Putative control of angiogenesis in hemangioblastomas by the von Hippel- Lindau tumor suppressor gene

Journal of Neuropathology and Experimental Neurology

Volumn 56, Issue 11, 1997, Pages 1242-1252

  Stratmann, Rembert ^a   Krieg, Marion ^a   Haas, Richard ^a   Plate, Karl H ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Hemangioblastoma; Vascular endothelial growth factor; VEGF receptor; von Hippel Lindau tumor suppressor gene

Indexed keywords

ALPHA TUBULIN; BETA ACTIN; MESSENGER RNA; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CARCINOMA CELL; CEREBELLUM; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; HEMANGIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; KIDNEY CARCINOMA; PRIORITY JOURNAL; STROMA CELL; TUMOR SUPPRESSOR GENE; VON HIPPEL LINDAU DISEASE;

EID: 0030831655     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199711000-00009     Document Type: Article

References (59)

1. Ferrara N. Vascular endothelial growth factor. Trends Cardiovasc Sci 1993;3:244-50
2. Klagsbrun M, Soker S. VEGF/VPF-the angiogenesis factor found? Curr Biol 1993;3:699-702
3. Plate KH, Breier G, Risau W. Molecular mechanisms of developmental and tumor angiogenesis. Brain Pathol 1994;4:207-18
4. Shalaby F, Rossant J, Yamaguchi TP, et al. Failure of blood-island formation and vasculogenesis in flk-1 deficient mice. Nature 1995; 376:62-66
5. Fong G-H, Rossant J, Gertsenstein M, Breitman ML. Role of the fit-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995;376:66-70
6. Carmeliet P, Ferreira V, Breier G, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996;380:435-39
7. Ferrara N, Carver-Moore K, Chen H, et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996;380:439-42
8. Breier G, Albrecht U, Sterrer S, Risau W. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell proliferation. Development 1992;114:521-32
9. Plate KH, Breier G, Weich HA, Risau W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 1992;359:845-48
10. Berkman RA, Merrill MJ, Reinhold WC, et al. Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms. J Clin Invest 1993;91:153-59
11. Plate KH, Breier G, Weich HA, Mennel HD, Risau W. Vascular endothelial growth factor and glioma angiogenesis: Coordinate induction of VEGF-receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms. Int J Cancer 1994;59:520-29
12. Weindel K, Moringlane JR, Marmé D, Weich HA. Detection and quantification of vascular endothelial growth factor/vascular permeability factor in brain tumor tissue and cyst fluid. Neurosurg 1994;35:439-49
13. Samoto K, Ikezaki K, Ono M, et al. Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors. Cancer Res 1995;55:1189-93
14. Shweiki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992;359:843-45
15. Plate KH, Breier G, Millauer B, Ullrich A, Risau W. Upregulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis. Cancer Res 1993;53: 5822-27
16. Ikeda E, Achen MG, Breier G, Risau W. Hypoxia-induced activation and increased mRNA stability of vascular endothelial growth factor (VEGF) in C6 glioma cells. J Biol Chem 1995;270:19761-66
17. Plate KH, Risau W. Angiogenesis in malignant gliomas. Glia 1995; 15:339-47
18. Damert A, Machein M, Breier G, et al. Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms. Cancer Res 1997;57: 3860-64
19. Wizigmann-Voos S, Breier G, Risau W, Plate KH Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau-disease associated and in sporadic hemangioblastomas. Cancer Res 1995;55:1358-64
20. Morii K, Tanaka R, Washiyama K, Kumanishi T, Kuwano R. Expression of vascular endothelial growth factor in capillary hemangioblastoma. Biochem Biophys Res Comm 1993;194:749-55
21. Lindau A. Studien ueber Kleinhirncysten. Acta Pathol Microbiol Scan 1926; Suppl. 1:1-126
22. Folkman J. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 1990;82:4-6
23. Kanno H, Kondo K, Ito S, et al. Somatic mutations of the von Hippel-Lindau tumor suppressor gene in sporadic central nervous system hemangioblastomas. Cancer Res 1994;54:4845-47
24. Oberstrass J, Reifenberger G, Reifenberger J, Wechsler W, Collins VP. Mutation of the von Hippel-Lindau tumor suppressor gene in capillary haemangioblastomas of the central nervous system. J Pathol 1996;179:151-56
25. Prowse AH, Webster AR, Richards FM, et al. Somatic inactivation of the VHL gene in Von Hippel-Lindau disease tumors. Am J Hum Genet 1997;60:765-71
26. Tse JY, Wong JH, Lo KW, Poon WS, Huang DP, Ng HK. Molecular genetic analysis of the von Hippel-Lindau disease tumor suppressor gene in familial and sporadic cerebellar hemangioblastomas. Am J Clin Pathol 1997;107:459-66
27. Latif F, Tory K, Gnarra J, et al. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 1993;260:1317-30
28. Wizigmann-Voos S, Plate KH. Pathology, genetics and cell biology of hemangioblastomas. Histol Histopathol 1996;11:1049-61
