Potentiation of ATP-responses at a recombinant P(2X2) receptor by neurotransmitters and related substances

British Journal of Pharmacology

Volumn 120, Issue 2, 1997, Pages 221-224

  Wildman, S S ^a   King, B F ^a   Burnstock, G ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Acidosis; ATP; P(2X) receptor; Potentiation; Xenopus oocytes

Indexed keywords

ADENOSINE; ADENOSINE TRIPHOSPHATE; ARACHIDONIC ACID; BRADYKININ; CALCITONIN GENE RELATED PEPTIDE; HISTAMINE; METENKEPHALIN; NERVE GROWTH FACTOR; NEUROTRANSMITTER; NICOTINE; NORADRENALIN; PURINE P2X RECEPTOR; RECEPTOR SUBTYPE; SEROTONIN; SUBSTANCE P;

ACIDIFICATION; ACIDOSIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FEMALE; NERVE CELL; NONHUMAN; OOCYTE; PH; PRIORITY JOURNAL; SENSORY NERVE; XENOPUS;

ADENOSINE TRIPHOSPHATE; ANIMALS; ARACHIDONIC ACID; BRADYKININ; DRUG SYNERGISM; FEMALE; HISTAMINE; HYDROGEN-ION CONCENTRATION; NEUROTRANSMITTER AGENTS; RECEPTORS, PURINERGIC P2; RECOMBINANT PROTEINS; XENOPUS;

EID: 0031035165     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700903     Document Type: Article

References (11)

1. ANDREEV, N.Y., DIMITRIEVA, N., KOLTZENBURG, M. & MCMAHON, S.B. (1995). Peripheral administration of nerve growth factor in the adult rat produces a thermal hyperalgesia that requires the presence of sympathetic post-ganglionic neurones. Pain, 63, 109-115.
2. BRAKE, A.J., WAGENBACH, M.J. & JULIUS, D. (1994). New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature, 371, 519-523.
3. BURNSTOCK, G. & KING, B.F. (1996). Numbering of cloned P2 purinoceptors. Drug Devel. Res., 38, 67-71.
4. 6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci., 16, 2495-2507.
5. JOHNSON, R.G. & SCARPA, A. (1976). Internal pH of isolated chromaffin granules. J. Biol. Chem., 251, 2189-2191.
6. 2X2 purinoceptor to ATP revealed by changing extracellular pH. Br. J. Pharmacol., 117, 1371-1373.
7. LEWIS, C., NEIDHART, S., HOLY, C., NORTH, R.A., BUELL, G. & SURPRENANT, A. (1995). Coexpression of P2X receptor subunits can account for ATP-gated currents in sensory neurons. Nature, 377, 432-435.
8. LI, C., PEOPLES, R.W. & WEIGHT, F.F. (1996). Acid pH augments excitatory action of ATP on a dissociated mammalian sensory neuron. NeuroReport, 7, 2151-2154.
9. NAKAZAWA, K. & OHNO, Y. (1996). Dopamine and 5-hydroxytryptamine selectively potentiate neuronal type ATP-receptor channels. Eur. J. Pharmacol., 296, 119-122.
10. 2Y1 purinoceptors. Br. J. Pharmacol., 119, 1006-1012.
11. STEEN, K.H., REEH, P.W., ANTON, F. & HANDWERKER, H.O. (1992). Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro. J. Neurosci., 12, 86-95.