-
1
-
-
0015749593
-
A general theory of carcinogenesis
-
Comings DE. A general theory of carcinogenesis. Proc Nat Acad Sci USA 1973;70:3324-8.
-
(1973)
Proc Nat Acad Sci USA
, vol.70
, pp. 3324-3328
-
-
Comings, D.E.1
-
3
-
-
0025312728
-
A genetic model of colorectal tumorigenesis
-
Fearon ER, Vogelstein B. A genetic model of colorectal tumorigenesis. Cell 1990;61:759-67.
-
(1990)
Cell
, vol.61
, pp. 759-767
-
-
Fearon, E.R.1
Vogelstein, B.2
-
4
-
-
0026562404
-
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
-
Su LK, Kinzler KW, Vogelstein B, et al. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 1992;256:668-70.
-
(1992)
Science
, vol.256
, pp. 668-670
-
-
Su, L.K.1
Kinzler, K.W.2
Vogelstein, B.3
-
5
-
-
0031445126
-
Von Hippel-Lindau disease
-
Maher E, Kaelin WG. von Hippel-Lindau disease. Medicine 1997; 76:381-91.
-
(1997)
Medicine
, vol.76
, pp. 381-391
-
-
Maher, E.1
Kaelin, W.G.2
-
6
-
-
16644373473
-
The role of VHL gene mutation in human cancer
-
In press
-
Kim WY and Kaelin WG. The role of VHL gene mutation in human cancer. J Clin Oncol. In press 2004.
-
(2004)
J Clin Oncol
-
-
Kim, W.Y.1
Kaelin, W.G.2
-
7
-
-
0027240519
-
Identification of the von Hippel-Lindau disease Tumor Suppressor Gene
-
Latif F, Tory K, Gnarra J, et al. Identification of the von Hippel-Lindau disease Tumor Suppressor Gene. Science 1993;260:1317-20.
-
(1993)
Science
, vol.260
, pp. 1317-1320
-
-
Latif, F.1
Tory, K.2
Gnarra, J.3
-
8
-
-
0029847090
-
Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients
-
Lubensky IA, Gnarra JR, Bertheau P, Walther MM, Linehan WM, Zhuang Z. Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients. Am J Pathol 1996;149:2089-94.
-
(1996)
Am J Pathol
, vol.149
, pp. 2089-2094
-
-
Lubensky, I.A.1
Gnarra, J.R.2
Bertheau, P.3
Walther, M.M.4
Linehan, W.M.5
Zhuang, Z.6
-
9
-
-
17044452288
-
HIF activation identifies early lesions in VHL kidneys: Evidence for site-specific tumor suppressor function in the nephron
-
Mandriota SJ, Turner KJ, Davies DR, et al. HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. Cancer Cell 2002;1:459-68.
-
(2002)
Cancer Cell
, vol.1
, pp. 459-468
-
-
Mandriota, S.J.1
Turner, K.J.2
Davies, D.R.3
-
10
-
-
0028072991
-
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
-
Herman JG, Latif F, Weng Y, et al. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA 1994;91:9700-4.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 9700-9704
-
-
Herman, J.G.1
Latif, F.2
Weng, Y.3
-
11
-
-
0029785838
-
Post-transcriptional regulation of vascular endothelial growth factor mRNA by the VHL tumor suppressor gene product
-
Gnarra JR, Zhou S, Merrill MJ, et al. Post-transcriptional regulation of vascular endothelial growth factor mRNA by the VHL tumor suppressor gene product. Proc Natl Acad Sci USA 1996;93:10589-94.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 10589-10594
-
-
Gnarra, J.R.1
Zhou, S.2
Merrill, M.J.3
-
12
-
-
0029090338
-
Tumor suppression by the human von Hippel-Lindau gene product
-
Iliopoulos O, Kibel A, Gray S, Kaelin WG. Tumor suppression by the human von Hippel-Lindau gene product. Nat Med 1995;1:822-6.
-
(1995)
Nat Med
, vol.1
, pp. 822-826
-
-
Iliopoulos, O.1
Kibel, A.2
Gray, S.3
Kaelin, W.G.4
-
13
-
-
0034192719
-
Comparative sequence analysis of the VHL tumor suppressor gene
-
Woodward E, Buchberger A, Clifford S, Hurst L, Affara N, Maher E. Comparative sequence analysis of the VHL tumor suppressor gene. Genomics 2000;65:253-65.
