Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 29, 2006, Pages 10961-10966

  Jiang, Zhengfan ^a   Georgel, Philippe ^a,c   Li, Chenglong ^a,d   Choe, Jungwoo ^a   Crozat, Karine ^a   Rutschmann, Sophie ^a   Du, Xin ^a   Bigby, Tim ^b   Mudd, Suzanne ^a   Sovath, Sosathya ^a   Wilson, Ian A ^a   Olson, Arthur ^a   Beutler, Bruce ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^c UNIVERSITÉ DE STRASBOURG   (France)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

Genetics; MyD88; Positional cloning; Signaling

Indexed keywords

ETHYLNITROSOUREA; INTERLEUKIN 1 RECEPTOR; LIPOPEPTIDE; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR;

ALPHA HELIX; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGOMERIZATION; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR BLOCKING; SITE DIRECTED MUTAGENESIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; ANIMALS; CELL LINE; GERM CELLS; HUMANS; LIPOPROTEINS; MICE; MICE, KNOCKOUT; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MYELOID DIFFERENTIATION FACTOR 88; PHENOTYPE; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 33746631265     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0603804103     Document Type: Article

References (27)

1. Beutler, B., Hoebe, K., Du, X. & Ulevitch, R. J. (2003) J. Leukocyte Biol. 74, 479-485.
2. Takeda, K. & Akira, S. (2001) Genes Cells 6, 733-742.
3. Akira, S., Takeda, K. & Kaisho, T. (2001) Nat. Immunol. 2, 675-680.
4. Kawai, T., Adachi, O., Ogawa, T., Takeda, K. & Akira, S. (1999) Immunity 11, 115-122.
5. Fitzgerald, K. A., Palsson-McDermott, E. M., Bowie, A. G., Jefferies, C. A., Mansell, A. S., Brady, G., Brint, E., Dunne, A., Gray, P., Harte, M. T., et al. (2001) Nature 413, 78-83.
6. Horng, T., Barton, G. M. & Medzhitov, R. (2001) Nat. Immunol. 2, 835-841.
7. Hoebe, K., Du, X., Georgel, P., Janssen, E., Tabeta, K., Kim, S. O., Goode, J., Lin, P., Mann, N., Mudd, S., et al. (2003) Nature 424, 743-748.
8. Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T. & Seya, T. (2003) Nat. Immunol. 4, 161-167.
9. Yamamoto, M., Sato, S., Hemmi, H., Uematsu, S., Hoshino, K., Kaisho, T., Takeuchi, O., Takeda, K. & Akira, S. (2003) Nat. Immunol. 4, 1144-1150.
10. Fitzgerald, K. A., Rowe, D. C., Barnes, B. J., Caffrey, D. R., Visintin, A., Latz, E., Monks, B., Pitha, P. M. & Golenbock, D. T. (2003) J. Exp. Med. 198, 1043-1055.
11. Li, C., Zienkiewicz, J. & Hawiger, J. (2005) J. Biol. Chem. 280, 26152-26159.
12. Poltorak, A., He, X., Smirnova, I., Liu, M. Y., Van, H. C., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) Science 282, 2085-2088.
13. Dunne, A., Ejdeback, M., Ludidi, P. L., O'Neill, L. A. & Gay, N. J. (2003) J. Biol. Chem. 278, 41443-41451.
14. Xu, Y., Tao, X., Shen, B., Horng, T., Medzhitov, R., Manley, J. L. & Tong, L. (2000) Nature 408, 111-115.
15. Buwitt-Beckmann, U., Heine, H., Wiesmuller, K. H., Jung, G., Brock, R., Akira, S. & Ulmer, A. J. (2005) Eur. J. Immunol. 35, 282-289.
16. Janssens, S., Burns, K., Vercammen, E., Tschopp, J. & Beyaert, R. (2003) FEBS Lett. 548, 103-107.
17. Tateuchi, O., Kawai, T., Muhlradt, P. F., Morr, M., Radolf, J. D., Zychlinsky, A., Takeda, K. & Akira, S. (2001) Int. Immunol. 13, 933-940.
18. Takeuchi, O., Kaufmann, A., Grote, K., Kawai, T., Hoshino, K., Morr, M., Muhlradt, P. F. & Akira, S. (2000) J. Immunol. 164, 554-557.
19. Strynadka, N. C., Eisenstein, M., Katchalski-Katzir, E., Shoichet, B. K., Kuntz, I. D., Abagyan, R., Totrov, M., Janin, J., Cherfils, J., Zimmerman, F., et al. (1996) Nat. Struct. Biol. 3, 233-239.
20. Sali, A. & Blundell, T. L. (1993) J. Mol. Biol. 234, 779-815.
21. Tao, X., Xu, Y., Zheng, Y., Beg, A. A. & Tong, L. (2002) Biochem. Biophys. Res. Commun. 299, 216-221.
22. Meng, G., Grabiec, A., Vallon, M., Ebe, B., Hampel, S., Bessler, W., Wagner, H. & Kirschning, C. J. (2003) J. Biol. Chem. 278, 39822-39829.
23. Toshchakov, V. U., Basu, S., Fenton, M. J. & Vogel, S. N. (2005) J. Immunol. 175, 494-500.
24. Jiang, Z., Georgel, P., Du, X., Shamel, L., Sovath, S., Mudd, S., Huber, M., Kalis, C., Keck, S., Galanos, C., et al. (2005) Nat. Immunol. 6, 565-570.
25. Thompson, J. D., Higgins, D. G. & Gibson, T. J. (1994) Nucleic Acids Res. 22, 4673-4680.
26. Laskowski, R. A., Rullmannn, J. A., MacArthur, M. W., Kaptein, R. & Thornton, J. M. (1996) J. Biomol. NMR 8, 477-486.
27. Weiner, S. J., Kollman, P. A., Case, D. A., Singh, U. C., Ohio, C., Alagona, G., Profeta, S. & Weiner, P. (1984) J. Am. Chem. Soc. 106, 765-784.