P2X3 receptor involvement in pain states

Molecular Neurobiology

Volumn 36, Issue 2, 2007, Pages 165-183

  Wirkner, Kerstin ^a   Sperlagh, Beata ^b   Illes, Peter ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Acute pain; Inflammation; Neurophatic pain; P2X3 receptor

Indexed keywords

5 [[(3 PHENOXYBENZYL)(1,2,3,4 TETRAHYDRO 1 NAPHTHYL)AMINO]CARBONYL]TRIMELLITIC ACID; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; DIZOCILPINE; PHENTOLAMINE; PURINERGIC P2X3 RECEPTOR; PURINERGIC P2Y RECEPTOR; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; SURAMIN; TETRAMETHYLPYRAZINE; PURINERGIC P2 RECEPTOR;

CANCER PAIN; DRUG EFFECT; ELECTROCARDIOGRAM; HUMAN; MIGRAINE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PAIN; REVIEW; VISCERAL PAIN; ANIMAL; CHEMISTRY; INFLAMMATION; METABOLISM; NEOPLASM; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; VISCERA;

ADENOSINE TRIPHOSPHATE; ANIMALS; HUMANS; INFLAMMATION; MIGRAINE DISORDERS; NEOPLASMS; NEURONS; PAIN; RECEPTORS, PURINERGIC P2; VISCERA;

EID: 38449111937     PISSN: 08937648     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12035-007-0033-y     Document Type: Review

References (184)

1. 1. HO Collier GW James C Schneider 1966 Antagonism by aspirin and fenamates of bronchoconstriction and nociception induced by adenosine-5′-triphosphate Nature 212 411 412 4381910 1:CAS:528:DyaF28XltFWjtLo%3D Collier HO, James GW, Schneider C (1966) Antagonism by aspirin and fenamates of bronchoconstriction and nociception induced by adenosine-5′-triphosphate. Nature 212:411–412
2. 2. T Bleehen CA Keele 1977 Observations on the algogenic actions of adenosine compounds on the human blister base preparation Pain 3 367 377 198725 1:CAS:528:DyaE2sXlvFCrtro%3D Bleehen T, Keele CA (1977) Observations on the algogenic actions of adenosine compounds on the human blister base preparation. Pain 3:367–377
3. 3. AA Coutts JL Jorizzo RA Eady MW Greaves G Burnstock 1981 Adenosine triphosphate-evoked vascular changes in human skin: mechanism of action Eur J Pharmacol 76 391 401 6173240 1:CAS:528:DyaL38XotVGiuw%3D%3D Coutts AA, Jorizzo JL, Eady RA, Greaves MW, Burnstock G (1981) Adenosine triphosphate-evoked vascular changes in human skin: mechanism of action. Eur J Pharmacol 76:391–401
4. 4. M Tsuda S Koizumi A Kita Y Shigemoto S Ueno K Inoue 2000 Mechanical allodynia caused by intraplantar injection of P2X receptor agonist in rats, involvement of heteromeric P2X2/3 receptor signaling in capsaicin-insensitive primary afferent neurons J Neurosci 20 RC90 10899177 1:STN:280:DC%2BD387os1Onuw%3D%3D Tsuda M, Koizumi S, Kita A, Shigemoto Y, Ueno S, Inoue K (2000) Mechanical allodynia caused by intraplantar injection of P2X receptor agonist in rats, involvement of heteromeric P2X2/3 receptor signaling in capsaicin-insensitive primary afferent neurons. J Neurosci 20:RC90
5. 5. SG Hamilton SB McMahon GR Lewin 2001 Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin J Physiol 534 437 445 11454962 1:CAS:528:DC%2BD3MXlvVSrsr8%3D Hamilton SG, McMahon SB, Lewin GR (2001) Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin. J Physiol 534:437–445
6. 6. K Inoue S Koizumi S Ueno 1996 Implication of ATP receptors in brain functions Prog Neurobiol 50 483 492 9015823 1:CAS:528:DyaK2sXhtVSqtrc%3D Inoue K, Koizumi S, Ueno S (1996) Implication of ATP receptors in brain functions. Prog Neurobiol 50:483–492
7. 7. H Mork M Ashina L Bendtsen J Olesen R Jensen 2003 Experimental muscle pain and tenderness following infusion of endogenous substances in humans Eur J Pain 7 145 153 12600796 1:CAS:528:DC%2BD3sXhsFGgtL0%3D Mork H, Ashina M, Bendtsen L, Olesen J, Jensen R (2003) Experimental muscle pain and tenderness following infusion of endogenous substances in humans. Eur J Pain 7:145–153
8. 8. DR Ferguson I Kennedy TJ Burton 1997 ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes—a possible sensory mechanism? J Physiol 505 Pt 2 503 511 9423189 1:CAS:528:DyaK1cXmtFOr Ferguson DR, Kennedy I, Burton TJ (1997) ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes—a possible sensory mechanism? J Physiol 505(Pt 2):503–511
9. 9. W Park I Masuda A Cardenal-Escarcena DL Palmer DJ McCarty 1996 Inorganic pyrophosphate generation from adenosine triphosphate by cell-free human synovial fluid J Rheumatol 23 665 671 8730124 1:CAS:528:DyaK28XislGrs74%3D Park W, Masuda I, Cardenal-Escarcena A, Palmer DL, McCarty DJ (1996) Inorganic pyrophosphate generation from adenosine triphosphate by cell-free human synovial fluid. J Rheumatol 23:665–671
10. 10. LM Ryan JW Rachow DJ McCarty 1991 Synovial fluid ATP, a potential substrate for the production of inorganic pyrophosphate J Rheumatol 18 716 720 1650841 1:CAS:528:DyaK3MXlsFKns74%3D Ryan LM, Rachow JW, McCarty DJ (1991) Synovial fluid ATP, a potential substrate for the production of inorganic pyrophosphate. J Rheumatol 18:716–720
11. 11. BA Chizh P Illes 2001 P2X receptors and nociception Pharmacol Rev 53 553 568 11734618 1:CAS:528:DC%2BD38XltVOlug%3D%3D Chizh BA, Illes P (2001) P2X receptors and nociception. Pharmacol Rev 53:553–568
12. 12. G Burnstock 2000 P2X receptors in sensory neurones Br J Anaesth 84 476 488 10823099 1:CAS:528:DC%2BD3cXivFWkurc%3D Burnstock G (2000) P2X receptors in sensory neurones. Br J Anaesth 84:476–488
13. 13. G Burnstock 2006 Historical review: ATP as a neurotransmitter Trends Pharmacol Sci 27 166 176 16487603 1:CAS:528:DC%2BD28XivVCmu7k%3D Burnstock G (2006) Historical review: ATP as a neurotransmitter. Trends Pharmacol Sci 27:166–176
14. 14. L Erb Z Liao CI Seye GA Weisman 2006 P2 Receptors, intracellular signaling Pflugers Arch 452 552 562 16586093 1:CAS:528:DC%2BD28XmsFOms7g%3D Erb L, Liao Z, Seye CI, Weisman GA (2006) P2 Receptors, intracellular signaling. Pflugers Arch 452:552–562
15. 15. RA North 2002 Molecular physiology of P2X receptors Physiol Rev 82 1013 1067 12270951 1:CAS:528:DC%2BD38Xot1Ggu78%3D North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82:1013–1067
16. 16. RR Ji H Baba GJ Brenner CJ Woolf 1999 Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity Nat Neurosci 2 1114 1119 10570489 1:CAS:528:DyaK1MXnslKqtL0%3D Ji RR, Baba H, Brenner GJ, Woolf CJ (1999) Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci 2:1114–1119
17. 17. A Nicke HG Baumert J Rettinger A Eichele G Lambrecht E Mutschler G Schmalzing 1998 P2X 1 and P2X 3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels EMBO J 17 3016 3028 9606184 1:CAS:528:DyaK1cXjvFejurk%3D Nicke A, Baumert HG, Rettinger J, Eichele A, Lambrecht G, Mutschler E, Schmalzing G (1998) P2X 1 and P2X 3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels. EMBO J 17:3016–3028
18. 18. J Rettinger A Aschrafi G Schmalzing 2000 Roles of individual n-glycans for ATP potency and expression of the rat P2X1 receptor J Biol Chem 275 33542 33547 10942758 1:CAS:528:DC%2BD3cXnvVyjs70%3D Rettinger J, Aschrafi A, Schmalzing G (2000) Roles of individual n-glycans for ATP potency and expression of the rat P2X1 receptor. J Biol Chem 275:33542–33547
19. 19. TM Egan JA Cox MM Voigt 2004 Molecular structure of P2X receptors Curr Top Med Chem 4 821 829 15078213 1:CAS:528:DC%2BD2cXjtVeju7o%3D Egan TM, Cox JA, Voigt MM (2004) Molecular structure of P2X receptors. Curr Top Med Chem 4:821–829
20. 20. TM Egan DS Samways Z Li 2006 Biophysics of P2X receptors Pflugers Arch 452 501 512 16708237 1:CAS:528:DC%2BD28XmsFOmsLc%3D Egan TM, Samways DS, Li Z (2006) Biophysics of P2X receptors. Pflugers Arch 452:501–512
21. 21. JR Gever DA Cockayne MP Dillon G Burnstock AP Ford 2006 Pharmacology of P2X channels Pflugers Arch 452 513 537 16649055 1:CAS:528:DC%2BD28XmsFOmsLs%3D Gever JR, Cockayne DA, Dillon MP, Burnstock G, Ford AP (2006) Pharmacology of P2X channels. Pflugers Arch 452:513–537
22. 22. S Hussl S Boehm 2006 Functions of neuronal P2Y receptors Pflugers Arch 452 538 551 16691392 1:CAS:528:DC%2BD28XmsFOmsLY%3D Hussl S, Boehm S (2006) Functions of neuronal P2Y receptors. Pflugers Arch 452:538–551
23. 23. I Kugelgen von 2006 Pharmacological profiles of cloned mammalian P2Y-receptor subtypes Pharmacol Ther 110 415 432 von Kugelgen I (2006) Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther 110:415–432
24. 24. A Brunschweiger CE Muller 2006 P2 receptors activated by uracil nucleotides—an update Curr Med Chem 13 289 312 16475938 1:CAS:528:DC%2BD28XhtVequrc%3D Brunschweiger A, Muller CE (2006) P2 receptors activated by uracil nucleotides—an update. Curr Med Chem 13:289–312
25. 25. BS Khakh 2001 Molecular physiology of P2X receptors and ATP signalling at synapses Nat Rev Neurosci 2 165 174 11256077 1:CAS:528:DC%2BD3MXitVyqs7k%3D Khakh BS (2001) Molecular physiology of P2X receptors and ATP signalling at synapses. Nat Rev Neurosci 2:165–174
