-
1
-
-
0025730640
-
A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
-
Andrews NC, Faller DV. 1991. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res 19:2499.
-
(1991)
Nucleic Acids Res
, vol.19
, pp. 2499
-
-
Andrews, N.C.1
Faller, D.V.2
-
2
-
-
0041465022
-
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
-
Berra E, Benizri E, Ginouves A, Volmat V, Roux D, Pouyssegur J. 2003. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J 22:4082-4090.
-
(2003)
EMBO J
, vol.22
, pp. 4082-4090
-
-
Berra, E.1
Benizri, E.2
Ginouves, A.3
Volmat, V.4
Roux, D.5
Pouyssegur, J.6
-
3
-
-
0032053823
-
The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
-
Brown JM, Giaccia AJ. 1998. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res 58:1408-1416.
-
(1998)
Cancer Res
, vol.58
, pp. 1408-1416
-
-
Brown, J.M.1
Giaccia, A.J.2
-
4
-
-
0242330181
-
Oxygen sensing in the hypoxic response pathway: Regulation of the hypoxia-inducible transcription factor
-
Bruick RK. 2003. Oxygen sensing in the hypoxic response pathway: Regulation of the hypoxia-inducible transcription factor. Genes Dev 17:2614-2623.
-
(2003)
Genes Dev
, vol.17
, pp. 2614-2623
-
-
Bruick, R.K.1
-
5
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick RK, McKnight SL. 2001. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294:1337-1340.
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
6
-
-
0037131271
-
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1 alpha
-
Chan DA, Sutphin PD, Denko NC, Giaccia AJ. 2002. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1 alpha. J Biol Chem 277:40112-40117.
-
(2002)
J Biol Chem
, vol.277
, pp. 40112-40117
-
-
Chan, D.A.1
Sutphin, P.D.2
Denko, N.C.3
Giaccia, A.J.4
-
7
-
-
0037432686
-
Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells
-
Cioffi CL, Liu XQ, Kosinski PA, Garay M, Bowen BR. 2003. Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells. Biochem Biophys Res Commun 303:947-953.
-
(2003)
Biochem Biophys Res Commun
, vol.303
, pp. 947-953
-
-
Cioffi, C.L.1
Liu, X.Q.2
Kosinski, P.A.3
Garay, M.4
Bowen, B.R.5
-
8
-
-
0030713446
-
Activator-protein-1 binding potentiates the hypoxia-induciblefactor-1- mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells
-
Damert A, Ikeda E, Risau W. 1997. Activator-protein-1 binding potentiates the hypoxia-induciblefactor-1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells. Biochem J 327:419-423.
-
(1997)
Biochem J
, vol.327
, pp. 419-423
-
-
Damert, A.1
Ikeda, E.2
Risau, W.3
-
9
-
-
1542300383
-
The von Hippel Lindau/Hypoxia inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase to low oxygen
-
del Peso L, Castellanos MC, Temes E, Martin-Puig S, Cuevas Y, Olmos G, Landazuri MO. 2003. The von Hippel Lindau/Hypoxia inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase to low oxygen. J Biol Chem 278:48690-48695.
-
(2003)
J Biol Chem
, vol.278
, pp. 48690-48695
-
-
Del Peso, L.1
Castellanos, M.C.2
Temes, E.3
Martin-Puig, S.4
Cuevas, Y.5
Olmos, G.6
Landazuri, M.O.7
-
10
-
-
0031835957
-
Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein
-
Ebert BL, Bunn HF. 1998. Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein. Mol Cell Biol 18:4089-4096.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 4089-4096
-
-
Ebert, B.L.1
Bunn, H.F.2
-
11
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson M, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. 2001. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107:43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
Mukherji, M.7
Metzen, E.8
Wilson, M.I.9
Dhanda, A.10
Tian, Y.M.11
Masson, M.12
Hamilton, D.L.13
Jaakkola, P.14
Barstead, R.15
Hodgkin, J.16
Maxwell, P.H.17
Pugh, C.W.18
Schofield, C.J.19
Ratcliffe, P.J.20
more..
