C75, a Fatty Acid Synthase Inhibitor, Modulates AMP-activated Protein Kinase to Alter Neuronal Energy Metabolism

Journal of Biological Chemistry

Volumn 279, Issue 5, 2004, Pages 3817-3827

  Landree, Leslie E ^a   Hanlon, Andrea L ^a   Strong, David W ^a   Rumbaugh, Gavin ^a,b   Miller, Ian M ^a   Thupari, Jagan N ^a   Connolly, Erin C ^a   Huganir, Richard L ^a,b   Richardson, Christine ^c   Witters, Lee A ^d   Kuhajda, Francis P ^a   Ronnett, Gabriele V ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

^d Dartmouth College   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; FATTY ACIDS; METABOLISM; NEUROLOGY;

HYPOTHALAMUS; NEURONS;

BIOCHEMISTRY;

(HYDROXYMETHYLGLUTARYL COA REDUCTASE (NADPH)) KINASE; (HYDROXYMETHYLGLUTARYL-COA REDUCTASE (NADPH)) KINASE; 4 METHYLENE 2 OCTYL 5 OXOFURAN 3 CARBOXYLIC ACID; 4-METHYLENE-2-OCTYL-5-OXOFURAN-3-CARBOXYLIC ACID; ACETYL COENZYME A CARBOXYLASE; ADENOSINE TRIPHOSPHATE; CARNITINE PALMITOYLTRANSFERASE; DRUG DERIVATIVE; ENZYME INHIBITOR; FATTY ACID; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; GAMMA BUTYROLACTONE; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MULTIENZYME COMPLEX; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL CELL; ARTICLE; BIOLOGICAL MODEL; BRAIN CELL; CELL CULTURE; CELL SURVIVAL; DRUG EFFECT; ELECTROPHYSIOLOGY; ENERGY BALANCE; ENERGY METABOLISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEEDING BEHAVIOR; FOOD INTAKE; GLUCOSE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; METABOLISM; NERVE CELL; NERVE CELL CULTURE; NONHUMAN; PATHOLOGY; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; RAT STRAIN; TIME; WEIGHT REDUCTION; WESTERN BLOTTING;

4-BUTYROLACTONE; ACETYL-COA CARBOXYLASE; ADENOSINE TRIPHOSPHATE; ANIMALS; BLOTTING, WESTERN; CARNITINE O-PALMITOYLTRANSFERASE; CELL SURVIVAL; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHYSIOLOGY; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS; GLUCOSE; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MODELS, BIOLOGICAL; MULTIENZYME COMPLEXES; NEURONS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

ANIMALIA;

EID: 9144219529     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M310991200     Document Type: Article

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