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Volumn , Issue , 2004, Pages 1025-1058

Pharmacologic Modification of Acute Cerebral Ischemia

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EID: 33645442981     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B0-44-306600-0/50061-4     Document Type: Chapter
Times cited : (4)

References (310)
  • 1
    • 0027982679 scopus 로고
    • Viability thresholds and the penumbra of focal ischemia
    • Hossmann K Viability thresholds and the penumbra of focal ischemia. Ann Neurol 1994, 36:557.
    • (1994) Ann Neurol , vol.36 , pp. 557
    • Hossmann, K.1
  • 2
    • 84970313210 scopus 로고
    • Neuroprotection in brain ischemia: An update (parts I and II)
    • 164
    • Ginsberg MD Neuroprotection in brain ischemia: An update (parts I and II). Neuroscientist 1995, 1:95. 164.
    • (1995) Neuroscientist , vol.1 , pp. 95
    • Ginsberg, M.D.1
  • 3
    • 0026770674 scopus 로고
    • The temporal relation of calcium-calmodulin binding and neuronal damage after global ischemia
    • DeGraba TJ, Ostrow PT, Strong RA, et al. The temporal relation of calcium-calmodulin binding and neuronal damage after global ischemia. Stroke 1992, 23:876.
    • (1992) Stroke , vol.23 , pp. 876
    • DeGraba, T.J.1    Ostrow, P.T.2    Strong, R.A.3
  • 4
    • 0029614765 scopus 로고
    • Neural apoptosis
    • Bredesen DE Neural apoptosis. Ann Neurol 1995, 38:839.
    • (1995) Ann Neurol , vol.38 , pp. 839
    • Bredesen, D.E.1
  • 6
    • 0018347695 scopus 로고
    • A new model of bilateral hemispheric ischemia in the unanesthetized rat
    • Pulsinelli WA, Brierley JB A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke 1979, 10:267.
    • (1979) Stroke , vol.10 , pp. 267
    • Pulsinelli, W.A.1    Brierley, J.B.2
  • 7
    • 0020067965 scopus 로고
    • Temporal profile of neuronal damage in a model of transient forebrain ischemia
    • Pulsinelli WA, Brierley JB, Plum F Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 1982, 11:491.
    • (1982) Ann Neurol , vol.11 , pp. 491
    • Pulsinelli, W.A.1    Brierley, J.B.2    Plum, F.3
  • 8
    • 0021247306 scopus 로고
    • Behavioural performance of rats following transient forebrain ischemia
    • Volpe BT, Pulsinelli WA, Tribuna J, Davis HP Behavioural performance of rats following transient forebrain ischemia. Stroke 1984, 15:558.
    • (1984) Stroke , vol.15 , pp. 558
    • Volpe, B.T.1    Pulsinelli, W.A.2    Tribuna, J.3    Davis, H.P.4
  • 9
    • 0022545394 scopus 로고
    • A model of focal ischemic stroke in rats: Reproducible extensive cortical infarction
    • Chen ST, Hsu CY, Hogan EL, et al. A model of focal ischemic stroke in rats: Reproducible extensive cortical infarction. Stroke 1986, 17:738.
    • (1986) Stroke , vol.17 , pp. 738
    • Chen, S.T.1    Hsu, C.Y.2    Hogan, E.L.3
  • 10
    • 0023786051 scopus 로고
    • Focal brain ischemia in rat: Method for reproducible neocortical infarction using tandem occlusion of the distal middle cerebral and ipsilateral common carotid arteries
    • Brint S, Jacewicz M, Kiessling M, et al. Focal brain ischemia in rat: Method for reproducible neocortical infarction using tandem occlusion of the distal middle cerebral and ipsilateral common carotid arteries. J Cereb Blood Flow Metab 1988, 8:474.
    • (1988) J Cereb Blood Flow Metab , vol.8 , pp. 474
    • Brint, S.1    Jacewicz, M.2    Kiessling, M.3
  • 11
    • 0026508278 scopus 로고
    • A new model of temporary focal neocortical ischemia in the rat
    • Buchan A, Xue D, Slivka A A new model of temporary focal neocortical ischemia in the rat. Stroke 1992, 23:273.