-
(2000)
Genomics
, vol.65
, pp. 253-265
-
-
Woodward, E.1
Buchberger, A.2
Clifford, S.3
Hurst, L.4
Affara, N.5
Maher, E.6
-
14
-
-
17944375360
-
Elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein A, Gleadle J, McNeill L, et al. Elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001;107:43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.1
Gleadle, J.2
McNeill, L.3
-
15
-
-
0034213624
-
Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila
-
Adryan B, Decker H-JH, Papas TS, Hsu T. Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila. Oncogene 2000;19:2803-11.
-
(2000)
Oncogene
, vol.19
, pp. 2803-2811
-
-
Adryan, B.1
Decker, H.-J.H.2
Papas, T.S.3
Hsu, T.4
-
16
-
-
0029772338
-
Expression pattern of the von Hippel-Lindau protein in human tissues
-
Los M, Jansen GH, Kaelin WG, Lips CJM, Blijham GH, Voest EE. Expression pattern of the von Hippel-Lindau protein in human tissues. Lab Invest 1996;75:231-8.
-
(1996)
Lab Invest
, vol.75
, pp. 231-238
-
-
Los, M.1
Jansen, G.H.2
Kaelin, W.G.3
Lips, C.J.M.4
Blijham, G.H.5
Voest, E.E.6
-
17
-
-
10544244175
-
Von Hippel-Lindau tumour suppressor gene. Localization of expression by in situ hybridization
-
Nagashima Y, Miyagi Y, Udagawa K, et al. Von Hippel-Lindau tumour suppressor gene. Localization of expression by in situ hybridization. J Pathol 1996;180:271-4.
-
(1996)
J Pathol
, vol.180
, pp. 271-274
-
-
Nagashima, Y.1
Miyagi, Y.2
Udagawa, K.3
-
18
-
-
0029926989
-
Expression of the von Hippel-Lindau disease tumour suppressor gene during human embryogenesis
-
Richards F, Schofield P, Fleming S, Maher E. Expression of the von Hippel-Lindau disease tumour suppressor gene during human embryogenesis. Human Mol Genet 1996;5:639-44.
-
(1996)
Human Mol Genet
, vol.5
, pp. 639-644
-
-
Richards, F.1
Schofield, P.2
Fleming, S.3
Maher, E.4
-
19
-
-
0029295649
-
Expression of the von Hippel-Lindau tumor-suppressor gene, VHL, in human fetal kidney and during mouse embryogenesis
-
Kessler P, Vasavada S, Rackley R, et al. Expression of the von Hippel-Lindau tumor-suppressor gene, VHL, in human fetal kidney and during mouse embryogenesis. Mol Med 1995;1:457-66.
-
(1995)
Mol Med
, vol.1
, pp. 457-466
-
-
Kessler, P.1
Vasavada, S.2
Rackley, R.3
-
20
-
-
0032555217
-
A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor
-
Schoenfeld A, Davidowitz E, Burk R. A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor. Proc Natl Acad Sci USA 1 1998;95:8817-22.
-
(1998)
Proc Natl Acad Sci USA 1
, vol.95
, pp. 8817-8822
-
-
Schoenfeld, A.1
Davidowitz, E.2
Burk, R.3
-
21
-
-
0033602089
-
Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity
-
Blankenship C, Naglich J, Whaley J, Seizinger B, Kley N. Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity. Oncogene 1999;18:1529-35.
-
(1999)
Oncogene
, vol.18
, pp. 1529-1535
-
-
Blankenship, C.1
Naglich, J.2
Whaley, J.3
Seizinger, B.4
Kley, N.5
-
22
-
-
0032578357
-
pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation
-
Iliopoulos O, Ohh M, Kaelin W. pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation. Proc Natl Acad Sci USA 1998;95:11661-6.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 11661-11666
-
-
Iliopoulos, O.1
Ohh, M.2
Kaelin, W.3
-
23
-
-
0035865958
-
Endoplasmic reticulum/cytosolic localization of von Hippel-Lindau gene products is mediated by a 64-amino acid region
-
Schoenfeld A, Davidowitz E, Burk R. Endoplasmic reticulum/cytosolic localization of von Hippel-Lindau gene products is mediated by a 64-amino acid region. Int J Cancer 2001;91:457-67.
