Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1

Nature Immunology

Volumn 7, Issue 6, 2006, Pages 598-605

  Saitoh, Tatsuya ^a   Tun Kyi, Adrian ^b   Ryo, Akihide ^c   Yamamoto, Masahiro ^d   Finn, Greg ^b   Fujita, Takashi ^e   Akira, Shizuo ^d,f   Yamamoto, Naoki ^a,g   Lu, Kun Ping ^b   Yamaoka, Shoji ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b HARVARD MEDICAL SCHOOL   (United States)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

^d OSAKA UNIVERSITY   (Japan)

^e KYOTO UNIVERSITY   (Japan)

^f JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^g NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; DOUBLE STRANDED RNA; INTERFERON REGULATORY FACTOR 3; ISOMERASE; PEPTIDYLPROLYL ISOMERASE PIN1; PROLINE; PROTEASOME; SERINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE DELETION; GENE REPRESSION; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; RNA INTERFERENCE; STIMULATION; UBIQUITINATION; VIRUS REPLICATION;

ANIMALS; CELLS, CULTURED; DEAD-BOX RNA HELICASES; DOWN-REGULATION; IMMUNITY, NATURAL; INTERFERON REGULATORY FACTOR-3; INTERFERON-BETA; MICE; MICE, INBRED STRAINS; PEPTIDYLPROLYL ISOMERASE; PHOSPHORYLATION; PROLINE; PROTEASOME ENDOPEPTIDASE COMPLEX; RNA HELICASES; RNA INTERFERENCE; RNA VIRUS INFECTIONS; RNA VIRUSES; RNA, DOUBLE-STRANDED; SERINE; TOLL-LIKE RECEPTOR 3; TRANS-ACTIVATION (GENETICS); UBIQUITIN;

EID: 33744499683     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1347     Document Type: Article

References (43)

