-
1
-
-
0036362771
-
DNA-binding activity of hypoxia-inducible factors (HIFs)
-
Camenisch, G., R. H. Wenger, and M. Gassmann. 2002. DNA-binding activity of hypoxia-inducible factors (HIFs). Methods Mol. Biol. 196:117-129.
-
(2002)
Methods Mol. Biol.
, vol.196
, pp. 117-129
-
-
Camenisch, G.1
Wenger, R.H.2
Gassmann, M.3
-
2
-
-
0032891708
-
Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): Heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1α
-
Chilov, D., G. Camenisch, I. Kvietikova, U. Ziegler, M. Gassmann, and R. H. Wenger. 1999. Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1α. J. Cell Sci. 112:1203-1212.
-
(1999)
J. Cell Sci.
, vol.112
, pp. 1203-1212
-
-
Chilov, D.1
Camenisch, G.2
Kvietikova, I.3
Ziegler, U.4
Gassmann, M.5
Wenger, R.H.6
-
3
-
-
0035339044
-
Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease
-
Clifford, S. C., M. E. Cockman, A. C. Smallwood, D. R. Mole, E. R. Woodward, P. H. Maxwell, P. J. Ratcliffe, and E. R. Maher. 2001. Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease. Hum. Mol. Genet. 10:1029-1038.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 1029-1038
-
-
Clifford, S.C.1
Cockman, M.E.2
Smallwood, A.C.3
Mole, D.R.4
Woodward, E.R.5
Maxwell, P.H.6
Ratcliffe, P.J.7
Maher, E.R.8
-
4
-
-
0036532224
-
X-chromosome inactivation and the search for chromosome-wide silencers
-
Cohen, D. E., and J. T. Lee. 2002. X-chromosome inactivation and the search for chromosome-wide silencers. Curr. Opin. Genet. Dev. 12:219-224.
-
(2002)
Curr. Opin. Genet. Dev.
, vol.12
, pp. 219-224
-
-
Cohen, D.E.1
Lee, J.T.2
-
5
-
-
0025008768
-
Tumor cells are the site of erythropoietin synthesis in human renal cancers associated with polycythemia
-
Da Silva, J. L., C. Lacombe, P. Bruneval, N. Casadevall, M. Leporrier, J. P. Camilleri, J. Bariety, P. Tambourin, and B. Varet. 1990. Tumor cells are the site of erythropoietin synthesis in human renal cancers associated with polycythemia. Blood 75:577-582.
-
(1990)
Blood
, vol.75
, pp. 577-582
-
-
Da Silva, J.L.1
Lacombe, C.2
Bruneval, P.3
Casadevall, N.4
Leporrier, M.5
Camilleri, J.P.6
Bariety, J.7
Tambourin, P.8
Varet, B.9
-
6
-
-
0029126892
-
Inhibition of transcription elongation by the VHL tumor suppressor protein
-
Duan, D. R., A. Pause, W. H. Burgess, T. Aso, D. Y. Chen, K. P. Garrett, R. C. Conaway, J. W. Conaway, W. M. Linehan, and R. D. Klausner. 1995. Inhibition of transcription elongation by the VHL tumor suppressor protein. Science 269:1402-1406.
-
(1995)
Science
, vol.269
, pp. 1402-1406
-
-
Duan, D.R.1
Pause, A.2
Burgess, W.H.3
Aso, T.4
Chen, D.Y.5
Garrett, K.P.6
Conaway, R.C.7
Conaway, J.W.8
Linehan, W.M.9
Klausner, R.D.10
-
7
-
-
0031870653
-
Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2α
-
Flamme, I., M. Krieg, and K. H. Plate. 1998. Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2α. Am. J. Pathol. 153:25-29.
-
(1998)
Am. J. Pathol.
, vol.153
, pp. 25-29
-
-
Flamme, I.1
Krieg, M.2
Plate, K.H.3
-
8
-
-
0027954044
-
Mutations of the VHL tumour suppressor gene in renal carcinoma
-
Gnarra, J. R., K. Tory, Y. Weng, L. Schmidt, M. H. Wei, H. Li, F. Latif, S. Liu, F. Chen, F. M. Duh, et al. 1994. Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat. Genet. 7:85-90.
-
(1994)
Nat. Genet.