-
(2001)
Int J Cancer
, vol.91
, pp. 457-467
-
-
Schoenfeld, A.1
Davidowitz, E.2
Burk, R.3
-
24
-
-
0030948396
-
Immunostaining of the von Hippel-Lindau gene product (pVHL) in normal and neoplastic human tissues
-
Corless CL, Kibel A, Iliopoulos O, Kaelin WGJ. Immunostaining of the von Hippel-Lindau gene product (pVHL) in normal and neoplastic human tissues. Hum Pathol 1997;28:459-64.
-
(1997)
Hum Pathol
, vol.28
, pp. 459-464
-
-
Corless, C.L.1
Kibel, A.2
Iliopoulos, O.3
Kaelin, W.G.J.4
-
25
-
-
0029028652
-
Characterization of the VHL tumor suppressor gene product: Localization, complex formation, and the effect of natural inactivating mutations
-
Duan DR, Humphrey JS, Chen DYT, et al. Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations. Proc Natl Acad Sci USA 1995;92:6495-9.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 6495-6499
-
-
Duan, D.R.1
Humphrey, J.S.2
Chen, D.Y.T.3
-
26
-
-
0031869573
-
Subcellular localization of the von Hippel-Lindau disease gene product is cell cycle-dependent
-
Ye Y, Vasavada S, Kuzmin I, Stackhouse T, Zbar B, Williams B. Subcellular localization of the von Hippel-Lindau disease gene product is cell cycle-dependent. Int J Cancer 1998;78:62-9.
-
(1998)
Int J Cancer
, vol.78
, pp. 62-69
-
-
Ye, Y.1
Vasavada, S.2
Kuzmin, I.3
Stackhouse, T.4
Zbar, B.5
Williams, B.6
-
27
-
-
0344026345
-
Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein
-
Lee S, Neumann M, Stearman R, et al. Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein. Mol Cell Biol 1999;19: 1486-97.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1486-1497
-
-
Lee, S.1
Neumann, M.2
Stearman, R.3
-
28
-
-
0036314978
-
Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein
-
Groulx I, Lee S. Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein. Mol Cell Biol 2002; 22:5319-36.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5319-5336
-
-
Groulx, I.1
Lee, S.2
-
29
-
-
0034214361
-
The von Hippel-Lindau tumor suppressor targets to mitochondria
-
Shiao YH, Resau JH, Nagashima K, Anderson LM, Ramakrishna G. The von Hippel-Lindau tumor suppressor targets to mitochondria. Cancer Res 2000;60:2816-9.
-
(2000)
Cancer Res
, vol.60
, pp. 2816-2819
-
-
Shiao, Y.H.1
Resau, J.H.2
Nagashima, K.3
Anderson, L.M.4
Ramakrishna, G.5
-
30
-
-
0037307858
-
The von Hippel-Lindau tumor suppressor protein: New insights into oxygen sensing and cancer
-
Kim W, Kaelin WG Jr. The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer. Curr Opin Genet Dev 2003;13:55-60.
-
(2003)
Curr Opin Genet Dev
, vol.13
, pp. 55-60
-
-
Kim, W.1
Kaelin Jr., W.G.2
-
31
-
-
0042342564
-
The von Hippel-Lindau protein, vascular endothelial growth factor, and kidney cancer
-
George DJ, Kaelin WG Jr. The von Hippel-Lindau protein, vascular endothelial growth factor, and kidney cancer. N Engl J Med 2003;349: 419-21.
-
(2003)
N Engl J Med
, vol.349
, pp. 419-421
-
-
George, D.J.1
Kaelin Jr., W.G.2
-
32
-
-
0041465022
-
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
-
Berra E, Benizri E, Ginouves A, Volmat V, Roux D, Pouyssegur J. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J 2003;22:4082-90.
-
(2003)
EMBO J
, vol.22
, pp. 4082-4090
-
-
Berra, E.1
Benizri, E.2
Ginouves, A.3
Volmat, V.4
Roux, D.5
Pouyssegur, J.6
-
33
-
-
0037108807
-
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
-
Ivan M, Haberberger T, Gervasi DC, et al. Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proc Natl Acad Sci USA 2002;99: 13459-64.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 13459-13464
-
-
Ivan, M.1
Haberberger, T.2
Gervasi, D.C.3
-
34
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick R, McKnight S. A Conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001;294:1337-40.
