Subcellular localization of the von Hippel-Lindau disease gene product is cell cycle-dependent

International Journal of Cancer

Volumn 78, Issue 1, 1998, Pages 62-69

  Ye, Ying ^a   Vasavada, Sandip ^a   Kuzmin, Igor ^b   Stackhouse, Thomas ^b   Zbar, Berton ^b   Williams, Bryan R G ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; ELONGIN; GENE PRODUCT; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; KIDNEY CARCINOMA; PRIORITY JOURNAL; PROTEIN LOCALIZATION; VON HIPPEL LINDAU DISEASE;

CARCINOMA, RENAL CELL; CELL LINE; CELL NUCLEUS; CYTOPLASM; HIPPEL-LINDAU DISEASE; HUMANS; INTERPHASE; KIDNEY NEOPLASMS; LIGASES; PROTEINS; RNA SPLICING; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 0031869573     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19980925)78:1<62::AID-IJC11>3.0.CO;2-7     Document Type: Article

References (37)

1. ASO, T., LANE, W.S., CONAWAY, J.W. and CONAWAY, R.C., Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. Science, 269, 1439-1443 (1995).
2. BEREZNEY, R. and COFFEY, D.S., Identification of a nuclear protein matrix. Biochem. Biophys. Res. Comm., 60, 1410-1417 (1974).
3. BLENCOWE, B.J., NICKERSON, J.A., ISSNER, R., PENMAN, S. and SHARP, P.A., Association of nuclear matrix antigens with exon-containing splicing complexes. J. Cell Biol. 127, 593-607 (1994).
4. CARROLL, D. and MARSHAK, D.R., Serum-stimulated cell growth causes oscillations in casein kinase II activity. J. biol. Chem., 264, 7345-7348 (1989).
5. CHEN, F., KISHIDA, T., DUH, F.-M., RENBAUM, P., ORCUTT, M.L., SCHMIDT, L. and ZBAR, B., Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene. Cancer Res., 55, 4804-4807 (1995).
6. DEBENEDETTE, M. and SNOW, E.C., Induction and regulation of casein kinase II during B lymphocyte activation. J. Immunol., 147, 2839-2845 (1991).
7. DUAN, D.R., HUMPHREY, J.S., CHEN, D.Y.T., WENG, Y., SUKEGAWA, J., LEE, S., GNARRA, J.R., LINEHAN, W.M. and KLAUSNER, R.D., Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations. Proc. nat. Acad. Sci. (Wash.), 92, 6459-6463 (1995a).
8. DUAN, D.R., PAUSE, A., BURGESS, W.H., ASO, T., CHEN, D.Y.T., GARRETT, K.P., CONAWAY, R.C., CONAWAY, J.W., LINEHAN, W.M. and KLAUSNER, R.D., Inhibition of transcription elongation by the VHL tumor suppressor protein. Science, 269, 1402-1406 (1995b).
9. FILHOL-COCHET, O., LOUE-MACKENBACH, P., COCHET, C. and CHAMBAZ, E.M., Casein kinase 2 and the cell response to growth factors. Cell mol. Biol. Res., 40, 529-537 (1994).
10. GARCIA-BUSTOS, J., HEITMAN, J. and HALL, M.N., Nuclear protein localization. Biochim. biophys. Acta, 1071, 83-101 (1991).
11. GNARRA, J.R., TORY, K., WENG, Y., SCHMIDT, L., WEI, M.H., LATIF, F., LI, H., LAUF, F., CHEN, F. and DUH, F.M., Mutations of the VHL tumour suppressor gene in renal carcinoma. Nature (Genet.), 7, 85-90 (1994).
12. GROSSMAN, H.B., WEIDEMEYER, G. and REN, L., Human renal carcinoma: characterization of five new cell lines. J. surg. Oncol., 28, 237-244 (1985).
13. 2/M in Saccharomyces cerevisiae. J. biol. Chem., 43, 25905-25914 (1995).
14. HASHIMURA, T., TUBBS, R.R., CONNELLY, R., CAULFIELD, M.J., TRINDADE, C.S., MCMAHON, J.T., GALETTI, T.P., EDINGER, M., SANDBERG, A.A., DAL CIN, P., SAIT, S.J. and PONTES, J.E., Characterization of two cell lines with distinct phenotypes and genotypes established from a patient with renal cell carcinoma. Cancer Res., 49, 7064-7071 (1989).
15. HERMAN, J.G., LATIF, F., WENG, Y., LERMAN, M.I., ZBAR, B., LIU, S., SAMID, D., DUAN, D.-S.R., GNARRA, J.R., LINEHAN, W.M. and BAYLIN, S.B., Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc. nat. Acad. Sci. (Wash.), 91, 9700-9704 (1994).
16. HUNT, T., Cytoplasmic anchoring proteins and the control of nuclear localization. Cell, 59, 949-951 (1989).