26. 26. XF Zhang P Han CR Faltynek MF Jarvis CC Shieh 2005 Functional expression of P2X7 receptors in non-neuronal cells of rat dorsal root ganglia Brain Res 1052 63 70 16005856 1:CAS:528:DC%2BD2MXnslyit70%3D Zhang XF, Han P, Faltynek CR, Jarvis MF, Shieh CC (2005) Functional expression of P2X7 receptors in non-neuronal cells of rat dorsal root ganglia. Brain Res 1052:63–70
27. 27. C Lewis S Neidhart C Holy RA North G Buell A Surprenant 1995 Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons Nature 377 432 435 7566120 1:CAS:528:DyaK2MXos1Slsr8%3D Lewis C, Neidhart S, Holy C, North RA, Buell G, Surprenant A (1995) Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature 377:432–435
28. 28. G Collo RA North E Kawashima E Merlo-Pich S Neidhart A Surprenant G Buell 1996 Cloning of P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels J Neurosci 16 2495 2507 8786426 1:CAS:528:DyaK28XitFKhtbc%3D Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G (1996) Cloning of P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J Neurosci 16:2495–2507
29. 29. Z Xiang X Bo G Burnstock 1998 Localization of ATP-gated P2X receptor immunoreactivity in rat sensory and sympathetic ganglia Neurosci Lett 256 105 108 9853714 1:CAS:528:DyaK1cXmvFWlt7g%3D Xiang Z, Bo X, Burnstock G (1998) Localization of ATP-gated P2X receptor immunoreactivity in rat sensory and sympathetic ganglia. Neurosci Lett 256:105–108
30. 30. K Kobayashi T Fukuoka H Yamanaka Y Dai K Obata A Tokunaga K Noguchi 2005 Differential expression patterns of MRNAs for P2X receptor subunits in neurochemically characterized dorsal root ganglion neurons in the rat J Comp Neurol 481 377 390 15593340 1:CAS:528:DC%2BD2MXnslWmsw%3D%3D Kobayashi K, Fukuoka T, Yamanaka H, Dai Y, Obata K, Tokunaga A, Noguchi K (2005) Differential expression patterns of MRNAs for P2X receptor subunits in neurochemically characterized dorsal root ganglion neurons in the rat. J Comp Neurol 481:377–390
31. 31. HZ Ruan LA Birder WC Groat de C Tai J Roppolo CA Buffington G Burnstock 2005 Localization of P2X and P2Y receptors in dorsal root ganglia of the cat J Histochem Cytochem 53 1273 1282 15923368 1:CAS:528:DC%2BD2MXhtVCgt7nE Ruan HZ, Birder LA, de Groat WC, Tai C, Roppolo J, Buffington CA, Burnstock G (2005) Localization of P2X and P2Y receptors in dorsal root ganglia of the cat. J Histochem Cytochem 53:1273–1282
32. 32. IP Chessell JP Hatcher C Bountra AD Michel JP Hughes P Green J Egerton M Murfin J Richardson WL Peck CB Grahames MA Casula Y Yiangou R Birch P Anand GN Buell 2005 Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain Pain 114 386 396 15777864 1:CAS:528:DC%2BD2MXitlCiu78%3D Chessell IP, Hatcher JP, Bountra C, Michel AD, Hughes JP, Green P, Egerton J, Murfin M, Richardson J, Peck WL, Grahames CB, Casula MA, Yiangou Y, Birch R, Anand P, Buell GN (2005) Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain 114:386–396
33. 33. WD Snider SB McMahon 1998 Tackling pain at the source: new ideas about nociceptors Neuron 20 629 632 9581756 1:CAS:528:DyaK1cXivVCjtbs%3D Snider WD, McMahon SB (1998) Tackling pain at the source: new ideas about nociceptors. Neuron 20:629–632
34. 34. DC Molliver DE Wright ML Leitner AS Parsadanian K Doster D Wen Q Yan WD Snider 1997 IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life Neuron 19 849 861 9354331 1:CAS:528:DyaK2sXntFersLg%3D Molliver DC, Wright DE, Leitner ML, Parsadanian AS, Doster K, Wen D, Yan Q, Snider WD (1997) IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. Neuron 19:849–861
35. 35. DL Bennett GJ Michael N Ramachandran JB Munson S Averill Q Yan SB McMahon JV Priestley 1998 A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury J Neurosci 18 3059 3072 9526023 1:CAS:528:DyaK1cXis1ejtbc%3D Bennett DL, Michael GJ, Ramachandran N, Munson JB, Averill S, Yan Q, McMahon SB, Priestley JV (1998) A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury. J Neurosci 18:3059–3072
36. 36. L Vulchanova MS Riedl SJ Shuster G Buell A Surprenant RA North R Elde 1997 Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals Neuropharmacology 36 1229 1242 9364478 1:CAS:528:DyaK2sXnt1emu7o%3D Vulchanova L, Riedl MS, Shuster SJ, Buell G, Surprenant A, North RA, Elde R (1997) Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals. Neuropharmacology 36:1229–1242
37. 37. EJ Bradbury G Burnstock SB McMahon 1998 The expression of P2X3 purinoreceptors in sensory neurons, effects of axotomy and glial-derived neurotrophic factor Mol Cell Neurosci 12 256 268 9828090 1:CAS:528:DyaK1cXnsVeqtr0%3D Bradbury EJ, Burnstock G, McMahon SB (1998) The expression of P2X3 purinoreceptors in sensory neurons, effects of axotomy and glial-derived neurotrophic factor. Mol Cell Neurosci 12:256–268
38. 38. CC Chen AN Akopian L Sivilotti D Colquhoun G Burnstock JN Wood 1995 A P2X purinoceptor expressed by a subset of sensory neurons Nature 377 428 431 7566119 1:CAS:528:DyaK2MXos1Slsr4%3D Chen CC, Akopian AN, Sivilotti L, Colquhoun D, Burnstock G, Wood JN (1995) A P2X purinoceptor expressed by a subset of sensory neurons. Nature 377:428–431
39. 39. PA Bland-Ward PP Humphrey 1997 Acute nociception mediated by hindpaw P2X receptor activation in the rat Br J Pharmacol 122 365 371 9313948 1:CAS:528:DyaK2sXmtlyrtL8%3D Bland-Ward PA, Humphrey PP (1997) Acute nociception mediated by hindpaw P2X receptor activation in the rat. Br J Pharmacol 122:365–371
40. 40. SJ Robertson MG Rae EG Rowan C Kennedy 1996 Characterization of a P2X-purinoceptor in cultured neurones of the rat dorsal root ganglia Br J Pharmacol 118 951 956 8799567 1:CAS:528:DyaK28Xkt1OqtLk%3D Robertson SJ, Rae MG, Rowan EG, Kennedy C (1996) Characterization of a P2X-purinoceptor in cultured neurones of the rat dorsal root ganglia. Br J Pharmacol 118:951–956
41. 41. SP Cook L Vulchanova KM Hargreaves R Elde EW McCleskey 1997 Distinct ATP receptors on pain-sensing and stretch-sensing neurons Nature 387 505 508 9168113 1:CAS:528:DyaK2sXjsF2gurs%3D Cook SP, Vulchanova L, Hargreaves KM, Elde R, McCleskey EW (1997) Distinct ATP receptors on pain-sensing and stretch-sensing neurons. Nature 387:505–508
42. 42. S Ueno M Tsuda T Iwanaga K Inoue 1999 Cell type-specific ATP-activated responses in rat dorsal root ganglion neurons Br J Pharmacol 126 429 436 10077235 1:CAS:528:DyaK1MXht1ers7g%3D Ueno S, Tsuda M, Iwanaga T, Inoue K (1999) Cell type-specific ATP-activated responses in rat dorsal root ganglion neurons. Br J Pharmacol 126:429–436
43. 43. RA North 2002 Molecular physiology of P2X receptors Physiol Rev 82 1013 1067 12270951 1:CAS:528:DC%2BD38Xot1Ggu78%3D North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82:1013–1067
44. 44. DA Cockayne SG Hamilton QM Zhu PM Dunn Y Zhong S Novakovic AB Malmberg G Cain A Berson L Kassotakis L Hedley WG Lachnit G Burnstock SB McMahon AP Ford 2000 Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice Nature 407 1011 1015 11069181 1:CAS:528:DC%2BD3cXnvVaqsLk%3D Cockayne DA, Hamilton SG, Zhu QM, Dunn PM, Zhong Y, Novakovic S, Malmberg AB, Cain G, Berson A, Kassotakis L, Hedley L, Lachnit WG, Burnstock G, McMahon SB, Ford AP (2000) Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature 407:1011–1015
45. 45. V Souslova P Cesare Y Ding AN Akopian L Stanfa R Suzuki K Carpenter A Dickenson S Boyce R Hill D Nebenuis-Oosthuizen AJ Smith EJ Kidd JN Wood 2000 Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors Nature 407 1015 1017 11069182 1:CAS:528:DC%2BD3cXnvVaqsbc%3D Souslova V, Cesare P, Ding Y, Akopian AN, Stanfa L, Suzuki R, Carpenter K, Dickenson A, Boyce S, Hill R, Nebenuis-Oosthuizen D, Smith AJ, Kidd EJ, Wood JN (2000) Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors. Nature 407:1015–1017
46. 46. F Vacca S Amadio G Sancesario G Bernardi C Volonte 2004 P2X3 receptor localizes into lipid rafts in neuronal cells J Neurosci Res 76 653 661 15139024 1:CAS:528:DC%2BD2cXks12ltL8%3D Vacca F, Amadio S, Sancesario G, Bernardi G, Volonte C (2004) P2X3 receptor localizes into lipid rafts in neuronal cells. J Neurosci Res 76:653–661
47. 47. P Keller K Simons 1998 Cholesterol is required for surface transport of influenza virus hemagglutinin J Cell Biol 140 1357 1367 9508769 1:CAS:528:DyaK1cXitFChs7w%3D Keller P, Simons K (1998) Cholesterol is required for surface transport of influenza virus hemagglutinin. J Cell Biol 140:1357–1367
48. 48. BA Tsui-Pierchala M Encinas J Milbrandt EM Johnson Jr. 2002 Lipid rafts in neuronal signaling and function Trends Neurosci 25 412 417 12127758 1:CAS:528:DC%2BD38XlsVOlsL8%3D Tsui-Pierchala BA, Encinas M, Milbrandt J, Johnson EM Jr. (2002) Lipid rafts in neuronal signaling and function. Trends Neurosci 25:412–417
49. 49. J Eriksson U Bongenhielm E Kidd B Matthews K Fried 1998 Distribution of P2X3 receptors in the rat trigeminal ganglion after inferior alveolar nerve injury Neurosci Lett 254 37 40 9780086 1:CAS:528:DyaK1cXmsFCltrg%3D Eriksson J, Bongenhielm U, Kidd E, Matthews B, Fried K (1998) Distribution of P2X3 receptors in the rat trigeminal ganglion after inferior alveolar nerve injury. Neurosci Lett 254:37–40
