P2X receptor-mediated excitation of nociceptive afferents in the normal and arthritic rat knee joint

British Journal of Pharmacology

Volumn 125, Issue 2, 1998, Pages 341-346

  Dowd, E ^a   McQueen, D S ^a   Chessell, I P ^b   Humphrey, P P A ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Arthritis; ATP; Nociception; P2X receptors; Pain; Sensory neurones

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; FREUND ADJUVANT; PENTOBARBITAL; PURINE P2X RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT;

AFFERENT NERVE GROUP 1; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; ARTICULAR CARTILAGE; CONTROLLED STUDY; MALE; NERVE FIBER C; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SENSORY NERVE;

ADENOSINE TRIPHOSPHATE; AFFERENT PATHWAYS; ANIMALS; ARTHRITIS; KNEE JOINT; MALE; PAIN MEASUREMENT; PYRIDOXAL PHOSPHATE; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2;

EID: 0031689402     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702080     Document Type: Article

References (36)

1. BIRRELL, G.J., MCQUEEN, D.S., IGGO, A., COLEMAN, R.A. & GRUBB, B.D. (1990). PGI2-induced activation and sensitisation of articular mechanonociceptors. Neurosci Lett., 124, 5-8.
2. BLAND-WARD, P.A. & HUMPHREY, P.P.A. (1997). Acute nociception mediated by hindpaw P2X receptor activation in the rat. Br. J. Pharmacol., 122, 365-371.
3. BLEEHAN, T. & KEELE, C.A. (1977). Observations on the algogenic actions of adenosine compounds on the human blister base preparation. Pain, 3, 267-377.
4. BORN, G.V., KRATZER, M.A. (1984). Source and concentration of extracellular adenosine triphosphate during haemostasis in rats, rabbits and man. J. Physiol., 354, 419-429.
5. BURNSTOCK, G. & WOOD, J.N. (1996). Purinergic receptors: their role in nociception and primary afferent neurotransmission. Curr. Opin. Neurobiol., 6, 526-532.
6. CATERINA, M.J., SCHUMACHER, M.A., TOMINAGA, M., ROSEN, T.A., LEVINE, J.D. & JULIUS, D. (1997). The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature, 389, 816-824.
7. CHEN, C.-C., AKOPIAN, L.S., COLQUOHOUN, D., BURNSTOCK, G. & WOOD, J.N. (1995). A P2X purinoceptor expressed by a subset of sensory neurons. Nature, 377, 428-431.
8. 6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci., 16, 2495-2507.
9. COOK, S.P., VULCHANOVA, L., HARGREAVES, M.N., ELDE, R. & MCCLESKEY, E.W. (1997). Distinct ATP receptors on pain-sensing and stretch-sensing neurones. Nature, 387, 505-508.
10. CRACK, B.E., BEUKERS, M.W., MCKECHNIE, K.C., IJZERMAN, A.P. & LEFF, P. (1994). Pharmacological analysis of ecto-ATPase inhibition: evidence for combined enzyme inhibition and receptor antagonism in P2X-purinoceptor ligands. Br. J. Pharmacol., 113, 1432-1438.
11. DI VIRGILIO, F., FERRARI, D., CHIOZZI, P., FALZONI, S., SANZ, J.M., DAL SUSINO, M., MUTINI, C., HANAU, S. & BARICORDI, O.R. (1996). Purinoceptor function in the immune system. Drug Dev. Res., 39, 319-329.
12. DOWD, E., GALLAR, J., MCQUEEN, D.S., CHESSELL, I.P., HUMPHREY, P.P.A. & BELMONTE, C. (1997a). Nociceptors of the cat and rat cornea are not excited by P2X purinoceptor agonists. Br. J. Pharmacol., 122, 348P.
13. DOWD, E., MCQUEEN, D.S., CHESSELL, I.P. & HUMPHREY, P.P.A. (1997b). Activation by P2X purinoceptor agonists of sensory nerves innervating the rat knee joint. Br. J. Pharmacol., 122, 286P.
14. FARR, M., GARVEY, K., BOLD, A.M., KENDALL, M.J. & BACON, P.A. (1985). Significance of the hydrogen ion concentration in synovial fluid in rheumatoid arthritis. Clin. Exp. Rheumatol., 3, 99-104.
