메뉴 건너뛰기




Volumn 92, Issue 1-3, 2000, Pages 9-15

SOCS-3 expression in leptin-sensitive neurons of the hypothalamus of fed and fasted rats

Author keywords

Adiposity; Arcuate nucleus; Dorsomedial nucleus; Fluorescence in situ hybridization; Immunocytochemistry; NPY; Obesity; POMC

Indexed keywords

LEPTIN; MESSENGER RNA; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN; PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNCLASSIFIED DRUG;

EID: 0034714047     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(00)00143-9     Document Type: Article
Times cited : (45)

References (56)
  • 1
    • 0032577376 scopus 로고    scopus 로고
    • Signals that regulate food intake and energy homeostasis
    • Woods S.C., Seeley R.J., Porte D. Jr., Schwartz M.W. Signals that regulate food intake and energy homeostasis. Science. 280:1998;1378-1383.
    • (1998) Science , vol.280 , pp. 1378-1383
    • Woods, S.C.1    Seeley, R.J.2    Porte D., Jr.3    Schwartz, M.W.4
  • 2
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M., et al. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:1994;425-432.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 4
    • 0028845877 scopus 로고
    • Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
    • Maffei M., Halaas J., Ravussin E., Pratley R.E., Lee G.H., Zhang Y., et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med. 1:1995;1155-1161.
    • (1995) Nat Med , vol.1 , pp. 1155-1161
    • Maffei, M.1    Halaas, J.2    Ravussin, E.3    Pratley, R.E.4    Lee, G.H.5    Zhang, Y.6
  • 5
    • 0029983180 scopus 로고    scopus 로고
    • Obese gene expression: Reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity
    • Mizuno T.M., Bergen H., Funabashi T., Kleopoulos S.P., Zhong Y.G., Bauman W.A., et al. Obese gene expression: reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity. Proc Natl Acad Sci USA. 93:1996;3434-3438.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3434-3438
    • Mizuno, T.M.1    Bergen, H.2    Funabashi, T.3    Kleopoulos, S.P.4    Zhong, Y.G.5    Bauman, W.A.6
  • 6
    • 0028793697 scopus 로고
    • Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
    • Frederich R.C., Hamann A., Anderson S., Lollmann B., Lowell B.B., Flier J.S., et al. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med. 1:1995;1311-1314.
    • (1995) Nat Med , vol.1 , pp. 1311-1314
    • Frederich, R.C.1    Hamann, A.2    Anderson, S.3    Lollmann, B.4    Lowell, B.B.5    Flier, J.S.6
  • 7
    • 0030601101 scopus 로고    scopus 로고
    • Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA
    • Hardie L.J., Rayner D.V., Holmes S., Trayhurn P. Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA. Biochem Biophys Res Commun. 223:1996;660-665.
    • (1996) Biochem Biophys Res Commun , vol.223 , pp. 660-665
    • Hardie, L.J.1    Rayner, D.V.2    Holmes, S.3    Trayhurn, P.4
  • 10
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield L.A., Smith F.J., Guisez Y., Devos R., Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 269:1995;546-549.
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 12
    • 13344280346 scopus 로고    scopus 로고
    • Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice
    • Schwartz M.W., Baskin D.G., Bukowski T.R., Kuijper J.L., Foster D., Lasser G., et al. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes. 45:1996;531-535.
    • (1996) Diabetes , vol.45 , pp. 531-535
    • Schwartz, M.W.1    Baskin, D.G.2    Bukowski, T.R.3    Kuijper, J.L.4    Foster, D.5    Lasser, G.6
  • 13
    • 0032963304 scopus 로고    scopus 로고
    • Model for the regulation of energy balance and adiposity by the central nervous system
    • Schwartz M.W., Baskin D.G., Kaiyala K.J., Woods S.C. Model for the regulation of energy balance and adiposity by the central nervous system. Am J Clin Nutr. 69:1999;584-596.
    • (1999) Am J Clin Nutr , vol.69 , pp. 584-596
    • Schwartz, M.W.1    Baskin, D.G.2    Kaiyala, K.J.3    Woods, S.C.4
  • 14
    • 0033000041 scopus 로고    scopus 로고
    • Leptin sensitive neurons in the hypothalamus
    • Baskin D.G., Hahn T.M., Schwartz M.W. Leptin sensitive neurons in the hypothalamus. Horm Metab Res. 31:1999;345-350.