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.1
McKnight, S.2
-
35
-
-
0035917313
-
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
-
Ivan M, Kondo K, Yang H, et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 2001;292:464-8.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
-
36
-
-
0035859692
-
HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation
-
Yu F, White S, Zhao Q, Lee F. HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc Natl Acad Sci USA 2001;98:9630-5.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 9630-9635
-
-
Yu, F.1
White, S.2
Zhao, Q.3
Lee, F.4
-
37
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola P, Mole D, Tian Y, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001;292:468-72.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.2
Tian, Y.3
-
38
-
-
0035941291
-
The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C
-
Okuda H, Saitoh K, Hirai S, et al. The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C. J Biol Chem 2001;276:43611-7.
-
(2001)
J Biol Chem
, vol.276
, pp. 43611-43617
-
-
Okuda, H.1
Saitoh, K.2
Hirai, S.3
-
39
-
-
0034617086
-
Inhibition of insulin-like growth factor-1-mediated cell signaling by the von Hippel-Lindau gene product in renal cancer
-
Datta K, Nambudripad R, Pal S, Zhou M, Cohen HT, Mukhopadhyay D. Inhibition of insulin-like growth factor-1-mediated cell signaling by the von Hippel-Lindau gene product in renal cancer. J Biol Chem 2000;275:20700-6.
-
(2000)
J Biol Chem
, vol.275
, pp. 20700-20706
-
-
Datta, K.1
Nambudripad, R.2
Pal, S.3
Zhou, M.4
Cohen, H.T.5
Mukhopadhyay, D.6
-
40
-
-
0035266403
-
The 104-123 amino acid sequence of the beta-domain of von Hippel-Lindau gene product is sufficient to inhibit renal tumor growth and invasion
-
Datta K, Sundberg C, Karumanchi SA, Mukhopadhyay D. The 104-123 amino acid sequence of the beta-domain of von Hippel-Lindau gene product is sufficient to inhibit renal tumor growth and invasion. Cancer Res 2001;61:1768-75.
-
(2001)
Cancer Res
, vol.61
, pp. 1768-1775
-
-
Datta, K.1
Sundberg, C.2
Karumanchi, S.A.3
Mukhopadhyay, D.4
-
41
-
-
0033600881
-
Direct interaction of the beta-domain of VHL tumor suppressor protein with the regulatory domain of atypical PKC isotypes
-
Okuda H, Hirai S, Takaki Y, et al. Direct interaction of the beta-domain of VHL tumor suppressor protein with the regulatory domain of atypical PKC isotypes. Biochem Biophys Res Commun 1999;263:491-7.
-
(1999)
Biochem Biophys Res Commun
, vol.263
, pp. 491-497
-
-
Okuda, H.1
Hirai, S.2
Takaki, Y.3
-
42
-
-
0030834249
-
The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity
-
Mukhopadhyay D, Knebelmann B, Cohen H, Ananth S, Sukhatme V. The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity. Mol Cell Biol 1997;17:5629-39.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 5629-5639
-
-
Mukhopadhyay, D.1
Knebelmann, B.2
Cohen, H.3
Ananth, S.4
Sukhatme, V.5
-
43
-
-
17144445958
-
An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association
-
Cohen H, Zhou M, Welsh A, et al. An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association. Biochem Biophys Res Commun 1999;266:43-50.
-
(1999)
Biochem Biophys Res Commun
, vol.266
, pp. 43-50
-
-
Cohen, H.1
Zhou, M.2
Welsh, A.3
-
44
-
-
0035955745
-
The von Hippel-Lindau protein interacts with heteronuclear ribonucleoprotein a2 and regulates its expression
-
Pioli PA, Rigby WF. The von Hippel-Lindau protein interacts with heteronuclear ribonucleoprotein a2 and regulates its expression. J Biol Chem 2001;276:40346-52.
-
(2001)
J Biol Chem
, vol.276
, pp. 40346-40352
-
-
Pioli, P.A.1
Rigby, W.F.2
-
45
-
-
0344838401
-
Von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination
-
Kuznetsova AV, Meller J, Schnell PO, et al. von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination. Proc Natl Acad Sci USA 2003;100:2706-11.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 2706-2711
-
-
Kuznetsova, A.V.1
Meller, J.2
Schnell, P.O.3
-
46
-
-
0042466570
-
Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel-Lindau protein
-
Na X, Duan HO, Messing EM, et al. Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel-Lindau protein. EMBO J 2003;22:4249-59.
