-
1
-
-
0036311620
-
Revealing the cost of Type II diabetes in Europe
-
B. Jonsson Revealing the cost of Type II diabetes in Europe Diabetologia 45 2002 S5 S12
-
(2002)
Diabetologia
, vol.45
-
-
Jonsson, B.1
-
2
-
-
0031717105
-
The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
-
D.G. Hardie, D. Carling, and M. Carlson The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu. Rev. Biochem. 67 1998 821 855
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 821-855
-
-
Hardie, D.G.1
Carling, D.2
Carlson, M.3
-
3
-
-
0038199737
-
Management of cellular energy by the AMP-activated protein kinase system
-
D.G. Hardie, J.W. Scott, D.A. Pan, and E.R. Hudson Management of cellular energy by the AMP-activated protein kinase system FEBS Lett. 546 2003 113 120
-
(2003)
FEBS Lett.
, vol.546
, pp. 113-120
-
-
Hardie, D.G.1
Scott, J.W.2
Pan, D.A.3
Hudson, E.R.4
-
4
-
-
0347318052
-
The AMP-activated protein kinase cascade--a unifying system for energy control
-
D. Carling The AMP-activated protein kinase cascade--a unifying system for energy control Trends Biochem. Sci. 29 2004 18 24
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 18-24
-
-
Carling, D.1
-
5
-
-
0028406897
-
Role of the AMP-activated protein kinase in the cellular stress response
-
J.M. Corton, J.G. Gillespie, and D.G. Hardie Role of the AMP-activated protein kinase in the cellular stress response Curr. Biol. 4 1994 315 324
-
(1994)
Curr. Biol.
, vol.4
, pp. 315-324
-
-
Corton, J.M.1
Gillespie, J.G.2
Hardie, D.G.3
-
6
-
-
0032973130
-
Dealing with energy demand: The AMP-activated protein kinase
-
B.E. Kemp, K.I. Mitchelhill, D. Stapleton, B.J. Michell, Z.-P. Chen, and L.A. Witters Dealing with energy demand: the AMP-activated protein kinase Trends Biochem. Sci. 24 1999 22 25
-
(1999)
Trends Biochem. Sci.
, vol.24
, pp. 22-25
-
-
Kemp, B.E.1
Mitchelhill, K.I.2
Stapleton, D.3
Michell, B.J.4
Chen, Z.-P.5
Witters, L.A.6
-
7
-
-
0032511053
-
AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes
-
M. Foretz, D. Carling, C. Guichard, P. Ferre, and F. Foufelle AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes J. Biol. Chem. 272 1998 14767 14771
-
(1998)
J. Biol. Chem.
, vol.272
, pp. 14767-14771
-
-
Foretz, M.1
Carling, D.2
Guichard, C.3
Ferre, P.4
Foufelle, F.5
-
8
-
-
0033949848
-
Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle
-
W. Winder, B. Holmes, D. Rubink, E. Jensen, M. Chen, and J. Holloszy Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle J. Appl. Physiol. 88 2000 2219 2226
-
(2000)
J. Appl. Physiol.
, vol.88
, pp. 2219-2226
-
-
Winder, W.1
Holmes, B.2
Rubink, D.3
Jensen, E.4
Chen, M.5
Holloszy, J.6
-
9
-
-
0023885305
-
The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains
-
S.K. Hanks, A.M. Quinn, and T. Hunter The protein kinase family: conserved features and deduced phylogeny of the catalytic domains Science 241 1988 42 52
-
(1988)
Science
, vol.241
, pp. 42-52
-
-
Hanks, S.K.1
Quinn, A.M.2
Hunter, T.3
-
10
-
-
0032567252
-
Functional domains of the α1 catalytic subunit of the AMP-activated protein kinase
-
B.E. Crute, K. Seefeld, J. Gamble, B.E. Kemp, and L.A. Witters Functional domains of the α1 catalytic subunit of the AMP-activated protein kinase J. Biol. Chem. 273 1998 35347 35354
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 35347-35354
-
-
Crute, B.E.1
Seefeld, K.2
Gamble, J.3
Kemp, B.E.4
Witters, L.A.5
-
11
-
-
0034141355
-
The regulation of AMP-activated protein kinase by phosphorylation
-
S.C. Stein, A. Woods, N.A. Jones, M.D. Davison, and D. Carling The regulation of AMP-activated protein kinase by phosphorylation Biochem. J. 345 2000 437 443
-
(2000)
Biochem. J.
