The P2Y agonist UTP activates cutaneous afferent fibers

Pain

Volumn 109, Issue 1-2, 2004, Pages 36-44

  Stucky, Cheryl L ^a   Medler, Karen A ^a   Molliver, Derek C ^b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Adenosine triphosphate; Capsaicin; Mechanotransduction; Mouse; P2X3; Pyrimidine; Sensory neuron

Indexed keywords

ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; CAPSAICIN; PURINE P2X RECEPTOR; PURINE P2Y2 RECEPTOR; PURINE P2Y4 RECEPTOR; PURINERGIC RECEPTOR STIMULATING AGENT; URIDINE TRIPHOSPHATE;

AFFERENT NERVE GROUP 1; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; MECHANORECEPTOR; MOUSE; MYELINATION; NERVE ENDING; NERVE FIBER C; NERVE POTENTIAL; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSORY NERVE; SIGNAL TRANSDUCTION; SKIN NERVE;

ACTION POTENTIALS; ADENOSINE TRIPHOSPHATE; ANIMALS; ANTINEOPLASTIC AGENTS; CAPSAICIN; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICE; MICE, INBRED C57BL; NERVE FIBERS; NEURAL CONDUCTION; NEURONS, AFFERENT; PAIN THRESHOLD; RECEPTORS, PURINERGIC P2; SKIN; URIDINE TRIPHOSPHATE;

EID: 1842685379     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2004.01.007     Document Type: Article

References (43)

