matthews, S., Fu, Y. H., Mulligan, J., Martin, G. M. and Schellenberg, G. D. (1997) Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group. Am. J. Hum. Genet. 60, 330-341.
-
(1997)
Am. J. Hum. Genet
, vol.60
, pp. 330-341
-
-
Yu, C.E.1
Oshima, J.2
Wijsman, E.M.3
Nakura, J.4
Miki, T.5
Piussan, C.6
Matthews, S.7
Fu, Y.H.8
Mulligan, J.9
Martin, G.M.10
Schellenberg, G.D.11
-
92
-
-
0031018953
-
Analysis of helicase gene mutations in Japanese Werner's syndrome patients
-
Goto, M., Imamura, O., Kuromitsu, J., Matsumoto, T., Yamabe, Y., Tokutake, Y., Suzuki, N., Mason, B., Drayna, D., Sugawara, M., Sugimoto, M. and Furuichi, Y. (1997) Analysis of helicase gene mutations in Japanese Werner's syndrome patients. Hum. Genet. 99, 191-193.
-
(1997)
Hum. Genet
, vol.99
, pp. 191-193
-
-
Goto, M.1
Imamura, O.2
Kuromitsu, J.3
Matsumoto, T.4
Yamabe, Y.5
Tokutake, Y.6
Suzuki, N.7
Mason, B.8
Drayna, D.9
Sugawara, M.10
Sugimoto, M.11
Furuichi, Y.12
-
93
-
-
0033028692
-
WRN mutations in Werner syndrome
-
Moser, M. J. , Oshima, J. and Monnat, R. J. Jr. (1999) WRN mutations in Werner syndrome. Hum. Mutat. 13, 271-279.
-
(1999)
Hum. Mutat
, vol.13
, pp. 271-279
-
-
Moser, M.J.1
Oshima, J.2
Monnat Jr., R.J.3
-
94
-
-
0035799620
-
Diverged nuclear localization of Werner helicase in human and mouse cells
-
Suzuki, T., Shiratori, M., Furuichi, Y. and Matsumoto, T. (2001) Diverged nuclear localization of Werner helicase in human and mouse cells. Oncogene 20, 2551-2558.
-
(2001)
Oncogene
, vol.20
, pp. 2551-2558
-
-
Suzuki, T.1
Shiratori, M.2
Furuichi, Y.3
Matsumoto, T.4
-
95
-
-
0030757524
-
DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system
-
Suzuki, N., Shimamoto, A., Imamura, O., Kuromitsu, J., Kitao, S., Goto, M. and Furuichi, Y. (1997) DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system. Nucleic Acids Res. 25, 2973-2978.
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 2973-2978
-
-
Suzuki, N.1
Shimamoto, A.2
Imamura, O.3
Kuromitsu, J.4
Kitao, S.5
Goto, M.6
Furuichi, Y.7
-
96
-
-
0032526583
-
Characterization of Werner syndrome protein DNA helicase activity: Directionality, substrate dependence and stimulation by replication protein A
-
Shen, J. C., Gray, M. D., Oshima, J. and Loeb, L. A. (1998) Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A. Nucleic Acids Res. 26, 2879-2885.
-
(1998)
Nucleic Acids Res
, vol.26
, pp. 2879-2885
-
-
Shen, J.C.1
Gray, M.D.2
Oshima, J.3
Loeb, L.A.4
-
97
-
-
0032545423
-
Werner syndrome protein. II. Characterization of the integral 3′ -> 5′ DNA exonuclease
-
Kamath-Loeb, A. S., Shen, J. C., Loeb, L. A. and Fry, M. (1998) Werner syndrome protein. II. Characterization of the integral 3′ -> 5′ DNA exonuclease. J. Biol. Chem. 273, 34145-34150.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 34145-34150
-
-
Kamath-Loeb, A.S.1
Shen, J.C.2
Loeb, L.A.3
Fry, M.4
-
98
-
-
0031686571
-
The premature ageing syndrome protein, WRN, is a 3′ -> 5′ exonuclease
-
Huang, S., Li, B., Gray, M. D., Oshima, J., Mian, I. S. and Campisi, J. (1998) The premature ageing syndrome protein, WRN, is a 3′ -> 5′ exonuclease. Nat. Genet. 20, 114-116.
