TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation

EMBO Journal

Volumn 25, Issue 17, 2006, Pages 4108-4119

  Kamon, Hokuto ^a   Kawabe, Takaya ^a   Kitamura, Hidemitsu ^b   Lee, Jihye ^a   Kamimura, Daisuke ^b   Kaisho, Tsuneyasu ^b   Akira, Shizuo ^c   Iwamatsu, Akihiro ^d   Koga, Hisashi ^e   Murakami, Masaaki ^a   Hirano, Toshio ^a,b,f  

^a OSAKA UNIVERSITY   (Japan)

^b RIKEN Center for Integrative Medical Sciences   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d Protein Research Network Inc   (Japan)

^e KAZUSA DNA RESEARCH INSTITUTE   (Japan)

^f OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

CD4+ T cells; Dendritic cells; GEF; MHC class II; Rho; TLR

Indexed keywords

ADAPTOR PROTEIN; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN CDC42; PROTEIN TRIF; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RHOB GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; CELL STIMULATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RNA INTERFERENCE; T LYMPHOCYTE ACTIVATION; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DENDRITIC CELLS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HISTOCOMPATIBILITY ANTIGENS CLASS II; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; PROTO-ONCOGENE PROTEINS; RHOA GTP-BINDING PROTEIN; RHOB GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 33748350079     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601286     Document Type: Article

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