50. 50. IJ Llewellyn-Smith G Burnstock 1998 Ultrastructural localization of P2X3 receptors in rat sensory neurons Neuroreport 9 2545 2550 9721930 1:CAS:528:DyaK1cXlvVClt74%3D 10.1097/00001756-199808030-00022 Llewellyn-Smith IJ, Burnstock G (1998) Ultrastructural localization of P2X3 receptors in rat sensory neurons. Neuroreport 9:2545–2550
51. 51. C Virginio RA North A Surprenant 1998 Calcium permeability and block at homomeric and heteromeric P2X2 and P2X3 receptors, and P2X receptors in rat nodose neurones J Physiol 510 Pt 1 27 35 9625864 1:CAS:528:DyaK1cXkvVKksrs%3D Virginio C, North RA, Surprenant A (1998) Calcium permeability and block at homomeric and heteromeric P2X2 and P2X3 receptors, and P2X receptors in rat nodose neurones. J Physiol 510(Pt 1):27–35
52. 52. S Thomas C Virginio RA North A Surprenant 1998 The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose neurones J Physiol 509 Pt 2 411 417 9575290 1:CAS:528:DyaK1cXktlCjtrc%3D Thomas S, Virginio C, North RA, Surprenant A (1998) The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose neurones. J Physiol 509(Pt 2):411–417
53. 53. O Krishtal N Lozovaya A Fedorenko I Savelyev I Chizhmakov 2006 The agonists for nociceptors are ubiquitous, but the modulators are specific: P2X receptors in the sensory neurons are modulated by cannabinoids Pflugers Arch 453 353 360 16741755 1:CAS:528:DC%2BD28Xht1WhsbvJ Krishtal O, Lozovaya N, Fedorenko A, Savelyev I, Chizhmakov I (2006) The agonists for nociceptors are ubiquitous, but the modulators are specific: P2X receptors in the sensory neurons are modulated by cannabinoids. Pflugers Arch 453:353–360
54. 54. HZ Ruan E Moules G Burnstock 2004 Changes in P2X3 purinoceptors in sensory ganglia of the mouse during embryonic and postnatal development Histochem Cell Biol 122 539 551 15549366 1:CAS:528:DC%2BD2MXksVKlsA%3D%3D Ruan HZ, Moules E, Burnstock G (2004) Changes in P2X3 purinoceptors in sensory ganglia of the mouse during embryonic and postnatal development. Histochem Cell Biol 122:539–551
55. 55. JC Petruska BY Cooper RD Johnson JG Gu 2000 Distribution patterns of different P2x receptor phenotypes in acutely dissociated dorsal root ganglion neurons of adult rats Exp Brain Res 134 126 132 11026733 1:CAS:528:DC%2BD3cXnsVers7k%3D Petruska JC, Cooper BY, Johnson RD, Gu JG (2000) Distribution patterns of different P2x receptor phenotypes in acutely dissociated dorsal root ganglion neurons of adult rats. Exp Brain Res 134:126–132
56. 56. BD Grubb RJ Evans 1999 Characterization of cultured dorsal root ganglion neuron P2X receptors Eur J Neurosci 11 149 154 9987019 1:STN:280:DyaK1M7ktFCqsA%3D%3D Grubb BD, Evans RJ (1999) Characterization of cultured dorsal root ganglion neuron P2X receptors. Eur J Neurosci 11:149–154
57. 57. Y Zhong PM Dunn M Bardini AP Ford DA Cockayne G Burnstock 2001 Changes in P2X receptor responses of sensory neurons from P2X3-deficient mice Eur J Neurosci 14 1784 1792 11860473 1:STN:280:DC%2BD387jvVShug%3D%3D Zhong Y, Dunn PM, Bardini M, Ford AP, Cockayne DA, Burnstock G (2001) Changes in P2X receptor responses of sensory neurons from P2X3-deficient mice. Eur J Neurosci 14:1784–1792
58. 58. DA Cockayne PM Dunn Y Zhong W Rong SG Hamilton GE Knight HZ Ruan B Ma P Yip P Nunn SB McMahon G Burnstock AP Ford 2005 P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP J Physiol 567 621 639 15961431 1:CAS:528:DC%2BD2MXhtVaqur%2FE Cockayne DA, Dunn PM, Zhong Y, Rong W, Hamilton SG, Knight GE, Ruan HZ, Ma B, Yip P, Nunn P, McMahon SB, Burnstock G, Ford AP (2005) P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP. J Physiol 567:621–639
59. 59. CE Jahr TM Jessell 1983 ATP excites a subpopulation of rat dorsal horn neurones Nature 304 730 733 6888539 1:CAS:528:DyaL3sXltFKktbo%3D Jahr CE, Jessell TM (1983) ATP excites a subpopulation of rat dorsal horn neurones. Nature 304:730–733
60. 60. J Li ER Perl 1995 ATP modulation of synaptic transmission in the spinal substantia gelatinosa J Neurosci 15 3357 3365 7751915 1:CAS:528:DyaK2MXls1ahtLo%3D Li J, Perl ER (1995) ATP modulation of synaptic transmission in the spinal substantia gelatinosa. J Neurosci 15:3357–3365
61. 61. H Shiokawa T Nakatsuka H Furue M Tsuda T Katafuchi K Inoue M Yoshimura 2006 Direct excitation of deep dorsal horn neurones in the rat spinal cord by the activation of postsynaptic P2X receptors J Physiol 573 753 763 16613873 1:CAS:528:DC%2BD28XntFGnsbg%3D Shiokawa H, Nakatsuka T, Furue H, Tsuda M, Katafuchi T, Inoue K, Yoshimura M (2006) Direct excitation of deep dorsal horn neurones in the rat spinal cord by the activation of postsynaptic P2X receptors. J Physiol 573:753–763
62. 62. G Collo S Neidhart E Kawashima M Kosco-Vilbois RA North G Buell 1997 Tissue distribution of the P2X7 receptor Neuropharmacology 36 1277 1283 9364482 1:CAS:528:DyaK2sXnt1emu7Y%3D Collo G, Neidhart S, Kawashima E, Kosco-Vilbois M, North RA, Buell G (1997) Tissue distribution of the P2X7 receptor. Neuropharmacology 36:1277–1283
63. 63. L Vulchanova U Arvidsson M Riedl J Wang G Buell A Surprenant RA North R Elde 1996 Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry Proc Natl Acad Sci U S A 93 8063 8067 8755603 1:CAS:528:DyaK28XksFSru7c%3D Vulchanova L, Arvidsson U, Riedl M, Wang J, Buell G, Surprenant A, North RA, Elde R (1996) Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry. Proc Natl Acad Sci U S A 93:8063–8067
64. 64. JG Gu 2003 P2X receptor-mediated modulation of sensory transmission to the spinal cord dorsal horn Neuroscientist 9 370 378 14580121 1:CAS:528:DC%2BD3sXoslajsbk%3D Gu JG (2003) P2X receptor-mediated modulation of sensory transmission to the spinal cord dorsal horn. Neuroscientist 9:370–378
65. 65. M Chen JG Gu 2005 A P2X receptor-mediated nociceptive afferent pathway to lamina I of the spinal cord Mol Pain 1 4 15813988 Chen M, Gu JG (2005) A P2X receptor-mediated nociceptive afferent pathway to lamina I of the spinal cord. Mol Pain 1:4
66. 66. L Vulchanova MS Riedl SJ Shuster LS Stone KM Hargreaves G Buell A Surprenant RA North R Elde 1998 P2X3 is expressed by DRG neurons that terminate in inner lamina II Eur J Neurosci 10 3470 3478 9824460 1:STN:280:DyaK1M%2Fks1yntA%3D%3D Vulchanova L, Riedl MS, Shuster SJ, Stone LS, Hargreaves KM, Buell G, Surprenant A, North RA, Elde R (1998) P2X3 is expressed by DRG neurons that terminate in inner lamina II. Eur J Neurosci 10:3470–3478
67. 67. T Nakatsuka H Furue M Yoshimura JG Gu 2002 Activation of central terminal vanilloid receptor-1 receptors and alpha beta-methylene-ATP-sensitive P2X receptors reveals a converged synaptic activity onto the deep dorsal horn neurons of the spinal cord J Neurosci 22 1228 1237 11850450 1:CAS:528:DC%2BD38XhsFeksrc%3D Nakatsuka T, Furue H, Yoshimura M, Gu JG (2002) Activation of central terminal vanilloid receptor-1 receptors and alpha beta-methylene-ATP-sensitive P2X receptors reveals a converged synaptic activity onto the deep dorsal horn neurons of the spinal cord. J Neurosci 22;1228–1237
68. 68. M Tsuda Y Shigemoto-Mogami S Koizumi A Mizokoshi S Kohsaka MW Salter K Inoue 2003 P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury Nature 424 778 783 12917686 1:CAS:528:DC%2BD3sXmt1ansbg%3D Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW, Inoue K (2003) P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 424:778–783
69. 69. K Inoue 2006 ATP receptors of microglia involved in pain Novartis Found Symp 276 263 272 16805436 1:CAS:528:DC%2BD2sXovFGrsbs%3D Inoue K (2006) ATP receptors of microglia involved in pain. Novartis Found Symp 276:263–272
70. 70. M Okada T Nakagawa M Minami M Satoh 2002 Analgesic effects of intrathecal administration of P2Y nucleotide receptor agonists UTP and UDP in normal and neuropathic pain model rats J Pharmacol Exp Ther 303 66 73 12235234 1:CAS:528:DC%2BD38XnsV2qsrs%3D Okada M, Nakagawa T, Minami M, Satoh M (2002) Analgesic effects of intrathecal administration of P2Y nucleotide receptor agonists UTP and UDP in normal and neuropathic pain model rats. J Pharmacol Exp Ther 303:66–73
71. 71. Z Gerevich SJ Borvendeg W Schroder H Franke K Wirkner W Norenberg S Furst C Gillen P Illes 2004 Inhibition of N-type voltage-activated calcium channels in rat dorsal root ganglion neurons by P2Y receptors is a possible mechanism of ADP-induced analgesia J Neurosci 24 797 807 14749424 1:CAS:528:DC%2BD2cXhsFOisbg%3D Gerevich Z, Borvendeg SJ, Schroder W, Franke H, Wirkner K, Norenberg W, Furst S, Gillen C, Illes P (2004) Inhibition of N-type voltage-activated calcium channels in rat dorsal root ganglion neurons by P2Y receptors is a possible mechanism of ADP-induced analgesia. J Neurosci 24;797–807
72. 72. Z Gerevich P Illes 2004 P2Y receptors and pain transmission Purinergic Signalling 1 3 10 1:CAS:528:DC%2BD2MXhvFKjs7o%3D 18404394 Gerevich Z, Illes P (2004) P2Y receptors and pain transmission. Purinergic Signalling 1:3–10