    • (1999) Horm Metab Res , vol.31 , pp. 345-350
    • Baskin, D.G.1    Hahn, T.M.2    Schwartz, M.W.3
  • 15
    • 0033436355 scopus 로고    scopus 로고
    • Insulin and leptin: Dual adiposity signals to the brain for the regulation of food intake and body weight
    • Baskin D.G., Lattemann D.F., Seeley R.J., Woods S.C., Porte D. Jr., Schwartz M.W. Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight. Brain Res. 848:1999;114-123.
    • (1999) Brain Res , vol.848 , pp. 114-123
    • Baskin, D.G.1    Lattemann, D.F.2    Seeley, R.J.3    Woods, S.C.4    Porte D., Jr.5    Schwartz, M.W.6
  • 17
    • 0029864416 scopus 로고    scopus 로고
    • Leptin enters the brain by a saturable system independent of insulin
    • Banks W.A., Kastin A.J., Huang W.T., Jaspan J.B., Maness L.M. Leptin enters the brain by a saturable system independent of insulin. Peptides. 17:1996;305-311.
    • (1996) Peptides , vol.17 , pp. 305-311
    • Banks, W.A.1    Kastin, A.J.2    Huang, W.T.3    Jaspan, J.B.4    Maness, L.M.5
  • 18
    • 0029881125 scopus 로고    scopus 로고
    • Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
    • Schwartz M.W., Peskind E., Raskind M., Boyko E.J., Porte D.J. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med. 2:1996;589-593.
    • (1996) Nat Med , vol.2 , pp. 589-593
    • Schwartz, M.W.1    Peskind, E.2    Raskind, M.3    Boyko, E.J.4    Porte, D.J.5
  • 20
    • 0007500186 scopus 로고    scopus 로고
    • Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats
    • Seeley R.J., Van Dijk G., Campfield L.A., Smith F.J., Burn P., Nelligan J.A., et al. Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats. Horm Metab Res. 28:1996;664-668.
    • (1996) Horm Metab Res , vol.28 , pp. 664-668
    • Seeley, R.J.1    Van Dijk, G.2    Campfield, L.A.3    Smith, F.J.4    Burn, P.5    Nelligan, J.A.6
  • 21
    • 0033562892 scopus 로고    scopus 로고
    • Leptin binding in the arcuate nucleus is increased during fasting
    • Baskin D.G., Breininger J.F., Bonigut S., Miller M.A. Leptin binding in the arcuate nucleus is increased during fasting. Brain Res. 828:1999;154-158.
    • (1999) Brain Res , vol.828 , pp. 154-158
    • Baskin, D.G.1    Breininger, J.F.2    Bonigut, S.3    Miller, M.A.4
  • 22
    • 0032489962 scopus 로고    scopus 로고
    • Regional localization of specific [I-125]leptin binding sites in rat forebrain
    • Corp E.S., Conze D.B., Smith F., Campfield L.A. Regional localization of specific [I-125]leptin binding sites in rat forebrain. Brain Res. 789:1996;40-47.
    • (1996) Brain Res , vol.789 , pp. 40-47
    • Corp, E.S.1    Conze, D.B.2    Smith, F.3    Campfield, L.A.4
  • 23
    • 0030942844 scopus 로고    scopus 로고
    • The leptin receptor
    • Tartaglia L.A. The leptin receptor. J Biol Chem. 272:1997;6093-6096.
    • (1997) J Biol Chem , vol.272 , pp. 6093-6096
    • Tartaglia, L.A.1
  • 24
    • 0031040793 scopus 로고    scopus 로고
    • Leptin receptor (OB-R) signaling - Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization
    • White D.W., Kuropatwinski K.K., Devos R., Baumann H., Tartaglia L.A. Leptin receptor (OB-R) signaling - cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization. J Biol Chem. 272:1997;4065-4071.
