Potential role for AMPA-ativated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus

Diabetes

Volumn 53, Issue 8, 2004, Pages 1953-1958

  McCrimmon, Rory J ^a   Fan, Xiaoning ^a   Ding, Yuyan ^a   Zhu, Wanling ^a   Jacob, Ralph J ^a   Sherwin, Robert S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; ADRENALIN; AICA RIBONUCLEOTIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DRUG DERIVATIVE; GLUCAGON; INSULIN; NORADRENALIN; RIBONUCLEOTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HYPOGLYCEMIA; HYPOTHALAMUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; ZONA INCERTA; ANIMAL; BLOOD; DRUG EFFECT; GLUCOSE CLAMP TECHNIQUE; HYPERINSULINISM; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; MICROINJECTION; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; BLOOD GLUCOSE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; EPINEPHRINE; GLUCAGON; GLUCOSE CLAMP TECHNIQUE; HYPERINSULINISM; HYPOGLYCEMIA; INFUSIONS, INTRAVENOUS; INSULIN; MALE; MICROINJECTIONS; NEURONS; NOREPINEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; RIBONUCLEOTIDES; VENTROMEDIAL HYPOTHALAMIC NUCLEUS;

EID: 3242811250     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.8.1953     Document Type: Article

References (41)

1. Cryer PE: Hypoglycaemia-associated autonomic failure. In Hypoglycaemia and Diabetes: Clinical and Physiological Aspects. BM Frier, BM Fisher, Eds. London, Edward Arnold, 1993, p. 275-283
2. The Diabetes Control and Complications Research Group: Hypoglycemia in the Diabetes Control and Complications Trial. Diabetes 46:271-286, 1997
3. Donovan CM, Halter JB, Bergman RN: Importance of hepatic glucoreceptors in sympathoadrenal response to hypoglycemia. Diabetes 40:155-158, 1991
4. Donovan CM, Hamilton-Wessler M, Halter JB, Bergman RN: Primacy of liver glucosensors in the sympathetic response to hypoglycemia. Proc Nat Acad Sci 91:2863-2867, 1994
5. Hevener AL, Bergman RN, Donovan CM: Novel glucosensor for hypoglycemia detection localized to the portal vein. Diabetes 46:1521-1525, 1997
6. Frizzell R, Jones E, Davis S, Biggers D, Myers S, Connolly C, Neal D, Jaspan J, Cherrington A: Counterregulation during hypoglycemia is directed by widespread brain regions. Diabetes 42:1253-1261, 1993
7. Borg WP, During MJ, Sherwin RS, Borg MA, Brines ML, Shulman GL: Ventromedial hypothalamic lesions in rats supress counterregulatory responses to hypoglycemia. J Clin Invest: 1677-1682, 1994
8. Borg WP, Sherwin RS, During MJ, Borg MA, Shulman GL: Local Ventromedial hypothalamus glucopenia triggers counterregulatory hormone release. Diabetes 44:180-184, 1995
9. Borg MA, Sherwin RS, During MJ, Borg WP, Shulman GI: Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. J Clin Invest 99:1677-1682, 1997
10. Biggers DW, Myers SR, Neal D, Stinson R, Cooper NB, Jaspan JB, Williams PE, Cherrington A: Role of the brain in counterregulation of insulin-induced hypoglycemia in dogs. Diabetes 37:7-16, 1989
11. Song Z, Levin B, McArdle J, Bakhos N, Routh V: Convergence of pre- and post-synaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus. Diabetes 50:2673-2681, 2001
12. Ritter S, Llewelyn-Smith J, Dinh TT: Subgroups of hindbrain catecholamine neurons are selectively activated by 2-deoxy-D-glucose induced metabolic change. Brain Res 805:41-54, 1998
13. Ritter S, Dinh TT, Zhang Y: Localization of hindbrain glucoreceptive sites controlling food intake and blood glucose. Brain Res 856:37-47, 2000
14. Yang X, Kow L, Funabashi T, Mobbs C: Hypothalamic glucose sensor: similarities to and differences from pancreatic β-cell mechanisms. Diabetes 48:1763-1772, 1999
15. Hardie D, Carling D: The AMP-activated protein kinase-fuel gauge of the mammalian cell? Eur J Biochem 246:259-273, 1997
16. Davies SP, Helps NR, Cohen PT, Hardie DG: 5′-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase: studies using bacterially expressed human protein phophatase-2C alpha and native bovine protein phosphatase-2AC. FEBS Lett 377:421-425, 1995