-
(1998)
Nat. Genet
, vol.20
, pp. 114-116
-
-
Huang, S.1
Li, B.2
Gray, M.D.3
Oshima, J.4
Mian, I.S.5
Campisi, J.6
-
99
-
-
0034660246
-
Characterization of the human and mouse WRN 3′ -> 5′ exonuclease
-
Huang, S., Beresten, S., Li, B., Oshima, J., Ellis, N. A. and Campisi, J. (2000) Characterization of the human and mouse WRN 3′ -> 5′ exonuclease. Nucleic Acids Res. 28, 2396-2405.
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 2396-2405
-
-
Huang, S.1
Beresten, S.2
Li, B.3
Oshima, J.4
Ellis, N.A.5
Campisi, J.6
-
100
-
-
0037189485
-
Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase
-
Brosh, R. M., Jr., Waheed, J. and Sommers, J. A. (2002) Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase. J. Biol. Chem. 277, 23236-23245.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 23236-23245
-
-
Brosh Jr., R.M.1
Waheed, J.2
Sommers, J.A.3
-
101
-
-
0347362703
-
Werner syndrome protein contains three structure-specific DNA binding domains
-
von Kobbe, C., Thoma, N. H., Czyzewski, B. K., Pavletich, N. P. and Bohr, V. A. (2003) Werner syndrome protein contains three structure-specific DNA binding domains. J. Biol. Chem. 278, 52997-53006.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 52997-53006
-
-
von Kobbe, C.1
Thoma, N.H.2
Czyzewski, B.K.3
Pavletich, N.P.4
Bohr, V.A.5
-
102
-
-
0034231844
-
Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPAupon replication arrest
-
1, 80-84
-
Constantinou, A., Tarsounas, M., Karow, J. K., Brosh, R. M., Bohr, V. A., Hickson, I. D. and West, S. C. (2000) Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPAupon replication arrest. EMBO Rep. 1, 80-84.
-
(2000)
EMBO Rep
-
-
Constantinou, A.1
Tarsounas, M.2
Karow, J.K.3
Brosh, R.M.4
Bohr, V.A.5
Hickson, I.D.6
West, S.C.7
-
103
-
-
33745084835
-
WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing
-
Perry, J. J., Yannone, S. M., Holden, L. G., Hitomi, C., Asaithamby, A., Han, S., Cooper, P. K., Chen, D. J. and Tainer, J. A. (2006) WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat. Struct. Mol. Biol. 13, 414-422.
-
(2006)
Nat. Struct. Mol. Biol
, vol.13
, pp. 414-422
-
-
Perry, J.J.1
Yannone, S.M.2
Holden, L.G.3
Hitomi, C.4
Asaithamby, A.5
Han, S.6
Cooper, P.K.7
Chen, D.J.8
Tainer, J.A.9
-
104
-
-
0036714151
-
Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein
-
Li, B. and Comai, L. (2002) Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein. Nucleic Acids Res. 30, 3653-3661.
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 3653-3661
-
-
Li, B.1
Comai, L.2
-
105
-
-
0034655912
-
Ku complex interacts with and stimulates the Werner protein
-
Cooper, M. P., Machwe, A., Orren, D. K., Brosh, R. M., Ramsden, D. and Bohr, V. A. (2000) Ku complex interacts with and stimulates the Werner protein. Genes Dev. 14, 907-912.
-
(2000)
Genes Dev
, vol.14
, pp. 907-912
-
-
Cooper, M.P.1
Machwe, A.2
Orren, D.K.3
Brosh, R.M.4
Ramsden, D.5
Bohr, V.A.6
-
106
-
-
0034283889
-
Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA
-
Shen, J. C. and Loeb, L. A. (2000) Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA. Nucleic Acids Res. 28, 3260-3268.
