Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

Molecular and Cellular Biology

Volumn 18, Issue 2, 1998, Pages 732-741

  Lonergan, Kim M ^a,b   Iliopoulos, Othon ^a,b   Ohh, Michael ^a,b   Kamura, Takumi ^c   Conaway, Ronald C ^c   Conaway, Joan Weliky ^c,d   Kaelin Jr , William G ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^d UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELONGATION FACTOR; MESSENGER RNA; ONCOPROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CAENORHABDITIS ELEGANS; HUMAN; HUMAN CELL; HYPOXIA; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; VON HIPPEL LINDAU DISEASE;

EID: 0031907152     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.2.732     Document Type: Article

References (51)

1. Aso, T., D. Haque, R. Barstead, R. Conaway, and J. Conaway. 1996. The inducible clongin A elongation activation domain: structure, function and interaction with clongin BC complex. EMBO J. 15:101-110.
2. Bai, C., P. Sen, K. Hofmann, L. Ma, M. Goebl, J. W. Harper, and S. J. Elledge. 1996. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86:263-274.
3. Berse, B., L. Brown, V. Livingston, H. Dvorak, and D. Senger. 1992. Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol. Biol. Cell 3:211-220.
4. Conaway, R., D. Reines, K. Garrett, W. Powell, and J. Conaway. 1996. Purification of RNA polymerase II general transcription factors from rat liver. Methods Enzymol. 273:194-207.
5. Conaway, R. C., J. W. Conaway, and W. G. Kaolin, Jr. Unpublished data.
6. Corless, C. L., A. Kibel, O. Iliopoulos, and W. G. Kaelin. 1997. Immunostaining of the von Hippel-Lindau gene product (pVHL) in normal and neoplastic human tissues. Hum. Pathol. 28:459-464.
7. Duan, D. R., A. Pause, W. Burgress, T. Aso, D. Y. T. Chen, K. P. Garrett, R. C. Conaway, J. W. Conaway, W. M. Linehan, and R. D. Klausner. 1995. Inhibition of transcriptional elongation by the VHL tumor suppressor protein. Science 269:1402-1406.
8. Foster, K., A. Prowse, A. van den Berg, S. Fleming, M. M. F. Hulsbeek, P. A. Crossey, F. M. Richards, P. Cairns, N. A. Affara, M. A. Ferguson-Smith, C. H. C. M. Buys, and E. R. Maher. 1994. Somatic mutations of the von Hippel-Lindau disease tumor suppressor gene in non-familial clear cell renal carcinoma. Hum. Mol. Genet. 3:2169-2173.
9. Garrett, K., T. Aso, J. Bradsher, S. Foundling, W. Lane, R. Conaway, and J. Conaway. 1995. Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog. Proc. Natl. Acad. Sci. USA 92:7172-7176.
10. Gnarra, J. R., D. R. Duan, Y. Weng, J. S. Humphrey, D. Y. T. Chen, S. Lee, A. Pause, C. F. Dudley, F. Latif, I. Kuzmin, L. Schmidt, F.-M. Duh, T. Stackhouse, F. Chen, T. Kishida, M. H. Wei, M. I. Lerman, B. Zbar, R. D. Klausner, and W. M. Linehan. 1996. Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal cell carcinoma (review). Biochim. Biophys. Acta 1242:201-210.
11. Gnarra, J. R., K. Tory, Y. Weng, L. Schmidt, M. H. Wei, H. Li, F. Latif, S. Liu, F. Chen, F.-M. Duh, I. Lubensky, D. R. Duan, C. Florence, R. Pozzatti, M. M. Walther, N. H. Bander, H. B. Grossman, H. Brauch, S. Pomer, J. D. Brooks, W. B. Isaacs, M. I. Lerman, B. Zbar, and W. M. Linehan. 1994. Mutations of the VHL tumour suppressor gene in renal carcinoma. Nature Genet. 7:85-90.
12. Gnarra, J. R., S. Zhou, M. J. Merrill, J. Wagner, A. Krumm, E. Papavassiliou, E. H. Oldfield, R. D. Klausner, and W. M. Linehan. 1996. Post-transcriptional regulation of vascular endothelial growth factor mRNA by the VHL tumor suppressor gene product. Proc. Natl. Acad. Sci. USA 93:10589-10594.
13. Harlow, E., L. V. Crawford, D. C. Pim, and N. M. Williamson. 1981. Monoclonal antibodies specific for simian virus 40 tumor antigens. J. Virol. 39: 861-869.
14. Harlow, E., and D. Lane. 1988. Antibodies - a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