17. Ferrer A, Caelles C, Massot N, Hegardt F: Activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase by adenosine 5′-monophosphate. Biochem Biophys Res Commun 132:497-504, 1985
18. Carling D, Zammit V, Hardie D: A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. FEBS Lett 223:217-222, 1987
19. Garton A, Campbell D, Carling D, Hardie D, Colbran R, Yeaman S: Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase: a possible anitlipolytic mechanism. Eur J Biochem 179: 249-254, 1989
20. Carling D, Hardie D: The substrate and sequence specificity of the AMP-activated protein kinase: phosphorylation of glycogen synthase and phosphorylase kinase. Biochim Biophys Acta 1012:81-86, 1989
21. Culmsee C, Monning J, Kemp B, Mattson M: AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation. J Mol Neuorsci 17:45-58, 2001
22. Mitchellhill K, Stapleton D, Gao G, House C, Michell B, Katsis F, Witters L, Kemp B: Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of the yeast Snf1 protein kinase. J Biol Chem 269:2361-2364, 1994
23. Stapleton D, Mitchellhill K, Gao G, Widmer J, Michell B, Teh T, House C, Fernandez C, Cox T, Witters L, Kemp BE: Mammalian AMP-activated protein kinase subfamily. J Biol Chem 271:611-614, 1996
24. Turnley A, Stapleton D, Mann R, Witters L, Kemp BE, Bartlett P: Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem 72:1707-1716, 1999
25. Gao G, Widmer J, Stapleton D, Teh T, Cox T, Kemp BE, Witters L: Catalytic subunits of porcine and rat 5′-AMP-activated protein kinase are members of the SNF1 protein kinase family. Biochim Biophys Acta 1266:73-82, 1995
26. Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates. New York, Academic, 1991
27. Powell AM, Sherwin RS, Shulman GI: Impaired hormonal responses to hypoglycemia in spontaneously diabetic and recurrently hypoglycemic rats. J Clin Invest 92:2667-2674, 1993
28. Winder W, Hardie D: AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol 277:E1-E10, 1999
29. Rutter GA, Da Silva Xavier G, Leclerc I: Roles of 5-AMP-activated protein kinase (AMPK) in mammalian glucose homerostasis. Biochem J 375:1-16, 2003
30. Bergaron R, Russell III R, Young L, Ren J, Marcucci M, Lee A, Shulman G: Effects of AMPK-activation on muscle glucose metabolism in conscious rats. Am J Physiol 276:E938-E944, 1999
31. Merrill G, Kurth EJ, Hardie D, Winder W: AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol 273:E1107-E1112, 1997
32. Mu J, Brozinick JJ, Valladares O, Bucan M, Birnbaum M: A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol Cell 7:1085-1094, 2001
33. Moore M, Connolly C, Cherrington A: Autoregulation of hepatic glucose production. Eur J Endocrinol 138:240-248, 1998
34. Edwards A: The hyperglycaemic response to stimulation of the hepatic sympathetic innervation in adrenalectomised cats and dogs. J Physiol 220:697-710, 1972
35. Edwards A, Silver M: Comparison of the hyperglycaemic and glycogenolytic responses to catecholamines with those to stimulation of the hepatic sympathetic innervation in the dog. J Physiol 223:571-593, 1972
36. Shimazu T, Fukuda A, Ban T: Reciprocal influences of the ventromedial and lateral hypothalamic nuclei on blood glucose level and liver glycogen content. Nature 210:1178-1179, 1966
37. Dallaporta M, Perrin J, Orsini J-C: Involvement of adenosine triphosphate-sensitive K+ channels in glucose-sensing in the rat solitary tract nucleus. Neurosci Lett 278:77-80, 2000
38. Hardie DG, Salt IP, Hawley SA, Davis SP: AMP-activated protein kinase: ultrasensitive system for monitoring cellular energy charge. Biochem J 338:717-722, 1999
39. Obici S, Feng Z, Morgan K, Stein D, Karkanias G, Rossetti L: Central administration of oleic acid inhibits glucose production and food intake. Diabetes 51:271-275, 2002
40. Obici S, Feng Z, Arduini A, Conti R, Rossetti L: Inhibition of carnitine palmityltransferase-1 decreases food intake and glucose production. Nat Med 9:756-761, 2003
41. Minokoshi Y, Young-Bu K, Peroni O, Fryer L, Muller C, Carling D, Kahn B: Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415:339-343, 2002