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 3260-3268
-
-
Shen, J.C.1
Loeb, L.A.2
-
107
-
-
0141567744
-
RecQ helicases: Suppressors of tumorigenesis and premature aging
-
Bachrati, C. Z. and Hickson, I. D. (2003) RecQ helicases: suppressors of tumorigenesis and premature aging. Biochem. J. 374, 577-606.
-
(2003)
Biochem. J
, vol.374
, pp. 577-606
-
-
Bachrati, C.Z.1
Hickson, I.D.2
-
109
-
-
10944225939
-
Pathways and functions of the Werner syndrome protein
-
Lee, J. W., Harrigan, J., Opresko, P. L. and Bohr, V. A. (2005) Pathways and functions of the Werner syndrome protein. Mech. Ageing Dev. 126, 79-86.
-
(2005)
Mech. Ageing Dev
, vol.126
, pp. 79-86
-
-
Lee, J.W.1
Harrigan, J.2
Opresko, P.L.3
Bohr, V.A.4
-
110
-
-
3543130605
-
Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells
-
Baird, D. M., Davis, T., Rowson, J., Jones, C. J. and Kipling, D. (2004) Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells. Hum. Mol. Genet. 13, 1515-1524.
-
(2004)
Hum. Mol. Genet
, vol.13
, pp. 1515-1524
-
-
Baird, D.M.1
Davis, T.2
Rowson, J.3
Jones, C.J.4
Kipling, D.5
-
111
-
-
0033545238
-
Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization
-
Shiratori, M., Sakamoto, S., Suzuki, N., Tokutake, Y., Kawabe, Y., Enomoto, T., Sugimoto, M., Goto, M., Matsumoto, T. and Furuichi, Y. (1999) Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization. J. Cell Biol. 144, 1-9.
-
(1999)
J. Cell Biol
, vol.144
, pp. 1-9
-
-
Shiratori, M.1
Sakamoto, S.2
Suzuki, N.3
Tokutake, Y.4
Kawabe, Y.5
Enomoto, T.6
Sugimoto, M.7
Goto, M.8
Matsumoto, T.9
Furuichi, Y.10
-
112
-
-
0035339672
-
A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA
-
Orren, D. K., Machwe, A., Karmakar, P., Piotrowski, J., Cooper, M. P. and Bohr, V. A. (2001) A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA. Nucleic Acids Res. 29, 1926-1934.
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 1926-1934
-
-
Orren, D.K.1
Machwe, A.2
Karmakar, P.3
Piotrowski, J.4
Cooper, M.P.5
Bohr, V.A.6
-
113
-
-
0037102588
-
Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus
-
Karmakar, P., Snowden, C. M., Ramsden, D. A. and Bohr, V. A. (2002) Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus. Nucleic Acids Res. 30, 3583-3591.
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 3583-3591
-
-
Karmakar, P.1
Snowden, C.M.2
Ramsden, D.A.3
Bohr, V.A.4
-
114
-
-
0037175018
-
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases
-
Opresko, P. L., von Kobbe, C., Laine, J. P., Harrigan, J., Hickson, I. D. and Bohr, V. A. (2002) Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases. J. Biol. Chem. 277, 41110-41119.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 41110-41119
-
-
Opresko, P.L.1
von Kobbe, C.2
Laine, J.P.3
Harrigan, J.4
Hickson, I.D.5
Bohr, V.A.6
-
115
-
-
2942637828
-
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric Dloops in a manner regulated by TRF1 and TRF2
-
Opresko, P. L., Otterlei, M., Graakjaer, J., Bruheim, P., Dawut, L., Kolvraa, S., May, A., Seidman, M. M. and Bohr, V. A. (2004) The Werner syndrome helicase and exonuclease cooperate to resolve telomeric Dloops in a manner regulated by TRF1 and TRF2. Mol. Cell 14, 763-774.