    • (1997) J Biol Chem , vol.272 , pp. 4065-4071
    • White, D.W.1    Kuropatwinski, K.K.2    Devos, R.3    Baumann, H.4    Tartaglia, L.A.5
  • 25
    • 0031436148 scopus 로고    scopus 로고
    • Divergent signaling capacities of the long and short isoforms of the leptin receptor
    • Bjorbaek C., Uotani S., da Silva B., Flier J.S. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem. 272:1997;32686-32695.
    • (1997) J Biol Chem , vol.272 , pp. 32686-32695
    • Bjorbaek, C.1    Uotani, S.2    Da Silva, B.3    Flier, J.S.4
  • 26
    • 0029845169 scopus 로고    scopus 로고
    • Localization of leptin receptor mRNA expression in mouse brain
    • Huang X.F., Koutcherov I., Lin S., Wang H.Q., Storlien L. Localization of leptin receptor mRNA expression in mouse brain. Neuroreport. 7:1996;2635-2638.
    • (1996) Neuroreport , vol.7 , pp. 2635-2638
    • Huang, X.F.1    Koutcherov, I.2    Lin, S.3    Wang, H.Q.4    Storlien, L.5
  • 27
    • 0029895233 scopus 로고    scopus 로고
    • Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
    • Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Trayhurn P., et al. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. 387:1996;113-116.
    • (1996) FEBS Lett , vol.387 , pp. 113-116
    • Mercer, J.G.1    Hoggard, N.2    Williams, L.M.3    Lawrence, C.B.4    Hannah, L.T.5    Trayhurn, P.6
  • 29
    • 0033065587 scopus 로고    scopus 로고
    • Leptin receptor long form splice variant protein expression in neuron cell bodies of the brain and colocalization with neuropeptide Y mRNA in the arcuate nucleus
    • Baskin D.G., Schwartz M.W., Seeley R.J., Woods S.W., Porte D. Jr., Breininger J.F., et al. Leptin receptor long form splice variant protein expression in neuron cell bodies of the brain and colocalization with neuropeptide Y mRNA in the arcuate nucleus. J Histochem Cytochem. 47:1999;353-362.
    • (1999) J Histochem Cytochem , vol.47 , pp. 353-362
    • Baskin, D.G.1    Schwartz, M.W.2    Seeley, R.J.3    Woods, S.W.4    Porte D., Jr.5    Breininger, J.F.6
  • 30
    • 0031895877 scopus 로고    scopus 로고
    • Increased expression of mRNA for the long form of the leptin receptor in the hypothalamus is associated with leptin hypersensitivity and fasting
    • Baskin D.G., Seeley R.J., Kuijper J.L., LoK S., Weigle D.S., Erickson J.C., et al. Increased expression of mRNA for the long form of the leptin receptor in the hypothalamus is associated with leptin hypersensitivity and fasting. Diabetes. 47:1998;538-544.
    • (1998) Diabetes , vol.47 , pp. 538-544
    • Baskin, D.G.1    Seeley, R.J.2    Kuijper, J.L.3    Lok, S.4    Weigle, D.S.5    Erickson, J.C.6
  • 31
    • 0032998652 scopus 로고    scopus 로고
    • Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus
    • Baskin D.G., Breininger J.F., Schwartz M.W. Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus. Diabetes. 48:1999;828-833.
    • (1999) Diabetes , vol.48 , pp. 828-833
    • Baskin, D.G.1    Breininger, J.F.2    Schwartz, M.W.3
  • 32
    • 0031010408 scopus 로고    scopus 로고
    • Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
    • Fei H., Okano H.J., Li C., Lee G., Zhao C., Darnell R., et al. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci USA. 94:1997;7001-7005.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 7001-7005
    • Fei, H.1    Okano, H.J.2    Li, C.3    Lee, G.4    Zhao, C.5    Darnell, R.6
  • 34
    • 0031963436 scopus 로고    scopus 로고
    • Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus
    • Hakansson M.L., Brown H., Ghilardi N., Skoda R.C., Meister B. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J Neurosci. 18:1998;559-572.
    • (1998) J Neurosci , vol.18 , pp. 559-572
    • Hakansson, M.L.1    Brown, H.2    Ghilardi, N.3    Skoda, R.C.4    Meister, B.5
  • 35
    • 0032130554 scopus 로고    scopus 로고
    • Colocalization of agouti-related protein and neuropeptide Y in arcuate nucleus neurons activated by fasting
    • Hahn T.M., Breininger J.F., Baskin D.G., Schwartz M.W. Colocalization of agouti-related protein and neuropeptide Y in arcuate nucleus neurons activated by fasting. Nat Neurosci. 1:1998;271-272.