-
13
-
-
0043234538
-
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
-
Hirsila M, Koivunen P, Gunzler V, Kivirikko KI, Myllyharju J. 2003. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem 278:30772-30780.
-
(2003)
J Biol Chem
, vol.278
, pp. 30772-30780
-
-
Hirsila, M.1
Koivunen, P.2
Gunzler, V.3
Kivirikko, K.I.4
Myllyharju, J.5
-
14
-
-
0030069177
-
Hypoxia and radiation response in human tumors
-
Hockel M, Schlenger K, Mitze M, Schaffer U, Vaupel P. 1996. Hypoxia and radiation response in human tumors. Semin Radiat Oncol 6:3-9.
-
(1996)
Semin Radiat Oncol
, vol.6
, pp. 3-9
-
-
Hockel, M.1
Schlenger, K.2
Mitze, M.3
Schaffer, U.4
Vaupel, P.5
-
15
-
-
0037490210
-
Hypoxia-inducible factor and its biomedical relevance
-
Huang LE, Bunn HF. 2003. Hypoxia-inducible factor and its biomedical relevance. J Biol Chem 278:19575-19578.
-
(2003)
J Biol Chem
, vol.278
, pp. 19575-19578
-
-
Huang, L.E.1
Bunn, H.F.2
-
16
-
-
0029753008
-
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
-
Huang LE, Arany Z, Livingston DM, Bunn HF. 1996. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem 271:32253-32259.
-
(1996)
J Biol Chem
, vol.271
, pp. 32253-32259
-
-
Huang, L.E.1
Arany, Z.2
Livingston, D.M.3
Bunn, H.F.4
-
17
-
-
0032493368
-
Regulation of hypoxia-inducible factor 1alpha is mediated by an U2-dependent degradation domain via the ubuquitin-proteasome pathway
-
Huang LE, Gu J, Schau M, Bunn HF. 1998. Regulation of hypoxia-inducible factor 1alpha is mediated by an U2-dependent degradation domain via the ubuquitin-proteasome pathway. Proc Natl Acad Sci USA 95:7987-7992.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 7987-7992
-
-
Huang, L.E.1
Gu, J.2
Schau, M.3
Bunn, H.F.4
-
18
-
-
0037131159
-
Sequence determinants in hypoxia-inducible factor-1 alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2 and PHD3
-
Huang J, Zhao Q, Mooney SM, Lee FS. 2002. Sequence determinants in hypoxia-inducible factor-1 alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2 and PHD3. J Biol Chem 277:39792-39800.
-
(2002)
J Biol Chem
, vol.277
, pp. 39792-39800
-
-
Huang, J.1
Zhao, Q.2
Mooney, S.M.3
Lee, F.S.4
-
19
-
-
0037119415
-
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway
-
Isaacs JS, Yung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM. 2002. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. J Biol Chem 277:29936-29944.
-
(2002)
J Biol Chem
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
Yung, Y.J.2
Mimnaugh, E.G.3
Martinez, A.4
Cuttitta, F.5
Neckers, L.M.6
-
20
-
-
0035917313
-
2 sensing
-
2 sensing. Science 292:464-468.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
21
-
-
0037108807
-
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
-
Ivan M, Haberberger T, Gervasi DC, Mickelson KS, Gunzler V, Kondo K, Yang H, Sorokina I, Canaway RC, Conaway JW, Kaelin WJ, Jr. 2002. Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proc Natl Acad Sci USA 99:13459-13464.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 13459-13464
-
-
Ivan, M.1
Haberberger, T.2
Gervasi, D.C.3
Mickelson, K.S.4
Gunzler, V.5
Kondo, K.6
Yang, H.7
Sorokina, I.8
Canaway, R.C.9
Conaway, J.W.10
Kaelin Jr., W.J.11
-
22
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation. Science 292:468-472.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Von Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Scholield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
23
-
-
0033975850
-
Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: Control of hypoxia-inducible factor-1 activity by nitric oxide
-
Kimura H, Weisz A, Kurashima Y, Hashimoto K, Ogura T, D'Acquisto F, Addeo R, Makuuchi M, Esumi H. 2000. Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: Control of hypoxia-inducible factor-1 activity by nitric oxide. Blood 95:189-197.