15. Herman, J. G., F. Latif, Y. Weng, M. I. Lerman, B. Zbar, S. Liu, D. Samid, D.-S. R. Duan, J. R. Gnarra, W. M. Linehan, and S. B. Baylin. 1994. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc. Natl. Acad. Sci. USA 91:9700-9704.
16. Hopkin, K. 1997. Regulating cellular processes: the power of protein degradation. J. NIH Res. 9:36-42.
17. Iliopoulos, O., C. Jiang, A. P. Levy, W. G. Kaelin, and M. A. Goldberg. 1996. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc. Natl. Acad. Sci. USA 93:10595-10599.
18. Iliopoulos, O., and W. G. Kaelin. 1997. The molecular basis of von Hippel-Lindau disease. Mol. Med. 3:289-293.
19. 17a. Iliopoulos, O., and W. G. Kaelin, Jr. Unpublished data.
20. Iliopoulos, O., A. Kibel, S. Gray, and W. G. Kaelin. 1995. Tumor suppression by the human von Hippel-Lindau gene product. Nature Med. 1:822-826.
21. Jackson, P. K. 1996. Cell cycle: cull and destroy. Curr. Biol. 6:1209-1212.
22. Kamitani, T., H. P. Nguyen, and E. T. H. Yeh. 1997. Preferential modification of nuclear proteins by a novel ubiquitin-like molecule. J. Biol. Chem. 272:14001-14004.
23. Kanno, H., K. Kondo, S. Ito, I. Yamamoto, S. Fujii, S. Torigoe, N. Sakai, M. Hosaka, T. Shuin, and M. Yao. 1994. Somatic mutations of the von Hippel-Lindau tumor suppressor gene in sporadic central nervous system hemangioblastomas. Cancer Res. 54:4845-4847.
24. Kibel, A., O. Iliopoulos, J. D. DeCaprio, and W. G. Kaelin. 1995. Binding of the von Hippel-Lindau tumor suppressor protein to elongin B and C. Science 269:1444-1446.
25. Kipreos, E. T., L. E. Lander, J. P. Wing, W. W. He, and E. M. Hedgecock. 1996. cul-1 is required for cell cycle exit in C. elegans and identities a novel gene family. Cell 85:829-839.
26. Kishida, T., T. M. Stackhouse, F. Chen, M. I. Lerman, and B. Zbar. 1995. Cellular proteins that bind the von Hippel-Lindau disease gene product: mapping of binding domains and the effect of missense mutations. Cancer Res. 55:4544-4548.
27. Kornitzer, D., B. Raboy, R. G. Kulka, and G. R. Fink. 1994. Regulated degradation of the transcription factor Gcn4. EMBO J. 13:6021-6030.
28. Koura, A. N., W. Liu, Y. Kitadai, R. K. Singh, R. Radinsky, and L. M. Ellis. 1996. Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by cell density. Cancer Res. 56:3891-3894.
29. Latif, F., K. Tory, J. Gnarra, M. Yao, F.-M. Duh, M. L. Orcutt, T. Stackhouse, I. Kuzmin, W. Modi, L. Geil, L. Schmidt, F. Zhou, H. Li, M. H. Wei, F. Chen, G. Glenn, P. Choyke, M. M. Walther, Y. Weng, D.-S. R. Duan, M. Dean, D. Glavac, F. M. Richards, P. A. Crossey, M. A. Ferguson-Smith, D. L. Pasiler, I. Chumakov, D. Cohen, A. C. Chinault, E. R. Maher, W. M. Linehan, B. Zbar, and M. I. Lerman. 1993. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 260:1317-1320.
30. Lee, S., D. Y. T. Chen, J. S. Humphrey, J. R. Gnarra, W. M. Linehan, and R. D. Klausner. 1996. Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density. Proc. Natl. Acad. Sci. USA 93:1770-1775.
31. Levy, A. P., N. S. Levy, and M. A. Goldberg. 1996. Hypoxia-inducible protein binding to vascular endothelial growth factor mRNA and its modulation by the von Hippel-Lindau protein. J. Biol. Chem. 271:25492-25497.
32. Levy, A. P., N. S. Levy, O. Iliopnulos, C. Jiang, W. G. Kaelin, and M. A. Goldberg. 1997. Regulation of vascular endothelial growth factor by hypoxia and its modulation by the von Hippel-Lindau tumor suppressor gene. Kidney Int. 51:575-578.
33. Los, M., G. H. Jansen, W. G. Kaelin, C. J. M. Lips, G. H. Blijham, and E. E. Voesi. 1996. Expression pattern of the von Hippel-Lindau protein in human tissues. Lab. Invest. 75:231-238.
34. Lubensky, I. A., J. R. Gnarra, P. Bertheau, M. M. Walther, W. M. Linehan, and Z. Zhuang. 1996. Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients. Am. J. Pathol. 149:2089-2094.