    • (1998) Nat Neurosci , vol.1 , pp. 271-272
    • Hahn, T.M.1    Breininger, J.F.2    Baskin, D.G.3    Schwartz, M.W.4
  • 36
    • 0030775971 scopus 로고    scopus 로고
    • Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
    • Schwartz M.W., Seeley R.J., Woods S.C., Weigle D.S., Campfield L.A., Burn P., et al. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes. 46:1997;2119-2123.
    • (1997) Diabetes , vol.46 , pp. 2119-2123
    • Schwartz, M.W.1    Seeley, R.J.2    Woods, S.C.3    Weigle, D.S.4    Campfield, L.A.5    Burn, P.6
  • 37
    • 0031733326 scopus 로고    scopus 로고
    • Effect of fasting and leptin deficiency on hypothalamic neuropeptide Y gene transcription in vivo revealed by expression of a lacZ reporter gene
    • Schwartz M.W., Erickson J.C., Baskin D.G., Palmiter R.D. Effect of fasting and leptin deficiency on hypothalamic neuropeptide Y gene transcription in vivo revealed by expression of a lacZ reporter gene. Endocrinology. 139:1998;2629-2635.
    • (1998) Endocrinology , vol.139 , pp. 2629-2635
    • Schwartz, M.W.1    Erickson, J.C.2    Baskin, D.G.3    Palmiter, R.D.4
  • 38
    • 0030928715 scopus 로고    scopus 로고
    • Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus
    • Cheung C.C., Clifton D.K., Steiner R.A. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology. 138:1997;4489-4492.
    • (1997) Endocrinology , vol.138 , pp. 4489-4492
    • Cheung, C.C.1    Clifton, D.K.2    Steiner, R.A.3
  • 39
    • 0030729210 scopus 로고    scopus 로고
    • Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
    • Thornton J.E., Cheung C.C., Clifton D.K., Steiner R.A. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology. 138:1997;5063-5066.
    • (1997) Endocrinology , vol.138 , pp. 5063-5066
    • Thornton, J.E.1    Cheung, C.C.2    Clifton, D.K.3    Steiner, R.A.4
  • 40
    • 0031888157 scopus 로고    scopus 로고
    • Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin
    • Mizuno T.M., Kleopoulos S.P., Bergen H.T., Roberts J.L., Priest C.A., Mobbs C.V., et al. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin. Diabetes. 47:1998;294-297.
    • (1998) Diabetes , vol.47 , pp. 294-297
    • Mizuno, T.M.1    Kleopoulos, S.P.2    Bergen, H.T.3    Roberts, J.L.4    Priest, C.A.5    Mobbs, C.V.6
  • 41
    • 0032436307 scopus 로고    scopus 로고
    • Leptin activates hypothalamic CART neurons projecting to the spinal cord
    • Elias C.F., Lee C., Kelly J., Aschkenasi C., Ahima R.S., Couceyro P.R., et al. Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron. 21:1998;1375-1385.
    • (1998) Neuron , vol.21 , pp. 1375-1385
    • Elias, C.F.1    Lee, C.2    Kelly, J.3    Aschkenasi, C.4    Ahima, R.S.5    Couceyro, P.R.6
  • 43
    • 0029762615 scopus 로고    scopus 로고
    • Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus
    • Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Morgan P.J., et al. Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J Neuroendocrinol. 8:1996;733-735.
    • (1996) J Neuroendocrinol , vol.8 , pp. 733-735
    • Mercer, J.G.1    Hoggard, N.2    Williams, L.M.3    Lawrence, C.B.4    Hannah, L.T.5    Morgan, P.J.6
  • 44
    • 0032014178 scopus 로고    scopus 로고
    • Identification of SOCS-3 as a potential mediator of central leptin resistance
    • Bjorbaek C., Elmquist J.K., Frantz J.D., Shoelson S.E., Flier J.S. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell. 1:1998;619-625.