, vol.345
, pp. 437-443
-
-
Stein, S.C.1
Woods, A.2
Jones, N.A.3
Davison, M.D.4
Carling, D.5
-
12
-
-
0029925785
-
Characterization of AMP-activated protein kinase β subunit and γ subunit--assembly of the heterotrimeric complex in vitro
-
A. Woods, P.C.F. Cheung, F.C. Smith, M.D. Davison, J. Scott, and R.K. Beri Characterization of AMP-activated protein kinase β subunit and γ subunit--assembly of the heterotrimeric complex in vitro J. Biol. Chem. 271 1996 10282 10290
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 10282-10290
-
-
Woods, A.1
Cheung, P.C.F.2
Smith, F.C.3
Davison, M.D.4
Scott, J.5
Beri, R.K.6
-
13
-
-
0038814313
-
A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias
-
E.R. Hudson, D.A. Pan, J. James, J.M. Lucocq, S.A. Hawley, and K.A. Green A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias Curr. Biol. 13 2003 861 866
-
(2003)
Curr. Biol.
, vol.13
, pp. 861-866
-
-
Hudson, E.R.1
Pan, D.A.2
James, J.3
Lucocq, J.M.4
Hawley, S.A.5
Green, K.A.6
-
14
-
-
0037799908
-
AMPK beta subunit targets metabolic stress sensing to glycogen
-
G. Polekhina, A. Gupta, B.J. Michell, B. Van Denderen, S. Murthy, and S.C. Feil AMPK beta subunit targets metabolic stress sensing to glycogen Curr. Biol. 13 2003 867 871
-
(2003)
Curr. Biol.
, vol.13
, pp. 867-871
-
-
Polekhina, G.1
Gupta, A.2
Michell, B.J.3
Van Denderen, B.4
Murthy, S.5
Feil, S.C.6
-
15
-
-
0024335432
-
The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase
-
D. Carling, and D.G. Hardie The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase Biochim. Biophys. Acta 1012 1989 81 86
-
(1989)
Biochim. Biophys. Acta
, vol.1012
, pp. 81-86
-
-
Carling, D.1
Hardie, D.G.2
-
16
-
-
0036064261
-
Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle
-
J.F.P. Wojtaszewski, S.B. Jørgensen, Y. Hellsten, D.G. Hardie, and E.A. Richter Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle Diabetes 51 2002 284 292
-
(2002)
Diabetes
, vol.51
, pp. 284-292
-
-
Wojtaszewski, J.F.P.1
Jørgensen, S.B.2
Hellsten, Y.3
Hardie, D.G.4
Richter, E.A.5
-
17
-
-
0031016272
-
The structure of a domain common to archaebacteria and the homocystinuria disease protein
-
A. Bateman The structure of a domain common to archaebacteria and the homocystinuria disease protein Trends Biochem. Sci. 22 1997 12 13
-
(1997)
Trends Biochem. Sci.
, vol.22
, pp. 12-13
-
-
Bateman, A.1
-
18
-
-
85047691317
-
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations
-
J.W. Scott, S.A. Hawley, K.A. Green, M. Anis, G. Stewart, and G.A. Scullion CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations J. Clin. Invest. 113 2004 274 284
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 274-284
-
-
Scott, J.W.1
Hawley, S.A.2
Green, K.A.3
Anis, M.4
Stewart, G.5
Scullion, G.A.6
-
19
-
-
0034654362
-
Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding
-
P.C.F. Cheung, I.P. Salt, S.P. Davies, D.G. Hardie, and D. Carling Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding Biochem. J. 346 2000 659 669
-
(2000)
Biochem. J.
, vol.346
, pp. 659-669
-
-
Cheung, P.C.F.1
Salt, I.P.2
Davies, S.P.3
Hardie, D.G.4
Carling, D.5
-
20
-
-
0035872209
-
Mutations in the γ2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: Evidence for the central role of energy compromise in disease pathogenesis
-
E. Blair, C. Redwood, H. Ashrafian, I. Ostman-Smith, and H. Watkins Mutations in the γ2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis Hum. Mol. Genet. 10 2001 1215 1220
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 1215-1220
-
-
Blair, E.1
Redwood, C.2
Ashrafian, H.3
Ostman-Smith, I.4
Watkins, H.5
-
21
-
-
0035859215
-
Identification of a gene responsible for familial Wolff-Parkinson-White syndrome
-
M.H. Gollob, M.S. Green, A.S.L. Tang, T. Gollob, A. Karibe, and A. Hassan Identification of a gene responsible for familial Wolff-Parkinson-White syndrome New Eng. J. Med. 344 2001 1823 1831
-
(2001)
New Eng. J. Med.