    • (1992) Stroke , vol.23 , pp. 273
    • Buchan, A.1    Xue, D.2    Slivka, A.3
  • 12
    • 0345251951 scopus 로고    scopus 로고
    • Increased therapeutic efficacy with rt-PA and anti-CD18 antibody treatment of stroke in the rat
    • Zhang RL, Zhang ZG, Chopp M Increased therapeutic efficacy with rt-PA and anti-CD18 antibody treatment of stroke in the rat. Neurology 1999, 52:273.
    • (1999) Neurology , vol.52 , pp. 273
    • Zhang, R.L.1    Zhang, Z.G.2    Chopp, M.3
  • 13
    • 0028128974 scopus 로고
    • Reperfusion-induced injury to the blood-brain barrier after middle cerebral artery occlusion in rats
    • Yang G, Betz L Reperfusion-induced injury to the blood-brain barrier after middle cerebral artery occlusion in rats. Stroke 1994, 25:1658.
    • (1994) Stroke , vol.25 , pp. 1658
    • Yang, G.1    Betz, L.2
  • 14
    • 0030856804 scopus 로고    scopus 로고
    • Reperfusion injury: Demonstration of brain damage produced by reperfusion after transient focal ischemia in rats
    • Aronowski J, Strong R, Grotta J Reperfusion injury: Demonstration of brain damage produced by reperfusion after transient focal ischemia in rats. J Cereb Blood Flow Metab 1997, 17:1048.
    • (1997) J Cereb Blood Flow Metab , vol.17 , pp. 1048
    • Aronowski, J.1    Strong, R.2    Grotta, J.3
  • 15
    • 0026022884 scopus 로고
    • Combined therapy with MK-801 and nimodipine for protection of ischemic brain damage
    • Uematsu D, Araki N, Greenberg J, et al. Combined therapy with MK-801 and nimodipine for protection of ischemic brain damage. Neurology 1991, 41:88.
    • (1991) Neurology , vol.41 , pp. 88
    • Uematsu, D.1    Araki, N.2    Greenberg, J.3
  • 16
    • 0026327718 scopus 로고
    • Tissue plasminogen activator plus glutamate antagonist improves outcome after embolic stroke
    • Zivin J, Mazzarella V Tissue plasminogen activator plus glutamate antagonist improves outcome after embolic stroke. Arch Neurol 1991, 48:1235.
    • (1991) Arch Neurol , vol.48 , pp. 1235
    • Zivin, J.1    Mazzarella, V.2
  • 17
    • 0028911203 scopus 로고
    • Monoclonal antibodies preventing leukocyte activation reduce experimental neurologic injury and enhance efficacy of thrombolytic therapy
    • Bowes M, Rothlein R, Fagan S, Zivin J Monoclonal antibodies preventing leukocyte activation reduce experimental neurologic injury and enhance efficacy of thrombolytic therapy. Neurology 1995, 45:815.
    • (1995) Neurology , vol.45 , pp. 815
    • Bowes, M.1    Rothlein, R.2    Fagan, S.3    Zivin, J.4
  • 18
    • 0000290142 scopus 로고
    • The current status of neuronal protective therapy: Why have all neuronal protective drugs worked in animals but none so far in stroke patients?
    • Grotta JC The current status of neuronal protective therapy: Why have all neuronal protective drugs worked in animals but none so far in stroke patients?. Cerebrovasc Dis 1994, 4:115.
    • (1994) Cerebrovasc Dis , vol.4 , pp. 115
    • Grotta, J.C.1
  • 19
    • 0037231768 scopus 로고    scopus 로고
    • New perspectives on developing acute stroke therapy
    • Fisher M, Ratan R New perspectives on developing acute stroke therapy. Ann Neurol 2003, 53:10.
    • (2003) Ann Neurol , vol.53 , pp. 10
    • Fisher, M.1    Ratan, R.2
  • 20
    • 0019582748 scopus 로고
    • Thresholds of focal cerebral ischemia in awake monkeys
    • Jones TH, Morawetz RB, Crowell RM, et al. Thresholds of focal cerebral ischemia in awake monkeys. J Neurosurg 1981, 54:773.
