Structure of the VHL-elonginC-elonginB complex: Implications for VHL tumor suppressor function

Science

Volumn 284, Issue 5413, 1999, Pages 455-461

  Stebbins, Charles E ^a   Kaelin Jr , William G ^b   Pavletich, Nikola P ^c  

^a Weill Cornell Graduate School of Biomedical Sciences   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BINDING SITE; CARCINOGENESIS; COMPLEX FORMATION; CRYSTALLOGRAPHY; DISEASE CLASSIFICATION; GENE CONTROL; GENE MUTATION; HUMAN; KIDNEY CANCER; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; TUMOR SUPPRESSOR GENE; VON HIPPEL LINDAU DISEASE;

AMINO ACID SEQUENCE; BINDING SITES; CELL CYCLE PROTEINS; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; GENES, TUMOR SUPPRESSOR; HIPPEL-LINDAU DISEASE; HUMANS; HYDROGEN BONDING; LIGASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; MUTATION, MISSENSE; NEOPLASMS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEINS; S-PHASE KINASE-ASSOCIATED PROTEINS; SURFACE PROPERTIES; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 0033574737     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.284.5413.455     Document Type: Article

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61. 2-terminal sequence and mass spectroscopic analyses, A. Batchelor for the pBB75 plasmid, M. Sullivan of the National Synchrotron Light Source X9 beam line and the staff of the Cornell High Energy Synchrotron Source MacChess for help with data collection, and C. Murray for administrative help. Coordinates have been deposited with the Brookhaven Protein Data Bank (accession code 1vcb).