, vol.7
, pp. 85-90
-
-
Gnarra, J.R.1
Tory, K.2
Weng, Y.3
Schmidt, L.4
Wei, M.H.5
Li, H.6
Latif, F.7
Liu, S.8
Chen, F.9
Duh, F.M.10
-
9
-
-
0030847165
-
Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice
-
Gnarra, J. R., J. M. Ward, F. D. Porter, J. R. Wagner, D. E. Devor, A. Grinberg, M. R. Emmert-Buck, H. Westphal, R. D. Klausner, and W. M. Linehan. 1997. Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proc. Natl. Acad. Sci. USA 94:9102-9107.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 9102-9107
-
-
Gnarra, J.R.1
Ward, J.M.2
Porter, F.D.3
Wagner, J.R.4
Devor, D.E.5
Grinberg, A.6
Emmert-Buck, M.R.7
Westphal, H.8
Klausner, R.D.9
Linehan, W.M.10
-
10
-
-
0035852668
-
Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor
-
Haase, V. H., J. N. Glickman, M. Socolovsky, and R. Jaenisch. 2001. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc. Natl. Acad. Sci. USA 98:1583-1588.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 1583-1588
-
-
Haase, V.H.1
Glickman, J.N.2
Socolovsky, M.3
Jaenisch, R.4
-
11
-
-
0032796677
-
Hepatic hemangioblastoma: An unusual presentation of von Hippel-Lindau disease
-
Hayasaka, K., Y. Tanaka, T. Satoh, and H. Mutoh. 1999. Hepatic hemangioblastoma: an unusual presentation of von Hippel-Lindau disease. J. Comput. Assist. Tomogr. 23:565-566.
-
(1999)
J. Comput. Assist. Tomogr.
, vol.23
, pp. 565-566
-
-
Hayasaka, K.1
Tanaka, Y.2
Satoh, T.3
Mutoh, H.4
-
12
-
-
0037223823
-
Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL
-
Hergovich, A., J. Liszrwan, R. Barry, P. Ballschmieter, and W. Krek. 2003. Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL. Nat. Cell Biol. 5:64-70.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 64-70
-
-
Hergovich, A.1
Liszrwan, J.2
Barry, R.3
Ballschmieter, P.4
Krek, W.5
-
13
-
-
0028072991
-
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
-
Herman, J. G., F. Latif, Y. Weng, M. I. Lerman, B. Zbar, S. Liu, D. Samid, D. S. Duan, J. R. Gnarra, W. M. Linehan, et al. 1994. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc. Natl. Acad. Sci. USA 91:9700-9704.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 9700-9704
-
-
Herman, J.G.1
Latif, F.2
Weng, Y.3
Lerman, M.I.4
Zbar, B.5
Liu, S.6
Samid, D.7
Duan, D.S.8
Gnarra, J.R.9
Linehan, W.M.10
-
14
-
-
0034753757
-
Clinical management of Von Hippel-Lindau (VHL) disease
-
Hes, F. J., R. B. van der Luijt, and C. J. Lips. 2001. Clinical management of Von Hippel-Lindau (VHL) disease. Neth. J. Med. 59:225-234.
-
(2001)
Neth. J. Med.
, vol.59
, pp. 225-234
-
-
Hes, F.J.1
Van Der Luijt, R.B.2
Lips, C.J.3
-
15
-
-
0035336706
-
Von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF
-
Hoffman, M. A., M. Ohh, H. Yang, J. M. Klco, M. Ivan, and W. G. Kaelin, Jr. 2001. von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF. Hum. Mol. Genet. 10:1019-1027.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 1019-1027
-
-
Hoffman, M.A.1
Ohh, M.2
Yang, H.3
Klco, J.M.4
Ivan, M.5
Kaelin Jr., W.G.6
-
16
-
-
0345491599
-
Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation
-
Hu, C. J., L. Y. Wang, L. A. Chodosh, B. Keith, and M. C. Simon. 2003. Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation. Mol. Cell. Biol. 23:9361-9374.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 9361-9374
-
-
Hu, C.J.1
Wang, L.Y.2
Chodosh, L.A.3
Keith, B.4
Simon, M.C.5
-
17
-
-
0029785321
-
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein
-
Iliopoulos, O., A. P. Levy, C. Jiang, W. G. Kaelin, Jr., and M. A. Goldberg. 1996. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc. Natl. Acad. Sci. USA 93:10595-10599.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 10595-10599
-
-
Iliopoulos, O.1
Levy, A.P.2
Jiang, C.3
Kaelin Jr., W.G.4
Goldberg, M.A.5
-
18
-
-
0035917313
-
2 sensing
-
2 sensing. Science 292:464-468.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
19
-
-
0033607291
-
Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex
-
Iwai, K., K. Yamanaka, T. Kamura, N. Minato, R. C. Conaway, J. W. Conaway, R. D. Klausner, and A. Pause. 1999. Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc. Natl. Acad. Sci. USA 96:12436-12441.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 12436-12441
-
-
Iwai, K.1
Yamanaka, K.2
Kamura, T.3
Minato, N.4
Conaway, R.C.5
Conaway, J.W.6
Klausner, R.D.7
Pause, A.8
-
20
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation. Science 292:468-472.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
21
-
-
0031971047
-
Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse
-
Jain, S., E. Maltepe, M. M. Lu, C. Simon, and C. A. Bradfield. 1998. Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse. Mech. Dev. 73:117-123.
