Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity

Oncogene

Volumn 18, Issue 8, 1999, Pages 1529-1535

  Blankenship, Catherine ^a,c   Naglich, Joseph G ^b   Whaley, Jean M ^b   Seizinger, Bernd ^a   Kley, Nikolai ^a  

^a GENOME THERAPEUTICS CORPORATION   (United States)

^b BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^c PRINCETON UNIVERSITY   (United States)

Author keywords

Elongins; Hs CUL2; pVHL; VEGF

Indexed keywords

AMINO ACID; GENE PRODUCT; VASCULOTROPIN;

ALLELE; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CARCINOGENESIS; CODON; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; MOLECULAR WEIGHT; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN BINDING; TRANSLATION INITIATION; TUMOR SUPPRESSOR GENE; VON HIPPEL LINDAU DISEASE;

EID: 0033602089     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1202473     Document Type: Article

References (33)

1. Acland P, Dixon M, Peters G and Dickson C. (1990). Nature, 343, 662-665.
2. Buckbinder L, Talbott R, Velasco-Miguel S, Takenaka I, Faha B, Seizinger BR and Kley N. (1995). Nature, 377, 646-649.
3. Corless CL, Kibel AS, Iliopoulos O and Kaelin WG. (1997). Human Pathol., 28, 459-464.
4. Duan DR, Pause A, Burgess WH, Aso T, Chen DYT, Garret KP, Conaway RC, Conaway JW, Linehan WM and Klausner RD. (1995a). Science, 269, 1402-1406.
5. Duan DR, Humphrey JS, Chen DYT, Weng Y, Sugekawa J, Lee S, Gnarra JR, Linehan WM and Klausner RD. (1995b). Proc. Natl. Acad. Sci. USA, 92, 6459-6463.
6. Gao J, Naglich JG, Laidlaw J, Whaley JM, Seizinger BR and Kley N. (1995). Cancer Res., 55, 743-747.
7. Gillman EC, Slusher LB, Martus NC and Hopper AK. (1991). Mol. Cell. Biol., 11, 2382-2390.
8. Gnarra JR, Tory K, Weng Y, Schmidt L, Wei MH, Li H, Latif F, Liu S, Chen F, Duh F-M, Lubensky I, Duan DR, Florence C, Pozzatti R, Walther MM, Bander NH, Grossman HB, Brauch H, Pomer S, Brooks JD, Isaacs WB, Lerman MI, Zbar B and Linehan WM. (1994). Nature Genet., 7, 85-90.
9. Gnarra JR, Zhou S, Merrill MJ, Wagner J, Agner J, Krumm A, Papavassiliou E, Oldfield E, Klausner R and Linehan WM. (1996). Proc. Natl. Acad. Sci. USA, 93, 10589-10594.
10. Gossen M and Bujard H. (1992). Proc. Natl. Acad. Sci. USA, 89, 5547-5551.
11. Harlow E and Lane D. (1988). Antibodies - a laboratory manual. Cold Spring Harbor Laboratory Press, Plainview, NY.
12. Herman JG, Latif F, Weng Y, Lerman MI, Zbar B, Liu S, Samid D, Duan DSR, Gnarra JR, Linehan WM and Baylin SB. (1994). Proc. Natl. Acad. Sci. USA, 91, 9700-9704.
13. Iizula N, Chen C, Yang G, Johannes G and Sarnov P. (1995). Curr. Top. Microbio. Immunol., 203, 155-177.
14. Iliopoulos O, Kibel A, Gray S and Kaelin WG. (1995). Nature Med., 1, 822-826.
15. Iliopoulos O, Levy A, Jiang C, Kaelin W and Goldberg MA. (1996). Proc. Natl. Acad. Sci. USA, 93, 10595-10599.
16. Kanno H, Kondo K, Ito S, Yamamoto I, Fuji S, Torigoe T, Sakai N, Hosaka M, Shuin T and Yao M. (1994). Cancer Res., 54, 4845-4847.
17. Kibel A, Iliopoulos O, De Caprio JA and Kaelin WG. (1995). Science, 269, 1444-1446.
18. Kishida T, Stackhouse TM, Chen F, Lerman MI and Zbar B. (1995). Cancer Res., 55, 4544-4548.
19. Knebelmann B, Ananth S, Cohen HT and Sukhatme VP. (1998). Cancer Res., 58, 226-231.
20. Latif F, Tory K, Gnarra J, Yao M, Duh FM, Orcutt ML, Stackhouse T, Kuzmin I, Modi W, Geil L, Schmidt L, Zhou F, Li H, Wei MH, Chen F, Glenn G, Choyke P, Walther MM, Weng Y, Duan DSR, Dean M, Glavac D, Richards FM, Crossey PA, Ferguson-Smith MA, Le Paslier D, Chumakov I, Cohen D, Chinault AC, Maher ER, Linehan WM, Zbar B and Lerman MI. (1993). Science, 260, 1317-1320.
21. Lee S, Chen DYT, Humphrey JS, Gnarra JR, Linehan WM and Klausner R. (1996). Proc. Natl. Acad. Sci. USA, 93, 1770-1775.
22. Lonergan KM, Iliopoulos O, Ohh M, Kamura T, Conaway RC, Conaway JW and Kaelin WG Jr. (1998). Mol. Cell. Biol., 18, 732-741.
23. Los M, Jansen GH, Kaelin WG, Lips CJM, Blijham GH and Voest EE. (1996). Lab. Invest., 75, 231-238.
24. Maher E and Kaelin WG. (1997). Medicine, 76, 387-391.
25. Mukhopadhyay D, Knebelmann B, Cohen HT, Ananth S and Sukhatme VP. (1997). Mol. Cell. Biol., 17, 5629-5639.
26. Ohh M, Yauch RL, Lonergan KM, Whaley JM, Stemmer-Rachaminov AD, Louis DN, Gavon BJ, Kley N, Kaelin WG and Iliopouplos O. (1998). Mol. Cell., 1, 959-968.
27. Pause A, Lee S, Worrell RA, Chen DY, Burgess WH, Linehan WM and Klausner RD. (1997). Proc. Natl. Acad. Sci. USA, 94, 2156-2161.
28. Shuin T, Kondo K, Torigoe S, Kishida T, Kubota Y, Hosaka M, Nagashima Y, Kitamura H, Latif F, Zbar B, Lerman MI and Yao M. (1994). Cancer Res., 54, 2852-2855.
29. Siemeister G, Weidel K, Mohrs K, Barleon B, Martiny-Baron G and Marme D. (1996). Cancer Res., 56, 2299-2301.
30. Vagner S, Gensac MC, Maret A, Bayard F, Amalric F, Prats H and Prats AC. (1995). Mol. Cell. Biol., 15, 35-44.
31. Whaley JM, Naglich J, Gelbert L, Hsia YE, Lamiell JM, Green JS, Collins D, Neumann HPH, Laidlaw J, Li FP, Klein-Szanto AJP, Seizinger BR and Kley N. (1994). Am. J. Human Genet., 55, 1092-1102.
32. Wizigmann-Voos S, Breier G, Risau W and Plate KH. (1995). Cancer Res., 55, 1358-1364.
33. Zbar B. (1995). Cancer Surveys, Genetics and Cancer: a second look, Ponder BAJ, Cavenee WK and Solomon E. (eds). Cold Spring Harbor Laboratory Press. pp. 219-232.