    • (1981) J Neurosurg , vol.54 , pp. 773
    • Jones, T.H.1    Morawetz, R.B.2    Crowell, R.M.3
  • 21
    • 0025913062 scopus 로고
    • Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia
    • Kaplan B, Brint S, Tanabe J, et al. Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia. Stroke 1991, 22:1032.
    • (1991) Stroke , vol.22 , pp. 1032
    • Kaplan, B.1    Brint, S.2    Tanabe, J.3
  • 22
    • 0037148929 scopus 로고    scopus 로고
    • Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia
    • Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002, 346:557.
    • (2002) N Engl J Med , vol.346 , pp. 557
    • Bernard, S.A.1    Gray, T.W.2    Buist, M.D.3
  • 23
    • 0037148926 scopus 로고    scopus 로고
    • Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest
    • The Hypothermia After Cardiac Arrest Study Group Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002, 346:549.
    • (2002) N Engl J Med , vol.346 , pp. 549
  • 24
    • 0033508013 scopus 로고    scopus 로고
    • Indefatigable CA1 sector neuroprotection with mild hypothermia induced 6 hours after severe forebrain ischemia in rats
    • Colbourne F, Li H, Buchan AM Indefatigable CA1 sector neuroprotection with mild hypothermia induced 6 hours after severe forebrain ischemia in rats. J Cereb Blood Flow Metab 1999, 19:742.
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 742
    • Colbourne, F.1    Li, H.2    Buchan, A.M.3
  • 25
    • 0344065373 scopus 로고    scopus 로고
    • Recommendations for standards regarding preclinical neuroprotective and restorative drug development
    • Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke 1999, 30:2752.
    • (1999) Stroke , vol.30 , pp. 2752
  • 26
    • 0034943173 scopus 로고    scopus 로고
    • Recommendations for clinical trial evaluation of acute stroke therapies
    • Recommendations for clinical trial evaluation of acute stroke therapies. Stroke 2001, 32:1598.
    • (2001) Stroke , vol.32 , pp. 1598
  • 27
    • 0344299275 scopus 로고    scopus 로고
    • Baseline NIH Stroke Scale score strongly predicts outcome after stroke
    • Adams HP, Davis PH, Leira EC, et al. Baseline NIH Stroke Scale score strongly predicts outcome after stroke. Neurology 1999, 53:126.
    • (1999) Neurology , vol.53 , pp. 126
    • Adams, H.P.1    Davis, P.H.2    Leira, E.C.3
  • 28
    • 0032730230 scopus 로고    scopus 로고
    • Does the National Institutes of Health Stroke Scale favor left hemisphere strokes?
    • Woo D, Broderick J, Kothari R, et al. Does the National Institutes of Health Stroke Scale favor left hemisphere strokes?. Stroke 1999, 30:2355.
    • (1999) Stroke , vol.30 , pp. 2355
    • Woo, D.1    Broderick, J.2    Kothari, R.3
  • 29
    • 0030889399 scopus 로고    scopus 로고
    • Repeat positron emission tomographic studies in transient middle cerebral artery occlusion in cats: Residual perfusion and efficacy of postischemic reperfusion
    • Heiss WD, Graf R, Lottgen J, et al. Repeat positron emission tomographic studies in transient middle cerebral artery occlusion in cats: Residual perfusion and efficacy of postischemic reperfusion. J Cereb Blood Flow Metab 1997, 17:388.
    • (1997) J Cereb Blood Flow Metab , vol.17 , pp. 388
    • Heiss, W.D.1    Graf, R.2    Lottgen, J.3
  • 30
    • 0033021740 scopus 로고    scopus 로고
    • Mapping the ischemic penumbra with PET: Implications for acute stroke treatment
    • Baron JC Mapping the ischemic penumbra with PET: Implications for acute stroke treatment. Cerebrovasc Dis 1999, 9:193.
    • (1999) Cerebrovasc Dis , vol.9 , pp. 193
    • Baron, J.C.1
  • 31
    • 0029864001 scopus 로고    scopus 로고
    • Prolonged persistence of substantial volumes of potentially viable brain tissue after stroke
    • Marchal G, Beaudoin V, Rioux P, et al. Prolonged persistence of substantial volumes of potentially viable brain tissue after stroke. Stroke 1996, 27:597.