15. FERRARI, D., CHIOZZI, P., FALZONI, S., HANAU, S. & DI VIRGILIO, F. (1997). Purinergic modulation of interleukin-1β release from microglial cells stimulated with bacterial endotoxin. J. Exp. Med., 185, 579-582.
16. FREDHOLM, B.B., ABBRACCHIO, M.P., BURNSTOCK, G., DALY, J.W., HARDEN, T.K., JACOBSON, K.A., LEFF, P. & WILLIAMS, M. (1994). Nomenclature and classification of purinoceptors. Pharmacol. Rev., 46, 143-156.
17. GORDON, J., (1986). Extracellular ATP: effects, sources and fate. Biochem J., 233, 309-319.
18. 2 in the sensitisation of mechanonociceptors in normal and inflamed ankle joints of the rat. Exp. Brain Res., 84, 383-392.
19. GUILBAUD, G., IGGO, A. & TEGNER, R. (1985). Sensory receptors in ankle joint capsules of normal and arthritic rats. Exp. Brain. Res., 58, 29-40.
20. HOLTON, P. (1959). The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves. J. Physiol., 145, 494-504.
21. JAHR, C.E. & JESSELL, T.M. (1983). ATP excites a subpopulation of rat dorsal horn neurones. Nature, 304, 730-733.
22. KHAKH, B.S., MICHEL, A.D. & HUMPHREY, P.P.A. (1995). Inhibition by ectoATPase and Ca-ATPase in rat vas deferens by P2 purinoceptor antagonists. Br. J. Pharmacol., 115, 2P.
23. LEWIS, C., NEIDHART, S., HOLY, C., NORTH, R.A., BUELL, G. & SUPRENANT, A. (1995). Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature, 377, 432-435.
24. LI, C., PEOPLES, R.W. & WEIGHT, F.F. (1996). Acid pH augments excitatory action of ATP on a dissociated mammalian sensory neuron. NeuroReport., 7, 2151-2154.
25. LI, C., PEOPLES, R.W. & WEIGHT, F.F. (1997). Enhancement of ATP-activated current by protons in dorsal root ganglion neurons. Pflügers Arch., 433, 446-454.
26. MATTHEWS, B., LI, F., KHAHK, B.S. & VONGSAVAN, N. (1997). Effects of ATP on sensory receptors in the dental pulp of cats. J. Physiol., 504, 128P.
27. MCQUEEN, D.S., BOND, S.M., MOORES, C., CHESSELL, I.P., HUMPHREY, P.P.A. & DOWD, E. (1998). Activation of P2X receptors for adenosine triphosphate evokes cardiorespiratory reflexes in anaesthetised rats. J. Physiol., 507, 843-855.
28. MCQUEEN, D.S., IGGO, A., BIRRELL, G.J. & GRUBB, B.D. (1991). Effects of paracetamol and aspirin on neural activity of joint mechanonociceptors in adjuvant arthritis. Br. J. Pharmacol., 104, 178-182.
29. MCQUEEN, D.S., MOORES, C., DOWD, E., BOND, S.M., CHESSELL, I.P. & HUMPHREY, P.P.A. (1997). P2X receptor activation evokes a Bezold-Jarisch like reflex in anaesthetised rats. Br. J. Pharmacol., 122, 246P.
30. NORTH, R.A. & BARNARD, E.A. (1997). Nucleotide receptors. Curr. Op. Neurobiol., 7, 346-357.
31. PARK, W., MASUDA, I., CARDENAL-ESCARCENA, A., PALMER, D.L. & MCCARTHY, D.J. (1996). Inorganic pyrophosphate generation from adenosine triphosphate by cell-free human synovial fluid. J. Rheumatol., 23, 665-671.
32. RAINSFORD, K.D. (1982). Adjuvant polyarthritis in rats: is this a satisfactory model for screening anti-arthritic drugs? Agents & Actions, 12, 452-458.
33. RYAN, L.M., RACHOW, J.W. & MCCARTY, D.J. (1991). Synovial fluid ATP: a potential source for the production of inorganic pyrophosphate. J. Rheumatol., 18, 716-720.
34. STOOP, R., SURPRENANT, A. & NORTH, R.A. (1997). Different sensitivities to pH of ATP-induced currents at four cloned P2X receptors. J. Neurophysiol., 78, 1837-1840.
35. TREZISE, D.J., KENNEDY, I. & HUMPHREY, P.P.A. (1993). Characterization of purinoceptors mediating depolarisation of rat isolated vagus nerve. Br. J. Pharmacol., 110, 1055-1060.
36. TULAMO, R.M., BRAMLAGE, L.R. & GABEL, A.A. (1989). Sequential clinical and synovial fluid changes associated with acute infectious arthritis in the horse. Equine Vet. 21, 325-331.