    • (1998) Mol Cell , vol.1 , pp. 619-625
    • Bjorbaek, C.1    Elmquist, J.K.2    Frantz, J.D.3    Shoelson, S.E.4    Flier, J.S.5
  • 45
    • 0031800490 scopus 로고    scopus 로고
    • The SOCS proteins: A new family of negative regulators of signal transduction
    • Nicholson S.E., Hilton D.J. The SOCS proteins: a new family of negative regulators of signal transduction. J Leukocyte Biol. 63:1998;665-668.
    • (1998) J Leukocyte Biol , vol.63 , pp. 665-668
    • Nicholson, S.E.1    Hilton, D.J.2
  • 47
    • 0033569730 scopus 로고    scopus 로고
    • The role of SOCS-3 in leptin signaling and leptin resistance
    • Bjorbaek C., El-Haschimi K., Frantz J.D., Flier J.S. The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem. 274:1999;30059-30065.
    • (1999) J Biol Chem , vol.274 , pp. 30059-30065
    • Bjorbaek, C.1    El-Haschimi, K.2    Frantz, J.D.3    Flier, J.S.4
  • 49
    • 0024473271 scopus 로고
    • 125I]labeled ligands with Amersham Hyperfilm beta-max
    • 125I]labeled ligands with Amersham Hyperfilm beta-max. Neurosci Lett. 104:1989;171-177.
    • (1989) Neurosci Lett , vol.104 , pp. 171-177
    • Baskin, D.G.1    Wimpy, T.H.2
  • 50
    • 0027414244 scopus 로고
    • Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide Y, galanin, and glutamic acid decarboxylase
    • Schwartz M.W., Sipols A.J., Grubin C.E., Baskin D.G. Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide Y, galanin, and glutamic acid decarboxylase. Brain Res Bull. 31:1993;361-367.
    • (1993) Brain Res Bull , vol.31 , pp. 361-367
    • Schwartz, M.W.1    Sipols, A.J.2    Grubin, C.E.3    Baskin, D.G.4
  • 51
    • 0033635093 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization of scarce leptin receptor mRNA using the enzyme-labelled fluorescent substrate method and tyramide signal amplification
    • In press
    • Baskin D.G., Breininger J.F. Fluorescence in situ hybridization of scarce leptin receptor mRNA using the enzyme-labelled fluorescent substrate method and tyramide signal amplification. J Histochem Cytochem. 2000;. In press.
    • (2000) J Histochem Cytochem
    • Baskin, D.G.1    Breininger, J.F.2
  • 53
    • 0030899391 scopus 로고    scopus 로고
    • The ELF-97 alkaline phosphatase substrate provides a bright, photostable, fluorescent signal amplification method for FISH
    • Paragas V.B., Zhang Y.Z., Haugland R.P., Singer V.L. The ELF-97 alkaline phosphatase substrate provides a bright, photostable, fluorescent signal amplification method for FISH. J Histochem Cytochem. 45:1997;345-357.
    • (1997) J Histochem Cytochem , vol.45 , pp. 345-357
    • Paragas, V.B.1    Zhang, Y.Z.2    Haugland, R.P.3    Singer, V.L.4
  • 54
    • 0033180532 scopus 로고    scopus 로고
    • Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
    • Elias C.F., Aschkenasi C., Lee C., Kelly J., Ahima R.S., Bjorbaek C., et al. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron. 23:1999;775-786.
    • (1999) Neuron , vol.23 , pp. 775-786
    • Elias, C.F.1    Aschkenasi, C.2    Lee, C.3    Kelly, J.4    Ahima, R.S.5    Bjorbaek, C.6
  • 55
    • 0031906674 scopus 로고    scopus 로고
    • Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei
    • Elmquist J.K., Ahima R.S., Elias C.F., Flier J.S., Saper C.B. Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc Natl Acad Sci USA. 95:1998;741-746.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 741-746
    • Elmquist, J.K.1    Ahima, R.S.2    Elias, C.F.3    Flier, J.S.4    Saper, C.B.5
  • 56
    • 0033082380 scopus 로고    scopus 로고
    • From lesions to leptin: Hypothalamic control of food intake and body weight
    • Elmquist J.K., Elias C.F., Saper C.B. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron. 22:1999;221-232.
    • (1999) Neuron , vol.22 , pp. 221-232
    • Elmquist, J.K.1    Elias, C.F.2    Saper, C.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.