73. 73. K Kobayashi T Fukuoka H Yamanaka Y Dai K Obata A Tokunaga K Noguchi 2006 Neurons and glial cells differentially express P2Y receptor MRNAs in the rat dorsal root ganglion and spinal cord J Comp Neurol 498 443 454 16874807 1:CAS:528:DC%2BD28XpsFGgur0%3D Kobayashi K, Fukuoka T, Yamanaka H, Dai Y, Obata K, Tokunaga A, Noguchi K (2006) Neurons and glial cells differentially express P2Y receptor MRNAs in the rat dorsal root ganglion and spinal cord. J Comp Neurol 498:443–454
74. 74. CL Stucky KA Medler DC Molliver 2004 The P2Y agonist UTP activates cutaneous afferent fibers Pain 109 36 44 15082124 1:CAS:528:DC%2BD2cXjtVCgur0%3D Stucky CL, Medler KA, Molliver DC (2004) The P2Y agonist UTP activates cutaneous afferent fibers. Pain 109:36–44
75. 75. K Yoshida T Nakagawa S Kaneko A Akaike M Satoh 2002 Adenosine 5′-triphosphate inhibits slow depolarization induced by repetitive dorsal root stimulation via P2Y purinoceptors in substantia gelatinosa neurons of the adult rat spinal cord slices with the dorsal root attached Neurosci Lett 320 121 124 11852177 1:CAS:528:DC%2BD38Xhtlert74%3D Yoshida K, Nakagawa T, Kaneko S, Akaike A, Satoh M (2002) Adenosine 5′-triphosphate inhibits slow depolarization induced by repetitive dorsal root stimulation via P2Y purinoceptors in substantia gelatinosa neurons of the adult rat spinal cord slices with the dorsal root attached. Neurosci Lett 320:121–124
76. 76. K Alexander W Niforatos B Bianchi EC Burgard KJ Lynch EA Kowaluk MF Jarvis BT Van 1999 Allosteric modulation and accelerated resensitization of human P2X(3) receptors by Cibacron blue J Pharmacol Exp Ther 291 1135 1142 10565834 1:CAS:528:DyaK1MXnslygu7Y%3D Alexander K, Niforatos W, Bianchi B, Burgard EC, Lynch KJ, Kowaluk EA, Jarvis MF, Van BT (1999) Allosteric modulation and accelerated resensitization of human P2X(3) receptors by Cibacron blue. J Pharmacol Exp Ther 291:1135–1142
77. 77. CJ Lewis A Surprenant RJ Evans 1998 2′,3′-O-(2,4,6-trinitrophenyl) adenosine 5′-triphosphate (TNP-ATP)—a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels Br J Pharmacol 124 1463 1466 9723959 1:CAS:528:DyaK1cXlsVWnurY%3D Lewis CJ, Surprenant A, Evans RJ (1998) 2′,3′-O-(2,4,6-trinitrophenyl) adenosine 5′-triphosphate (TNP-ATP)—a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. Br J Pharmacol 124:1463–1466
78. 78. SG Hamilton J Warburton A Bhattacharjee J Ward SB McMahon 2000 ATP in human skin elicits a dose-related pain response which is potentiated under conditions of hyperalgesia Brain 123 Pt 6 1238 1246 10825361 Hamilton SG, Warburton J, Bhattacharjee A, Ward J, McMahon SB (2000) ATP in human skin elicits a dose-related pain response which is potentiated under conditions of hyperalgesia. Brain 123(Pt 6):1238–1246
79. 79. E Sokolova A Skorinkin I Moiseev A Agrachev A Nistri R Giniatullin 2006 Experimental and modeling studies of desensitization of P2X3 receptors Mol Pharmacol 70 373 382 16627751 1:CAS:528:DC%2BD28XmsFyms78%3D Sokolova E, Skorinkin A, Moiseev I, Agrachev A, Nistri A, Giniatullin R (2006) Experimental and modeling studies of desensitization of P2X3 receptors. Mol Pharmacol 70:373–382
80. 80. JW Phillis MH O’Regan LM Perkins 1993 Adenosine 5′-triphosphate release from the normoxic and hypoxic in vivo rat cerebral cortex Neurosci Lett 151 94 96 8469442 1:CAS:528:DyaK3sXks12mtbY%3D Phillis JW, O’Regan MH, Perkins LM (1993) Adenosine 5′-triphosphate release from the normoxic and hypoxic in vivo rat cerebral cortex. Neurosci Lett 151:94–96
81. 81. AI Kuzmin VL Lakomkin VI Kapelko G Vassort 1998 Interstitial ATP level and degradation in control and postmyocardial infarcted rats Am J Physiol 275 C766 C771 9730960 1:CAS:528:DyaK1cXmtFSqsb4%3D Kuzmin AI, Lakomkin VL, Kapelko VI, Vassort G (1998) Interstitial ATP level and degradation in control and postmyocardial infarcted rats. Am J Physiol 275:C766–C771
82. 82. M Tsuda Y Shigemoto-Mogami S Ueno S Koizumi H Ueda T Iwanaga K Inoue 2002 Downregulation of P2X3 receptor-dependent sensory functions in A/J inbred mouse strain Eur J Neurosci 15 1444 1450 12028354 Tsuda M, Shigemoto-Mogami Y, Ueno S, Koizumi S, Ueda H, Iwanaga T, Inoue K (2002) Downregulation of P2X3 receptor-dependent sensory functions in A/J inbred mouse strain. Eur J Neurosci 15:1444–1450
83. 83. MF Jarvis EC Burgard S McGaraughty P Honore K Lynch TJ Brennan A Subieta BT Van J Cartmell B Bianchi W Niforatos K Kage H Yu J Mikusa CT Wismer CZ Zhu K Chu CH Lee AO Stewart J Polakowski BF Cox E Kowaluk M Williams J Sullivan C Faltynek 2002 A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat Proc Natl Acad Sci U S A 99 17179 17184 12482951 1:CAS:528:DC%2BD3sXhvV2qsQ%3D%3D Jarvis MF, Burgard EC, McGaraughty S, Honore P, Lynch K, Brennan TJ, Subieta A, Van BT, Cartmell J, Bianchi B, Niforatos W, Kage K, Yu H, Mikusa J, Wismer CT, Zhu CZ, Chu K, Lee CH, Stewart AO, Polakowski J, Cox BF, Kowaluk E, Williams M, Sullivan J, Faltynek C (2002) A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci U S A 99:17179–17184
84. 84. S McGaraughty MF Jarvis 2005 Antinociceptive properties of a non-nucleotide P2X3/P2X2/3 receptor antagonist Drug News Perspect 18 501 507 16391720 1:CAS:528:DC%2BD28Xit1Grtrw%3D McGaraughty S, Jarvis MF (2005) Antinociceptive properties of a non-nucleotide P2X3/P2X2/3 receptor antagonist. Drug News Perspect 18:501–507
85. 85. SD Liang Y Gao CS Xu BH Xu SN Mu 2004 Effect of tetramethylpyrazine on acute nociception mediated by signaling of P2X receptor activation in rat Brain Res 995 247 252 14672814 1:CAS:528:DC%2BD3sXps1Gkt7k%3D Liang SD, Gao Y, Xu CS, Xu BH, Mu SN(2004) Effect of tetramethylpyrazine on acute nociception mediated by signaling of P2X receptor activation in rat. Brain Res 995:247–252
86. 86. J Barclay S Patel G Dorn G Wotherspoon S Moffatt L Eunson S Abdel’al F Natt J Hall J Winter S Bevan W Wishart A Fox P Ganju 2002 Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain J Neurosci 22 8139 8147 12223568 1:CAS:528:DC%2BD38Xnt12rsL0%3D Barclay J, Patel S, Dorn G, Wotherspoon G, Moffatt S, Eunson L, Abdel’al S, Natt F, Hall J, Winter J, Bevan S, Wishart W, Fox A, Ganju P (2002) Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain. J Neurosci 22:8139–8147
87. 87. A Tjølsen OG Berge S Hunskaar JH Rosland K Hole 1992 The formalin test, an evaluation of the method Pain 51 5 17 1454405 Tjølsen A, Berge OG, Hunskaar S, Rosland JH, Hole K (1992) The formalin test, an evaluation of the method. Pain 51:5–17
88. 88. J Sawynok A Reid 1997 Peripheral adenosine 5′-triphosphate enhances nociception in the formalin test via activation of a purinergic P2X receptor Eur J Pharmacol 330 115 121 9253943 1:CAS:528:DyaK2sXkt1Sht7o%3D Sawynok J, Reid A (1997) Peripheral adenosine 5′-triphosphate enhances nociception in the formalin test via activation of a purinergic P2X receptor. Eur J Pharmacol 330:115–121
89. 89. MF Jarvis CT Wismer E Schweitzer H Yu BT Van KJ Lynch EC Burgard EA Kowaluk 2001 Modulation of BzATP and induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, Cibacron blue Br J Pharmacol 132 259 269 11156585 1:CAS:528:DC%2BD3MXhtFCit7o%3D Jarvis MF, Wismer CT, Schweitzer E, Yu H, Van BT, Lynch KJ, Burgard EC, Kowaluk EA (2001) Modulation of BzATP and induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, Cibacron blue. Br J Pharmacol 132:259–269
90. 90. M Tsuda S Ueno K Inoue 1999 Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice Br J Pharmacol 128 1497 1504 10602329 1:CAS:528:DyaK1MXotFSitrw%3D Tsuda M, Ueno S, Inoue K (1999) Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice. Br J Pharmacol 128:1497–1504
91. 91. M Tsuda S Ueno K Inoue 1999 In vivo pathway of thermal hyperalgesia by intrathecal administration of alpha,beta-methylene ATP in mouse spinal cord: involvement of the glutamate-NMDA receptor system Br J Pharmacol 127 449 456 10385245 1:CAS:528:DyaK1MXjs1yqsLc%3D Tsuda M, Ueno S, Inoue K (1999) In vivo pathway of thermal hyperalgesia by intrathecal administration of alpha,beta-methylene ATP in mouse spinal cord: involvement of the glutamate-NMDA receptor system. Br J Pharmacol 127:449–456
92. 92. T Nakatsuka JG Gu 2001 ATP P2X receptor-mediated enhancement of glutamate release and evoked EPSCs in dorsal horn neurons of the rat spinal cord J Neurosci 21 6522 6531 11517241 1:CAS:528:DC%2BD3MXmt1Wjurw%3D Nakatsuka T, Gu JG (2001) ATP P2X receptor-mediated enhancement of glutamate release and evoked EPSCs in dorsal horn neurons of the rat spinal cord. J Neurosci 21:6522–6531
93. 93. T Nakatsuka K Tsuzuki JX Ling H Sonobe JG Gu 2003 Distinct roles of P2X receptors in modulating glutamate release at different primary sensory synapses in rat spinal cord J Neurophysiol 89 3243 3252 12783958 1:CAS:528:DC%2BD3sXlsFaju7w%3D Nakatsuka T, Tsuzuki K, Ling JX, Sonobe H, Gu JG (2003) Distinct roles of P2X receptors in modulating glutamate release at different primary sensory synapses in rat spinal cord. J Neurophysiol 89:3243–3252