    • (1996) Stroke , vol.27 , pp. 597
    • Marchal, G.1    Beaudoin, V.2    Rioux, P.3
  • 32
    • 0034098132 scopus 로고    scopus 로고
    • New magnetic resonance imaging methods for cerebrovascular disease: Emerging clinical applications
    • Neumann-Haeflin T, Moseley ME, Albers GW New magnetic resonance imaging methods for cerebrovascular disease: Emerging clinical applications. Ann Neurol 2000, 31:559.
    • (2000) Ann Neurol , vol.31 , pp. 559
    • Neumann-Haeflin, T.1    Moseley, M.E.2    Albers, G.W.3
  • 33
    • 0035318736 scopus 로고    scopus 로고
    • Stroke magnetic resonance imaging within 6 hours after onset of hyperacute cerebral ischemia
    • Schellinger PD, Fieback JB, Jansen O, et al. Stroke magnetic resonance imaging within 6 hours after onset of hyperacute cerebral ischemia. Ann Neurol 2001, 49:460.
    • (2001) Ann Neurol , vol.49 , pp. 460
    • Schellinger, P.D.1    Fieback, J.B.2    Jansen, O.3
  • 34
    • 0032738040 scopus 로고    scopus 로고
    • The ischemic penumbra: Operationally defined by diffusion perfusion MRI
    • Schlaug G, Benfield A, Baird AE, et al. The ischemic penumbra: Operationally defined by diffusion perfusion MRI. Neurology 1999, 53:1528.
    • (1999) Neurology , vol.53 , pp. 1528
    • Schlaug, G.1    Benfield, A.2    Baird, A.E.3
  • 35
    • 0033854924 scopus 로고    scopus 로고
    • Secondary decline in apparent diffusion coefficient and neurological outcome after a short period of focal brain ischemia in rats
    • Li F, Silva MD, Liu KF, et al. Secondary decline in apparent diffusion coefficient and neurological outcome after a short period of focal brain ischemia in rats. Ann Neurol 2000, 48:236.
    • (2000) Ann Neurol , vol.48 , pp. 236
    • Li, F.1    Silva, M.D.2    Liu, K.F.3
  • 36
    • 0034117736 scopus 로고    scopus 로고
    • Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging
    • Kidwell CS, Saver JL, Mattiello J, et al. Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging. Ann Neurol 2000, 47:462.
    • (2000) Ann Neurol , vol.47 , pp. 462
    • Kidwell, C.S.1    Saver, J.L.2    Mattiello, J.3
  • 37
    • 0033757829 scopus 로고    scopus 로고
    • Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 010 Investigators
    • Warach S, Pettigrew LC, Dashe JF, et al. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 010 Investigators. Ann Neurol 2000, 48:713.
    • (2000) Ann Neurol , vol.48 , pp. 713
    • Warach, S.1    Pettigrew, L.C.2    Dashe, J.F.3
  • 38
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
    • Tissue plasminogen activator for acute ischemic stroke The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med 1995, 333:1581.
    • (1995) N Engl J Med , vol.333 , pp. 1581
  • 39
    • 0034600485 scopus 로고    scopus 로고
    • Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: A randomized controlled trial. The GAIN International Investigators
    • Lees KR, Asplund K, Carolei A, et al. Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: A randomized controlled trial. The GAIN International Investigators. Lancet 2000, 355:1949.
    • (2000) Lancet , vol.355 , pp. 1949
    • Lees, K.R.1    Asplund, K.2    Carolei, A.3
  • 40
    • 0035666857 scopus 로고    scopus 로고
    • Magnesium for neuroprotection in ischaemic stroke: Rationale for use and evidence of effectiveness
    • Muir KW Magnesium for neuroprotection in ischaemic stroke: Rationale for use and evidence of effectiveness. CNS Drugs 2001, 15:921.
    • (2001) CNS Drugs , vol.15 , pp. 921
    • Muir, K.W.1
  • 41
    • 0036901469 scopus 로고    scopus 로고
    • Oral citicoline in acute ischemic stroke: An individual patient data pooling analysis of clinical trials
    • Davalos A, Castillo J, Alvarez-Sabin J, et al. Oral citicoline in acute ischemic stroke: An individual patient data pooling analysis of clinical trials. Stroke 2002, 33:2850.
