CD14 is required for MyD88-independent LPS signaling

Nature Immunology

Volumn 6, Issue 6, 2005, Pages 565-570

  Jiang, Zhengfan ^a   Georgel, Philippe ^a   Du, Xin ^a   Shamel, Louis ^a   Sovath, Sosathya ^a   Mudd, Suzanne ^a   Huber, Michael ^b   Kalis, Christoph ^b   Keck, Simone ^c   Galanos, Chris ^c   Freudenberg, Marina ^c   Beutler, Bruce ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF FREIBURG   (Germany)

^c MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; DIMER; INTERFERON; LIGAND; LIPID A; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN MD 2; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 6; TUMOR NECROSIS FACTOR; DIFFERENTIATION ANTIGEN; IMMUNOGLOBULIN RECEPTOR; LY ANTIGEN; LY96 PROTEIN, MOUSE; MULTIPROTEIN COMPLEX; MYD88 PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TLR4 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ARTICLE; CELL MUTANT; CYTOLYSIS; GENE MUTATION; HOMOZYGOTE; IMMUNE RESPONSE; INTERFERON PRODUCTION; MACROPHAGE; MICROORGANISM; MOUSE; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RECESSIVE GENE; SHOCK; STOP CODON; VESICULAR STOMATITIS VIRUS; ANIMAL; BIOSYNTHESIS; C3H MOUSE; C57BL MOUSE; CHEMISTRY; DRUG EFFECT; GENETICS; IMMUNOLOGY; IN VITRO STUDY; METABOLISM; MOUSE MUTANT; MUTATION; PATHOGENICITY; PERITONEUM MACROPHAGE; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, CD14; ANTIGENS, DIFFERENTIATION; ANTIGENS, LY; INTERFERON TYPE I; LIPOPOLYSACCHARIDES; LYMPHOCYTE ANTIGEN 96; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MULTIPROTEIN COMPLEXES; MUTATION; MYELOID DIFFERENTIATION FACTOR 88; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; VESICULAR STOMATITIS-INDIANA VIRUS;

EID: 20644469429     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1207     Document Type: Article

References (24)

1. O'Brien, A.D. et al. Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene. J. Immunol. 124, 20-24 (1980).
2. Rosenstreich, D.L., Weinblatt, A.C. & O'Brien, A.D. Genetic control of resistance to infection in mice. CRC Crit. Rev. Immunol. 3, 263-330 (1982).
3. Galanos, C. et al. Endotoxic properties of chemically synthesized lipid A part structures. Comparison of synthetic lipid A precursor and synthetic analogues with biosynthetic lipid A precursor and free lipid A. Eur. J. Biochem. 140, 221-227 (1984).
4. Galanos, C. et al. Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities. Eur. J. Biochem. 148, 1-5 (1985).
5. Tobias, P.S., Mathison, J.C. & Ulevitch, R.J. A family of lipopolysaccharide binding proteins involved in responses to gram-negative sepsis. J. Biol. Chem. 263, 13479-13481 (1988).
6. Tobias, P.S., Soldau, K. & Ulevitch, R.J. Identification of a lipid A binding site in the acute phase reactant lipopolycaccharide binding protein. J. Biol. Chem. 264, 10867-10871 (1989).
7. Schumann, R.R. et al. Structure and function of lipopolysaccharide binding protein. Science 249, 1429-1431 (1990).
8. Wright, S.D., Ramos, R.A., Tobias, P.S., Ulevitch, R.J. & Mathison, J.C. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249, 1431-1433 (1990).
9. Poltorak, A. et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085-2088 (1998).
10. Nagai, Y. et al. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat. Immunol. 3, 667-672 (2002).
11. Hoebe, K. et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signaling. Nature 424, 743-748 (2003).
12. Yamamoto, M. et al. Role of adapter Trif in the MyD88-independent Toll-like receptor signaling pathway. Science 301, 640-643 (2003).
13. Yamamoto, M. et al. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat. Immunol. 4, 1144-1150 (2003).
14. Beutler, B. Inferences, questions and possibilities in Toll-like receptor signalling. Nature 430, 257-263 (2004).
15. Kawai, T., Adachi, O., Ogawa, T., Takeda, K. & Akira, S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11, 115-122 (1999).
16. Yamamoto, M. et al. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 420, 324-329 (2002).
17. Horng, T., Barton, G.M., Flavell, R.A. & Medzhitov, R. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 420, 329-333 (2002).
18. Karaghiosoff, M. et al. Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock. Nat. Immunol. 4, 471-477 (2003).
19. Hoebe, K. et al. CD36 is a sensor of diacylglycerides. Nature 433, 523-527 (2005).
20. Poltorak, A., Ricciardi-Castagnoli, P., Citterio, A. & Beutler, B. Physical contact between LPS and Tlr4 revealed by genetic complementation. Proc. Natl. Acad. Sci. USA 97, 2163-2167 (2000).
21. Lien, E. et al. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. J. Clin. Invest. 105, 497-504 (2000).
22. Lund, J.M. et al. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc. Natl. Acad. Sci. USA 101, 5598-5603 (2004).
23. Kim, J.I. et al. Crystal structure of CD14 and its implications for lipopolysaccharide signaling. J. Biol. Chem. 280, 11347-11351 (2005).
24. Jiang, Z., Mak, T.W., Sen, G. & Li, X. Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-β. Proc. Natl. Acad. Sci. USA 101, 3533-3538 (2004).