94. 94. CT Wismer CR Faltynek MF Jarvis S McGaraughty 2003 Distinct neurochemical mechanisms are activated following administration of different P2X receptor agonists into the hindpaw of a rat Brain Res 965 187 193 12591137 1:CAS:528:DC%2BD3sXht1Kms7Y%3D Wismer CT, Faltynek CR, Jarvis MF, McGaraughty S (2003) Distinct neurochemical mechanisms are activated following administration of different P2X receptor agonists into the hindpaw of a rat. Brain Res 965:187–193
95. 95. SG Hamilton A Wade SB McMahon 1999 The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat Br J Pharmacol 126 326 332 10051152 1:CAS:528:DyaK1MXhslamt7s%3D Hamilton SG, Wade A, McMahon SB (1999) The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat. Br J Pharmacol 126:326–332
96. 96. JL Gordon 1986 Extracellular ATP: effects, sources and fate Biochem J 233 309 319 3006665 1:CAS:528:DyaL28XmsVansQ%3D%3D Gordon JL (1986) Extracellular ATP: effects, sources and fate. Biochem J 233:309–319
97. 97. MW Verghese TB Kneisler JA Boucheron 1996 P2U agonists induce chemotaxis and actin polymerization in human neutrophils and differentiated HL60 cells J Biol Chem 271 15597 15601 8663069 1:CAS:528:DyaK28XjvFWhsrw%3D Verghese MW, Kneisler TB, Boucheron JA (1996) P2U agonists induce chemotaxis and actin polymerization in human neutrophils and differentiated HL60 cells. J Biol Chem 271:15597–15601
98. 98. P Bodin G Burnstock 1998 Increased release of ATP from endothelial cells during acute inflammation Inflamm Res 47 351 354 9754870 1:CAS:528:DyaK1cXls1CntLg%3D Bodin P, Burnstock G (1998) Increased release of ATP from endothelial cells during acute inflammation. Inflamm Res 47:351–354
99. 99. MJ Bours EL Swennen F Virgilio Di BN Cronstein PC Dagnelie 2006 Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation Pharmacol Ther 112 358 404 16784779 1:CAS:528:DC%2BD28XhtVGjt7vF Bours MJ, Swennen EL, Di Virgilio F, Cronstein BN, Dagnelie PC (2006) Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther 112:358–404
100. 100. T Bleehen F Hobbiger CA Keele 1976 Identification of algogenic substances in human erythrocytes J Physiol 262 131 149 994034 1:CAS:528:DyaE2sXltlSjtA%3D%3D Bleehen T, Hobbiger F, Keele CA (1976) Identification of algogenic substances in human erythrocytes. J Physiol 262:131–149
101. 101. PW Reeh KH Steen 1996 Tissue acidosis in nociception and pain Prog Brain Res 113 143 151 9009732 1:CAS:528:DyaK2sXhslKqu7w%3D Reeh PW, Steen KH (1996) Tissue acidosis in nociception and pain. Prog Brain Res 113:143–151
102. 102. K Zimmermann PW Reeh B Averbeck 2002 ATP can enhance the proton-induced CGRP release through P2Y receptors and secondary PGE(2) release in isolated rat dura mater Pain 97 259 265 12044622 1:CAS:528:DC%2BD38XktVartr0%3D Zimmermann K, Reeh PW, Averbeck B (2002) ATP can enhance the proton-induced CGRP release through P2Y receptors and secondary PGE(2) release in isolated rat dura mater. Pain 97:259–265
103. 103. BF King SS Wildman LE Ziganshina J Pintor G Burnstock 1997 Effects of extracellular pH on agonism and antagonism at a recombinant P2X2 receptor Br J Pharmacol 121 1445 1453 9257926 1:CAS:528:DyaK2sXlt1Wjtro%3D King BF, Wildman SS, Ziganshina LE, Pintor J, Burnstock G (1997) Effects of extracellular pH on agonism and antagonism at a recombinant P2X2 receptor. Br J Pharmacol 121:1445–1453
104. 104. K Nakazawa M Liu K Inoue Y Ohno 1997 pH dependence of facilitation by neurotransmitters and divalent cations of P2X2 purinoceptor/channels Eur J Pharmacol 337 309 314 9430430 1:CAS:528:DyaK2sXmsVKlsL8%3D Nakazawa K, Liu M, Inoue K, Ohno Y (1997) pH dependence of facilitation by neurotransmitters and divalent cations of P2X2 purinoceptor/channels. Eur J Pharmacol 337:309–314
105. 105. GY Xu LY Huang 2002 Peripheral inflammation sensitizes P2X receptor-mediated responses in rat dorsal root ganglion neurons J Neurosci 22 93 102 11756492 1:CAS:528:DC%2BD38XislWnsg%3D%3D Xu GY, Huang LY (2002) Peripheral inflammation sensitizes P2X receptor-mediated responses in rat dorsal root ganglion neurons. J Neurosci 22:93–102
106. 106. R Ambalavanar M Moritani D Dessem 2005 Trigeminal P2X3 receptor expression differs from dorsal root ganglion and is modulated by deep tissue inflammation Pain 117 80 291 Ambalavanar R, Moritani M, Dessem D (2005) Trigeminal P2X3 receptor expression differs from dorsal root ganglion and is modulated by deep tissue inflammation. Pain 117:80–291
107. 107. R Ambalavanar M Moritani A Moutanni P Gangula C Yallampalli D Dessem 2006 Deep tissue inflammation upregulates neuropeptides and evokes nociceptive behaviors which are modulated by a neuropeptide antagonist Pain 120 53 68 16359792 1:CAS:528:DC%2BD28XjsF2ntg%3D%3D Ambalavanar R, Moritani M, Moutanni A, Gangula P, Yallampalli C, Dessem D (2006) Deep tissue inflammation upregulates neuropeptides and evokes nociceptive behaviors which are modulated by a neuropeptide antagonist. Pain 120:53–68
108. 108. E Fabbretti M D’Arco A Fabbro M Simonetti A Nistri R Giniatullin 2006 Delayed upregulation of ATP P2X3 receptors of trigeminal sensory neurons by calcitonin gene-related peptide J Neurosci 26 6163 6171 16763024 1:CAS:528:DC%2BD28XmtFSlsL4%3D Fabbretti E, D’Arco M, Fabbro A, Simonetti M, Nistri A, Giniatullin R (2006) Delayed upregulation of ATP P2X3 receptors of trigeminal sensory neurons by calcitonin gene-related peptide. J Neurosci 26:6163–6171
109. 109. B Driessen W Reimann N Selve E Friderichs R Bultmann 1994 Antinociceptive effect of intrathecally administered P2-purinoceptor antagonists in rats Brain Res 666 182 188 7882028 1:CAS:528:DyaK2MXisFars70%3D Driessen B, Reimann W, Selve N, Friderichs E, Bultmann R (1994) Antinociceptive effect of intrathecally administered P2-purinoceptor antagonists in rats. Brain Res 666:182–188
110. 110. LC Stanfa VK Kontinen AH Dickenson 2000 Effects of spinally administered P2X receptor agonists and antagonists on the responses of dorsal horn neurones recorded in normal, carrageenan-inflamed and neuropathic rats Br J Pharmacol 129 351 359 10694242 1:CAS:528:DC%2BD3cXpslyrtw%3D%3D Stanfa LC, Kontinen VK, Dickenson AH (2000) Effects of spinally administered P2X receptor agonists and antagonists on the responses of dorsal horn neurones recorded in normal, carrageenan-inflamed and neuropathic rats. Br J Pharmacol 129:351–359
111. 111. M Shinoda N Ozaki H Asai K Nagamine Y Sugiura 2005 Changes in P2X3 receptor expression in the trigeminal ganglion following monoarthritis of the temporomandibular joint in rats Pain 116 42 51 15936887 1:CAS:528:DC%2BD2MXlsFGhsbg%3D Shinoda M, Ozaki N, Asai H, Nagamine K, Sugiura Y (2005) Changes in P2X3 receptor expression in the trigeminal ganglion following monoarthritis of the temporomandibular joint in rats. Pain 116:42–51
112. 112. Y Dai T Fukuoka H Wang H Yamanaka K Obata A Tokunaga K Noguchi 2004 Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons Pain 108 258 266 15030945 1:CAS:528:DC%2BD2cXitFejtrg%3D Dai Y, Fukuoka T, Wang H, Yamanaka H, Obata K, Tokunaga A, Noguchi K (2004) Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons. Pain 108:258–266
113. 113. SG Hamilton SB McMahon 2000 ATP as a peripheral mediator of pain J Auton Nerv Syst 81 187 194 10869719 1:CAS:528:DC%2BD3cXktlKqtLk%3D Hamilton SG, McMahon SB (2000) ATP as a peripheral mediator of pain. J Auton Nerv Syst 81:187–194
114. 114. E Dowd DS McQueen IP Chessell PP Humphrey 1998 P2X receptor-mediated excitation of nociceptive afferents in the normal and arthritic rat knee joint Br J Pharmacol 125 341 346 9786507 1:CAS:528:DyaK1cXmtlClurg%3D Dowd E, McQueen DS, Chessell IP, Humphrey PP (1998) P2X receptor-mediated excitation of nociceptive afferents in the normal and arthritic rat knee joint. Br J Pharmacol 125:341–346
115. 115. P Honore K Kage J Mikusa AT Watt JF Johnston JR Wyatt CR Faltynek MF Jarvis K Lynch 2002 Analgesic profile of intrathecal P2X(3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats Pain 99 11 19 12237180 1:CAS:528:DC%2BD38XntVWrtL4%3D Honore P, Kage K, Mikusa J, Watt AT, Johnston JF, Wyatt JR, Faltynek CR, Jarvis MF, Lynch K (2002) Analgesic profile of intrathecal P2X(3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats. Pain 99:11–19
116. 116. G Dell’Antonio A Quattrini ED Cin A Fulgenzi ME Ferrero 2002 Relief of inflammatory pain in rats by local use of the selective P2X7 ATP receptor inhibitor, oxidized ATP Arthritis Rheum 46 3378 3385 12483745 1:CAS:528:DC%2BD3sXjslGhuw%3D%3D Dell’Antonio G, Quattrini A, Cin ED, Fulgenzi A, Ferrero ME (2002) Relief of inflammatory pain in rats by local use of the selective P2X7 ATP receptor inhibitor, oxidized ATP. Arthritis Rheum 46:3378–3385
117. 117. G Dell’Antonio A Quattrini CE Dal A Fulgenzi ME Ferrero 2002 Antinociceptive effect of a new P(2Z)/P2X7 antagonist, oxidized ATP, in arthritic rats Neurosci Lett 327 87 90 12098642 1:CAS:528:DC%2BD38XkvFyrs70%3D Dell’Antonio G, Quattrini A, Dal CE, Fulgenzi A, Ferrero ME (2002) Antinociceptive effect of a new P(2Z)/P2X7 antagonist, oxidized ATP, in arthritic rats. Neurosci Lett 327:87–90