-
(1998)
Mech. Dev.
, vol.73
, pp. 117-123
-
-
Jain, S.1
Maltepe, E.2
Lu, M.M.3
Simon, C.4
Bradfield, C.A.5
-
22
-
-
0036718539
-
Molecular basis of the VHL hereditary cancer syndrome
-
Kaelin, W. G., Jr. 2002. Molecular basis of the VHL hereditary cancer syndrome. Nat. Rev. Cancer 2:673-682.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 673-682
-
-
Kaelin Jr., W.G.1
-
23
-
-
0033597443
-
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
-
Kamura, T., D. M. Koepp, M. N. Conrad, D. Skowyra, R. J. Moreland, O. Iliopoulos, W. S. Lane, W. G. Kaelin, Jr., S. J. Elledge, R. C. Conaway, J. W. Harper, and J. W. Conaway. 1999. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Science 284:657-661.
-
(1999)
Science
, vol.284
, pp. 657-661
-
-
Kamura, T.1
Koepp, D.M.2
Conrad, M.N.3
Skowyra, D.4
Moreland, R.J.5
Iliopoulos, O.6
Lane, W.S.7
Kaelin Jr., W.G.8
Elledge, S.J.9
Conaway, R.C.10
Harper, J.W.11
Conaway, J.W.12
-
24
-
-
0345708353
-
The mammalian basic helix-loop-helix/PAS family of transcriptional regulators
-
Kewley, R. J., M. L. Whitelaw, and A. Chapman-Smith. 2004. The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. Int. J. Biochem. Cell Biol. 36:189-204.
-
(2004)
Int. J. Biochem. Cell Biol.
, vol.36
, pp. 189-204
-
-
Kewley, R.J.1
Whitelaw, M.L.2
Chapman-Smith, A.3
-
25
-
-
0029147430
-
Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C
-
Kibel, A., O. Iliopoulos, J. A. DeCaprio, and W. G. Kaelin, Jr. 1995. Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C. Science 269:1444-1446.
-
(1995)
Science
, vol.269
, pp. 1444-1446
-
-
Kibel, A.1
Iliopoulos, O.2
DeCaprio, J.A.3
Kaelin Jr., W.G.4
-
26
-
-
0035868277
-
Perivenous expression of the mRNA of the three hypoxia-inducible factor alpha-subunits, HIF1α, HIF2α and HIF3α, in rat liver
-
Kietzmann, T., Y. Cornesse, K. Brechtel, S. Modaressi, and K. Jungermann. 2001. Perivenous expression of the mRNA of the three hypoxia-inducible factor alpha-subunits, HIF1α, HIF2α and HIF3α, in rat liver. Biochem. J. 354:531-537.
-
(2001)
Biochem. J.
, vol.354
, pp. 531-537
-
-
Kietzmann, T.1
Cornesse, Y.2
Brechtel, K.3
Modaressi, S.4
Jungermann, K.5
-
27
-
-
2342597973
-
Inhibition of HIF2α is sufficient to suppress pVHL-defective tumor growth
-
Kondo, K., W. Y. Kim, M. Lechpammer, and W. G. Kaelin, Jr. 2003. Inhibition of HIF2α is sufficient to suppress pVHL-defective tumor growth. PLoS Biol 1:E83.
-
(2003)
PLoS Biol.
, vol.1
-
-
Kondo, K.1
Kim, W.Y.2
Lechpammer, M.3
Kaelin Jr., W.G.4
-
28
-
-
0036528246
-
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
-
Kondo, K., J. M. Klco, E. Nakamura, M. Lechpammer, and W. G. Kaelin. 2002. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 1:237-246.
-
(2002)
Cancer Cell
, vol.1
, pp. 237-246
-
-
Kondo, K.1
Klco, J.M.2
Nakamura, E.3
Lechpammer, M.4
Kaelin, W.G.5
-
29
-
-
0034676331
-
Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
-
Krieg, M., R. Haas, H. Brauch, T. Acker, I. Flamme, and K. H. Plate. 2000. Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function. Oncogene 19:5435-5443.