-
(2004)
Mol. Cell
, vol.14
, pp. 763-774
-
-
Opresko, P.L.1
Otterlei, M.2
Graakjaer, J.3
Bruheim, P.4
Dawut, L.5
Kolvraa, S.6
May, A.7
Seidman, M.M.8
Bohr, V.A.9
-
116
-
-
0942290416
-
TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA
-
Machwe, A., Xiao, L. and Orren, D. K. (2004) TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA. Oncogene 23, 149-156.
-
(2004)
Oncogene
, vol.23
, pp. 149-156
-
-
Machwe, A.1
Xiao, L.2
Orren, D.K.3
-
117
-
-
25444533047
-
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates
-
Opresko, P. L., Mason, P. A., Podell, E. R., Lei, M., Hickson, I. D., Cech, T. R. and Bohr, V. A. (2005) POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J. Biol. Chem. 280, 32069-32080.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 32069-32080
-
-
Opresko, P.L.1
Mason, P.A.2
Podell, E.R.3
Lei, M.4
Hickson, I.D.5
Cech, T.R.6
Bohr, V.A.7
-
118
-
-
0035936559
-
SGS1 is required for telomere elongation in the absence of telomerase
-
Huang, P., Pryde, F. E., Lester, D., Maddison, R. L., Borts, R. H., Hickson, I. D. and Louis, E. J. (2001) SGS1 is required for telomere elongation in the absence of telomerase. Curr. Biol. 11, 125-129.
-
(2001)
Curr. Biol
, vol.11
, pp. 125-129
-
-
Huang, P.1
Pryde, F.E.2
Lester, D.3
Maddison, R.L.4
Borts, R.H.5
Hickson, I.D.6
Louis, E.J.7
-
119
-
-
0035865143
-
The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase
-
Johnson, F. B., Marciniak, R. A., McVey, M., Stewart, S. A., Hahn, W. C. and Guarente, L. (2001) The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase. EMBO J. 20, 905-913.
-
(2001)
EMBO J
, vol.20
, pp. 905-913
-
-
Johnson, F.B.1
Marciniak, R.A.2
McVey, M.3
Stewart, S.A.4
Hahn, W.C.5
Guarente, L.6
-
120
-
-
0035853104
-
Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase
-
Cohen, H. and Sinclair, D. A. (2001) Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase. Proc. Natl. Acad. Sci. USA 98, 3174-3179.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 3174-3179
-
-
Cohen, H.1
Sinclair, D.A.2
-
121
-
-
32644444037
-
Evidence that the S. cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence
-
Azam, M., Lee, J. Y., Abraham, V., Chanoux, R., Schoenly, K. A. and Johnson, F. B. (2006) Evidence that the S. cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence. Nucleic Acids Res. 34, 506-516.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 506-516
-
-
Azam, M.1
Lee, J.Y.2
Abraham, V.3
Chanoux, R.4
Schoenly, K.A.5
Johnson, F.B.6
-
122
-
-
27644443332
-
Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway
-
Laud, P. R., Multani, A. S., Bailey, S. M., Wu, L., Ma, J., Kingsley, C., Lebel, M., Pathak, S., DePinho, R. A. and Chang, S. (2005) Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway. Genes Dev. 19, 2560-2570.
-
(2005)
Genes Dev
, vol.19
, pp. 2560-2570
-
-
Laud, P.R.1
Multani, A.S.2
Bailey, S.M.3
Wu, L.4
Ma, J.5
Kingsley, C.6
Lebel, M.7
Pathak, S.8
DePinho, R.A.9
Chang, S.10
-
123
-
-
10344256183
-
Defective telomere lagging strand synthesis in cells lacking WRN helicase activity
-
Crabbe, L., Verdun, R. E., Haggblom, C. I. and Karlseder, J. (2004) Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science 306, 1951-1953.
-
(2004)
Science
, vol.306
, pp. 1951-1953
-
-
Crabbe, L.1
Verdun, R.E.2
Haggblom, C.I.3
Karlseder, J.4
-
124
-
-
0036537074
-
Designer skin: Lineage commitment in postnatal epidermis
-
Niemann, C. and Watt, F. M. (2002) Designer skin: lineage commitment in postnatal epidermis. Trends Cell Biol. 12, 185-192.
