Absence of innate MyD88 signaling promotes inducible allograft acceptance

Journal of Immunology

Volumn 177, Issue 8, 2006, Pages 5307-5316

  Walker, Wendy E ^a   Nasr, Isam W ^a   Camirand, Geoffrey ^a   Tesar, Bethany M ^a   Booth, Carmen J ^a   Goldstein, Daniel R ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b 3 FMP ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYELOID DIFFERENTIATION FACTOR 88;

ALLOGRAFT; ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DENDRITIC CELL; INFLAMMATION; INNATE IMMUNITY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; SKIN TRANSPLANTATION; T LYMPHOCYTE ACTIVATION; TRANSPLANTATION TOLERANCE;

EID: 33749515463     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.8.5307     Document Type: Article

References (44)

1. Bennett, L. E., M. C. Keck, O. P. Daily, R. J. Novick, and J. D. Hosenpud. 2000. Worldwide thoracic organ transplantation: a report from the UNOS/ISHLT International Registry for Thoracic Organ Transplantation. Clin. Transplant. 31-44.
2. Hosenpud, J. D., L. E. Bennett, B. M. Keck, M. M. Boucek, and R. J. Novick. 2001. The Registry of the International Society for Heart and Lung Transplantation: 18th Official Report-2001. J. Heart Lung Transplant. 20: 805-815.
3. Lechler, R., M. Sykes, A. Thomson, and L. A. Turka. 2005. Organ transplantation-how much of the promise has been realized? Nat. Med. 11: 605-613.
4. Miller, L. W., D. C. Naftel, R. C. Bourge, J. K. Kirklin, S. C. Brozena, J. Jarcho, R. E. Hobbs, and R. M. Mills. 1994. Infection after heart transplantation: a multiinstitutional study. Cardiac Transplant Research Database Group. J. Heart Lung Transplant 13: 381-392.
5. Cornell, L., and R. Colvin. 2005. Chronic allograft nephropathy. Curr. Opin. Nephrol. Hypertens. 14: 229-234.
6. Akira, S., and K. Takeda. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4: 499-511.
7. Leadbetter, E. A., I. R. Rifkin, A. M. Hohlbaum, B. C. Beaudette, M. J., Shlomchik and A. Marshak-Rothstein. 2002. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416: 603-607.
8. Iwasaki, A., and R. Medzhitov. 2004. Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 5: 987-995.
9. + T cell-mediated suppression by dendritic cells. Science 299: 1033-1036.
10. Caramalho, I., T. Lopes-Carvalho, D. Ostler, S. Zelenay, M. Haury, and J. Demengeot. 2003. Regulatory T cells selectively express Toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 197: 403-411.
11. Goldstein, D. R., B. M. Tesar, S. Akira, and F. G. Lakkis. 2003. Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection. J. Clin. Invest. 111: 1571-1578.
12. Boros, P., and J. S. Bromberg. 2006. New cellular and molecular immune pathways in ischemia/reperfusion injury. Am. J. Transplant. 6: 652-658.
13. Zhai, Y., X. Shen, R. O'Connell, F. Gao, C. Lassman, R. W. Busuttil, G. Cheng, and J. W. Kupiec-Weglinski. 2004. Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. J. Immunol. 173: 7115-7119.
14. Oyama, J. I., C. Blais, Jr., X. Liu, M. Pu, L. Kobzik, R. A. Kelly, and T. Bourcier. 2004. Reduced myocardial ischemia-reperfusion injury in Toll-like receptor 4-deficient mice. Circulation 109: 784-789.
15. Tesar, B. M., J. Zhang, Q. Li, and D. R. Goldstein. 2004. Th1 immune responses to fully MHC mismatched allografts are diminished in the absence of MyD88, a Toll like receptor signal adaptor protein. Am. J. Transplant. 4: 1429-1439.
16. Konieczny, B. T., Z. Dai, E. T. Elwood, S. Saleem, P. S. Linsley, F. K. Baddoura, C. P. Larsen, T. C. Pearson, and F. G. Lakkis. 1998. IFN-γ is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways. J. Immunol. 160: 2059-2064.
17. Dai, Z., and F. G. Lakkis. 1999. The role of cytokines, CTLA-4 and costimulation in transplant tolerance and rejection. Curr. Opin. Immunol. 11: 504-508.
18. Steinmuller, D. 2001. Skin allograft rejection by stable hematopoietic chimeras that accept organ allografts still is an enigma. Transplantation 72: 122-126.
19. Nash, J., M. Peters, and P. Bell. 1977. Comparative survival of pancreatic islets, heart, kidney and skin allografts in rats, with and without enhancement. Transplantation 24: 70-73.
20. Davis, W. C., I. F. C. McKenzie, and R. W. Melvold. 1980. A comparison of skin and heart graft rejection patterns in H-2 mutant mice. Transplantation 29: 189-192.
21. Jones, N. D., S. E. Turvey, A. Van Maurik, M. Hara, C. I. Kingsley, C. H. Smith, A. L. Mellor, P. J. Morris, and K. J. Wood. 2001. Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection. J. Immunol. 166: 2824-2830.
22. Tesar, B. M., G. Chalasani, L. Smith-Diggs, F. K. Baddoura, F. G. Lakkis, and D. R. Goldstein. 2004. Direct antigen presentation by a xenograft induces immunity independently of secondary lymphoid organs. J. Immunol. 173: 4377-4386.
23. Wekerle, T., J. Kurtz, S. Bigenzahn, Y. Takeuchi, and M. Sykes. 2002. Mechanisms of transplant tolerance induction using costimulatory blockade. Curr. Opin. Immunol. 14: 592-600.
24. + T cells play a critical role in costimulation blockade-resistant allograft rejection. J. Clin. Invest. 104: 1715-1722.
25. Adachi, O., T. Kawai, K. Takeda, M. Matsumoto, H. Tsutsui, M. Sakagami, K. Nakanishi, and S. Akira. 1998. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9: 143-150.
26. Schnare, M., G. M. Barton, A. C. Holt, K. Takeda, S. Akira, and R. Medzhitov. 2001. Toll-like receptors control activation of adaptive immune responses. Nat. Immunol. 2: 947-950.
27. Pasare, C., and R. Medzhitov. 2004. Toll-dependent control mechanisms of CD4 T cell activation. Immunity 21: 733-741.
28. + Treg development and function during allergic airway inflammation in vivo. J. Clin. Invest. 115: 313-325.
29. Medzhitov, R. 2001. Toll-like receptors and innate immunity. Nature Rev. Immunol. 1: 135-145.
30. Walsh, P. T., D. K. Taylor and L. A. Turka. 2004. Tregs and transplantation tolerance. J. Clin. Invest. 114: 1398-1403.
31. + T regulatory cells. J. Immunol. 176: 3301-3305.
32. Haynes, L., S. M. Eaton, E. M. Burns, M. Rincon, and S. L. Swain. 2004. Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo. J. Immunol. 172: 5194-5199.
33. Samoilova, E. B., J. L. Horton, B. Hilliard, T. S. T. Liu, and Y. Chen. 1998. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J. Immunol. 161: 6480-6486.
34. Kaisho, T., O. Takeuchi, T. Kawai, K. Hoshino, and S. Akira. 2001. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J. Immunol. 166: 5688-5694.
35. Bettelli, E., Y. Carrier, W. Gao, T. Korn, T. B. Strom, M. Oukka, H. L. Weiner, and V. K. Kuchroo. 2006. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 11: 235-238.
36. + T cells to immobilized anti-TCR monoclonal antibody. J. Immunol. 152: 1618-1628.
37. Sho, M., K. Kishimoto, H. Harada, M. Livak, A. Sanchez-Fueyo, A. Yamada, X. X. Zheng, T. B. Strom, G. P. Basadonna, M. H. Sayegh, and D. M. Rothstein. 2005. Requirements for induction and maintenance of peripheral tolerance in stringent allograft models. Proc. Natl. Acad. Sci. 102: 13230-13235.
38. Le Moine, A., M. Goldman, and D. Abramowicz. 2002. Multiple pathways to allograft rejection. Transplantation 73: 1373-1381.
39. Gordon, S. 2002. Pattern recognition receptors: doubling up for the innate immune response. Cell 111: 927-930.
40. Philpott, D. J., and S. E. Girardin. 2004. The role of Toll-like receptors and Nod proteins in bacterial infection. Mol. Immunol. 41: 1099-1108.
41. Mason, A., P. L. Mottram, A. Mirisklavos, G. J. Clurne, and T. E. Mander. 1988. A comparison of cyclosporine, donor specific transfusion and antilymphocyte serum suppression of skin, hear and fetal islet allograft rejection in mice. Transplantation 45: 1155-1157.
42. Bingaman, A. W., J. Ha, S. Y. Waitze, M. M. Durham, H. R. Cho, C. Tucker-Burden, R. Hendrix, S. R. Cowan, T. C. Pearson, and C. P. Larsen. 2000. Vigorous allograft rejection in the absence of danger. J. Immunol. 164: 3065-3071.
43. Thornley, T. B., M. A., Brehm, T. G. Markees, L. D. Shultz, J. P. Mordes, R. M. Welsh, A. A. Rossini, and D. L. Greiner. 2006. TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts. J. Immunol. 176: 1561-1570.
44. Adams, A. B., M. A. Williams, T. R. Jones, N. Shirasugi, M. M. Durham, S. M. Kaech, E. J. Wherry, T. Onami, J. G. Lanier, K. E. Kokko, et al. 2003. Heterologous immunity provides a potent barrier to transplantation tolerance. J. Clin. Invest. 111: 1887-1895.