-
(2000)
Oncogene
, vol.19
, pp. 5435-5443
-
-
Krieg, M.1
Haas, R.2
Brauch, H.3
Acker, T.4
Flamme, I.5
Plate, K.H.6
-
30
-
-
0032211161
-
Coexpression of erythropoietin and vascular endothelial growth factor in nervous system tumors associated with von Hippel-Lindau tumor suppressor gene loss of function
-
Krieg, M., H. H. Marti, and K. H. Plate. 1998. Coexpression of erythropoietin and vascular endothelial growth factor in nervous system tumors associated with von Hippel-Lindau tumor suppressor gene loss of function. Blood 92:3388-3393.
-
(1998)
Blood
, vol.92
, pp. 3388-3393
-
-
Krieg, M.1
Marti, H.H.2
Plate, K.H.3
-
31
-
-
0025739379
-
Simplified mammalian DNA isolation procedure
-
Laird, P. W., A. Zijderveld, K. Linders, M. A. Rudnicki, R. Jaenisch, and A. Berns. 1991. Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19:4293.
-
(1991)
Nucleic Acids Res.
, vol.19
, pp. 4293
-
-
Laird, P.W.1
Zijderveld, A.2
Linders, K.3
Rudnicki, M.A.4
Jaenisch, R.5
Berns, A.6
-
32
-
-
0141816848
-
Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene
-
Ma, W., L. Tessarollo, S. B. Hong, M. Baba, E. Southon, T. C. Back, S. Spence, C. G. Lobe, N. Sharma, G. W. Maher, S. Pack, A. O. Vortmeyer, C. Guo, B. Zbar, and L. S. Schmidt. 2003. Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene. Cancer Res. 63:5320-5328.
-
(2003)
Cancer Res.
, vol.63
, pp. 5320-5328
-
-
Ma, W.1
Tessarollo, L.2
Hong, S.B.3
Baba, M.4
Southon, E.5
Back, T.C.6
Spence, S.7
Lobe, C.G.8
Sharma, N.9
Maher, G.W.10
Pack, S.11
Vortmeyer, A.O.12
Guo, C.13
Zbar, B.14
Schmidt, L.S.15
-
33
-
-
0029007151
-
Tissue non-specific alkaline phosphatase is expressed in both embryonic and extraembryonic lineages during mouse embryogenesis but is not required for migration of primordial germ cells
-
MacGregor, G. R., B. P. Zambrowicz, and P. Soriano. 1995. Tissue non-specific alkaline phosphatase is expressed in both embryonic and extraembryonic lineages during mouse embryogenesis but is not required for migration of primordial germ cells. Development 121:1487-1496.
-
(1995)
Development
, vol.121
, pp. 1487-1496
-
-
MacGregor, G.R.1
Zambrowicz, B.P.2
Soriano, P.3
-
34
-
-
0031445126
-
Von Hippel-Lindau disease
-
Baltimore
-
Maher, E. R., and W. G. Kaelin, Jr. 1997. von Hippel-Lindau disease. Medicine (Baltimore) 76:381-391.
-
(1997)
Medicine
, vol.76
, pp. 381-391
-
-
Maher, E.R.1
Kaelin Jr., W.G.2
-
35
-
-
0036527785
-
The contribution of VHL substrate binding and HIF-1α to the phenotype of vhl loss in renal cell carcinoma
-
Maranchi, J. K., J. R. Vasselli, J. Riss, J. S. Bonifacio, W. M. Linehan, and R. D. Klausner. 2002. The contribution of VHL substrate binding and HIF-1α to the phenotype of vhl loss in renal cell carcinoma. Cancer Cell 1:247-253.
-
(2002)
Cancer Cell
, vol.1
, pp. 247-253
-
-
Maranchi, J.K.1
Vasselli, J.R.2
Riss, J.3
Bonifacio, J.S.4
Linehan, W.M.5
Klausner, R.D.6
-
36
-
-
0034116801
-
Role of chromosome 3p12-p21 tumour suppressor genes in clear cell renal cell carcinoma: Analysis of VHL dependent and VHL independent pathways of tumorigenesis
-
Martinez, A., P. Fullwood, K. Kondo, T. Kishida, M. Yao, E. R. Maher, and F. Latif. 2000. Role of chromosome 3p12-p21 tumour suppressor genes in clear cell renal cell carcinoma: analysis of VHL dependent and VHL independent pathways of tumorigenesis. Mol. Pathol. 53:137-144.