-
(2002)
Trends Cell Biol
, vol.12
, pp. 185-192
-
-
Niemann, C.1
Watt, F.M.2
-
125
-
-
0036683057
-
Role of integrins in regulating epidermal adhesion, growth and differentiation
-
Watt, F. M. (2002) Role of integrins in regulating epidermal adhesion, growth and differentiation. EMBO J. 21, 3919-3926.
-
(2002)
EMBO J
, vol.21
, pp. 3919-3926
-
-
Watt, F.M.1
-
126
-
-
0030778620
-
c-Myc promotes differentiation of human epidermal stem cells
-
Gandarillas, A. and Watt, F. M. (1997) c-Myc promotes differentiation of human epidermal stem cells. Genes Dev. 11, 2869-2882.
-
(1997)
Genes Dev
, vol.11
, pp. 2869-2882
-
-
Gandarillas, A.1
Watt, F.M.2
-
127
-
-
0035901594
-
c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny
-
Arnold, I. and Watt, F. M. (2001) c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny. Curr. Biol. 11, 558-568.
-
(2001)
Curr. Biol
, vol.11
, pp. 558-568
-
-
Arnold, I.1
Watt, F.M.2
-
128
-
-
0037663490
-
Werner syndrome protein limits MYC-induced cellular senescence
-
Grandori, C., Wu, K. J., Fernandez, P., Ngouenet, C., Grim, J., Clurman, B. E., Moser, M. J., Oshima, J., Russell, D. W., Swisshelm, K., Frank, S., Amati, B., Dalla-Favera, R. and Monnat, R. J. Jr. (2003) Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev. 17, 1569-1574.
-
(2003)
Genes Dev
, vol.17
, pp. 1569-1574
-
-
Grandori, C.1
Wu, K.J.2
Fernandez, P.3
Ngouenet, C.4
Grim, J.5
Clurman, B.E.6
Moser, M.J.7
Oshima, J.8
Russell, D.W.9
Swisshelm, K.10
Frank, S.11
Amati, B.12
Dalla-Favera, R.13
Monnat Jr., R.J.14
-
129
-
-
0032573157
-
A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
-
Lebel, M. and Leder, P. (1998) A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc. Natl. Acad. Sci. USA 95, 13097-13102.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 13097-13102
-
-
Lebel, M.1
Leder, P.2
-
130
-
-
0036200960
-
Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue
-
Lebel, M. (2002) Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue. Carcinogenesis 23, 213-216.
-
(2002)
Carcinogenesis
, vol.23
, pp. 213-216
-
-
Lebel, M.1
-
131
-
-
0242585417
-
Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice
-
Lebel, M., Lavoie, J., Gaudreault, I., Bronsard, M. and Drouin, R. (2003) Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice. Am. J. Pathol. 162, 1559-1569.
-
(2003)
Am. J. Pathol
, vol.162
, pp. 1559-1569
-
-
Lebel, M.1
Lavoie, J.2
Gaudreault, I.3
Bronsard, M.4
Drouin, R.5
-
132
-
-
0033978881
-
Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene
-
Wang, L., Ogburn, C. E., Ware, C. B., Ladiges, W. C., Youssoufian, H., Martin, G. M. and Oshima, J. (2000) Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene. Genetics 154, 357-362.
-
(2000)
Genetics
, vol.154
, pp. 357-362
-
-
Wang, L.1
Ogburn, C.E.2
Ware, C.B.3
Ladiges, W.C.4
Youssoufian, H.5
Martin, G.M.6
Oshima, J.7
-
133
-
-
17544402913
-
Mutations in the WRN gene in mice accelerate mortality in a p53-null background
-
Lombard, D. B., Beard, C., Johnson, B., Marciniak, R. A., Dausman, J., Bronson, R., Buhlmann, J. E., Lipman, R., Curry, R., Sharpe, A., Jaenisch, R. and Guarente, L. (2000) Mutations in the WRN gene in mice accelerate mortality in a p53-null background. Mol. Cell. Biol. 20, 3286-3291.