1. Taniguchi, T., Ogasawara, K., Takaoka, A. & Tanaka, N. IRF family of transcription factors as regulators of host defense. Annu. Rev. Immunol. 19, 623-655 (2001).
2. Hiscott, J. et al. Convergence of the NF-κB and interferon signaling pathways in the regulation of antiviral defense and apoptosis. Ann. NY Acad. Sci. 1010, 237-248 (2003).
3. Takeda, K. & Akira, S. Toll-like receptors in innate immunity. Int. Immunol. 17, 1-14 (2005).
4. Alexopoulou, L., Holt, A.C., Medzhitov, R. & Flavell, R.A. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413, 732-738 (2001).
5. Yoneyama, M. et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 5, 730-737 (2004).
6. Poltorak, A. et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene. Science 282, 2085-2088 (1998).
7. Doyle, S. et al. IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity 17, 251-263 (2002).
8. Yoneyama, M. et al. Direct triggering of the type I interferon system by virus infection: Activation of a transcription factor complex containing IRF3 and CBP/p300. EMBO J. 17, 1087-1095 (1998).
9. Mori, M. et al. Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation. J. Biol. Chem. 279, 9698-9702 (2004).
10. Lin, R., Heylbroeck, C., Pitha, P.M. & Hiscott, J. Virus-dependent phosphorylation of the IRF3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol. Cell. Biol. 18, 2986-2996 (1998).
11. Lin, R., Mamane, Y. & Hiscott, J. Structural and functional analysis of interferon regulatory factor 3: Localization of the transactivation and autoinhibitory domains. Mol. Cell. Biol. 19, 2465-2474 (1999).
12. Servant, M.J. et al. Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3. J. Biol. Chem. 276, 355-363 (2001).
13. Karpova, A.Y., Trost, M., Murray, J.M., Cantley, L.C. & Howley, P.M. Interferon regulatory factor-3 is an in vivo target of DNA-PK. Proc. Natl. Acad. Sci. USA 99, 2818-2823 (2002).
14. Fitzgerald, K.A. et al. IKKε and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 4, 491-496 (2003).
15. Sharma, S. et al. Triggering the interferon antiviral response through an IKK-related pathway. Science 300, 1148-1151 (2003).
16. McWhirter, S.M. et al. IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proc. Natl. Acad. Sci. USA 101, 233-238 (2004).
17. Hemmi, H. et al. The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J. Exp. Med. 199, 1641-1650 (2004).
18. Wulf, G., Finn, G., Suizu, F. & Lu, K.P. Phosphorylation-specific prolyl isomerization: Is there an underlying theme? Nat. Cell Biol. 7, 435-441 (2005).
19. Lu, K.P., Hanes, S.D. & Hunter, T. A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature 380, 544-547 (1996).
20. Ryo, A. et al. Pin1 regulates turnover and subcellular localization of β-catenin by inhibiting its interaction with APC. Nat. Cell Biol. 3, 793-801 (2001).
21. Wulf, G.M., Liou, Y.C., Ryo, A., Lee, S.W. & Lu, K.P. Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage. J. Biol. Chem. 277, 47976-47979 (2002).
22. Zacchi, P. et al. The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature 419, 853-857 (2002).
23. Zheng, H. et al. The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature 419, 849-853 (2002).
24. Ryo, A. et al. PIN1 is an E217 target gene essential for Neu/Ras-induced transformation of mammary epithelial cells. Mol. Cell. Biol. 22, 5281-5295 (2002).
25. Liou, Y.C. et al. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature 424, 556-561 (2003).
26. Ryo, A. et al. Regulation of NF-κB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol. Cell 12, 1413-1426 (2003).
27. Mantovani, F. et al. Pin1 links the activities of c-Abl and p300 in regulating p73 function. Mol. Cell 14, 625-636 (2004).
28. Yeh, E. et al. A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat. Cell Biol. 6, 308-318 (2004).
29. Yamamoto, M. et al. Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling. J. Immunol. 169, 6668-6672 (2002).
30. Saitoh, T. et al. A20 is a negative regulator of IFN regulatory factor 3 signaling. J. Immunol. 174, 1507-1512 (2005).
31. Sato, M. et al. Distinct and essential roles of transcription factors IRF3 and IRF-7 in response to viruses for IFN-α/β gene induction. Immunity 13, 539-548 (2000).
32. Lipford, J.R. & Deshaies, R.J. Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation. Nat. Cell Biol. 5, 845-850 (2003).
33. Bao, L. et al. Prevalent overexpression of prolyl isomerase Pin1 in human cancers. Am. J. Pathol. 164, 1727-1737 (2004).
34. Stojdl, D.F. et al. VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents. Cancer Cell 4, 263-275 (2003).
35. Sakaguchi, S. et al. Essential role of IRF3 in lipopolysaccharide-induced interferon-β gene expression and endotoxin shock. Biochem. Biophys. Res. Commun. 306, 860-866 (2003).
36. Hsu, L.C. et al. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature 428, 341-345 (2004).
37. Heylbroeck, C. et al. The IRF3 transcription factor mediates Sendai virus-induced apoptosis. J. Virol. 74, 3781-3792 (2000).
38. Honda, K. et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434, 772-777 (2005).
39. Sears, R. et al. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev. 14, 2501-2514 (2000).
40. Saitoh, T. et al. TWEAK induces NF-κB2 p100 processing and long lasting NF-κB activation. J. Biol. Chem. 278, 36005-36012 (2003).
41. Momoi, Y. et al. Pertussis toxin enhances human immunodeficiency virus type 1 replication. AIDS Res. Hum. Retroviruses 16, 373-379 (2000).
42. Morita, S., Kojima, T. & Kitamura, T. Plat-E: An efficient and stable system for transient packaging of retroviruses. Gene Ther. 7, 1063-1066 (2000).
43. o arrest. Biochem. Biophys. Res. Commun. 265, 658-663 (1999).