Experimental and modeling studies of desensitization of P2X3 receptors

Molecular Pharmacology

Volumn 70, Issue 1, 2006, Pages 373-382

  Sokolova, Elena ^a   Skorinkin, Andrei ^a,b   Moiseev, Igor ^a   Agrachev, Andrei ^a   Nistri, Andrea ^a   Giniatullin, Rashid ^a,c  

^a SISSA   (Italy)

^b RUSSIAN ACADEMY OF SCIENCES   (Russian Federation)

^c KAZAN STATE MEDICAL UNIVERSITY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLTHIOADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CARBENE; PURINE P2X3 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR STIMULATING AGENT;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; EXPERIMENTAL STUDY; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; SENSORY NERVE CELL;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIA, SPINAL; HUMANS; KINETICS; MEMBRANE POTENTIALS; MICE; MODELS, BIOLOGICAL; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, PURINERGIC P2; THIONUCLEOTIDES;

EID: 33745232481     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.023564     Document Type: Article

References (43)

1. Baker TS, Dormand JR, Gilmore JP, and Prince PJ (1996) Continuous approximation with embedded Runge-Kutta methods. Appl Numl Math 22:51-62.
2. Bowie D and Lange GD (2002) Functional stoichiometry of glutamate receptor desensitization. J Neurosci 22:3392-3403.
3. Burgard EC, Niforatos W, Van Beissen T, Lynch KJ, Touma E, Metzger RE, Kowaluk EA, and Jarvis MF (1999) P2X receptor-mediated ionic currents in dorsal root ganglion neurons. J Neurophysiol 82:1590-1598.
4. Burnstock G (2001) Purine-mediated signalling in pain and visceral perception. Trends Pharmacol Sci 22:182-188.
5. 3-deficient mice. Nature (Lond) 407:951-952.
6. Cook SP and McCleskey EW (2002) Cell damage excites nociceptors through release of cytosolic ATP. Pain 95:41-47.
7. 2+ by speeding recovery of P2X receptors from desensitization. J Neurosci 18:9238-9244.
8. 2 purinoceptors. J Gen Physiol 113:695-720.
9. 3 receptor-channels in rat dorsal root ganglion neurons. Eur J Pharmacol 521:34-38.
10. Giniatullin R, Nistri A, and Yakel JL (2005) Desensitization of nicotinic ACh receptors: shaping cholinergic signaling. Trends Neurosci 28:371-378.
11. 2+ on rat DRG neurons in culture. Neuropharmacology 44:132-140.
12. Grubb BD and Evans RJ (1999) Characterization of cultured dorsal root ganglion neuron P2X receptors. Eur J Neurosci 11:149-154.
13. 2+-sensing modulatory sites. J Biol Chem 279:53109-53115.
14. He M-L, Gonzalez-Iglesias AE, Tomic M, and Stojilkovic SS (2005) Release and extracellular metabolism of ATP by ecto-nucleotidase eNTPDase 1-3 in hypothalamic and pituitary cells. Purinergic Signal 1:135-144.
15. Jacobson KA, Jarvis MF, and Williams M (2002) Purine and pyrimidine (P2) receptors as drug targets. J Med Chem 45:4057-4093.
16. 2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci USA 99:17179-17184.
17. Jonas P (1993) AMPA-type glutamate receptors-nonselective cation channels mediating fast excitatory transmission in the CNS. EXS 66:61-76.
18. A channel responses to brief agonist pulses. Neuron 15:181-191.
19. Jones MV and Westbrook GL (1996) The impact of receptor desensitization on fast synaptic transmission. Trends Neurosci 19:96-101.
20. Katz B and Thesleff S (1957) A study of the desensitization produced by acetylcholine at the motor end-plate. J Physiol (Lond) 138:63-80.
21. Krishtal OA, Marchenko SM, and Obukhov AG (1988) Cationic channels activated by extracellular ATP in rat sensory neurons. Neuroscience 27:995-1000.
22. Kuzmin AI, Lakomkin VL, Kapelko VI, and Vassort G (1998) Interstitial ATP level and degradation in control and postmyocardial infracted rats. Am J Physiol 275:C766-C771.
23. Lazarowski ER, Boucher RC, and Harden TK (2003) Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules. Mol Pharmacol 64:785-795.
24. 7 nicotinic receptors in rat hippocampal neurons. Brain Res 882:155-168.
25. 3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels. EMBO (Eur Mol Biol Organ) J 17:3016-3028.
26. Nishiyama A, Majid DS, Taher KA, Miyatake A, and Navar LG (2000) Relation between renal interstitial ATP concentrations and autoregulation-mediated changes in renal vascular resistance. Circ Res 86:656-662.
27. North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82:1013-1067.
28. 3 receptors and peripheral pain mechanisms. J Physiol (Lond) 554:301-308.
29. 2 neuronal nicotinic receptors. J Physiol (Lond) 553:857-871.
30. Patneau DK and Mayer ML (1991) Kinetic analysis of interactions between kainate and AMPA: evidence for activation of a single receptor in mouse hippocampal neurons. Neuron 6:785-798.
31. Phillis JW, O'Regan MH, and Perkins LM (1993) Adenosine 5′-triphosphate release from the normoxic and hypoxic in vivo rat cerebral cortex. Neurosci Lett 151:94-96.
32. 3 receptors by nanomolar agonist. J Neurosci 25:7359-7365.
33. Raman IM and Trussell LO (1995) The mechanism of alpha-amino-3-hydroxy-5- methyl-4-isoxazolepropionate receptor desensitization after removal of glutamate. Biophys J 68:137-146.
34. Rang HP and Ritter JM (1969) A new kind of drug antagonism: evidence that agonists cause a molecular change in acetylcholine receptors. Mol Pharmacol 5:394-411.
35. Rang HP and Ritter JM (1970a) On the mechanism of desensitization at cholinergic receptors. Mol Pharmacol 6:357-382.
36. Rang HP and Ritter JM (1970b) The relationship between desensitization and the metaphilic effect at cholinergic receptors. Mol Pharmacol 6:383-390.
37. Reitstetter R, Lukas RJ, and Gruener R (1999) Dependence of nicotinic acetylcholine receptor recovery from desensitization on the duration of agonist exposure. J Pharmacol Exp Ther 289:656-660.
38. 1 receptor at nanomolar ATP concentrations. J Gen Physiol 121:451-461.
39. Simonetti M, Fabro A, D'Arco M, Zweyer M, Nistri A, Giniatullin R, and Fabbrett E (2006) Comparison of P2X and TRPV1 receptors in ganglia or primary culture of trigeminal neurons and their modulation by NGF or serotonin. Mol Pain 2:11.
40. Skorinkin A, Nistri A, and Giniatullin R (2003) Bimodal action of protons on ATP currents of rat PC12 cells. Gen Physiol 122:33-44.
41. A and cationic P2X ionotropic receptors of rat dorsal root ganglion neurons. J Neurosci 21:4958-4968.
42. 3 receptors provides a novel and sensitive approach for their rapid up or downregulation. Br J Pharmacol 141:1048-1058.
43. 3 receptors. Nature (Lond) 407:1015-1017.