1. Anderson C.M., Parkinson F.E. Potential signalling roles for UTP and UDP: sources, regulation and release of uracil nucleotides. Trends Pharmacol Sci. 18:(10):1997;387-392.
2. Bhave G., Karim F., Carlton S.M., Gereau R.W. IV. Peripheral group I metabotropic glutamate receptors modulate nociception in mice. Nat Neurosci. 4:(4):2001;417-423.
3. Bland-Ward P.A., Humphrey P.P. Acute nociception mediated by hindpaw P2X receptor activation in the rat. Br J Pharmacol. 122:(2):1997;365-371.
4. Bleehen T., Keele C.A. Observations on the algogenic actions of adenosine compounds on the human blister base preparation. Pain. 3:(4):1977;367-377.
5. Bradbury E.J., Burnstock G., McMahon S.B. The expression of P2X3 purinoreceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor. Mol Cell Neurosci. 12:(4-5):1998;256-268.
6. Burnstock G. Current status of purinergic signalling in the nervous system. Prog Brain Res. 120:1999;3-10.
7. Chen C.C., Akopian A.N., Sivilotti L., Colquhoun D., Burnstock G., Wood J.N. A P2X purinoceptor expressed by a subset of sensory neurons. Nature. 377:(6548):1995;428-431.
8. Cockayne D.A., Hamilton S.G., Zhu Q.M., Dunn P.M., Zhong Y., Novakovic S., Malmberg A.B., Cain G., Berson A., Kassotakis L., Hedley L., Lachnit W.G., Burnstock G., McMahon S.B., Ford A.P. Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature. 407:(6807):2000;1011- 1015.
9. Cook S.P., McCleskey E.W. Cell damage excites nociceptors through release of cytosolic ATP. Pain. 95:(1-2):2002;41-47.
10. Cook S.P., Vulchanova L., Hargreaves K.M., Elde R., McCleskey E.W. Distinct ATP receptors on pain-sensing and stretch-sensing neurons. Nature. 387:(6632):1997;505-508.
11. Dray A., Perkins M. Bradykinin and inflammatory pain. Trends Neurosci. 16:(3):1993;99-104.
12. Freeland K., Liu Y.Z., Latchman D.S. Distinct signalling pathways mediate the cAMP response element (CRE)- dependent activation of the calcitonin gene-related peptide gene promoter by cAMP and nerve growth factor. Biochem J. 345:(Pt 2):2000;233-238.
13. Guo A., Vulchanova L., Wang J., Li X., Elde R. Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites. Eur J Neurosci. 11:(3):1999;946-958.
14. Hamilton S.G., Wade A., McMahon S.B. The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat. Br J Pharmacol. 126:(1):1999;326-332.
15. Hamilton S.G., Warburton J., Bhattacharjee A., Ward J., McMahon S.B. ATP in human skin elicits a dose-related pain response which is potentiated under conditions of hyperalgesia. Brain. 123:(Pt 6):2000;1238-1246.
16. Hamilton S.G., McMahon S.B., Lewin G.R. Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin. J Physiol. 534:(Pt 2):2001;437-445.
17. Harden T.K., Lazarowski E.R., Boucher R.C. Release, metabolism and interconversion of adenine and uridine nucleotides: implications for G protein-coupled P2 receptor agonist selectivity. Trends Pharmacol Sci. 18:(2):1997;43-46.
18. Huang H., Wu X., Nicol G.D., Meller S., Vasko M.R. ATP augments peptide release from rat sensory neurons in culture through activation of P2Y receptors. J Pharmacol Exp Ther. 306:2003;1137-1144.
19. Kage K., Niforatos W., Zhu C.Z., Lynch K.J., Honore P., Jarvis M.F. Alteration of dorsal root ganglion P2X3 receptor expression and function following spinal nerve ligation in the rat. Exp Brain Res. 147:(4):2002;511-519.
20. Koltzenburg M., Stucky C.L., Lewin G.R. Receptive properties of mouse sensory neurons innervating hairy skin. J Neurophysiol. 78:(4):1997;1841-1850.
21. Kress M., Koltzenburg M., Reeh P.W., Handwerker H.O. Responsiveness and functional attributes of electrically localized terminals of cutaneous C-fibers in vivo and in vitro. J Neurophysiol. 68:(2):1992;581-595.
22. von Kugelgen I., Wetter A. Molecular pharmacology of P2Y-receptors. Naunyn Schmiedebergs Arch Pharmacol. 362:(4-5):2000;310-323.
23. Lazarowski E.R., Homolya L., Boucher R.C., Harden T.K. Direct demonstration of mechanically induced release of cellular UTP and its implication for uridine nucleotide receptor activation. J Biol Chem. 272:(39):1997;24348-24354.
24. Lazarowski E.R., Harden T.K. Quantitation of extracellular UTP using a sensitive enzymatic assay. Br J Pharmacol. 127:(5):1999;1272-1278.
25. Lazarowski E.R., Boucher R.C., Harden T.K. Constitutive release of ATP and evidence for major contribution of ecto-nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrations. J Biol Chem. 275:(40):2000;31061-31068.
26. Lewis C., Neidhart S., Holy C., North R.A., Buell G., Surprenant A. Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature. 377:(6548):1995;432-435.
27. Molliver D.C., Cook S.P., Carlsten J.A., Wright D.E., McCleskey E.W. ATP and UTP excite sensory neurons and induce CREB phosphorylation through the metabotropic receptor, P2Y2. Eur J Neurosci. 16:(10):2002;1850-1860.
28. 2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity. J Neurosci. 23:(14):2003;6058-6062.
29. Nakamura F., Strittmatter S.M. P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation. Proc Natl Acad Sci USA. 93:(19):1996;10465-10470.
30. Nicol G.D., Vasko M.R., Evans A.R. Prostaglandins suppress an outward potassium current in embryonic rat sensory neurons. J Neurophysiol. 77:(1):1997;167-176.
31. Okada M., Nakagawa T., Minami M., Satoh M. Analgesic effects of intrathecal administration of P2Y nucleotide receptor agonists UTP and UDP in normal and neuropathic pain model rats. J Pharmacol Exp Ther. 303:(1):2002;66-73.
32. Qian J., Yehia G., Molina C., Fernandes A., Donnelly R., Anjaria D., Gascon P., Rameshwar P. Cloning of human preprotachykinin-I promoter and the role of cyclic adenosine 5′-monophosphate response elements in its expression by IL-1 and stem cell factor. J Immunol. 166:(4):2001;2553-2561.
33. Ralevic V., Burnstock G. Receptors for purines and pyrimidines. Pharmacol Rev. 50:(3):1998;413-492.
34. Ryan L.M., Rachow J.W., McCarty D.J. Synovial fluid ATP: a potential substrate for the production of inorganic pyrophosphate. J Rheumatol. 18:(5):1991;716-720.
35. Saiag B., Bodin P., Shacoori V., Catheline M., Rault B., Burnstock G. Uptake and flow-induced release of uridine nucleotides from isolated vascular endothelial cells. Endothelium. 2:1995;279-285.
36. Sanada M., Yasuda H., Omatsu-Kanbe M., Sango K., Isono T., Matsuura H., Kikkawa R. Increase in intracellular Ca(2+) and calcitonin gene-related peptide release through metabotropic P2Y receptors in rat dorsal root ganglion neurons. Neuroscience. 111:(2):2002;413-422.
37. Souslova V., Cesare P., Ding Y., Akopian A.N., Stanfa L., Suzuki R., Carpenter K., Dickenson A., Boyce S., Hill R., Nebenuis-Oosthuizen D., Smith A.J., Kidd E.J., Wood J.N. Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors. Nature. 407:(6807):2000;1015-1017.
38. Svichar N., Shmigol A., Verkhratsky A., Kostyuk P. ATP induces Ca2+ release from IP3-sensitive Ca2+ stores exclusively in large DRG neurones. NeuroReport. 8:(7):1997;1555-1559.
39. Tao X., Finkbeiner S., Arnold D.B., Shaywitz A.J., Greenberg M.E. Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron. 20:(4):1998;709-726.
40. Ueno S., Tsuda M., Iwanaga T., Inoue K. Cell type-specific ATP-activated responses in rat dorsal root ganglion neurons. Br J Pharmacol. 126:(2):1999;429-436.
41. Vulchanova L., Riedl M.S., Shuster S.J., Stone L.S., Hargreaves K.M., Buell G., Surprenant A., North R.A., Elde R. P2X3 is expressed by DRG neurons that terminate in inner lamina II. Eur J Neurosci. 10:(11):1998;3470-3478.
42. Zhong Y., Dunn P.M., Bardini M., Ford A.P., Cockayne D.A., Burnstock G. Changes in P2X receptor responses of sensory neurons from P2X3-deficient mice. Eur J Neurosci. 14:(11):2001;1784-1792.
43. Zimmermann K., Reeh P.W., Averbeck B. ATP can enhance the proton-induced CGRP release through P2Y receptors and secondary PGE(2) release in isolated rat dura mater. Pain. 97:(3):2002;259-265.