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 3286-3291
-
-
Lombard, D.B.1
Beard, C.2
Johnson, B.3
Marciniak, R.A.4
Dausman, J.5
Bronson, R.6
Buhlmann, J.E.7
Lipman, R.8
Curry, R.9
Sharpe, A.10
Jaenisch, R.11
Guarente, L.12
-
134
-
-
0036233108
-
Preparation of the gene targeted knockout mice for human premature aging diseases, Werner syndrome, and Rothmund-Thomson syndrome caused by the mutation of DNA helicases
-
Ichikawa, K., Noda, T. and Furuichi, Y. (2002) Preparation of the gene targeted knockout mice for human premature aging diseases, Werner syndrome, and Rothmund-Thomson syndrome caused by the mutation of DNA helicases. Nippon Yakurigaku Zasshi 119, 219-226.
-
(2002)
Nippon Yakurigaku Zasshi
, vol.119
, pp. 219-226
-
-
Ichikawa, K.1
Noda, T.2
Furuichi, Y.3
-
135
-
-
3543043128
-
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
-
Chang, S., Multani, A. S., Cabrera, N. G., Naylor, M. L., Laud, P., Lombard, D., Pathak, S., Guarente, L. and DePinho, R. A. (2004) Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat. Genet. 36, 877-882.
-
(2004)
Nat. Genet
, vol.36
, pp. 877-882
-
-
Chang, S.1
Multani, A.S.2
Cabrera, N.G.3
Naylor, M.L.4
Laud, P.5
Lombard, D.6
Pathak, S.7
Guarente, L.8
DePinho, R.A.9
-
136
-
-
4544301617
-
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes
-
Du, X., Shen, J., Kugan, N., Furth, E. E., Lombard, D. B., Cheung, C., Pak, S., Luo, G., Pignolo, R. J., DePinho, R. A., Guarente, L. and Johnson, F. B. (2004) Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Mol. Cell. Biol. 24, 8437-8446.
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 8437-8446
-
-
Du, X.1
Shen, J.2
Kugan, N.3
Furth, E.E.4
Lombard, D.B.5
Cheung, C.6
Pak, S.7
Luo, G.8
Pignolo, R.J.9
DePinho, R.A.10
Guarente, L.11
Johnson, F.B.12
-
137
-
-
0032939991
-
Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome
-
Kitao, S., Shimamoto, A., Goto, M., Miller, R. W., Smithson, W. A., Lindor, N. M. and Furuichi, Y. (1999) Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome. Nat. Genet. 22, 82-84.
-
(1999)
Nat. Genet
, vol.22
, pp. 82-84
-
-
Kitao, S.1
Shimamoto, A.2
Goto, M.3
Miller, R.W.4
Smithson, W.A.5
Lindor, N.M.6
Furuichi, Y.7
-
138
-
-
0029654348
-
Nucleotide excision repair syndromes: Molecular basis and clinical symptoms
-
Bootsma, D., Weeda, G., Vermeulen, W., van Vuuren, H., Troelstra, C., van der Spek, P. and Hoeijmakers, J. (1995) Nucleotide excision repair syndromes: molecular basis and clinical symptoms. Philos. Trans. R Soc. Lond. B. Biol. Sci. 347, 75-81.
-
(1995)
Philos. Trans. R Soc. Lond. B. Biol. Sci
, vol.347
, pp. 75-81
-
-
Bootsma, D.1
Weeda, G.2
Vermeulen, W.3
van Vuuren, H.4
Troelstra, C.5
van der Spek, P.6
Hoeijmakers, J.7
-
139
-
-
0030820485
-
Human cancer and DNA repair-deficient diseases
-
Sarasin, A. and Stary, A. (1997) Human cancer and DNA repair-deficient diseases. Cancer Detect. Prev. 21, 406-411.
-
(1997)
Cancer Detect. Prev
, vol.21
, pp. 406-411
-
-
Sarasin, A.1
Stary, A.2
-
140
-
-
0034054019
-
Nucleotide excision repair and human syndromes
-
de Boer, J. and Hoeijmakers, J. H. (2000) Nucleotide excision repair and human syndromes. Carcinogenesis 21, 453-460.
-
(2000)
Carcinogenesis
, vol.21
, pp. 453-460
-
-
de Boer, J.1
Hoeijmakers, J.H.2
-
141
-
-
0035827305
-
The 14th Datta Lecture. TFIIH: From transcription to clinic
-
Egly, J. M. (2001) The 14th Datta Lecture. TFIIH: from transcription to clinic. FEBS Lett. 498, 124-128.
-
(2001)
FEBS Lett
, vol.498
, pp. 124-128
-
-
Egly, J.M.1
-
142
-
-
0942268166
-
DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy
-
Lehmann, A. R. (2003) DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy. Biochimie 85, 1101-1111.
-
(2003)
Biochimie
, vol.85
, pp. 1101-1111
-
-
Lehmann, A.R.1
-
143
-
-
30344477373
-
Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome
-
Macris, M. A., Krejci, L., Bussen, W., Shimamoto, A. and Sung, P. (2006) Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome. DNA Repair (Amst) 5, 172-180.
-
(2006)
DNA Repair (Amst)
, vol.5
, pp. 172-180
-
-
Macris, M.A.1
Krejci, L.2
Bussen, W.3
Shimamoto, A.4
Sung, P.5
-
144
-
-
3543007196
-
Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide
-
Garcia, P. L., Liu, Y., Jiricny, J., West, S. C. and Janscak, P. (2004) Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide. EMBO J. 23, 2882-2891.
-
(2004)
EMBO J
, vol.23
, pp. 2882-2891
-
-
Garcia, P.L.1
Liu, Y.2
Jiricny, J.3
West, S.C.4
Janscak, P.5
-
145
-
-
23044517287
-
Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1
-
Sharma, S., Sommers, J. A., Choudhary, S., Faulkner, J. K., Cui, S., Andreoli, L., Muzzolini, L., Vindigni, A. and Brosh, R. M. Jr. (2005) Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1. J. Biol. Chem. 280, 28072-28084.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 28072-28084
-
-
Sharma, S.1
Sommers, J.A.2
Choudhary, S.3
Faulkner, J.K.4
Cui, S.5
Andreoli, L.6
Muzzolini, L.7
Vindigni, A.8
Brosh Jr., R.M.9
-
146
-
-
27144460601
-
The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability
-
Petkovic, M., Dietschy, T., Freire, R., Jiao, R. and Stagljar, I. (2005) The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability. J. Cell Sci. 118, 4261-4269.
-
(2005)
J. Cell Sci
, vol.118
, pp. 4261-4269
-
-
Petkovic, M.1
Dietschy, T.2
Freire, R.3
Jiao, R.4
Stagljar, I.5
-
147
-
-
10744225050
-
Growth retardation and skin abnormalities of the Recql4-deficient mouse
-
Hoki, Y., Araki, R., Fujimori, A., Ohhata, T., Koseki, H., Fukumura, R., Nakamura, M., Takahashi, H., Noda, Y., Kito, S. and Abe, M. (2003) Growth retardation and skin abnormalities of the Recql4-deficient mouse. Hum. Mol. Genet. 12, 2293-2299.
-
(2003)
Hum. Mol. Genet
, vol.12
, pp. 2293-2299
-
-
Hoki, Y.1
Araki, R.2
Fujimori, A.3
Ohhata, T.4
Koseki, H.5
Fukumura, R.6
Nakamura, M.7
Takahashi, H.8
Noda, Y.9
Kito, S.10
Abe, M.11
-
148
-
-
33646048761
-
Recql4 haploinsufficiency in mice leads to defects in osteoblast progenitors: Implications for low bone mass phenotype
-
Yang, J., Murthy, S., Winata, T., Werner, S., Abe, M., Prahalad, A. K. and Hock, J. M. (2006) Recql4 haploinsufficiency in mice leads to defects in osteoblast progenitors: Implications for low bone mass phenotype. Biochem. Biophys. Res. Commun. 344, 346-352.