118. 118. JM Labasi N Petrushova C Donovan S McCurdy P Lira MM Payette W Brissette JR Wicks L Audoly CA Gabel 2002 Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response J Immunol 168 6436 6445 12055263 1:CAS:528:DC%2BD38XksFWmu78%3D Labasi JM, Petrushova N, Donovan C, McCurdy S, Lira P, Payette MM, Brissette W, Wicks JR, Audoly L, Gabel CA (2002) Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J Immunol 168:6436–6445
119. 119. CJ Woolf QP Ma A Allchorne S Poole 1996 Peripheral cell types contributing to the hyperalgesic action of nerve growth factor in inflammation J Neurosci 16 2716 2723 8786447 1:CAS:528:DyaK28XitFKgsr4%3D Woolf CJ, Ma QP, Allchorne A, Poole S (1996) Peripheral cell types contributing to the hyperalgesic action of nerve growth factor in inflammation. J Neurosci 16:2716–2723
120. 120. CJ Woolf A Allchorne B Safieh-Garabedian S Poole 1997 Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor alpha Br J Pharmacol 121 417 424 9179382 1:CAS:528:DyaK2sXjs1Kmt7g%3D Woolf CJ, Allchorne A, Safieh-Garabedian B, Poole S (1997) Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor alpha. Br J Pharmacol 121:417–424
121. 121. TA Samad KA Moore A Sapirstein S Billet A Allchorne S Poole JV Bonventre CJ Woolf 2001 Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity Nature 410 471 475 11260714 1:CAS:528:DC%2BD3MXisFahsrs%3D Samad TA, Moore KA, Sapirstein A, Billet S, Allchorne A, Poole S, Bonventre JV, Woolf CJ (2001) Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature 410:471–475
122. 122. J Sawynok 2006 Adenosine and ATP receptors Handb Exp Pharmacol 177 309 328 10.1007/978-3-540-33823-9_11 Sawynok J (2006) Adenosine and ATP receptors. Handb Exp Pharmacol 177:309–328
123. 123. D Ferrari P Chiozzi S Falzoni SM Dal G Collo G Buell F DiVirgilio 1997 ATP-mediated cytotoxicity in microglial cells Neuropharmacology 36 1295 1301 9364484 1:CAS:528:DyaK2sXnt1elsr4%3D Ferrari D, Chiozzi P, Falzoni S, Dal SM, Collo G, Buell G, DiVirgilio F (1997) ATP-mediated cytotoxicity in microglial cells. Neuropharmacology 36:1295–1301
124. 124. S Visentin M Renzi C Frank A Greco G Levi 1999 Two different ionotropic receptors are activated by ATP in rat microglia J Physiol 519 723 736 10457086 1:CAS:528:DyaK1MXmslGjsbY%3D Visentin S, Renzi M, Frank C, Greco A, Levi G (1999) Two different ionotropic receptors are activated by ATP in rat microglia. J Physiol 519:723–736
125. 125. LR Watkins SF Maier 2002 Beyond neurons: evidence that immune and glial cells contribute to pathological pain states Physiol Rev 82 981 1011 12270950 1:CAS:528:DC%2BD38Xot1Ggu74%3D Watkins LR, Maier SF (2002) Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev 82:981–1011
126. 126. K Farber H Kettenmann 2005 Physiology of microglial cells Brain Res Brain Res Rev 48 133 143 15850652 Farber K, Kettenmann H (2005) Physiology of microglial cells. Brain Res Brain Res Rev 48:133–143
127. 127. M Paukert R Osteroth HS Geisler U Brandle E Glowatzki JP Ruppersberg S Grunder 2001 Inflammatory mediators potentiate ATP-gated channels through the P2X(3) subunit J Biol Chem 276 21077 21082 11264291 1:CAS:528:DC%2BD3MXksFGlsbk%3D Paukert M, Osteroth R, Geisler HS, Brandle U, Glowatzki E, Ruppersberg JP, Grunder S (2001) Inflammatory mediators potentiate ATP-gated channels through the P2X(3) subunit. J Biol Chem 276:21077–21082
128. 128. SS Wildman BF King G Burnstock 1997 Potentiation of ATP-responses at a recombinant P2X2 receptor by neurotransmitters and related substances Br J Pharmacol 120 221 224 9117113 1:CAS:528:DyaK2sXot12hsA%3D%3D Wildman SS, King BF, Burnstock G (1997) Potentiation of ATP-responses at a recombinant P2X2 receptor by neurotransmitters and related substances. Br J Pharmacol 120:221–224
129. 129. F Amaya H Wang M Costigan AJ Allchorne JP Hatcher J Egerton T Stean V Morissset D Grose IP Chessell S Tate PJ Green CJ Woolf 2006 The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity J Neurosci 26 12852 12860 17167076 1:CAS:528:DC%2BD2sXhs1Ciug%3D%3D Amaya F, Wang H, Costigan M, Allchorne AJ, Hatcher JP, Egerton J, Stean T, Morissset V, Grose D, Chessell IP, Tate S, Green PJ, Woolf CJ (2006) The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity. J Neurosci 26:12852–12860
130. 130. RR Ji K Befort GJ Brenner CJ Woolf 2002 ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity J Neurosci 22 478 485 11784793 1:CAS:528:DC%2BD38XmsVOgsw%3D%3D Ji RR, Befort K, Brenner GJ, Woolf CJ (2002) ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. J Neurosci 22:478–485
131. 131. RR Ji TA Samad SX Jin R Schmoll CJ Woolf 2002 P38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia Neuron 36 57 68 12367506 1:CAS:528:DC%2BD38XnvVGns7s%3D Ji RR, Samad TA, Jin SX, Schmoll R, Woolf CJ (2002) P38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron 36:57–68
132. 132. MS Ramer EJ Bradbury SB McMahon 2001 Nerve growth factor induces P2X(3) expression in sensory neurons J Neurochem 77 864 875 11331415 1:CAS:528:DC%2BD3MXjs1Wlsbg%3D Ramer MS, Bradbury EJ, McMahon SB (2001) Nerve growth factor induces P2X(3) expression in sensory neurons. J Neurochem 77:864–875
133. 133. BF King M Liu J Pintor J Gualix MT Miras-Portugal G Burnstock 1999 Diinosine pentaphosphate (IP5I) is a potent antagonist at recombinant rat P2X1 receptors Br J Pharmacol 128 981 988 10556935 1:CAS:528:DyaK1MXnt1Wlt7c%3D King BF, Liu M, Pintor J, Gualix J, Miras-Portugal MT, Burnstock G (1999) Diinosine pentaphosphate (IP5I) is a potent antagonist at recombinant rat P2X1 receptors. Br J Pharmacol 128:981–988
134. 134. O Dery CU Corvera M Steinhoff NW Bunnett 1998 Proteinase-activated receptors, novel mechanisms of signaling by serine proteases Am J Physiol 274 C1429 C1452 9696685 1:CAS:528:DyaK1cXktVCkt70%3D Dery O, Corvera CU, Steinhoff M, Bunnett NW (1998) Proteinase-activated receptors, novel mechanisms of signaling by serine proteases. Am J Physiol 274:C1429–C1452
135. 135. M Steinhoff N Vergnolle SH Young M Tognetto S Amadesi HS Ennes M Trevisani MD Hollenberg JL Wallace GH Caughey SE Mitchell LM Williams P Geppetti EA Mayer NW Bunnett 2000 Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism Nat Med 6 151 158 10655102 1:CAS:528:DC%2BD3cXosFyqtw%3D%3D Steinhoff M, Vergnolle N, Young SH, Tognetto M, Amadesi S, Ennes HS, Trevisani M, Hollenberg MD, Wallace JL, Caughey GH, Mitchell SE, Williams LM, Geppetti P, Mayer EA, Bunnett NW (2000) Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med 6:151–158
136. 136. WJ Zhu Y Dai T Fukuoka H Yamanaka K Kobayashi K Obata S Wang K Noguchi 2006 Agonist of proteinase-activated receptor 2 increases painful behavior produced by alpha, beta-methylene adenosine 5′-triphosphate Neuroreport 17 1257 1261 16951565 1:CAS:528:DC%2BD28XptVGgu78%3D Zhu WJ, Dai Y, Fukuoka T, Yamanaka H, Kobayashi K, Obata K, Wang S, Noguchi K (2006) Agonist of proteinase-activated receptor 2 increases painful behavior produced by alpha, beta-methylene adenosine 5′-triphosphate. Neuroreport 17:1257–1261
137. 137. I Shimizu T Iida Y Guan C Zhao SN Raja MF Jarvis DA Cockayne MJ Caterina 2005 Enhanced thermal avoidance in mice lacking the ATP receptor P2X3 Pain 116 96 108 15927378 1:CAS:528:DC%2BD2MXlsFGhtrw%3D Shimizu I, Iida T, Guan Y, Zhao C, Raja SN, Jarvis MF, Cockayne DA, Caterina MJ (2005) Enhanced thermal avoidance in mice lacking the ATP receptor P2X3. Pain 116:96–108
138. 138. M Fukui A Takishita N Zhang T Nakagawa M Minami M Satoh 2004 Involvement of locus coeruleus noradrenergic neurons in supraspinal antinociception by alpha,beta-methylene-ATP in rats J Pharmacol Sci 94 153 160 14978353 1:CAS:528:DC%2BD2cXhvVCgtrg%3D Fukui M, Takishita A, Zhang N, Nakagawa T, Minami M, Satoh M (2004) Involvement of locus coeruleus noradrenergic neurons in supraspinal antinociception by alpha,beta-methylene-ATP in rats. J Pharmacol Sci 94:153–160
139. 139. M Fukui T Nakagawa M Minami M Satoh S Kaneko 2006 Inhibitory role of supraspinal P2X3/P2X2/3 subtypes on nociception in rats Mol Pain 2 19 16753051 Fukui M, Nakagawa T, Minami M, Satoh M, Kaneko S (2006) Inhibitory role of supraspinal P2X3/P2X2/3 subtypes on nociception in rats. Mol Pain 2:19
140. 140. R Baron 2006 Mechanisms of disease: neuropathic pain—a clinical perspective Nat Clin Pract Neurol 2 95 106 16932531 Baron R (2006) Mechanisms of disease: neuropathic pain—a clinical perspective. Nat Clin Pract Neurol 2:95–106
141. 141. Y Chen Y Shu Z Zhao 1999 Ectopic purinergic sensitivity develops at sites of chronic nerve constriction injury in rat Neuroreport 10 2779 2782 10511439 1:STN:280:DyaK1MvjvFCmtQ%3D%3D 10.1097/00001756-199909090-00015 Chen Y, Shu Y, Zhao Z (1999) Ectopic purinergic sensitivity develops at sites of chronic nerve constriction injury in rat. Neuroreport 10:2779–2782