-
(2003)
EMBO J
, vol.22
, pp. 4249-4259
-
-
Na, X.1
Duan, H.O.2
Messing, E.M.3
-
47
-
-
0037131189
-
The von Hippel-Lindau (VHL) tumor suppressor stabilizes novel PHD protein Jade-1
-
Zhou MI, Wang H, Ross JJ, Kuzmin I, Xu C, Cohen HT. The von Hippel-Lindau (VHL) tumor suppressor stabilizes novel PHD protein Jade-1. J Biol Chem 2002;277:39887-98.
-
(2002)
J Biol Chem
, vol.277
, pp. 39887-39898
-
-
Zhou, M.I.1
Wang, H.2
Ross, J.J.3
Kuzmin, I.4
Xu, C.5
Cohen, H.T.6
-
48
-
-
0036290499
-
Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor
-
Li Z, Wang D, Na X, Schoen SR, Messing EM, Wu G. Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor. Biochem Biophys Res Commun 2002; 294:700-9.
-
(2002)
Biochem Biophys Res Commun
, vol.294
, pp. 700-709
-
-
Li, Z.1
Wang, D.2
Na, X.3
Schoen, S.R.4
Messing, E.M.5
Wu, G.6
-
49
-
-
0037085456
-
Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein
-
Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G. Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J Biol Chem 2002;277:4656-62.
-
(2002)
J Biol Chem
, vol.277
, pp. 4656-4662
-
-
Li, Z.1
Na, X.2
Wang, D.3
Schoen, S.R.4
Messing, E.M.5
Wu, G.6
-
50
-
-
0032085240
-
The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix
-
Ohh M, Yauch RL, Lonergan KM, et al. The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol Cell 1998;1:959-68.
-
(1998)
Mol Cell
, vol.1
, pp. 959-968
-
-
Ohh, M.1
Yauch, R.L.2
Lonergan, K.M.3
-
51
-
-
0032211360
-
Von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids
-
Lieubeau-Teillet B, Rak J, Jothy S, Iliopoulos O, Kaelin W, Kerbel R. von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids. Cancer Res 1998;58:4957-62.
-
(1998)
Cancer Res
, vol.58
, pp. 4957-4962
-
-
Lieubeau-Teillet, B.1
Rak, J.2
Jothy, S.3
Iliopoulos, O.4
Kaelin, W.5
Kerbel, R.6
-
52
-
-
0037223823
-
Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL
-
Hergovich A, Lisztwan J, Barry R, Ballschmieter P, Krek W. Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL. Nat Cell Biol 2003;5:64-70.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 64-70
-
-
Hergovich, A.1
Lisztwan, J.2
Barry, R.3
Ballschmieter, P.4
Krek, W.5
-
53
-
-
0036528246
-
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
-
Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 2002;1:237-46.
-
(2002)
Cancer Cell
, vol.1
, pp. 237-246
-
-
Kondo, K.1
Klco, J.2
Nakamura, E.3
Lechpammer, M.4
Kaelin, W.G.5
-
54
-
-
2342597973
-
Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth
-
Kondo K, Kim WY, Lechpammer M, Kaelin WG Jr. Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth. PLoS Biol 2003;1:E83.
-
(2003)
PLoS Biol
, vol.1
-
-
Kondo, K.1
Kim, W.Y.2
Lechpammer, M.3
Kaelin Jr., W.G.4
-
55
-
-
0036527785
-
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma
-
Maranchie JK, Vasselli JR, Riss J, Bonifacino JS, Linehan WM, Klausner RD. The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell 2002;1:247-55.
-
(2002)
Cancer Cell
, vol.1
, pp. 247-255
-
-
Maranchie, J.K.1
Vasselli, J.R.2
Riss, J.3
Bonifacino, J.S.4
Linehan, W.M.5
Klausner, R.D.6
-
56
-
-
1342280515
-
Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors
-
Zimmer M, Doucette D, Siddiqui N, Iliopoulos O. Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors. Mol Cancer Res 2004;2:89-95.
-
(2004)
Mol Cancer Res
, vol.2
, pp. 89-95
-
-
Zimmer, M.1
Doucette, D.2
Siddiqui, N.3
Iliopoulos, O.4
-
57
-
-
1542577673
-
Rhebbing up mTOR: New insights on TSC1 and TSC2, and the pathogenesis of tuberous sclerosis
-
Kwiatkowski DJ. Rhebbing up mTOR: new insights on TSC1 and TSC2, and the pathogenesis of tuberous sclerosis. Cancer Biol. Ther 2003;2:471-6.