-
(2000)
Mol. Pathol.
, vol.53
, pp. 137-144
-
-
Martinez, A.1
Fullwood, P.2
Kondo, K.3
Kishida, T.4
Yao, M.5
Maher, E.R.6
Latif, F.7
-
37
-
-
0030816109
-
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
-
Maxwell, P. H., G. U. Dachs, J. M. Gleadle, L. G. Nicholls, A. L. Harris, I. J. Stratford, O. Hankinson, C. W. Pugh, and P. J. Ratcliffe. 1997. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc. Natl. Acad. Sci. USA 94:8104-8109.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 8104-8109
-
-
Maxwell, P.H.1
Dachs, G.U.2
Gleadle, J.M.3
Nicholls, L.G.4
Harris, A.L.5
Stratford, I.J.6
Hankinson, O.7
Pugh, C.W.8
Ratcliffe, P.J.9
-
38
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell, P. H., M. S. Wiesener, G. W. Chang, S. C. Clifford, E. C. Vaux, M. E. Cockman, C. C. Wykoff, C. W. Pugh, E. R. Maher, and P. J. Ratcliffe. 1999. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399:271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
39
-
-
16244367299
-
Multiple splice variants of the human HIF-3α locus are targets of the VHL E3 ubiquitin ligase complex
-
Maynard, M. A., H. Qi, J. Chung, E. H. Lee, Y. Kondo, S. Hara, R. C. Conaway, J. W. Conaway, and M. Ohh. 2003. Multiple splice variants of the human HIF-3α locus are targets of the VHL E3 ubiquitin ligase complex. J. Biol. Chem. 21:21.
-
(2003)
J. Biol. Chem.
, vol.21
, pp. 21
-
-
Maynard, M.A.1
Qi, H.2
Chung, J.3
Lee, E.H.4
Kondo, Y.5
Hara, S.6
Conaway, R.C.7
Conaway, J.W.8
Ohh, M.9
-
40
-
-
0026460626
-
Case report: Multiple hepatic and pulmonary haemangioblastomas - A new manifestation of von Hippel-Lindau disease
-
McGrath, F. P., R. G. Gibney, D. C. Morris, D. A. Owen, and S. R. Erb. 1992. Case report: multiple hepatic and pulmonary haemangioblastomas - a new manifestation of von Hippel-Lindau disease. Clin. Radiol. 45:37-39.
-
(1992)
Clin. Radiol.
, vol.45
, pp. 37-39
-
-
McGrath, F.P.1
Gibney, R.G.2
Morris, D.C.3
Owen, D.A.4
Erb, S.R.5
-
41
-
-
0032085240
-
The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix
-
Ohh, M., R. L. Yauch, K. M. Lonergan, J. M. Whaley, A. O. Stemmer-Rachamimov, D. N. Louis, B. J. Gavin, N. Kley, W. G. Kaelin, Jr., and O. Iliopoulos. 1998. The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol. Cell 1:959-968.
-
(1998)
Mol. Cell
, vol.1
, pp. 959-968
-
-
Ohh, M.1
Yauch, R.L.2
Lonergan, K.M.3
Whaley, J.M.4
Stemmer-Rachamimov, A.O.5
Louis, D.N.6
Gavin, B.J.7
Kley, N.8
Kaelin Jr., W.G.9
Iliopoulos, O.10
-
42
-
-
0027934684
-
An analysis of regulatory elements in the phosphoenolpyruvate carboxykinase (GTP) gene which are responsible for its tissue-specific expression and metabolic control in transgenic mice
-
Patel, Y. M., J. S. Yun, J. Liu, M. M. McGrane, and R. W. Hanson. 1994. An analysis of regulatory elements in the phosphoenolpyruvate carboxykinase (GTP) gene which are responsible for its tissue-specific expression and metabolic control in transgenic mice. J. Biol. Chem. 269:5619-5628.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 5619-5628
-
-
Patel, Y.M.1
Yun, J.S.2
Liu, J.3
McGrane, M.M.4
Hanson, R.W.5
-
43
-
-
0030953635
-
The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
-
Pause, A., S. Lee, R. A. Worrell, D. Y. Chen, W. H. Burgess, W. M. Linehan, and R. D. Klausner. 1997. The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc. Natl. Acad. Sci. USA 94:2156-2161.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 2156-2161
-
-
Pause, A.1
Lee, S.2
