Investigation into the role of P2X 3/P2X 2/3 receptors in neuropathic pain following chronic constriction injury in the rat: An electrophysiological study

British Journal of Pharmacology

Volumn 148, Issue 6, 2006, Pages 845-852

  Sharp, Caroline J ^a   Reeve, Alison J ^a   Collins, Sue D ^a   Martindale, Jo C ^a   Summerfield, Scott G ^a   Sargent, Becky S ^a   Bate, Simon T ^a   Chessell, Iain P ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Chronic constriction injury; Dorsal horn electrophysiology; Neuropathic pain; P2X 3 P2X 2 3 receptors

Indexed keywords

5 [[(3 PHENOXYBENZYL)(1,2,3,4 TETRAHYDRO 1 NAPHTHALENYL)AMINO]CARBONYL] 1,2,4 BENZENETRICARBOXYLIC ACID; 5 [[5 IODO 2 (1 METHYLETHYL) 4 (METHOXY)PHENYL]OXY] 2,4 PYRIMIDINEDIAMINE; A 317491; ANTINOCICEPTIVE AGENT; PURINE P2X2 RECEPTOR; PURINE P2X2 RECEPTOR ANTAGONIST; PURINE P2X3 RECEPTOR; PURINE P2X3 RECEPTOR ANTAGONIST; PURINE RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

AFFERENT NERVE GROUP 1; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG PENETRATION; DRUG POTENCY; ELECTROPHYSIOLOGY; EVOKED SOMATOSENSORY RESPONSE; EVOKED SPINAL CORD RESPONSE; INHIBITION KINETICS; MALE; NERVE COMPRESSION; NERVE FIBER C; NERVE INJURY; NEUROPATHIC PAIN; NEUROPHARMACOLOGY; NEUROPHYSIOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION; SPINAL CORD;

ANIMALS; CONSTRICTION, PATHOLOGIC; EVOKED POTENTIALS; MALE; NERVE FIBERS, UNMYELINATED; NEURALGIA; PHENOLS; POLYCYCLIC COMPOUNDS; RATS; RECEPTORS, PURINERGIC P2; RECEPTORS, PURINERGIC P2X2; RECEPTORS, PURINERGIC P2X3; SPINAL CORD;

EID: 33746032539     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706790     Document Type: Article

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