, vol.344
, pp. 1823-1831
-
-
Gollob, M.H.1
Green, M.S.2
Tang, A.S.L.3
Gollob, T.4
Karibe, A.5
Hassan, A.6
-
22
-
-
0036167225
-
Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy
-
M. Arad, D.W. Benson, A.R. Perez-Atayde, W.J. McKenna, E.A. Sparks, and R.J. Kanter Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy J. Clin. Invest. 109 2002 357 362
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 357-362
-
-
Arad, M.1
Benson, D.W.2
Perez-Atayde, A.R.3
McKenna, W.J.4
Sparks, E.A.5
Kanter, R.J.6
-
23
-
-
0037185021
-
Functional analysis of mutations in the γ2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome
-
T. Daniel, and D. Carling Functional analysis of mutations in the γ2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome J. Biol. Chem. 277 2003 51017 51024
-
(2003)
J. Biol. Chem.
, vol.277
, pp. 51017-51024
-
-
Daniel, T.1
Carling, D.2
-
24
-
-
0029993727
-
Active and inactive protein kinases: Structural basis for regulation
-
L.N. Johnson, M.E.M. Noble, and D.J. Owen Active and inactive protein kinases: structural basis for regulation Cell 85 1996 149 158
-
(1996)
Cell
, vol.85
, pp. 149-158
-
-
Johnson, L.N.1
Noble, M.E.M.2
Owen, D.J.3
-
25
-
-
0041305909
-
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases
-
S.P. Hong, F.C. Leiper, A. Woods, D. Carling, and M. Carlson Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases Proc. Natl. Acad. Sci. USA 100 2003 8839 8843
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 8839-8843
-
-
Hong, S.P.1
Leiper, F.C.2
Woods, A.3
Carling, D.4
Carlson, M.5
-
26
-
-
0041700137
-
Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex
-
C.M. Sutherland, S.A. Hawley, R.R. McCartney, A. Leech, M.J.R. Stark, and M.C. Schmidt Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex Curr. Biol. 13 2003 1299 1305
-
(2003)
Curr. Biol.
, vol.13
, pp. 1299-1305
-
-
Sutherland, C.M.1
Hawley, S.A.2
McCartney, R.R.3
Leech, A.4
Stark, M.J.R.5
Schmidt, M.C.6
-
27
-
-
0028845251
-
2+/calmodulin activates the calmodulin-dependent protein kinase-I cascade, via 3 independent mechanisms
-
2+/calmodulin activates the calmodulin-dependent protein kinase-I cascade, via 3 independent mechanisms J. Biol. Chem. 270 1995 27186 27191
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 27186-27191
-
-
Hawley, S.A.1
Selbert, M.A.2
Goldstein, E.G.3
Edelman, A.M.4
Carling, D.5
Hardie, D.G.6
-
28
-
-
0032495530
-
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
-
A. Hemminki, D. Markie, I. Tomlinson, E. Avizienyte, S. Roth, and A. Loukola A serine/threonine kinase gene defective in Peutz-Jeghers syndrome Nature 391 1998 184 187
-
(1998)
Nature
, vol.391
, pp. 184-187
-
-
Hemminki, A.1
Markie, D.2
Tomlinson, I.3
Avizienyte, E.4
Roth, S.5
Loukola, A.6
-
29
-
-
0031974516
-
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
-
D.E. Jenne, H. Reimann, J.I. Nezu, W. Friedel, S. Loff, and R. Jeschke Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase Nat. Genet. 18 1998 38 43
-
(1998)
Nat. Genet.
, vol.18
, pp. 38-43
-
-
Jenne, D.E.1
Reimann, H.2
Nezu, J.I.3
Friedel, W.4
Loff, S.5
Jeschke, R.6
-
30
-
-
12144287284
-
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
-
J.M. Lizcano, O. Goransson, R. Toth, M. Deak, N.A. Morrice, J. Boudeau, S.A. Hawley, L. Udd, T.P. Makela, D.G. Hardie, and D.R. Alessi LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 EMBO J. 23 2004 833 843
-
(2004)
EMBO J.
, vol.23
, pp. 833-843
-
-
Lizcano, J.M.1
Goransson, O.2
Toth, R.3
Deak, M.4
Morrice, N.A.5
Boudeau, J.6
Hawley, S.A.7
Udd, L.8
Makela, T.P.9
Hardie, D.G.10
Alessi, D.R.11
-
31
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade
-
S.A. Hawley, J. Boudeau, J.L. Reid, K.J. Mustard, L. Udd, and T.P. Makela Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade J. Biol. 2 2003
-
(2003)
J. Biol.
, vol.2
-
-
Hawley, S.A.1
Boudeau, J.2
Reid, J.L.3
Mustard, K.J.4
Udd, L.5
Makela, T.P.6
-
32
-
-
0141753981
-
MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm
-
J. Boudeau, A.F. Baas, M. Deak, N.A. Morrice, A. Kieloch, and M. Schutkowski MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm EMBO J. 22 2003 5102 5114
-
(2003)
EMBO J.