-
(2003)
Cancer Biol Ther
, vol.2
, pp. 471-476
-
-
Kwiatkowski, D.J.1
-
58
-
-
0033559663
-
Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice
-
Kobayashi T, Minowa O, Kuno J, Mitani H, Hino O, Noda T. Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice. Cancer Res 1999;59: 1206-11.
-
(1999)
Cancer Res
, vol.59
, pp. 1206-1211
-
-
Kobayashi, T.1
Minowa, O.2
Kuno, J.3
Mitani, H.4
Hino, O.5
Noda, T.6
-
59
-
-
0032741978
-
Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background
-
Onda H, Lueck A, Marks PW, Warren HB, Kwiatkowski DJ. Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. J Clin Invest 1999;104:687-95.
-
(1999)
J Clin Invest
, vol.104
, pp. 687-695
-
-
Onda, H.1
Lueck, A.2
Marks, P.W.3
Warren, H.B.4
Kwiatkowski, D.J.5
-
60
-
-
0038662963
-
Renal carcinogenesis: Genotype, phenotype and dramatype
-
Hino O, Kobayashi T, Momose S, Kikuchi Y, Adachi H, Okimoto K. Renal carcinogenesis: genotype, phenotype and dramatype. Cancer Sci 2003;94:142-7.
-
(2003)
Cancer Sci
, vol.94
, pp. 142-147
-
-
Hino, O.1
Kobayashi, T.2
Momose, S.3
Kikuchi, Y.4
Adachi, H.5
Okimoto, K.6
-
61
-
-
0041920901
-
TSC2 regulates VEGF through mTOR-dependent and -independent pathways
-
Brugarolas JB, Vazquez F, Reddy A, Sellers WR, Kaelin WG Jr. TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell 2003;4:147-58.
-
(2003)
Cancer Cell
, vol.4
, pp. 147-158
-
-
Brugarolas, J.B.1
Vazquez, F.2
Reddy, A.3
Sellers, W.R.4
Kaelin Jr., W.G.5
-
62
-
-
0037842275
-
Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene
-
Liu M, Poellinger L, Walker C. Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene. Cancer Res 2003;63:2675-80.
-
(2003)
Cancer Res
, vol.63
, pp. 2675-2680
-
-
Liu, M.1
Poellinger, L.2
Walker, C.3
-
63
-
-
0036789574
-
Regulation of hypoxia-inducible factor lalpha expression and function by the mammalian target of rapamycin
-
Hudson CC, Liu M, Chiang GG, et al. Regulation of hypoxia-inducible factor lalpha expression and function by the mammalian target of rapamycin. Mol Cell Biol 2002;22:7004-14.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7004-7014
-
-
Hudson, C.C.1
Liu, M.2
Chiang, G.G.3
-
64
-
-
0042031047
-
A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets
-
Arsham AM, Howell JJ, Simon MC. A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J Biol Chem 2003;278:29655-60.
-
(2003)
J Biol Chem
, vol.278
, pp. 29655-29660
-
-
Arsham, A.M.1
Howell, J.J.2
Simon, M.C.3
-
65
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
Zhong H, Chiles K, Feldser D, et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000;60:1541-5.
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
-
66
-
-
0141705466
-
Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin
-
El-Hashemite N, Walker V, Zhang H, Kwiatkowski DJ. Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin. Cancer Res 2003;63:5173-7.
-
(2003)
Cancer Res
, vol.63
, pp. 5173-5177
-
-
El-Hashemite, N.1
Walker, V.2
Zhang, H.3
Kwiatkowski, D.J.4
-
67
-
-
0036219609
-
Hsp90 inhibitors as novel cancer chemotherapeutic agents
-
Neckers L. Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol. Med 2002;8:S55-61.
-
(2002)
Trends Mol Med
, vol.8
-
-
Neckers, L.1
-
68
-
-
0035048449
-
Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes
-
Kim MS, Kwon HJ, Lee YM, et al. Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nat Med 2001;7:437-43.
-
(2001)
Nat Med
, vol.7
, pp. 437-443
-
-
Kim, M.S.1
Kwon, H.J.2
Lee, Y.M.3
-
69
-
-
1242271198
-
Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: Mechanism and therapeutic implications
-
Rapisarda A, Uranchimeg B, Sordet O, Pommier Y, Shoemaker RH, Melillo G. Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. Cancer Res 2004;64:1475-82.