Worrell, R.A.3
Chen, D.Y.4
Burgess, W.H.5
Linehan, W.M.6
Klausner, R.D.7
-
44
-
-
2342583527
-
Searching for the hereditary causes of renal-cell carcinoma
-
Pavlovich, C. P., and L. S. Schmidt. 2004. Searching for the hereditary causes of renal-cell carcinoma. Nat. Rev. Cancer 4:381-393.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 381-393
-
-
Pavlovich, C.P.1
Schmidt, L.S.2
-
45
-
-
0032898369
-
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase
-
Postic, C., M. Shiota, K. D. Niswender, T. L. Jetton, Y. Chen, J. M. Moates, K. D. Shelton, J. Lindner, A. D. Cherrington, and M. A. Magnuson. 1999. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J. Biol. Chem. 274:305-315.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 305-315
-
-
Postic, C.1
Shiota, M.2
Niswender, K.D.3
Jetton, T.L.4
Chen, Y.5
Moates, J.M.6
Shelton, K.D.7
Lindner, J.8
Cherrington, A.D.9
Magnuson, M.A.10
-
46
-
-
0026023764
-
Hepatic hemangioblastoma. An unusual presentation in a patient with von Hippel-Lindau disease
-
Rojiani, A. M., D. A. Owen, K. Berry, B. Woodhurst, F. H. Anderson, C. H. Scudamore, and S. Erb. 1991. Hepatic hemangioblastoma. An unusual presentation in a patient with von Hippel-Lindau disease. Am. J. Surg. Pathol. 15:81-86.
-
(1991)
Am. J. Surg. Pathol.
, vol.15
, pp. 81-86
-
-
Rojiani, A.M.1
Owen, D.A.2
Berry, K.3
Woodhurst, B.4
Anderson, F.H.5
Scudamore, C.H.6
Erb, S.7
-
47
-
-
12944265473
-
Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin
-
Ruschitzka, F. T., R. H. Wenger, T. Stallmach, T. Quaschning, C. de Wit, K. Wagner, R. Labugger, M. Kelm, G. Noll, T. Rulicke, S. Shaw, R. L. Lindberg, B. Rodenwaldt, H. Lutz, C. Bauer, T. F. Luscher, and M. Gassmann. 2000. Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin. Proc. Natl. Acad. Sci. USA 97:11609-11613.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 11609-11613
-
-
Ruschitzka, F.T.1
Wenger, R.H.2
Stallmach, T.3
Quaschning, T.4
De Wit, C.5
Wagner, K.6
Labugger, R.7
Kelm, M.8
Noll, G.9
Rulicke, T.10
Shaw, S.11
Lindberg, R.L.12
Rodenwaldt, B.13
Lutz, H.14
Bauer, C.15
Luscher, T.F.16
Gassmann, M.17
-
48
-
-
0033870727
-
Hypoxia-inducible factor-1α is a positive factor in solid tumor growth
-
Ryan, H. E., M. Poloni, W. McNulty, D. Elson, M. Gassmann, J. M. Arbeit, and R. S. Johnson. 2000. Hypoxia-inducible factor-1α is a positive factor in solid tumor growth. Cancer Res. 60:4010-4015.
-
(2000)
Cancer Res.
, vol.60
, pp. 4010-4015
-
-
Ryan, H.E.1
Poloni, M.2
McNulty, W.3
Elson, D.4
Gassmann, M.5
Arbeit, J.M.6
Johnson, R.S.7
-
49
-
-
0344826529
-
-/- mice
-
-/- mice. Nat. Genet. 35:331-340.
-
(2003)
Nat. Genet.
, vol.35
, pp. 331-340
-
-
Scortegagna, M.1
Ding, K.2
Oktay, Y.3
Gaur, A.4
Thurmond, F.5
Yan, L.J.6
Marck, B.T.7
Matsumoto, A.M.8
Shelton, J.M.9
Richardson, J.A.10
Bennett, M.J.11
Garcia, J.A.12
-
50
-
-
0035313697
-
HIF-1 and mechanisms of hypoxia sensing
-
Semenza, G. L. 2001. HIF-1 and mechanisms of hypoxia sensing. Curr. Opin. Cell Biol. 13:167-171.
-
(2001)
Curr. Opin. Cell Biol.
, vol.13
, pp. 167-171
-
-
Semenza, G.L.1
-
51
-
-
0033233243
-
2 homeostasis by hypoxia-inducible factor 1
-
2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell Dev. Biol. 15:551-578.
-
(1999)
Annu. Rev. Cell Dev. Biol.
, vol.15
, pp. 551-578
-
-
Semenza, G.L.1
-
52
-
-
0032923739
-
Generalized lacZ expression with the ROSA26 Cre reporter strain
-
Soriano, P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21:70-71.
