A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 13, 2003, Pages 7971-7976

  Bartfai, Tamas ^a   Behrens, M Margarita ^a   Gaidarova, Svetlana ^a   Pemberton, Janell ^a   Shivanyuk, Alexander ^a   Rebek Jr , Julius ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

BB loop; Fever; IL 1 signaling; Protein protein interaction

Indexed keywords

HYDROCINNAMOYLVALYLPYRROLIDINE; INTERLEUKIN 1 RECEPTOR; PYRROLIDINE DERIVATIVE; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG EFFECT; DRUG SYNTHESIS; FEVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, DIFFERENTIATION; BLOTTING, WESTERN; DENSITOMETRY; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENES, DOMINANT; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTATION; MYELOID DIFFERENTIATION FACTOR 88; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PYRROLIDINES; RECEPTORS, IMMUNOLOGIC; RECEPTORS, INTERLEUKIN-1; SIGNAL TRANSDUCTION; SPLEEN; TIME FACTORS; TUMOR CELLS, CULTURED; VALINE;

ANIMALIA; BACTERIA (MICROORGANISMS); MURINAE;

EID: 0037596457     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0932746100     Document Type: Article

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