35. Mahajan, R., C. Delphin, T. Guan, L. Gerace, and F. Melchior. 1997. A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. Cell 88:97-107.
36. Marsilio, E., S. H. Cheng, B. Schaffhausen, E. Paucha, and D. M. Livingston. 1991. The T/t common region of simian virus 40 large T antigen contains a distinct transformation-governing sequence. J. Virol. 65:5647-5652.
37. McKusick, V. A. 1992. Mendelian inheritance in man. The Johns Hopkins University Press, Baltimore, Md.
38. Morii, K., R. Tanaka, K. Washiyama, T. Kumanishi, and R. Kuwano. 1993. Expression of vascular endothelial growth factor in capillary hemangioblastoma. Biochem. Biophys. Res. Commun. 194:749-755.
39. Mukhopadhyay, D., B. Knebelmann, H. Cohen, S. Ananth, and V. Sukhatme. 1997. The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity. Mol. Cell. Biol. 17:5629-5639.
40. Pause, A., S. Lee, R. A. Worrell, D. Y. T. Chen, W. H. Burgess, W. M. Linehan, and R. D. Klausner. 1997. The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc. Natl. Acad. Sci. USA 94:2156-2161.
41. Sato, K., K. Terada, T. Sugiyama, S. Takahashi, M. Saito, M. Moriyama, H. Kakinuma, Y. Suzuki, M. Kato, and T. Kato. 1994. Frequent overexpression of vascular endothelial growth factor gene in human renal cell carcinoma. Tohoku J. Exp. Med. 173:355-360.
42. Shuin, T., K. Kondo, S. Torigoe, T. Kishida, Y. Kubota, M. Hosaka, Y. Nagashima, H. Kitamura, F. Latif, B. Zbar, M. I. Lerman, and M. Yao. 1994. Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas. Cancer Res. 54:2852-2855.
43. Siemeister, G., K. Weindel, K. Mohrs, B. Barleon, G. Martiny-Baron, and D. Marme. 1996. Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein. Cancer Res. 56:2299-2301.
44. Takagi, Y., R. Conaway, and J. Conaway. 1996. Characterization of elongin C functional domain required for interaction with elongin B and activation of elongin A. J. Biol. Chem. 271:1-7.
45. Takahashi, A., H. Sasaki, S. Kim, K. Tobisu, T. Kakizoe, T. Tsukamoto, Y. Kumamoto, T. Sugimura, and M. Terada. 1994. Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis. Cancer Res. 54:4233-4237.
46. Tsuchiya, H., T. Iseda, and O. Hino. 1996. Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product. Cancer Res. 56:2881-2885.
47. Whaley, J. M., J. Naglich, L. Gelbert, Y. E. Hsia, J. M. Lamiell, J. S. Green, D. Collins, H. P. H. Neumann, J. Laidlaw, F. P. Li, A. J. P. Klein-Szanto, B. R. Seizinger, and N. Kley. 1994. Germ-line mutations in the von Hippel-Lindau tumor suppressor gene are similar to somatic von Hippel-Lindau aberrations in sporadic renal cell carcinoma. Am. J. Hum. Genet. 55:1092-1102.
48. Wilson, I. A., D. H. Haft, E. D. Getzoff, J. A. Tainer, R. A. Lerner, and S. Brenner. 1985. Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition. Proc. Natl. Acad. Sci. USA 82:5255-5259.
49. Wizigmann-Voos, S., G. Breier, W. Risau, and K. Plate. 1995. Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas. Cancer Res. 55:1358-1364.
50. Zbar, B., T. Kishida, F. Chen, L. Schmidt, E. R. Maher, F. M. Richards, P. A. Crossey, A. R. Webster, N. A. Affara, M. A. Ferguson-Smith, H. Brauch, D. Glavac, H. P. H. Neumann, S. Tisherman, J. J. Mulvihill, D. Gross, T. Shuin, J. Whaley, B. Seizinger, N. Kley, S. Olschwang, C. Boisson, S. Richard, C. H. M. Lips, M. W. Linehan, and M. Lerman. 1996. Germline mutations in the von Hippel-Lindau (VHL) gene in families from North America, Europe, and Japan. Hum. Mutat. 8:348-357.
51. Zhuang, Z., P. Bertheau, M. Emmert-Buck, L. Liotta, J. Gnarra, W. Linehan, and I. Lubensky. 1995. A microscopic dissection technique for archival DNA analysis of specific cell populations in lesions < 1mm in size. Am. J Pathol. 146:620-625.