-
(2004)
Cancer Res
, vol.64
, pp. 1475-1482
-
-
Rapisarda, A.1
Uranchimeg, B.2
Sordet, O.3
Pommier, Y.4
Shoemaker, R.H.5
Melillo, G.6
-
70
-
-
0036682284
-
Identification of small molecule inhibitors of hypoxia-inducible factor I transcriptional activation pathway
-
Rapisarda A, Uranchimeg B, Scudiero DA, et al. Identification of small molecule inhibitors of hypoxia-inducible factor I transcriptional activation pathway. Cancer Res 2002;62:4316-24.
-
(2002)
Cancer Res
, vol.62
, pp. 4316-4324
-
-
Rapisarda, A.1
Uranchimeg, B.2
Scudiero, D.A.3
-
71
-
-
0142144338
-
The thioredoxin redox inhibitors I-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation
-
Welsh SJ, Williams RR, Birmingham A, Newman DJ, Kirkpatrick DL, Powis G. The thioredoxin redox inhibitors I-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation. Mol Cancer Ther 2003;2:235-43.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 235-243
-
-
Welsh, S.J.1
Williams, R.R.2
Birmingham, A.3
Newman, D.J.4
Kirkpatrick, D.L.5
Powis, G.6
-
72
-
-
4444369682
-
Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha
-
Welsh S, Williams R, Kirkpatrick L, Paine-Murrieta G, Powis G. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Mol Cancer Ther 2004;3: 233-44.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 233-244
-
-
Welsh, S.1
Williams, R.2
Kirkpatrick, L.3
Paine-Murrieta, G.4
Powis, G.5
-
73
-
-
10744231706
-
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
-
Mabjeesh NJ, Escuin D, LaVallee TM, et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF Cancer Cell 2003;3:363-75.
-
(2003)
Cancer Cell
, vol.3
, pp. 363-375
-
-
Mabjeesh, N.J.1
Escuin, D.2
LaVallee, T.M.3
-
74
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
-
Mendel DB, Laird AD, Xin X, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 2003;9:327-37.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 327-337
-
-
Mendel, D.B.1
Laird, A.D.2
Xin, X.3
-
76
-
-
0034282515
-
Effects of PTK787/ZK 222584, a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinases, on primary tumor, metastasis, vessel density, and blood flow in a murine renal cell carcinoma model
-
Drevs J, Hofmann I, Hugenschmidt H, et al. Effects of PTK787/ZK 222584, a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinases, on primary tumor, metastasis, vessel density, and blood flow in a murine renal cell carcinoma model. Cancer Res 2000; 60:4819-24.
-
(2000)
Cancer Res
, vol.60
, pp. 4819-4824
-
-
Drevs, J.1
Hofmann, I.2
Hugenschmidt, H.3
-
77
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
-
Yang J, Haworth L, Sherry R, et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003;349:427-34.
-
(2003)
N Engl J Med
, vol.349
, pp. 427-434
-
-
Yang, J.1
Haworth, L.2
Sherry, R.3
-
78
-
-
0038476608
-
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
-
Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003;111:1287-95.
-
(2003)
J Clin Invest
, vol.111
, pp. 1287-1295
-
-
Bergers, G.1
Song, S.2
Meyer-Morse, N.3
Bergsland, E.4
Hanahan, D.5
-
79
-
-
0032952010
-
Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
-
Benjamin LE, Golijanin D, Itin A, Pode D, Keshet E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 1999;103: 159-65.
-
(1999)
J Clin Invest
, vol.103
, pp. 159-165
-
-
Benjamin, L.E.1
Golijanin, D.2
Itin, A.3
Pode, D.4
Keshet, E.5
-
80
-
-
0031964099
-
Transforming growth factor alpha is a target for the von Hippel-Lindau tumor suppressor
-
Knebelmann B, Ananth S, Cohen H, Sukhatme V. Transforming growth factor alpha is a target for the von Hippel-Lindau tumor suppressor. Cancer Res 1998;58:226-31.
-
(1998)
Cancer Res
, vol.58
, pp. 226-231
-
-
Knebelmann, B.1
Ananth, S.2
Cohen, H.3
Sukhatme, V.4
-
81
-
-
0035852630
-
Role of transforming growth factor-alpha in VHL-/- clear cell renal carcinoma cell proliferation: A possible mechanism coupling von Hippel-Lindau tumor suppressor inactivation and tumorigenesis
-
de Paulsen N, Brychzy A, Fournier M-C, et al. Role of transforming growth factor-alpha in VHL-/- clear cell renal carcinoma cell proliferation: a possible mechanism coupling von Hippel-Lindau tumor suppressor inactivation and tumorigenesis. Proc Natl Acad Sci USA 2001; 13:1387-92.
