Purinergic sensory neurotransmission in the urinary bladder: An in vitro study in the rat

BJU International

Volumn 84, Issue 7, 1999, Pages 854-860

  Namasivayam, S ^a   Eardley, I ^a   Morrison, J F B ^b  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^b UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

Afferent nerves; ATP; Bladder; Distension; Rat

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; PURINE RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR STIMULATING AGENT; SODIUM CHLORIDE; SURAMIN;

ANIMAL TISSUE; ARTICLE; BLADDER; BLADDER DISTENSION; BLADDER PRESSURE; CONTROLLED STUDY; DRUG CLEARANCE; EXPERIMENTAL MODEL; MECHANORECEPTOR; NONHUMAN; PELVIC NERVE; PRIORITY JOURNAL; RAT; SENSORY NERVE CONDUCTION; STATISTICAL ANALYSIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; MALE; NEURONS, AFFERENT; RATS; RATS, WISTAR; SURAMIN; SYNAPTIC TRANSMISSION; URINARY BLADDER;

EID: 0032708267     PISSN: 14644096     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-410x.1999.00310.x     Document Type: Article

References (28)

1. 1 Holton P. The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves. J Physiol 1959; 145: 494-504
2. 2 Brading AF. Physiology of bladder smooth muscle. In Torrens M, Morrison JFB eds, Physiology of the Lower Urinary Tract. Berlin: Springer Verlag, 1987: 161-91
3. 3 Fujii K. Evidence for adenosine triphosphate as an excitatory transmitter in guinea pig, rabbit and pig urinary bladder. J Physiol 1988; 404: 39-52
4. 4 Chen C-C, Akopian AN, Sivilotti L, Colquhoun D, Burnstock G, Wood JN. A P2X purinoceptor expressed by a subset of sensory neurons. Nature 1995; 377: 428-31
5. 5 Pelleg A, Hurt CM. Mechanism of action of ATP on canine pulmonary vagal C fibre nerve terminals. J Physiol 1996; 490: 265-75
6. 1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation. Proc Nat Acad Sci USA 1996; 93: 10465 -70
7. 7 Wang Y, Roman R, Lidofsky SD, Fritz JG. Autocrine signalling through ATP release represents a novel mechanism for cell, regulation. Pror Nat Acad Sci USA 1996; 93: 12020-5
8. 8 Ferguson DR, Kennedy J, Burton TJ. ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes - a possible sensory mechanism? J Physiol 1997; 505: 503-11
9. 9 Inoue T, Gabella G. The interface between epithelium and lamina propria in the rat urinary bladder. Arch Hist Cytol 1992; 55: 157-63
10. 10 Namasivayam S, Eardley I, Morrison JFB. A novel in vitro bladder pelvic nerve afferent model in the rat. Br J Urol 1998; 82: 902-5
11. 3H]-α,β-methylene ATP, a radioligand labelling P2-purinoceptors. J Aut Nerv Sys 1989; 28: 85-8
12. 12 Hoyle CHV, Knight GE, Burnstock G. Suramin antagonizes responses to P2-purinoceptor agonists and purinergic nerve stimulation in the guinea-pig urinary bladder and taenia coli. Br J Pharm 1990; 99: 617-21
13. 13 Langworthy OR. Innervation of the pelvic organs of the rat. Invest Urol 1965; 2: 491-511
14. 14 Purinton PT, Fletcher TF, Bradley WE. Gross and light microscopic features of the pelvic plexus in the rat. Anat Rec 1975; 175: 697-706
15. 15 Hulsebosch CE, Coggeshall RE. An analysis of the axon populations in the nerves to the pelvic viscera in the rat. J Comp Neurol 1982; 211: 1-10
16. 16 Applebaum AE, Vance WH, Coggleshall RM Segmental localisation of sensory cells that innervate the bladder. J Comp Neurol 1980; 192: 203-9
17. 17 Yokokawa K, Tohyama M, Shiosaka S et al. Distribution of calcitonin gene-related peptide-containing fibres in the urinary bladder of the rat and their origin. Cell Tissue Res 1986; 244: 271-8
18. 18 Wakabayashi Y, Tomoyoshi T, Fujimiya M, Arai R, Maeda T. Substance P-containing axon terminals in the mucosa of the human urinary bladder: pre-embedding immunohistochemistry using cryostat sections for electron microscopy. Histochemistry 1993; 100: 401-7
19. 19 Gabella G. The structural relations between nerve fibres and muscle cells in the urinary bladder of the rat. J Neurocytol 1995; 24: 159-87
20. 20 Burnstock G. A basis for distinguishing two types of purinergic receptor. In Straub RW, Bolis L, eds, Cell Membrane Receptors for Drugs and Hormones; a Multidisciplinary Approach. New York: Raven Press, 1978: 107-18
21. 21 Abbracchio M, Burnstock G. Purinoceptors: are there families of P2X and P2Y purinoceptors? Pharm Therap 1994; 64: 445-75
22. 22 Burnstock G, King B. The numbering of cloned P2 purinoreptors. Drug Dev Res 1996; 38: 67-71
23. 23 Burnstock G. Developments and perspectives of the purinoceptor concept. J Aut Pharm 1996; 16: 295-302
24. 3H] α,β-methylene ATP binding sites in rat brain and spinal cord. Neuroreport 1994; 5: 1601-4
25. 6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J Neurosci 1996; 16: 2495-507
26. 7). Science 1996; 272: 735-8
27. 27 Iggo A. Tension receptors in the stomach and urinary bladder. J Physiol 1955; 128: 293-607
28. 28 Jiang W, Kibble A, Morrison JFB. Functional properties of urinary bladder afferents in the in vivo rat pelvic nerve. J Neurosci 1999; in press