-
(2000)
Blood
, vol.95
, pp. 189-197
-
-
Kimura, H.1
Weisz, A.2
Kurashima, Y.3
Hashimoto, K.4
Ogura, T.5
D'Acquisto, F.6
Addeo, R.7
Makuuchi, M.8
Esumi, H.9
-
24
-
-
0036210708
-
The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent
-
Laderoute KR, Calaoagan JM, Gustafson-Brown C, Knapp AM, Li G-C, Mendonca HL, Ryan HE, Wang Z, Johnson RS. 2002. The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent. Mol Cell Biol 22:2515-2023.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2515-12023
-
-
Laderoute, K.R.1
Calaoagan, J.M.2
Gustafson-Brown, C.3
Knapp, A.M.4
Li, G.-C.5
Mendonca, H.L.6
Ryan, H.E.7
Wang, Z.8
Johnson, R.S.9
-
25
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch
-
Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML. 2002a. Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch. Science 295:858-861.
-
(2002)
Science
, vol.295
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
26
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK. 2002b. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 16:1466-1471.
-
(2002)
Genes Dev
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
27
-
-
0036433394
-
Mammalian EGLN genes have distinct patterns of mRNA expression and regulation
-
Lieb ME, Menzies K, Moschella MC, Ni R, Taubman MB. 2002. Mammalian EGLN genes have distinct patterns of mRNA expression and regulation. Biochem Cell Biol 80:421-426.
-
(2002)
Biochem Cell Biol
, vol.80
, pp. 421-426
-
-
Lieb, M.E.1
Menzies, K.2
Moschella, M.C.3
Ni, R.4
Taubman, M.B.5
-
28
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon PC, Hirota K, Semenza GL. 2001. FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15:2675-2686.
-
(2001)
Genes Dev
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
29
-
-
0036527785
-
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma
-
Maranchie JK, Vasselli JR, Riss J, Bonifacino JS, Linehan WM, Klausner RD. 2002. The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell 1:247-255.
-
(2002)
Cancer Cell
, vol.1
, pp. 247-255
-
-
Maranchie, J.K.1
Vasselli, J.R.2
Riss, J.3
Bonifacino, J.S.4
Linehan, W.M.5
Klausner, R.D.6
-
30
-
-
0027461553
-
Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines: Evidence for a widespread oxygen-sensing mechanism
-
Maxwell PH, Pugh CW, Ratcliffe PJ. 1993. Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines: Evidence for a widespread oxygen-sensing mechanism. Proc Natl Acad Sci USA 90:2423-2427.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 2423-2427
-
-
Maxwell, P.H.1
Pugh, C.W.2
Ratcliffe, P.J.3
-
31
-
-
0037386143
-
Intracellular localisation of human HIF-1 alpha hydroxylases: Implications for oxygen sensing
-
Metzen E, Berchner-pfannschmidt U, Stengel P, Marxsen JH, Stolze I, Kalinger M, Huang QW, Wotzlaw C, Hellwig-Burgel T, Jelkmann W, Acker H, Fandrey J. 2003. Intracellular localisation of human HIF-1 alpha hydroxylases: Implications for oxygen sensing. J Cell Sci 116:1319-1326.