29. Neumann HPH, Lips CJM, Hsia YE, Zbar B. Von Hippel-Lindau syndrome. Brain Pathol 1995;5:181-93
30. Aso T, Lane WS, Conaway JW, Conaway RC. Elongin (SIII): A multisubunit regulator of elongation by RNA polymerase II. Science 1995;269:1439-43
31. Duan DR, Pause A, Burgess WH, et al. Inhibition of transcription by the VHL tumor suppressor protein. Science 1995;269:1402-6
32. Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG Jr. Binding of the von Hippel-Lindau tumor suppressor gene to Elongin B and C. Science 1995;269:1444-46
33. Siemeister G, Weindel K, Mohrs K, Barleon B, Martiny-Baron G, Marmé D. Reversion of deregulated expression of vascular endothelial growth factor in human renal cell carcinoma cells by von Hippel-Lindau tumor suppressor protein. Cancer Res 1996;56: 2299-2301
34. Iliopoulos O, Levy AP, Jiang C, Kaelin WG Jr, Goldberg MA. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc Natl Acad Sci USA 1996;93:10595-99
35. Gnarra JR, Zhou S, Merill MJ, et al. Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene. Proc Natl Acad Sci USA 1996;93: 10589-94
36. Tsuchiya H, Iseda T, Hino O. Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product. Cancer Res 1996;56:2881-85
37. Pause A, Lee S, Worrell RA, et al. The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc Natl Acad Sci USA 1997;94:2156-61
38. Levy AP, Levy NS, Goldberg MA. Hypoxia-inducible protein binding to vascular endothelial growth factor mRNA and its modulation by the von Hippel-Lindau protein. J Biol Chem 1996;271:25492-97
39. Iliopoulos O, Kibel A, Gray S, Kaelin WG Jr. Tumour suppression by the human von Hippel-Lindau gene product. Nature Med 1995; 1:822-26
40. Harlow E, Lane D. Antibodies. A laboratory manual. Cold Spring Harbor Laboratory, 1988
41. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning. A laboratory manual. Cold Spring Harbor Laboratory, 1989
42. Stratmann A, Jeserich G. Molecular cloning and tissue expression of a cDNA encoding IP-1-a PO-like glycoprotein of trout myelin. J Neurochem 1995;64:2427-36
43. Chomczinsky P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-59
44. Böhling T, Hatva E, Plate KH, Haltia M, Alitalo K. Von Hippel-Lindau disease and capillary haemangioblastoma. In: Kleihues P, Cavenee WK, eds. Pathology and genetics of tumours of the nervous system. Lyon: IARC;1997:179-81
45. Vortmeyer AO, Gnarra JR, Emmert-Buck MR, et al. Von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease. Hum Pathol 1997;28:540-43
46. Yamaguchi TP, Dumont DJ, Conlon RA, Breitman ML, Rossant J. flk-1. an flt-1 related receptor tyrosine kinase is an early marker for endothelial cell precursors. Development 1993;118:489-98
47. Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997;275:964-67
48. Kennedy M, Firpo M, Choi K, et al. A common precursor for primitive erythropoiesis and definite haematopoiesis. Nature 1997; 386:488-93
49. Baldwin SH, Shen HM, Yan H-C, et al. Platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31): Alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development. Development 1994;120:2539-53
50. Hatva E, Böhling T, Jääskeläinen J, Persico MG, Haltia M, Alitalo K. Vascular growth factors and receptors in capillary hemangioblastomas and hemangiopericytomas. Am J Pathol 1996;148:763-75
51. Böhling T, Mäenpää A, Timonen T, Vantunen L, Paetau A, Haltia M. Different expression of adhesion molecules on stromal cells and endothelial cells of capillary hemangioblastoma. Acta Neuropath 1996;92:461-66
52. Reifenberger G, Reifenberger J, Bilzer T, Wechsler W, Collins VP. Coexpression of transforming growth factor-α and epidermal growth factor in capillary hemangioblastomas of the central nervous system. Am J Pathol 1995;147:245-50
53. Goldwitz D, Barthels D, Lorenzon N, Jungblut A, Wille W. NCAM gene expression during the development of cerebellum and dentate gyrus in the mouse. Brain Res 1990;52:151-60
54. Torp SH, Helseth E, Dalen A, Unsgaard G. Epidermal growth factor receptor expression in human gliomas. Cancer Immun Immunother 1991;33:61-64
55. Kessler PM, Vasavada SP, Rackley RR, et al. Expression of the von Hippel-Lindau tumor suppressor gene, VHL, in human fetal kidney and during mouse embryogenesis. Mol Med 1995;1:457-66
56. Richards FM, Schofield PN, Fleming S, Maher ER. Expression of the von Hippel-Lindau disease tumour suppressor gene during human embryogenesis. Hum Mol Genetics 1996;5:639-44
57. Los M, Jansen GH, Kaelin WG, Lips CJM, Blijham GH, Voest EE. Expression pattern of the von Hippel-Lindau protein in human tissues. Lab Invest 1996;75:231-38
58. Corless CL, Kibel AS, Iliopoulos O, Kaelin WG Jr. Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues. Hum Pathol 1997;28:459-64
59. Scholz W. Selective neuronal necrosis and its topistic pattern in hypoxemia and oligemia. J Neuropathol Exp Neurol 1953;12:249-61