17. ILIOPOULOS, O., GRAY, S., KIBEL, A. and KAELIN, W.G., Characterization of pVHL, the product of the von Hippel-Lindau (VHL) disease gene. Proc. Amer. Ass. Cancer Res., 36, 194 (1995a).
18. ILIOPOULOS, O., KIBEL, A., GRAY, S. and KAELIN, W.G., JR., Tumour suppression by the human von Hippel-Lindau gene product. Nature (Med.), 8, 822-826 (1995b).
19. KIBEL, A., ILIOPOULOS, O., DECAPRIO, J.A. and KAELIN, W.G., Binding of the von Hippel-Lindau tumor suppressor protein to elongins B and C. Science, 269, 1444-1446 (1995).
20. KISHIDA, T., STACKHOUSE, T.M., CHEN, F., LERMAN, M.I. and ZBAR, B., Cellular proteins that bind the von Hippel-Lindau disease gene product: mapping of binding domains and the effect of missense mutations. Cancer Res., 55, 4544-4548 (1995).
21. LARSSON, S., CHARLIEU, J.-P., MIYAGAWA, K., ENGELKAMP, D., RASSOULZA-DEGAN, M., ROSS, A., CUZIN, F., VAN HEYNINGEN, V. and HASTIE, N.D., Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing. Cell, 81, 391-401 (1995).
22. LATIF, F. and 30 OTHERS, Identification of the von Hippel-Lindau disease tumor suppressor gene. Science, 260, 1317-1320 (1993).
23. LEE, S., CHEN, D.Y.T., HUMPHREY, J., GNARRA, J.R., LINEHAN, W.M. and KLAUSNER, R.D., Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density. Proc. nat. Acad. Sci. (Wash.), 93, 1770-1775 (1996).
24. MAHER, E.R., ISELIUS, L., YATES, J.R., LITTLER, M., BENJAMIN, C., HARRIS, R., SAMPSON, J., WILLIAMS, A., FERGUSON-SMITH, M.A. and MORTON, N., Von Hippel-Lindau disease: a genetic study. J. med. Genet., 28, 443-447 (1991).
25. MARTINY-BARON, G. and MARME, D., VEGF-mediated tumour angiogenesis: a new target for cancer therapy. Curr. Opin. Biotechnol., 6, 675-680 (1995).
26. MOLL, T., TEBB, G., SURANA, U., ROBITSCH, H. and NASMYTH, K., The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SW15. Cell, 66, 743-758 (1991).
27. MUKHOPADHYAY, D., KNEBELMANN, B., COHEN, H.T., ANANTH, S. and SUKHATME, V.P., The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity. Mol. cell. Biol., 17, 5629-5639 (1997).
28. NYMAN, U., HALLMAN, H., HADLACZKY, G., PETTERSSON, I., SHARP, G. and RINGERTZ, N.R., Intranuclear localization of snRNP antigens. J. Cell Biol., 102, 137-144 (1986).
29. OSAKA, M., NAGASHIMA, Y., KITAMURA, H., LATIF, F., ZBAR, B., LERMAN, M.I. and YAO, M., Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas. Cancer Res., 54, 2852-2855 (1994).
30. PAL, S., CLAFFEY, K.P., DVORAK, H.F. and MUKHOPADHYAY, D., The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways. J. biol. Chem., 272, 27509-27512 (1997).
31. PAUSE, A., LEE, S., WORRELL, R.A., CHEN, D.Y., BURGESS, W.H., LINEHAN, W.M. and KLAUSNER, R.D., The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc. nat. Acad. Sci. (Wash.), 94, 2156-2161 (1997).
32. RIHS, H.-P., JANS, D.A., FAN, H. and PETERS, R., The rate of nuclear cytoplasmic protein transport is determined by the casein kinase II site flanking the nuclear localization sequence of the SV40 T-antigen. EMBO J., 10, 633-639 (1991).
33. SIEMEISTER, G., WEINDEL, K., MOHRS, K., BARLEON, B., MARTINY-BARON, G. and MARME, D., Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein. Cancer Res., 56, 2299-2301 (1996).
34. SPECTOR, D.L., FU, X. and MANIATIS, T., Associations between distinct pre-mRNA splicing components and the cell nucleus. EMBO J., 10, 3467-3481 (1991).
35. STROUBOULIS, J. and WOLFFE, A.P., Functional compartmentalization of the nucleus. J. Cell. Sci., 109, 1991-2000 (1996).
36. TSUCHIYA, H., ISEDA, T. and HINO, O., Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product. Cancer Res., 56, 2881-2885 (1996).
37. YE, Y., RAYCHAUDHURI, B., GURNEY, A., CAMPBELL, C.E. and WILLIAMS, B.R.G., Regulation of WT1 by phosphorylation: inhibition of DNA binding, alteration of transcriptional activity and cellular translocation. EMBO J., 15, 5606-5615 (1996).