-
(2003)
J Cell Sci
, vol.116
, pp. 1319-1326
-
-
Metzen, E.1
Berchner-Pfannschmidt, U.2
Stengel, P.3
Marxsen, J.H.4
Stolze, I.5
Kalinger, M.6
Huang, Q.W.7
Wotzlaw, C.8
Hellwig-Burgel, T.9
Jelkmann, W.10
Acker, H.11
Fandrey, J.12
-
32
-
-
0029891739
-
Drosophila melanogaster SL2 cells contain a hypoxically inducible DNA binding complex which recognises mammalian HIF-binding sites
-
Nagao M, Ebert BL, Ratcliffe PJ, Pugh CW. 1996. Drosophila melanogaster SL2 cells contain a hypoxically inducible DNA binding complex which recognises mammalian HIF-binding sites. FEBS Lett 387:161-166.
-
(1996)
FEBS Lett
, vol.387
, pp. 161-166
-
-
Nagao, M.1
Ebert, B.L.2
Ratcliffe, P.J.3
Pugh, C.W.4
-
33
-
-
0028859483
-
2-responsive sequences on the tyrosine hydroxylase gene
-
2-responsive sequences on the tyrosine hydroxylase gene. J Biol Chem 270:23774-23779.
-
(1995)
J Biol Chem
, vol.270
, pp. 23774-23779
-
-
Norris, M.L.1
Millhorn, D.E.2
-
34
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
-
Ravi R, Mookerjee B, Bhujwalla ZJM, Satter CH, Artemov D, Zeng Q, Dillehay LE, Madan A, Semenza GL, Bedi A. 2000. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α. Genes Dev 14:34-44.
-
(2000)
Genes Dev
, vol.14
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.J.M.3
Satter, C.H.4
Artemov, D.5
Zeng, Q.6
Dillehay, L.E.7
Madan, A.8
Semenza, G.L.9
Bedi, A.10
-
35
-
-
0031740332
-
Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16
-
Rossi FMV, Guicherit OM, Spicher A, Kringstein AM, Fatyol K, Blakely BT, Blau H. 1998. Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16. Nat Genet 20:389-393.
-
(1998)
Nat Genet
, vol.20
, pp. 389-393
-
-
Rossi, F.M.V.1
Guicherit, O.M.2
Spicher, A.3
Kringstein, A.M.4
Fatyol, K.5
Blakely, B.T.6
Blau, H.7
-
36
-
-
0033233243
-
2 homeostasis by hypoxia-inducible factor 1
-
2 homeostasis by hypoxia-inducible factor 1. Rev Cell Dev Biol 15:551-578.
-
(1999)
Rev Cell Dev Biol
, vol.15
, pp. 551-578
-
-
Semenza, G.L.1
-
37
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. 2003. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 10:721-732.
-
(2003)
Nat Rev Cancer
, vol.10
, pp. 721-732
-
-
Semenza, G.L.1
-
38
-
-
0026075610
-
Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene
-
Semenza GL, Nejfelt MK, Chi SM, Antonarakis SE. 1991. Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene. Proc Natl Acad Sci USA 88:5680-5684.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 5680-5684
-
-
Semenza, G.L.1
Nejfelt, M.K.2
Chi, S.M.3
Antonarakis, S.E.4
-
39
-
-
0036320934
-
2- regulated gene expression
-
2-regulated gene expression. FASEB J 16:1151-1162.
-
(2002)
FASEB J
, vol.16
, pp. 1151-1162
-
-
Wenger, R.H.1
-
40
-
-
0034649507
-
Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling
-
Wykoff CC, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ. 2000. Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling. Oncogene 19:6297-6305.
-
(2000)
Oncogene
, vol.19
, pp. 6297-6305
-
-
Wykoff, C.C.1
Pugh, C.W.2
Maxwell, P.H.3
Harris, A.L.4
Ratcliffe, P.J.5
-
41
-
-
0035859692
-
HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation
-
Yu F, White SB, Zhao Q, Lee FS. 2001. HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc Natl Acad Sci USA 98:9630-9635.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 9630-9635
-
-
Yu, F.1
White, S.B.2
Zhao, Q.3
Lee, F.S.4
-
42
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, Simons JW. 1999. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59:5830-5835.
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
Buechler, P.7
Isaacs, W.B.8
Semenza, G.L.9
Simons, J.W.10
|