-
(2001)
Proc Natl Acad Sci USA
, vol.13
, pp. 1387-1392
-
-
De Paulsen, N.1
Brychzy, A.2
Fournier, M.-C.3
-
82
-
-
0033995015
-
Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor
-
Sweeney W, Chen Y, Nakanishi K, Frost P, Avner E. Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor. Kidney Int 2000;57:33-40.
-
(2000)
Kidney Int
, vol.57
, pp. 33-40
-
-
Sweeney, W.1
Chen, Y.2
Nakanishi, K.3
Frost, P.4
Avner, E.5
-
83
-
-
0028501443
-
Renal cysts in transgenic mice expressing transforming growth factor-alpha
-
Lowden D, Lindemann G, Merlino G, Barash B, Calvet J, Gattone V. n. Renal cysts in transgenic mice expressing transforming growth factor-alpha. J Lab Clin Med 1994;124:386-94.
-
(1994)
J Lab Clin Med
, vol.124
, pp. 386-394
-
-
Lowden, D.1
Lindemann, G.2
Merlino, G.3
Barash, B.4
Calvet, J.5
Gattone, V.6
-
84
-
-
0035852668
-
Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor
-
Haase V, Glickman J, Socolovsky M, Jaenisch R. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Natl Acad Sci USA 2001;98:1583-8.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 1583-1588
-
-
Haase, V.1
Glickman, J.2
Socolovsky, M.3
Jaenisch, R.4
-
85
-
-
0141816848
-
Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene
-
Ma W, Tessarollo L, Hong SB, et al. Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene. Cancer Res 2003;63: 5320-8.
-
(2003)
Cancer Res
, vol.63
, pp. 5320-5328
-
-
Ma, W.1
Tessarollo, L.2
Hong, S.B.3
-
86
-
-
0037120977
-
VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma
-
Yao M, Yoshida M, Kishida T, et al. VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma. J Natl Cancer Inst 2002;94:1569-75.
-
(2002)
J Natl Cancer Inst
, vol.94
, pp. 1569-1575
-
-
Yao, M.1
Yoshida, M.2
Kishida, T.3
-
87
-
-
0032514685
-
Down-regulation of transmembrance carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes
-
Ivanov S, Kuzmin I, Wei M-H, et al. Down-regulation of transmembrance carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes. Proc Natl Acad Sci USA 1998;95:12596-601.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 12596-12601
-
-
Ivanov, S.1
Kuzmin, I.2
Wei, M.-H.3
-
88
-
-
0034676331
-
Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
-
Krieg M, Haas R, Brauch H, Acker T, Flamme I, Plate K. Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function. Oncogene 2000;19:5435-43.
-
(2000)
Oncogene
, vol.19
, pp. 5435-5443
-
-
Krieg, M.1
Haas, R.2
Brauch, H.3
Acker, T.4
Flamme, I.5
Plate, K.6
-
89
-
-
0035394516
-
Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1 alpha in clear cell renal carcinomas
-
Wiesener M, Munchenhagen P, Berger I, et al. Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1 alpha in clear cell renal carcinomas. Cancer Res 2001; 61:5215-22.
-
(2001)
Cancer Res
, vol.61
, pp. 5215-5222
-
-
Wiesener, M.1
Munchenhagen, P.2
Berger, I.3
-
90
-
-
0035107383
-
Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer
-
Ivanov S, Liao SY, Ivanova A, et al. Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. Am J Pathol 2001;158:905-19.
-
(2001)
Am J Pathol
, vol.158
, pp. 905-919
-
-
Ivanov, S.1
Liao, S.Y.2
Ivanova, A.3
-
91
-
-
0034671307
-
Hypoxia-inducible expression of tumor-associated carbonic anhydrases
-
Wykoff CC, Beasley NJ, Watson PH, et al. Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res 2000; 60:7075-83.
-
(2000)
Cancer Res
, vol.60
, pp. 7075-7083
-
-
Wykoff, C.C.1
Beasley, N.J.2
Watson, P.H.3
-
92
-
-
2442665663
-
Gleevec: Prototype or outlier?
-
2004
-
Kaelin WG Jr. Gleevec: prototype or outlier? Sci STKE, 2004: PE12. 2004.
-
(2004)
Sci STKE
-
-
Kaelin Jr., W.G.1
|