Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors

Molecular Endocrinology

Volumn 11, Issue 4, 1997, Pages 415-423

  McKee, Karen Kulju ^a   Palyha, Oksana C ^a   Feighner, Scott D ^a   Hreniuk, Donna L ^a   Tan, Carina P ^a   Phillips, Michael S ^a   Smith, Roy G ^a   Van Der Ploeg, Lex H T ^a,b   Howard, Andrew D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Biostatist and Res Data Systems   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 3 METHYL N [2,3,4,5 TETRAHYDRO 2 OXO 1 [[2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL] 1H 1 BENZAZEPIN 3 YL]BUTANAMIDE; GROWTH HORMONE DERIVATIVE; GROWTH HORMONE RECEPTOR; GROWTH HORMONE RELEASING FACTOR; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; SOMATOSTATIN;

ADENOHYPOPHYSIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GROWTH HORMONE RELEASE; HORMONE RECEPTOR INTERACTION; HYPOTHALAMUS; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA; SUS SCROFA;

EID: 0031003664     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.11.4.9908     Document Type: Article

References (26)

1. Frohman LA 1987 Diseases of the Anterior Pituitary. In: Felig P (ed) Endocrinology and Metabolism. McGraw-Hill, New York, pp 264-270
2. Strobl JS, Thomas MJ 1994 Human growth hormone. Pharmacol Rev 46:1-34
3. Plotsky P, Vale WW 1985 Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophyseal portal circulation in the rat. Science 230:461-463
4. Tannenbaum GS 1991 Neuroendocrine control of growth hormone secretion. Acta Paediatr Scand Suppl 372:5-16
5. Bertherat J, Bluet-Pajot MT, Epelbaum J 1995 Neuroendocrine regulation of growth hormone. Eur J Endocrinol 132:12-24
6. Chipman JJ 1993 Recent advances in hGH clinical research. J Pediatr Endocrinol 6:325-328
7. Jorgensen JOL, Christiansen JS 1993 Growth hormone therapy, brave new senescence: GH in adults. Nature 341:1247-1248
8. Bowers CY, Sartor O, Reynolds GA 1984 Design, synthesis and biological activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology 14:1537-1545
9. Bowers CY, Reynolds GA, Durham D 1990 Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone. J Clin Endocrinol Metab 70:975-982
10. Cheng K, Chan WWS, Barreto A, Convey EM, Smith RG 1989 The synergistic effects of His-D-Tyr-Ala-Trp-D-Phe-Lys-amide on growth hormone (GH)-releasing factor-stimulated GH release and intrcellular adenosine 3′,5′-monophosphate accumulation in rat primary pituitary cell culture. Endocrinology 124:2791-2798
11. Cheng K, Chan WWS, Butler B, Barrato A, Smith RG 1991 Evidence for a role of protein kinase-C in His-D-Trp-Ala-D-Phe-Lys-amide induced growth hormone release from rat primary pituitary cells. Endocrinology 129:3337-3342
12. Smith RG, Cheng K, Schoen WR, Pong S-S, Hickey G, Jacks T, Butler B, Chan WW, Chaung L-YP, Judith F, Taylor J, Wyvratt MJ, Fisher M-H 1993 A nonpeptidyl growth hormone secretagogue. Science 260:1640-1643
13. Patchett AA, Nargund RA, Tata JR, Chen M-M, Barakat KJ, Johnston DBR, Cheng K, Chan WW-S, Butler B, Hickey G, Jacks T, Scheim K, Pong S-S, Chaung L-YP, Chen HY, Frazer E, Leung KH, Chiu S-HL, Smith RG 1995 Design and biological activities of L-163, 191 (MK-0677): a potent and orally active growth hormone secretagogue. Proc Natl Acad Sci USA 92:7001-7005
14. Gertz BA, Barrett JS, Eisenhandler R, Krupa DA, Wittreich JM, Seibold JR, Schneider SH 1993 Growth hormone response in man to L-692,429, a novel nonpeptide mimic of growth hormone-releasing peptide-6. J Clin Endocrinol Metab 77:1393-1397
15. Smith RG, Pong S-S, Hickey G, Jacks T, Cheng K, Leonard R, Cohen CJ, Arena JA, Chang CH, Drisko J, Wyvratt M, Fisher M, Nargund R, Patchett AA 1996 Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland. Recent Prog Horm Res 52:261-286
16. Pong S-S, Chaung L-YP, Dean DC, Nargund RP, Patchett AA, Smith RG 1996 Identification of a new G protein-linked receptor for growth hormone secretagogues. Mol Endocrinol 10:57-61
17. Dean, DC, Nargund RP, Pong S-S, Chaung L-YP, Griffin PR, Melillo DG, Ellsworth RL, Van Der Ploeg LHT, Patchett AA, Smith RG 1996 Development of a high specific activity sulfur-35 sulfonamide radioligand that allowed the identification of a new growth hormone secretagogue receptor. J Med Chem 39:1767-1770
18. Bresson-Bepoldin, L, Duffy-Barbe L 1994 GHRP-6 induces a biphasic calcium response in rat pituitary somatotrophs. Cell Calcium 15:247-258
19. Mau, SE, Witt MR, Bjerrum OJ, Saermark T, Vilhardt H 1995 Growth hormone releasing hexapeptide (GHRP-6) activates the inositol (1, 4, 5)-triphosphate/diacylglycerol pathway in rat anterior pituitary cells. J Recept Signal Transduction Res 15:311-323
20. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PL, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee K-K, Pong S-S, Chaung L-Y, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji D, Dean DC, Melillo DG, Patchett AA, Nargund R, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JA, Smith RG, Van der Ploeg LHT 1996 A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273:974-977
21. Hinuma S, Hosaoya M, Ogi K, Tanaka H, Nagai Y, Onda H 1994 Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene. Biochim Biophys Acta 1219:251-259
22. Fan NC, Jeung E-B, Peng C, Olofsson JI, Krisinger J, Leung PCK 1994 The human gonadotropin-releasing hormone (GnRH) receptor gene: cloning, genomic organization and chromosomal assignment. Mol Cell Endocrinol 103:R1-6
23. Probst WC, Snyder LA, Schuster DI, Brosius J, Sealfon SC 1992 Sequence alignment of the G-protein coupled receptor superfamily. DNA Cell Biol 11:1-20
24. Jackson L, Kline AD, Barr MA, Kock S 1993 de Lange Syndrome: a clinical review of 310 individuals. Am J Med Genet 47:940-946
25. Guan X-M, Yu H, Palyha OC, McKee KK, Feighner SD, Sirinathsinghji DJS, Smith RG, Van Der Ploeg LHT, Howard AD 1997 Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Mol Brain Res, in press
26. Button D, Brownstein M 1993 Aequorin-expressing mammalian cell lines used to report Ca2+ mobilization. Cell Calcium 14:663-671