-
(1999)
Nat. Genet.
, vol.21
, pp. 70-71
-
-
Soriano, P.1
-
53
-
-
0141988698
-
Predominant role of hypoxia-inducible transcription factor (Hif)-1α versus Hif-2α in regulation of the transcriptional response to hypoxia
-
Sowter, H. M., R. R. Raval, J. W. Moore, P. J. Ratcliffe, and A. L. Harris. 2003. Predominant role of hypoxia-inducible transcription factor (Hif)-1α versus Hif-2α in regulation of the transcriptional response to hypoxia. Cancer Res. 63:6130-6134.
-
(2003)
Cancer Res.
, vol.63
, pp. 6130-6134
-
-
Sowter, H.M.1
Raval, R.R.2
Moore, J.W.3
Ratcliffe, P.J.4
Harris, A.L.5
-
54
-
-
0141828145
-
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
-
Staller, P., J. Sulitkova, J. Lisztwan, H. Moch, E. J. Oakeley, and W. Krek. 2003. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 425:307-311.
-
(2003)
Nature
, vol.425
, pp. 307-311
-
-
Staller, P.1
Sulitkova, J.2
Lisztwan, J.3
Moch, H.4
Oakeley, E.J.5
Krek, W.6
-
55
-
-
0035159670
-
HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia
-
Stroka, D. M., T. Burkhardt, I. Desbaillets, R. H. Wenger, D. A. Neil, C. Bauer, M. Gassmann, and D. Candinas. 2001. HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia. FASEB J. 15:2445-2453.
-
(2001)
FASEB J.
, vol.15
, pp. 2445-2453
-
-
Stroka, D.M.1
Burkhardt, T.2
Desbaillets, I.3
Wenger, R.H.4
Neil, D.A.5
Bauer, C.6
Gassmann, M.7
Candinas, D.8
-
56
-
-
0141790822
-
Transgenic mice overexpressing erythropoietin adapt to excessive erythrocytosis by regulating blood viscosity
-
Vogel, J., I. Kiessling, K. Heinicke, T. Stallmach, P. Ossent, O. Vogel, M. Aulmann, T. Frietsch, H. Schmid-Schonbein, W. Kuschinsky, and M. Gassmann. 2003. Transgenic mice overexpressing erythropoietin adapt to excessive erythrocytosis by regulating blood viscosity. Blood 102:2278-2284.
-
(2003)
Blood
, vol.102
, pp. 2278-2284
-
-
Vogel, J.1
Kiessling, I.2
Heinicke, K.3
Stallmach, T.4
Ossent, P.5
Vogel, O.6
Aulmann, M.7
Frietsch, T.8
Schmid-Schonbein, H.9
Kuschinsky, W.10
Gassmann, M.11
-
57
-
-
10744226679
-
Developmental arrest of angioblastic lineage initiates tumorigenesis in von Hippel-Lindau disease
-
Vortmeyer, A. O., S. Frank, S. Y. Jeong, K. Yuan, B. Ikejiri, Y. S. Lee, D. Bhowmick, R. R. Lonser, R. Smith, G. Rodgers, E. H. Oldfield, and Z. Zhuang. 2003. Developmental arrest of angioblastic lineage initiates tumorigenesis in von Hippel-Lindau disease. Cancer Res. 63:7051-7055.
-
(2003)
Cancer Res.
, vol.63
, pp. 7051-7055
-
-
Vortmeyer, A.O.1
Frank, S.2
Jeong, S.Y.3
Yuan, K.4
Ikejiri, B.5
Lee, Y.S.6
Bhowmick, D.7
Lonser, R.R.8
Smith, R.9
Rodgers, G.10
Oldfield, E.H.11
Zhuang, Z.12
-
58
-
-
0030958304
-
Von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangio-blastoma associated with von Hippel-Lindau disease
-
Vortmeyer, A. O., J. R. Gnarra, M. R. Emmert-Buck, D. Katz, W. M. Linehan, E. H. Oldfield, and Z. Zhuang. 1997. von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangio-blastoma associated with von Hippel-Lindau disease. Hum. Pathol. 28:540-543.
-
(1997)
Hum. Pathol.
