Up-regulation of P2X3 receptor during stretch of bladder urothelial cells from patients with interstitial cystitis

Journal of Urology

Volumn 171, Issue 1, 2004, Pages 448-452

  Sun, Yan ^a   Chai, Toby C ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

Adenosine triphosphate; Bladder; Interstitial cystitis; Purinoceptor P2X3; Urothelium

Indexed keywords

ACTIN; ADENOSINE TRIPHOSPHATE; PURINE P2 RECEPTOR; RECEPTOR SUBTYPE;

ARTICLE; BLADDER; CONTROLLED STUDY; DENSITOMETRY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; INTERSTITIAL CYSTITIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRETCHING; UPREGULATION; UROTHELIUM;

EID: 0346848810     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000099660.46774.3c     Document Type: Article

References (18)

1. Birder, L. A., Kanai, A. J., de Groat, W. C., Kiss, S., Nealen, M. L., Burke, N. E. et al: Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells. Proc Natl Acad Sci USA, 98: 13396, 2001
2. Ferguson, D. R., Kennedy, I. and Burton, T. J.: ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes - a possible sensory mechanism? J Physiol, 505: 503, 1997
3. Knight, G. E., Bodin, P., De Groat, W. C. and Burnstock, G.: ATP is released from guinea pig ureter epithelium on distension. Am J Physiol Renal Physiol, 282: F281, 2002
4. Sun, Y., Keay, S., De Deyne, P. G. and Chai, T. C.: Augmented stretch activated adenosine triphosphate release from bladder uroepithelial cells in patients with interstitial cystitis. J Urol, 166: 1951, 2001
5. MacKenzie, A. B., Surprenant, A. and North, R. A.: Functional and molecular diversity of purinergic ion channel receptors. Ann N Y Acad Sci, 868: 716, 1999
6. Cockayne, D. A., Hamilton, S. G., Zhu, Q. M., Dunn, P. M., Zhong, Y., Novakovic, S. et al: Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature, 407: 1011, 2000
7. Vlaskovska, M., Kasakov, L., Rong, W., Bodin, P., Bardini, M., Cockayne, D. A. et al: P2X3 knock-out mice reveal a major sensory role for urothelially released ATP. J Neurosci, 21: 5670, 2001
8. Elneil, S., Skepper, J. N., Kidd, E. J., Williamson, J. G. and Ferguson, D. R.: Distribution of P2X(1) and P2X(3) receptors in the rat and human urinary bladder. Pharmacology, 63: 120, 2001
9. Gillenwater, J. Y. and Wein, A. J.: Summary of the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases Workshop on Interstitial Cystitis, National Institutes of Health, Bethesda, Maryland, August 28-29, 1987. J Urol, 140: 203, 1988
10. Trifillis, A. L., Cui, X., Jacobs, S. and Warren, J. W.: Culture of bladder epithelium from cystoscopic biopsies of patients with interstitial cystitis. J Urol, 153: 243, 1995
11. Machelon, V. and Nome, F.: Cellular distribution and relative amounts of vascular endothelium growth factor mRNA in granulosa cells from human preovulatory follicles. Eur Cytokine Net, 10: 393, 1999
12. North, R. A.: Molecular physiology of P2X receptors. Physiol Rev, 82: 1013, 2002
13. Palea, S., Artibani, W., Ostardo, E., Trist, D. G. and Pietra, C.: Evidence for purinergic neurotransmission in human urinary bladder affected by interstitial cystitis. J Urol, 150: 2007, 1993
14. McMurray, G., Dass, N. and Brading, A. F.: Purinoceptor subtypes mediating contraction and relaxation of marmoset urinary bladder smooth muscle. Br J Pharmacol, 123: 1579, 1998
15. Sun, Y. and Chai, T. C.: Effects of dimethyl sulphoxide and heparin on stretch-activated ATP release by bladder urothelial cells from patients with interstitial cystitis. BJU Int, 90: 381, 2002
16. Sun, Y., MaLossi, J., Jacobs, S. C. and Chai, T. C.: Effect of doxazosin on stretch-activated adenosine triphosphate release in bladder urothelial cells from patients with benign prostatic hyperplasia. Urology, 60: 351, 2002
17. Keay, S., Kleinberg, M., Zhang, C.-O., Hise, M. K. and Warren, J. W.: Bladder epithelial cells from patients with interstitial cystitis produce an inhibitor of heparin-binding epidermal growth factor-like growth factor production. J Urol, 164: 2112, 2000
18. Keay, S. and Warren, J. W.: A hypothesis for the etiology of interstitial cystitis based upon inhibition of bladder epithelial repair. Med Hypotheses, 51: 79, 1998