-
(2006)
Biochem. Biophys. Res. Commun
, vol.344
, pp. 346-352
-
-
Yang, J.1
Murthy, S.2
Winata, T.3
Werner, S.4
Abe, M.5
Prahalad, A.K.6
Hock, J.M.7
-
149
-
-
15544389502
-
Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome
-
Mann, M. B., Hodges, C. A., Barnes, E., Vogel, H., Hassold, T. J. and Luo, G. (2005) Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome. Hum. Mol. Genet. 14, 813-825.
-
(2005)
Hum. Mol. Genet
, vol.14
, pp. 813-825
-
-
Mann, M.B.1
Hodges, C.A.2
Barnes, E.3
Vogel, H.4
Hassold, T.J.5
Luo, G.6
-
150
-
-
33748744378
-
Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability
-
Sharma, S., Doherty, K. M. and Brosh, R. M. Jr. (2006) Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem. J. 398, 319-337.
-
(2006)
Biochem. J
, vol.398
, pp. 319-337
-
-
Sharma, S.1
Doherty, K.M.2
Brosh Jr., R.M.3
-
151
-
-
0037965769
-
Functional relation among RecQ family helicases RecQL1, RecQL5, and BLM in cell growth and sister chromatid exchange formation
-
Wang, W., Seki, M., Narita, Y., Nakagawa, T., Yoshimura, A., Otsuki, M., Kawabe, Y., Tada, S., Yagi, H., Ishii, Y. and Enomoto, T. (2003) Functional relation among RecQ family helicases RecQL1, RecQL5, and BLM in cell growth and sister chromatid exchange formation. Mol. Cell. Biol. 23, 3527-3535.
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 3527-3535
-
-
Wang, W.1
Seki, M.2
Narita, Y.3
Nakagawa, T.4
Yoshimura, A.5
Otsuki, M.6
Kawabe, Y.7
Tada, S.8
Yagi, H.9
Ishii, Y.10
Enomoto, T.11
-
152
-
-
33847228012
-
RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability
-
Sharma, S., Stumpo, D. J., Balajee, A. S., Bock, C. B., Lansdorp, P. M., Brosh, R. M. Jr. and Blackshear, P. J. (2007) RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Mol. Cell. Biol. 27, 1784-1794.
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 1784-1794
-
-
Sharma, S.1
Stumpo, D.J.2
Balajee, A.S.3
Bock, C.B.4
Lansdorp, P.M.5
Brosh Jr., R.M.6
Blackshear, P.J.7
-
153
-
-
0034164070
-
Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta
-
Shimamoto, A., Nishikawa, K., Kitao, S. and Furuichi, Y. (2000) Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta. Nucleic Acids Res. 28, 1647-1655.
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 1647-1655
-
-
Shimamoto, A.1
Nishikawa, K.2
Kitao, S.3
Furuichi, Y.4
-
154
-
-
33750980979
-
Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork
-
Kanagaraj, R., Saydam, N., Garcia, P. L., Zheng, L. and Janscak, P. (2006) Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork. Nucleic Acids Res. 34, 5217-5231.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 5217-5231
-
-
Kanagaraj, R.1
Saydam, N.2
Garcia, P.L.3
Zheng, L.4
Janscak, P.5
-
155
-
-
17644410077
-
Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers
-
Hu, Y., Lu, X., Barnes, E., Yan, M., Lou, H. and Luo, G. (2005) Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers. Mol. Cell. Biol. 25, 3431-3442.
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 3431-3442
-
-
Hu, Y.1
Lu, X.2
Barnes, E.3
Yan, M.4
Lou, H.5
Luo, G.6
|