Deletion of Ku80 causes early aging independent of chronic inflammation and Rag-1-induced DSBs

Mechanisms of Ageing and Development

Volumn 128, Issue 11-12, 2007, Pages 601-608

  Holcomb, Valerie B ^a   Vogel, Hannes ^b   Hasty, Paul ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

DNA double strand breaks; Nonhomologous end joining; Opportunistic infection; Rag 1; V(D)J recombination

Indexed keywords

DOUBLE STRANDED DNA; KU ANTIGEN; PROTEIN KU80; RAG1 PROTEIN; RAG2 PROTEIN; UNCLASSIFIED DRUG;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MATURATION; CELL PROLIFERATION; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; DISEASE COURSE; DNA REPAIR; DNA STRAND BREAKAGE; FEMALE; GENE DELETION; GENE SEQUENCE; HISTOLOGY; INFLAMMATION; LIFESPAN; LYMPHOCYTE; MALE; MOUSE; NONHUMAN; OSTEOPENIA; POLYMERASE CHAIN REACTION; PREMATURE AGING; PRIORITY JOURNAL; PROTEIN ASSEMBLY; SEX DIFFERENCE; SKIN ATROPHY; SKIN FIBROBLAST;

AGE FACTORS; AGING, PREMATURE; ANIMALS; ANTIGENS, NUCLEAR; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; DNA BREAKS, DOUBLE-STRANDED; DNA-BINDING PROTEINS; FIBROBLASTS; GENE DELETION; GENOTYPE; HOMEODOMAIN PROTEINS; INFLAMMATION; LONGEVITY; MICE; MICE, KNOCKOUT; MICE, SCID; PHENOTYPE; SEVERE COMBINED IMMUNODEFICIENCY; SEVERITY OF ILLNESS INDEX;

ANIMALIA; MUS;

EID: 37349074760     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2007.08.006     Document Type: Article

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