142. 142. SK Park K Chung JM Chung 2000 Effects of purinergic and adrenergic antagonists in a rat model of painful peripheral neuropathy Pain 87 171 179 10924810 1:CAS:528:DC%2BD3cXltlWhur0%3D Park SK, Chung K, Chung JM (2000) Effects of purinergic and adrenergic antagonists in a rat model of painful peripheral neuropathy. Pain 87:171–179
143. 143. Y Chen GW Li C Wang Y Gu LY Huang 2005 Mechanisms underlying enhanced P2X receptor-mediated responses in the neuropathic pain state Pain 119 38 48 16298067 1:CAS:528:DC%2BD2MXhtlSjsb3N Chen Y, Li GW, Wang C, Gu Y, Huang LY (2005) Mechanisms underlying enhanced P2X receptor-mediated responses in the neuropathic pain state. Pain 119:38–48
144. 144. SD Novakovic LC Kassotakis IB Oglesby JA Smith RM Eglen AP Ford JC Hunter 1999 Immunocytochemical localization of P2X3 purinoceptors in sensory neurons in naive rats and following neuropathic injury Pain 80 273 282 10204740 1:CAS:528:DyaK1MXht1Oks7s%3D Novakovic SD, Kassotakis LC, Oglesby IB, Smith JA, Eglen RM, Ford AP, Hunter JC (1999) Immunocytochemical localization of P2X3 purinoceptors in sensory neurons in naive rats and following neuropathic injury. Pain 80:273–282
145. 145. K Tsuzuki E Kondo T Fukuoka D Yi H Tsujino M Sakagami K Noguchi 2001 Differential regulation of P2X(3) MRNA expression by peripheral nerve injury in intact and injured neurons in the rat sensory ganglia Pain 91 351 360 11275393 1:CAS:528:DC%2BD3MXitF2qtrg%3D Tsuzuki K, Kondo E, Fukuoka T, Yi D, Tsujino H, Sakagami M, Noguchi K (2001) Differential regulation of P2X(3) MRNA expression by peripheral nerve injury in intact and injured neurons in the rat sensory ganglia. Pain 91:351–360
146. 146. K Kage W Niforatos CZ Zhu KJ Lynch P Honore MF Jarvis 2002 Alteration of dorsal root ganglion P2X3 receptor expression and function following spinal nerve ligation in the rat Exp Brain Res 147 511 519 12444483 1:CAS:528:DC%2BD38XovVWhtL0%3D Kage K, Niforatos W, Zhu CZ, Lynch KJ, Honore P, Jarvis MF (2002) Alteration of dorsal root ganglion P2X3 receptor expression and function following spinal nerve ligation in the rat. Exp Brain Res 147:511–519
147. 147. Y Yiangou P Facer R Birch L Sangameswaran R Eglen P Anand 2000 P2X3 receptor in injured human sensory neurons Neuroreport 11 993 996 10790870 1:CAS:528:DC%2BD3cXivFOgsLk%3D Yiangou Y, Facer P, Birch R, Sangameswaran L, Eglen R, Anand P (2000) P2X3 receptor in injured human sensory neurons. Neuroreport 11:993–996
148. 148. G Dorn S Patel G Wotherspoon M Hemmings-Mieszczak J Barclay FJ Natt P Martin S Bevan A Fox P Ganju W Wishart J Hall 2004 SiRNA relieves chronic neuropathic pain Nucleic Acids Res 32 e49 15026538 Dorn G, Patel S, Wotherspoon G, Hemmings-Mieszczak M, Barclay J, Natt FJ, Martin P, Bevan S, Fox A, Ganju P, Wishart W, Hall J (2004) SiRNA relieves chronic neuropathic pain. Nucleic Acids Res 32:e49
149. 149. CJ Sharp AJ Reeve SD Collins JC Martindale SG Summerfield BS Sargent ST Bate IP Chessell 2006 Investigation into the role of P2X(3)/P2X(2/3) receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study Br J Pharmacol 148 845 852 16770326 1:CAS:528:DC%2BD28XmvFamt7Y%3D Sharp CJ, Reeve AJ, Collins SD, Martindale JC, Summerfield SG, Sargent BS, Bate ST, Chessell IP (2006) Investigation into the role of P2X(3)/P2X(2/3) receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study. Br J Pharmacol 148:845–852
150. 150. Z Seltzer R Dubner Y Shir 1990 A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury Pain 43 205 218 1982347 1:STN:280:DyaK3M3gsVejtA%3D%3D Seltzer Z, Dubner R, Shir Y (1990) A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain 43:205–218
151. 151. R Dowman T Darcey H Barkan V Thadani D Roberts 2007 Human intracranially-recorded cortical responses evoked by painful electrical stimulation of the sural nerve Neuroimage 34 743 763 17097306 1:STN:280:DC%2BD28jgsFCmsA%3D%3D Dowman R, Darcey T, Barkan H, Thadani V, Roberts D (2007) Human intracranially-recorded cortical responses evoked by painful electrical stimulation of the sural nerve. Neuroimage 34:743–763
152. 152. JM Schwab L Guo HJ Schluesener 2005 Spinal cord injury induces early and persistent lesional P2X4 receptor expression J Neuroimmunol 163 185 189 15885321 1:CAS:528:DC%2BD2MXktVGluro%3D Schwab JM, Guo L, Schluesener HJ (2005) Spinal cord injury induces early and persistent lesional P2X4 receptor expression. J Neuroimmunol 163:185–189
153. 153. AG Rabchevsky JD Degos PA Dreyfus 1999 Peripheral injections of Freund’s adjuvant in mice provoke leakage of serum proteins through the blood–brain barrier without inducing reactive gliosis Brain Res 832 84 96 10375654 1:CAS:528:DyaK1MXjs1Sjs7w%3D Rabchevsky AG, Degos JD, Dreyfus PA (1999) Peripheral injections of Freund’s adjuvant in mice provoke leakage of serum proteins through the blood–brain barrier without inducing reactive gliosis. Brain Res 832:84–96
154. 154. G Burnstock DG Satchell A Smythe 1972 A comparison of the excitatory and inhibitory effects of non-adrenergic, non-cholinergic nerve stimulation and exogenously applied ATP on a variety of smooth muscle preparations from different vertebrate species Br J Pharmacol 46 234 242 4631338 1:CAS:528:DyaE3sXisVOgtg%3D%3D Burnstock G, Satchell DG, Smythe A (1972) A comparison of the excitatory and inhibitory effects of non-adrenergic, non-cholinergic nerve stimulation and exogenously applied ATP on a variety of smooth muscle preparations from different vertebrate species. Br J Pharmacol 46:234–242
155. 155. LA Birder AJ Kanai WC Groat de S Kiss ML Nealen NE Burke KE Dineley S Watkins IJ Reynolds MJ Caterina 2001 Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells Proc Natl Acad Sci U S A 98 13396 13401 11606761 1:CAS:528:DC%2BD3MXosFygtbY%3D Birder LA, Kanai AJ, de Groat WC, Kiss S, Nealen ML, Burke NE, Dineley KE, Watkins S, Reynolds IJ, Caterina MJ (2001) Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells. Proc Natl Acad Sci U S A 98;13396–13401
156. 156. F Cervero JM Laird 2004 Understanding the signaling and transmission of visceral nociceptive events J Neurobiol 61 45 54 15362152 1:CAS:528:DC%2BD2cXovVajtr8%3D Cervero F, Laird JM (2004) Understanding the signaling and transmission of visceral nociceptive events. J Neurobiol 61:45–54
157. 157. S Namasivayam I Eardley JF Morrison 1999 Purinergic sensory neurotransmission in the urinary bladder: an in vitro study in the rat BJU Int 84 854 860 10532986 1:STN:280:DC%2BD3c%2FgsVKqtw%3D%3D Namasivayam S, Eardley I, Morrison JF (1999) Purinergic sensory neurotransmission in the urinary bladder: an in vitro study in the rat. BJU Int 84:854–860
158. 158. S Studeny A Torabi MA Vizzard 2005 P2X2 and P2X3 receptor expression in postnatal and adult rat urinary bladder and lumbosacral spinal cord Am J Physiol Regul Integr Comp Physiol 289 R1155 R1168 15947072 1:CAS:528:DC%2BD2MXhtFensb3M Studeny S, Torabi A, Vizzard MA (2005) P2X2 and P2X3 receptor expression in postnatal and adult rat urinary bladder and lumbosacral spinal cord. Am J Physiol Regul Integr Comp Physiol 289:R1155–R1168
159. 159. M Vlaskovska L Kasakov W Rong P Bodin M Bardini DA Cockayne AP Ford G Burnstock 2001 P2X3 knock-out mice reveal a major sensory role for urothelially released ATP J Neurosci 21 5670 5677 11466438 1:CAS:528:DC%2BD3MXlsV2gt7o%3D Vlaskovska M, Kasakov L, Rong W, Bodin P, Bardini M, Cockayne DA, Ford AP, Burnstock G (2001) P2X3 knock-out mice reveal a major sensory role for urothelially released ATP. J Neurosci 21:5670–5677
160. 160. HV Tempest AK Dixon WH Turner S Elneil LA Sellers DR Ferguson 2004 P2X and P2X receptor expression in human bladder urothelium and changes in interstitial cystitis BJU Int 93 1344 1348 15180635 1:CAS:528:DC%2BD2cXmt1ertLY%3D Tempest HV, Dixon AK, Turner WH, Elneil S, Sellers LA, Ferguson DR (2004) P2X and P2X receptor expression in human bladder urothelium and changes in interstitial cystitis. BJU Int 93:1344–1348
161. 161. Y Sun TC Chai 2004 Up-regulation of P2X3 receptor during stretch of bladder urothelial cells from patients with interstitial cystitis J Urol 171 448 452 14665953 1:CAS:528:DC%2BD3sXps1yqtrg%3D Sun Y, Chai TC (2004) Up-regulation of P2X3 receptor during stretch of bladder urothelial cells from patients with interstitial cystitis. J Urol 171:448–452
162. 162. SJ Borvendeg M Al-Khrasani P Rubini W Fischer C Allgaier K Wirkner HM Himmel C Gillen P Illes 2003 Subsensitivity of P2X but not vanilloid 1 receptors in dorsal root ganglia of rats caused by cyclophosphamide cystitis Eur J Pharmacol 474 71 75 12909197 1:CAS:528:DC%2BD3sXlvFyms70%3D Borvendeg SJ, Al-Khrasani M, Rubini P, Fischer W, Allgaier C, Wirkner K, Himmel HM, Gillen C, Illes P (2003) Subsensitivity of P2X but not vanilloid 1 receptors in dorsal root ganglia of rats caused by cyclophosphamide cystitis. Eur J Pharmacol 474:71–75
