The von Hippel-Lindau Tumor Suppressor Protein Mediates Ubiquitination of Activated Atypical Protein Kinase C

Journal of Biological Chemistry

Volumn 276, Issue 47, 2001, Pages 43611-43617

  Okuda, Heiwa ^a   Saitoh, Kojiro ^b   Hirai, Syu Ichi ^c   Iwai, Kazuhiro ^b,d   Takaki, Yasuyuki ^a   Baba, Masaya ^c   Minato, Nagahiro ^b   Ohno, Shigeo ^c   Shuin, Taro ^a  

^a KOCHI MEDICAL SCHOOL   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

^d OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DEGRADATION; TUMORS;

CELL POLARITY;

PROTEINS;

ELONGATION FACTOR; ELONGIN B; ELONGIN C; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN; PROTEIN CUL2; PROTEIN KINASE C; PROTEIN RBX1; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; ISOENZYME; LIGASE; MULTIENZYME COMPLEX; PROTEASOME; PROTEIN KINASE C LAMBDA; VHL PROTEIN, HUMAN;

ALPHA CHAIN; ARTICLE; CELL FREE SYSTEM; CELL GROWTH; CELL POLARITY; CELL STIMULATION; COMPLEX FORMATION; ENZYME ACTIVATION; ENZYME DEGRADATION; GENETIC HETEROGENEITY; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; TARGET CELL; TUMOR SUPPRESSOR GENE; VON HIPPEL LINDAU DISEASE; CELL LINE; DRUG EFFECT; HYDROLYSIS; METABOLISM; PHYSIOLOGY; PROTEIN BINDING;

CELL LINE; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ENZYME ACTIVATION; HIPPEL-LINDAU DISEASE; HUMANS; HYDROLYSIS; ISOENZYMES; LIGASES; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN KINASE C; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 0035941291     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M107880200     Document Type: Article

References (39)

