Analgesic profile of intrathecal P2X3 antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats

Pain

Volumn 99, Issue 1-2, 2002, Pages 11-19

  Honore, Prisca ^a   Kage, Karen ^a   Mikusa, Joseph ^a   Watt, Andrew T ^b   Johnston, Joseph F ^b   Wyatt, Jacqueline R ^b   Faltynek, Connie R ^a   Jarvis, Michael F ^a   Lynch, Kevin ^a  

^a ABBOTT LABORATORIES   (United States)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

Inflammatory pain; Mechanical allodynia; Neuropathic pain; Nociceptive behavior; P2X3 antisense; Thermal hyperalgesia

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTISENSE OLIGONUCLEOTIDE; FORMALDEHYDE; FREUND ADJUVANT; ISIS 120176; ISIS 124450; ISIS 29848; PURINE P2X RECEPTOR; UNCLASSIFIED DRUG;

ALLODYNIA; ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CHRONIC INFLAMMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; MALE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL GANGLION;

ACUTE DISEASE; ADENOSINE TRIPHOSPHATE; ANIMALS; ANTINEOPLASTIC AGENTS; CHRONIC DISEASE; HYPERALGESIA; INJECTIONS, SPINAL; LIGATION; MALE; NEURALGIA; NEUROGENIC INFLAMMATION; NOCICEPTORS; OLIGONUCLEOTIDES, ANTISENSE; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2; SPINAL NERVES;

EID: 0036711339     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(02)00032-5     Document Type: Article

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