163. 163. DP Poole P Castelucci HL Robbins R Chiocchetti JB Furness 2002 The distribution of P2X3 purine receptor subunits in the guinea pig enteric nervous system Auton Neurosci 101 39 47 12462358 1:CAS:528:DC%2BD3sXptFWi Poole DP, Castelucci P, Robbins HL, Chiocchetti R, Furness JB (2002) The distribution of P2X3 purine receptor subunits in the guinea pig enteric nervous system. Auton Neurosci 101:39–47
164. 164. DR Robinson PA McNaughton ML Evans GA Hicks 2004 Characterization of the primary spinal afferent innervation of the mouse colon using retrograde labelling Neurogastroenterol Motil 16 113 124 14764211 1:STN:280:DC%2BD2c%2Fmtlyjuw%3D%3D Robinson DR, McNaughton PA, Evans ML, Hicks GA (2004) Characterization of the primary spinal afferent innervation of the mouse colon using retrograde labelling. Neurogastroenterol Motil 16:113–124
165. 165. M Camilleri 2001 Pathophysiology in irritable bowel syndrome Drug News Perspect 14 268 278 12813590 1:STN:280:DC%2BD3s3osFGnuw%3D%3D Camilleri M (2001) Pathophysiology in irritable bowel syndrome. Drug News Perspect 14:268–278
166. 166. Y Yiangou P Facer PA Baecker AP Ford CH Knowles CL Chan NS Williams P Anand 2001 ATP-gated ion channel P2X(3) is increased in human inflammatory bowel disease Neurogastroenterol Motil 13 365 369 11576396 1:STN:280:DC%2BD3MrjtlCktQ%3D%3D Yiangou Y, Facer P, Baecker PA, Ford AP, Knowles CH, Chan CL, Williams NS, Anand P (2001) ATP-gated ion channel P2X(3) is increased in human inflammatory bowel disease. Neurogastroenterol Motil 13:365–369
167. 167. AJ Kirkup CE Booth IP Chessell PP Humphrey D Grundy 1999 Excitatory effect of P2X receptor activation on mesenteric afferent nerves in the anaesthetised rat J Physiol 520 551 563 10523422 1:CAS:528:DyaK1MXntlGksbY%3D Kirkup AJ, Booth CE, Chessell IP, Humphrey PP, Grundy D (1999) Excitatory effect of P2X receptor activation on mesenteric afferent nerves in the anaesthetised rat. J Physiol 520:551–563
168. 168. G Wynn W Rong Z Xiang G Burnstock 2003 Purinergic mechanisms contribute to mechanosensory transduction in the rat colorectum Gastroenterology 125 1398 1409 14598256 1:CAS:528:DC%2BD3sXpslyru70%3D Wynn G, Rong W, Xiang Z, Burnstock G (2003) Purinergic mechanisms contribute to mechanosensory transduction in the rat colorectum. Gastroenterology 125:1398–1409
169. 169. G Wynn B Ma HZ Ruan G Burnstock 2004 Purinergic component of mechanosensory transduction is increased in a rat model of colitis Am J Physiol Gastrointest Liver Physiol 287 G647 G657 15331354 1:CAS:528:DC%2BD2cXnvVeis7g%3D Wynn G, Ma B, Ruan HZ, Burnstock G (2004) Purinergic component of mechanosensory transduction is increased in a rat model of colitis. Am J Physiol Gastrointest Liver Physiol 287:G647–G657
170. 170. AJ Page CM Martin LA Blackshaw 2002 Vagal mechanoreceptors and chemoreceptors in mouse stomach and esophagus Neurophysiol 87 2095 2103 1:CAS:528:DC%2BD38Xjt1Chsrk%3D Page AJ, Martin CM, Blackshaw LA (2002) Vagal mechanoreceptors and chemoreceptors in mouse stomach and esophagus. Neurophysiol 87:2095–2103
171. 171. SM Brierley R Carter W Jones III L Xu DR Robinson GA Hicks GF Gebhart LA Blackshaw 2005 Differential chemosensory function and receptor expression of splanchnic and pelvic colonic afferents in mice J Physiol 567 267 281 15946967 1:CAS:528:DC%2BD2MXps1Omsbc%3D Brierley SM, Carter R, Jones W, III, Xu L, Robinson DR, Hicks GA, Gebhart GF, Blackshaw LA (2005) Differential chemosensory function and receptor expression of splanchnic and pelvic colonic afferents in mice. J Physiol 567:267–281
172. 172. P Honore J Mikusa B Bianchi H McDonald J Cartmell C Jarvis MF Faltynek 2002 TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice, comparison with reference analgesics Pain 96 99 105 11932066 1:CAS:528:DC%2BD38XisV2lurs%3D Honore P, Mikusa J, Bianchi B, McDonald H, Cartmell J, Faltynek C, Jarvis MF (2002) TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice, comparison with reference analgesics. Pain 96:99–105
173. 173. PL Durham 2006 Calcitonin gene-related peptide (CGRP) and migraine Headache 46 Suppl. 1 S3 S8 16927957 Durham PL (2006) Calcitonin gene-related peptide (CGRP) and migraine. Headache 46(Suppl. 1):S3–S8
174. 174. G Juhasz T Zsombok B Jakab J Nemeth J Szolcsanyi G Bagdy 2005 Sumatriptan causes parallel decrease in plasma calcitonin gene-related peptide (CGRP) concentration and migraine headache during nitroglycerin induced migraine attack Cephalalgia 25 179 183 15689192 1:STN:280:DC%2BD2M%2FmtVyqsA%3D%3D Juhasz G, Zsombok T, Jakab B, Nemeth J, Szolcsanyi J, Bagdy G (2005) Sumatriptan causes parallel decrease in plasma calcitonin gene-related peptide (CGRP) concentration and migraine headache during nitroglycerin induced migraine attack. Cephalalgia 25:179–183
175. 175. G Natura GS Banchet von HG Schaible 2005 Calcitonin gene-related peptide enhances TTX-resistant sodium currents in cultured dorsal root ganglion neurons from adult rats Pain 116 194 204 15927395 1:CAS:528:DC%2BD2MXlvFeitbc%3D Natura G, von Banchet GS, Schaible HG (2005) Calcitonin gene-related peptide enhances TTX-resistant sodium currents in cultured dorsal root ganglion neurons from adult rats. Pain 116:194–204
176. 176. N White G Burnstock 2006 P2 receptors and cancer Trends Pharmacol Sci 27 211 217 16530853 1:CAS:528:DC%2BD28Xjs1Wmtbw%3D White N, Burnstock G (2006) P2 receptors and cancer. Trends Pharmacol Sci 27:211–217
177. 177. Y Maehara H Kusumoto H Anai T Kusumoto K Sugimachi 1987 Human tumor tissues have higher ATP contents than normal tissues Clin Chim Acta 169 341 343 3427788 1:CAS:528:DyaL1cXjsFKmsA%3D%3D Maehara Y, Kusumoto H, Anai H, Kusumoto T, Sugimachi K (1987) Human tumor tissues have higher ATP contents than normal tissues. Clin Chim Acta 169:341–343
178. 178. K Dang K Bielfeldt K Lamb GF Gebhart 2005 Gastric ulcers evoke hyperexcitability and enhance P2X receptor function in rat gastric sensory neurons J Neurophysiol 93 3112 3119 15673552 1:CAS:528:DC%2BD2MXlsV2qurc%3D Dang K, Bielfeldt K, Lamb K, Gebhart GF (2005) Gastric ulcers evoke hyperexcitability and enhance P2X receptor function in rat gastric sensory neurons. J Neurophysiol 93:3112–3119
179. 179. DM Cain PW Wacnik L Eikmeier A Beitz GL Wilcox DA Simone 2001 Functional interactions between tumor and peripheral nerve in a model of cancer pain in the mouse Pain Med 2 15 23 15102313 1:STN:280:DC%2BD2c3gsFKrsQ%3D%3D Cain DM, Wacnik PW, Eikmeier L, Beitz A, Wilcox GL, Simone DA (2001) Functional interactions between tumor and peripheral nerve in a model of cancer pain in the mouse. Pain Med 2:15–23
180. 180. LS Gilchrist DM Cain C Harding-Rose AN Kov G Wendelschafer-Crabb WR Kennedy DA Simone 2005 Re-organization of P2X3 receptor localization on epidermal nerve fibers in a murine model of cancer pain Brain Res 1044 197 205 15885218 1:CAS:528:DC%2BD2MXktVOgtro%3D Gilchrist LS, Cain DM, Harding-Rose C, Kov AN, Wendelschafer-Crabb G, Kennedy WR, Simone DA (2005) Re-organization of P2X3 receptor localization on epidermal nerve fibers in a murine model of cancer pain. Brain Res 1044:197–205
181. 181. WR Kennedy G Wendelschafer-Crabb 1999 Utility of the skin biopsy method in studies of diabetic neuropathy Electroencephalogr Clin Neurophysiol Suppl 50 553 559 10689508 1:STN:280:DC%2BD3c7lsVSqug%3D%3D Kennedy WR, Wendelschafer-Crabb G (1999) Utility of the skin biopsy method in studies of diabetic neuropathy. Electroencephalogr Clin Neurophysiol Suppl 50:553–559
182. 182. K Nagamine N Ozaki M Shinoda H Asai H Nishiguchi K Mitsudo I Tohnai M Ueda Y Sugiura 2006 Mechanical allodynia and thermal hyperalgesia induced by experimental squamous cell carcinoma of the lower gingiva in rats J Pain 7 659 670 16942952 Nagamine K, Ozaki N, Shinoda M, Asai H, Nishiguchi H, Mitsudo K, Tohnai I, Ueda M, Sugiura Y (2006) Mechanical allodynia and thermal hyperalgesia induced by experimental squamous cell carcinoma of the lower gingiva in rats. J Pain 7:659–670
183. 183. W Rong G Burnstock KM Spyer 2000 P2X purinoceptor-mediated excitation of trigeminal lingual nerve terminals in an in vitro intra-arterially perfused rat tongue preparation J Physiol 524 891 902 10790166 1:CAS:528:DC%2BD3cXjvFGgtrk%3D Rong W, Burnstock G, Spyer KM (2000) P2X purinoceptor-mediated excitation of trigeminal lingual nerve terminals in an in vitro intra-arterially perfused rat tongue preparation. J Physiol 524:891–902
184. 184. CA Jones C Vial LA Sellers PPA Humphrey RJ Evans IP Chessell 2004 Functional regulation of P2X 6 receptors by n-linked glycosylation: identification of a novel αβ-methylene ATP-sensitive phenotype Mol Pharmacol 65 979 985 15044628 1:CAS:528:DC%2BD2cXivFaltb8%3D Jones CA, Vial C, Sellers LA, Humphrey PPA, Evans RJ, Chessell IP (2004) Functional regulation of P2X 6 receptors by n-linked glycosylation: identification of a novel αβ-methylene ATP-sensitive phenotype. Mol Pharmacol 65:979–985