1. Kaelin, W. G., and Maher, E. R. (1998) Trends Genet. 14, 423-426
2. Pause, A., Lee, S., Worrell, R. A., Chen, D. Y. T., Burgess, W. H., Linehan, W. M., and Klausner, R. D. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 2156-2161
3. Kamura, T., Koepp, D. M., Conrad, M. N., Skowyra, D., Morel, R. J., Iliopoulos, O., Lane, W. S., Kaelin, W. G., Elledge, S. J., Conaway, R. C., Harper, J. W., and Conaway, J. W. (1999) Science 284, 657-661
4. Iwai, K., Yamanaka, K., Kamura, T., Minato, N., Conaway, R. C., Conaway, J. W., Klausner, R. D., and Pause, A. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 12436-12441
5. Patton, E. E., Willems, A. R., and Tyers, M. (1998) Trends Genet. 14, 236-243
6. Maxwell, P. H., Wiesener, M. S., Chang, G. W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., and Ratcliffe, P. J. (1999) Nature 399, 271-275
7. Ohh, M., Park, C. W., Ivan, M., Hoffman, M. A., Kim, T. Y., Huang, L. E., Pavletich, N., Chau, V., and Kaelin, W. G. (2000) Nat. Cell Biol. 2, 423-427
8. Cockman, M. E., Masson, N., Mole, D. R., Jaakkola, P., Chang, G. W., Clifford, S. C., Maher, E. R., Pugh, C. W., Ratcliffe, P. J., and Maxwell, P. H. (2000) J. Biol. Chem. 275, 25733-25741
9. Tanimoto, K., Makino, Y., Pereira, T., and Poellinger, L. (2000) EMBO J. 19, 4298-4309
10. Kamura, T., Sato, S., Iwai, K., Czyzyk-Krzeska, M., Conaway, R. C., and Conaway, J. W. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 10430-10435
11. Chen, F., Kishida, T., Duh, F. M., Renbaum, P., Orcutt, M. L., Schmidt, L., and Zbar, B. (1995) Cancer Res. 55, 4804-4807
12. Baba, M., Hirai, S., Kawakami, S., Kishida, T., Sakai, N., Kaneko, S., Yao, M., Shuin, T., Kubota, Y., Hosaka, M., and Ohno, S. (2001) Oncogene 20, 2727-2736
13. Kamada, M., Suzuki, K., Kato, Y., Okuda, H., and Shuin, T. (2001) Cancer Res. 61, 4184-4189
14. Ohh, M., Yauch, R. L., Lonergan, K. M., Whaley, J. M., Stemmer-Rachamimov, A. O., Louis, D. N., Gavin, B. J., Kley, N., Kaelin, W. G., and Iliopoulos, O. (1998) Mol. Cell 1, 959-968
15. Mukhopadhyay, D., Knebelmann, B., Cohen, H. T., Ananth, S., and Sukhatme, V. P. (1997) Mol. Cell. Biol. 17, 5629-5639
16. Pal, S., Claffey, K. P., Dvorak, H. F., and Mukhopadhyay, D. (1997) J. Biol. Chem. 272, 27509-27512
17. Okuda, H., Hirai, S., Takaki, Y., Kamada, M., Baba, M., Sakai, N., Kishida, T., Kaneko, S., Yao, M., Ohno, S., and Shuin, T. (1999) Biochem. Biophys. Res. Commun. 263, 491-497
18. Nishizuka, Y. (1995) FASEB J. 9, 484-496
19. Berra, E., Municio, M. M., Sanz, L., Frutos, S., Diaz-Meco, M. T., and Moscat, J. (1997) Mol. Cell. Biol. 17, 4346-4354
20. Diaz-Meco, M. T., Municio, M. M., Frutos, S., Sanchez, P., Lozano, J., Sanz, L., and Moscat, J. (1996) Cell 86, 777-786
21. Izumi, Y., Hirose, T., Tamai, Y., Hirai, S., Nagashima, Y., Fujimoto, T., Tabuse, Y., Kemphues, K. J., and Ohno, S. (1998) J. Cell Biol. 143, 95-106
22. Joberty, G., Petersen, C., Gao, L., and Macara, I. G. (2000) Nat. Cell Biol. 2, 531-539
23. Lin, D., Edwards, A. S., Fawcett, J. P., Mbamalu, G., Scott, J. D., and Pawson, T. (2000) Nat. Cell Biol. 2, 540-547
24. Petronczki, M., and Knoblich, J. A. (2001) Nat. Cell Biol. 3, 43-49
25. Suzuki, A., Yamanaka, T., Hirose, T., Manabe, N., Mizuno, K., Shimizu, M., Akimoto, K., Izumi, Y., Ohnishi, T., and Ohno, S. (2001) J. Cell Biol. 152, 1183-1196
26. Yamanaka, T., Horikoshi, Y., Suzuki, A., Sugiyama, Y., Kitamura, K., Maniwa, R., Nagai, Y., Yamashita, A., Hirose, T., Ishikawa, H., and Ohno, S. (2001) Genes Cells 6, 721-731
27. Akimoto, K., Nakaya, M., Yamanaka, T., Tanaka, J., Matsuda, S., Weng, Q. P., Avruch, J., and Ohno, S. (1998) Biochem. J. 335, 417-424
28. Akimoto, K., Mizuno, K., Osada, S., Hirai, S., Tanuma, S., Suzuki, K., and Ohno, S. (1994) J. Biol. Chem. 269, 12677-12683
29. Stebbins, C. E., Kaelin, W. G., and Pavletich, N. P. (1999) Science 284, 455-461
30. Akimoto, K., Takahashi, R., Moriya, S., Nishioka, N., Takayanagi, J., Kimura, K., Fukui, Y., Osada, S., Mizuno, K., Hirai, S., Kazlauskas, A., and Ohno, S. (1996) EMBO J. 15, 788-798
31. Hershko, A., and Ciechanover, A. (1998) Annu. Rev. Biochem. 67, 425-479
32. Nakanishi, H., Brewer, K. A., and Exton, J. H. (1993) J. Biol. Chem. 268, 13-16
33. Le Good, J. A., Ziegler, W. H., Parekh, D. B., Alessi, D. R., Cohen, P., and Parker, P. J. (1998) Science 281, 2042-2045
34. Lu, Z., Liu, D., Hornia, A., Devonish, W., Pagano, M., and Foster, D. A. (1998) Mol. Cell. Biol. 18, 839-845
35. Maniatis, T. (1999) Genes Dev. 13, 505-510
36. Carrano, A. C., Eytan, E., Hershko, A., and Pagano, M. (1999) Nat. Cell Biol. 1, 193-199
37. Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., and Kaelin, W. G. (2001) Science 292, 464-468
38. Jaakkola, P., Mole, D. R., Tian, Y. M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., Maxwell, P. H., Pugh, C. W., and Ratcliffe, P. J. (2001) Science 292, 468-472
39. Coghlan, M. P., Chou, M. M., and Carpenter, C. L. (2000) Mol. Cell. Biol. 20, 2880-2889