, vol.28
, pp. 540-543
-
-
Vortmeyer, A.O.1
Gnarra, J.R.2
Emmert-Buck, M.R.3
Katz, D.4
Linehan, W.M.5
Oldfield, E.H.6
Zhuang, Z.7
-
59
-
-
0035863943
-
Chronic inborn erythrocytosis leads to cardiac dysfunction and premature death in mice overexpressing erythropoietin
-
Wagner, K. F., D. M. Katschinski, J. Hasegawa, D. Schumacher, B. Meller, U. Gembruch, U. Schramm, W. Jelkmann, M. Gassmann, and J. Fandrey. 2001. Chronic inborn erythrocytosis leads to cardiac dysfunction and premature death in mice overexpressing erythropoietin. Blood 97:536-542.
-
(2001)
Blood
, vol.97
, pp. 536-542
-
-
Wagner, K.F.1
Katschinski, D.M.2
Hasegawa, J.3
Schumacher, D.4
Meller, B.5
Gembruch, U.6
Schramm, U.7
Jelkmann, W.8
Gassmann, M.9
Fandrey, J.10
-
60
-
-
1942501666
-
Patent ductus venosus and dioxin resistance in mice harboring a hypomorphic Arnt allele
-
Walisser, J. A., M. K. Bunger, E. Glover, E. B. Harstad, and C. A. Bradfield. 2004. Patent ductus venosus and dioxin resistance in mice harboring a hypomorphic Arnt allele. J. Biol. Chem. 279:16326-16331.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 16326-16331
-
-
Walisser, J.A.1
Bunger, M.K.2
Glover, E.3
Harstad, E.B.4
Bradfield, C.A.5
-
61
-
-
9444283176
-
Differentiating the functional role of hypoxia-inducible factor (HIF)-1α and HIF-2α (EPAS-1) by the use of RNA interference: Erythropoietin is a HIF-2α target gene in Hep3B and Kelly cells
-
Warnecke, C., Z. Zaborowska, J. Kurreck, V. A. Erdmann, U. Frei, M. Wiesener, and K. U. Eckardt. 2004. Differentiating the functional role of hypoxia-inducible factor (HIF)-1α and HIF-2α (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2α target gene in Hep3B and Kelly cells. FASEB J. 18:1462-1464.
-
(2004)
FASEB J.
, vol.18
, pp. 1462-1464
-
-
Warnecke, C.1
Zaborowska, Z.2
Kurreck, J.3
Erdmann, V.A.4
Frei, U.5
Wiesener, M.6
Eckardt, K.U.7
-
62
-
-
0036320934
-
2- regulated gene expression
-
2-regulated gene expression. FASEB J. 16:1151-1162.
-
(2002)
FASEB J.
, vol.16
, pp. 1151-1162
-
-
Wenger, R.H.1
-
63
-
-
0037315337
-
Widespread hypoxia-inducible expression of HIF-2α in distinct cell populations of different organs
-
Wiesener, M. S., J. S. Jurgensen, C. Rosenberger, C. K. Scholze, J. H. Horstrup, C. Warnecke, S. Mandriota, I. Bechmann, U. A. Frei, C. W. Pugh, P. J. Ratcliffe, S. Bachmann, P. H. Maxwell, and K. U. Eckardt. 2003. Widespread hypoxia-inducible expression of HIF-2α in distinct cell populations of different organs. FASEB J. 17:271-273.
-
(2003)
FASEB J.
, vol.17
, pp. 271-273
-
-
Wiesener, M.S.1
Jurgensen, J.S.2
Rosenberger, C.3
Scholze, C.K.4
Horstrup, J.H.5
Warnecke, C.6
Mandriota, S.7
Bechmann, I.8
Frei, U.A.9
Pugh, C.W.10
Ratcliffe, P.J.11
Bachmann, S.12
Maxwell, P.H.13
Eckardt, K.U.14
-
64
-
-
0035394516
-
Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1α in clear cell renal carcinomas
-
Wiesener, M. S., P. M. Munchenhagen, I. Berger, N. V. Morgan, J. Roigas, A. Schwiertz, J. S. Jurgensen, G. Gruber, P. H. Maxwell, S. A. Loning, U. Frei, E. R. Maher, H. J. Grone, and K. U. Eckardt. 2001. Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1α in clear cell renal carcinomas. Cancer Res. 61:5215-5222.
-
(2001)
Cancer Res.
, vol.61
, pp. 5215-5222
-
-
Wiesener, M.S.1
Munchenhagen, P.M.2
Berger, I.3
Morgan, N.V.4
Roigas, J.5
Schwiertz, A.6
Jurgensen, J.S.7
Gruber, G.8
Maxwell, P.H.9
Loning, S.A.10
Frei, U.11
Maher, E.R.12
Grone, H.J.13
Eckardt, K.U.14
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