, vol.22
, pp. 5102-5114
-
-
Boudeau, J.1
Baas, A.F.2
Deak, M.3
Morrice, N.A.4
Kieloch, A.5
Schutkowski, M.6
-
33
-
-
0742270597
-
Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor
-
C.C. Milburn, J. Boudeau, M. Deak, D.R. Alessi, and D.M. Van Aalten Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor Nat. Struct. Mol. Biol. 11 2004 193 200
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 193-200
-
-
Milburn, C.C.1
Boudeau, J.2
Deak, M.3
Alessi, D.R.4
Van Aalten, D.M.5
-
34
-
-
0037122766
-
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
-
Y. Minokoshi, Y.B. Kim, O.D. Peroni, L.G. Fryer, C. Muller, and D. Carling Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase Nature 415 2002 339 343
-
(2002)
Nature
, vol.415
, pp. 339-343
-
-
Minokoshi, Y.1
Kim, Y.B.2
Peroni, O.D.3
Fryer, L.G.4
Muller, C.5
Carling, D.6
-
35
-
-
0036851817
-
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
-
T. Yamauchi, J. Kamon, Y. Minokoshi, Y. Ito, H. Waki, and S. Uchida Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase Nature Med. 8 2002 1288 1295
-
(2002)
Nature Med.
, vol.8
, pp. 1288-1295
-
-
Yamauchi, T.1
Kamon, J.2
Minokoshi, Y.3
Ito, Y.4
Waki, H.5
Uchida, S.6
-
36
-
-
0035936764
-
Obesity and the regulation of energy balance
-
B.M. Spiegelman, and J.S. Flier Obesity and the regulation of energy balance Cell 104 2001 531 543
-
(2001)
Cell
, vol.104
, pp. 531-543
-
-
Spiegelman, B.M.1
Flier, J.S.2
-
37
-
-
1842582870
-
AMP-activated protein kinase plays a role in the control of food intake
-
U. Andersson, K. Filipsson, C.R. Abbott, A. Woods, K. Smith, and S.R. Bloom AMP-activated protein kinase plays a role in the control of food intake J. Biol. Chem. 279 2004 12005 12008
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 12005-12008
-
-
Andersson, U.1
Filipsson, K.2
Abbott, C.R.3
Woods, A.4
Smith, K.5
Bloom, S.R.6
-
38
-
-
1842484296
-
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
-
Y. Minokoshi, T. Alquier, N. Furukawa, Y.B. Kim, A. Lee, and B. Xue AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus Nature 428 2004 569 574
-
(2004)
Nature
, vol.428
, pp. 569-574
-
-
Minokoshi, Y.1
Alquier, T.2
Furukawa, N.3
Kim, Y.B.4
Lee, A.5
Xue, B.6
-
39
-
-
2442631468
-
C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase
-
E.K. Kim, I. Miller, S. Aja, L.E. Landree, M. Pinn, and J. McFadden C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase J. Biol. Chem. 279 2004 19970 19976
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 19970-19976
-
-
Kim, E.K.1
Miller, I.2
Aja, S.3
Landree, L.E.4
Pinn, M.5
McFadden, J.6
-
40
-
-
3142677140
-
Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase
-
M.S. Kim, J.Y. Park, C. Namkoong, P.G. Jang, J.W. Ryu, and H.S. Song Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase Nat. Med. 10 2004 727 733
-
(2004)
Nat. Med.
, vol.10
, pp. 727-733
-
-
Kim, M.S.1
Park, J.Y.2
Namkoong, C.3
Jang, P.G.4
Ryu, J.W.5
Song, H.S.6
-
41
-
-
0037067666
-
The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct pathways
-
L.G. Fryer, A.P. Patel, and D. Carling The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct pathways J. Biol. Chem. 277 2002 25226 25232
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 25226-25232
-
-
Fryer, L.G.1
Patel, A.P.2
Carling, D.3
-
42
-
-
0036324142
-
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism
-
S.A. Hawley, A.E. Gadalla, G.S. Olsen, and D.G. Hardie The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism Diabetes 51 2002 2420 2425
-
(2002)
Diabetes
, vol.51
, pp. 2420-2425
-
-
Hawley, S.A.1
Gadalla, A.E.2
Olsen, G.S.3
Hardie, D.G.4
|