ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity

Journal of Neuroscience

Volumn 22, Issue 2, 2002, Pages 478-485

  Ji, Ru Rong ^a   Befort, Katia ^a   Brenner, Gary J ^a   Woolf, Clifford J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

ERK; Inflammatory pain; MAP kinase; Neurokinin 1; Prodynorphin; Spinal cord

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; FREUND ADJUVANT; GENE PRODUCT; MITOGEN ACTIVATED PROTEIN KINASE; NEUROKININ 1 RECEPTOR; PRODYNORPHIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HEAT; HYPERALGESIA; INFLAMMATION; MALE; MECHANICAL STIMULATION; NOCICEPTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; TRANSCRIPTION REGULATION;

EID: 0037080003     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-02-00478.2002     Document Type: Article

References (63)

1. Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain
2. Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation
3. Phosphorylated cAMP response element binding protein increases in neurokinin-1 receptor-immunoreactive neurons in rat spinal cord in response to formalin-induced nociception
4. The MAPK cascade is required for mammalian associative learning
5. Localization of trkA receptors in chemically identified subgroups of adult rat sensory neurones
6. Neuronal adaptation to amphetamine and dopamine: Molecular mechanisms of prodynorphin gene regulation in rat striatum
7. Altered nociception, analgesia and aggression in mice lacking the receptor for substance P
8. Activity-dependent neuronal plasticity following tissue injury and inflammation
9. A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation
10. Identification of a novel inhibitor of mitogen-activated protein kinase kinase
11. BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway
12. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
13. Molecular characterization of a functional cDNA encoding the rat substance P receptor
14. Organization, structure and expression of the gene encoding the rat substance P receptor
15. Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain states
16. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
17. Effects of spinal kappa-opioid receptor agonists on the responsiveness of nociceptive superficial dorsal horn neurons
18. Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: Stimulus specificity, behavioral parameters and opioid receptor binding
19. 2+ stimulation of CREB-dependent transcription and Erk nuclear translocation
20. Making new connections: Role of ERK/MAP kinase signaling in neuronal plasticity
21. Phosphorylation of transcription factor CREB in rat spinal cord after formalin-induced hyperalgesia: Relationship to c-fos induction
22. Neuronal plasticity and signal transduction in nociceptive neurons: Implications for the initiation and maintenance of pathological pain
23. Expression of neuropeptide Y and neuropeptide Y (Y1) receptor mRNA in rat spinal cord and dorsal root ganglia following peripheral tissue inflammation
24. Central and peripheral response to galanin induced by inflammation
25. Repetitive transcranial magnetic stimulation activates specific neural regions
26. Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity
27. Neuroprotection by estrogen via extracellular signal-regulated kinase against quinolinic acid-induced cell death in the rat hippocampus
28. Spinally administered dynorphin A produces long-lasting allodynia: Involvement of NMDA but not opioid receptors
29. Cyclie GMP pathway is critical for inducing long-term sensitization of nociceptive sensory neurons
30. Morphine, the NMDA receptor antagonist MK801 and tachykinin NK1 receptor antagonist RP67580 attenuate the development of inflammation-induced progressive tactile hypersensitivity
31. Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats
32. Preserved acute pain and reduced neuropathic pain in mice lacking PKC gamma
33. Brain-derived neurotrophic factor-a centrally acting modulator of tactile stimulus-induced inflammatory pain hypersensitivity
34. Neurokinin-1 receptors on lumbar spinothalamic neurons in the rat
35. NK-1 and NK-3 type tachykinin receptor mRNA expression in the rat spinal cord dorsal horn is increased during adjuvant or formalin-induced nociception
36. Transcription factor regulation of prodynorphin gene expression following rat hindpaw inflammation
37. IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life
38. Peripheral inflammation is associated with increased dynorphin immunoreactivity in both projection and local circuit neurons in the superficial dorsal horn of the rat lumbar spinal cord
39. Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons
40. Enhancement of the antiallodynic and antinociceptive efficacy of spinal morphine by antisera to dynorphin A (1-13) or MK-801 in a nerve-ligation model of peripheral neuropathy
41. Transmission of chronic nociception by spinal neurons expressing the substance P receptor
42. Noxious stimulus induces the preprotachykinin-A gene expression in the rat dorsal root ganglion: A quantitative study using in situ hybridization histochemistry
43. Circadian regulation of cAMP response element-mediated gene expression in the suprachiasmatic nuclei
44. An isobolographic analysis of the effect of N-methyl-D-aspartate and NK1 tachykinin receptor antagonists on inflammatory hyperalgesia in the rat
45. The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus
46. In situ hybridization histochemistry and immunohistochemistry reveal an increase in spinal dynorphin biosynthesis in rat model of peripheral inflammation and hyperalgesia
47. An interleukin-1b-mediated induction of Cox-2 in the central nervous system contributes to inflammatory pain hypersensitivity
48. Inflammation-induced upregulation of NK1 receptor mRNA in dorsal horn neurons
49. Extracellular signal-regulated kinase (ERK) controls immediate early gene induction on corticostrital stimulation
50. Unilateral inflammation of the hindpaw in rats as a model of prolonged noxious stimulation: Alterations in behavior and nociceptive thresholds
51. The contribution of spinal cord neurokinin-1 receptor signaling to pain
52. The spinal contribution of substance P to the generation and maintenance of inflammatory hyperalgesia in the rat
53. Pronociceptive actions of dynorphin maintain chronic neuropathic pain
54. Differential activities of intrathecal MK-801 or morphine to alter responses to thermal and mechanical stimuli in normal or nerve-injured rats
55. ERK plays a regulatory role in induction of LTP by theta frequency stimulation and its modulation by b-adrenergic receptors
56. Differential expression of immediate early genes in the hippocampus and spinal cord
57. Evidence for a central component of post-injury pain hypersensitivity
58. Transcriptional and post-translational plasticity and the generation of inflammatory pain
59. Neuronal plasticity: Increasing the gain in pain
60. Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat
61. Null mutations lacking substance: Elucidating pain mechanisms by genetic pharmacology
62. Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAPK/ERK-dependent mechanism
63. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase