Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 49, 2005, Pages 17717-17722

  Li, Xiao Dong ^a   Sun, Lijun ^a   Seth, Rashu B ^a   Pineda, Gabriel ^a   Chen, Zhijian J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

I b kinase; IFN regulatory factor 3; NF b; Retinoic acid induced gene i

Indexed keywords

CYSTEINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERFERON INDUCING AGENT; INTERFERON REGULATORY FACTOR 3; MITOCHONDRIAL ANTIVIRAL SIGNALING PROTEIN; MITOCHONDRIAL PROTEIN; PROTEIN NS3 4A; SERINE PROTEINASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HEPATITIS C; HEPATITIS C VIRUS; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; INNATE IMMUNITY; INTERFERON INDUCTION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REPLICON;

AMINO ACID SEQUENCE; CARRIER PROTEINS; CELL LINE; CYSTEINE; HEPACIVIRUS; HUMANS; IMMUNITY, NATURAL; INTERFERON-BETA; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; VIRAL NONSTRUCTURAL PROTEINS; VIRAL PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 29144462494     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0508531102     Document Type: Article

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