    • (2002) Stroke , vol.33 , pp. 2850
    • Davalos, A.1    Castillo, J.2    Alvarez-Sabin, J.3
  • 42
    • 0034780566 scopus 로고    scopus 로고
    • Combination Therapy Stroke Trial: Recombinant tissue-type plasminogen activator with/without lubeluzole
    • Grotta J Combination Therapy Stroke Trial: Recombinant tissue-type plasminogen activator with/without lubeluzole. Cerebrovasc Dis 2001, 12:258.
    • (2001) Cerebrovasc Dis , vol.12 , pp. 258
    • Grotta, J.1
  • 43
    • 84942628122 scopus 로고    scopus 로고
    • The Field Administration of Stroke Therapy-Magnesium (FAST-MAG) pilot trial: A study of prehospital neuroprotective therapy.
    • Abstract presented at the Ongoing Clinical Trials Session, 26th International Stroke Conference, February 13-15, 2001, Fort Lauderdale, FL
    • Saver JL, Kidwell CS, Leary M, et al: The Field Administration of Stroke Therapy-Magnesium (FAST-MAG) pilot trial: A study of prehospital neuroprotective therapy. Abstract presented at the Ongoing Clinical Trials Session, 26th International Stroke Conference, February 13-15, 2001, Fort Lauderdale, FL.
    • Saver, J.L.1    Kidwell, C.S.2    Leary, M.3
  • 44
    • 0000680442 scopus 로고    scopus 로고
    • Effect of intravenous recombinant tissue plasminogen activator on ischemic stroke lesion size measure by computed tomography The National Institute of Neurological Disorders and Stroke (NINDS) rt-PA Stroke Study Group
    • Effect of intravenous recombinant tissue plasminogen activator on ischemic stroke lesion size measure by computed tomography The National Institute of Neurological Disorders and Stroke (NINDS) rt-PA Stroke Study Group. Stroke 2000, 31:2912.
    • (2000) Stroke , vol.31 , pp. 2912
  • 45
    • 84942628123 scopus 로고
    • Neurologic scales in the assessment of stroke
    • International Business Communications, Southbourough, MA, J. Grotta, L. Miller, A.M. Buchan (Eds.)
    • Hantson L Neurologic scales in the assessment of stroke. Ischemic Stroke: Recent Advances in Understanding and Therapy 1995, International Business Communications, Southbourough, MA. J. Grotta, L. Miller, A.M. Buchan (Eds.).
    • (1995) Ischemic Stroke: Recent Advances in Understanding and Therapy
    • Hantson, L.1
  • 47
    • 0029807710 scopus 로고    scopus 로고
    • Use of a global test for multiple outcomes in stroke trials with application to the National Institute of Neurological Disorders and Stroke t-PA stroke trial
    • Tilley BC, Marler J, Geller N, et al. Use of a global test for multiple outcomes in stroke trials with application to the National Institute of Neurological Disorders and Stroke t-PA stroke trial. Stroke 1996, 27:2136.
    • (1996) Stroke , vol.27 , pp. 2136
    • Tilley, B.C.1    Marler, J.2    Geller, N.3
  • 48
    • 0010452459 scopus 로고
    • Nitrendipine block of cardiac calcium channels: High-affinity binding to the inactivated state
    • Bean BP Nitrendipine block of cardiac calcium channels: High-affinity binding to the inactivated state. Proc Natl Acad Sci U S A 1984, 81:6388.
    • (1984) Proc Natl Acad Sci U S A , vol.81 , pp. 6388
    • Bean, B.P.1
  • 49
    • 0034792905 scopus 로고    scopus 로고
    • Nimodipine in animal model experiments of focal cerebral ischemia: a systematic review
    • Horn J, de Haan RJ, Verneulen M, et al. Nimodipine in animal model experiments of focal cerebral ischemia: a systematic review. Stroke 2001, 32:2433.
    • (2001) Stroke , vol.32 , pp. 2433
    • Horn, J.1    de Haan, R.J.2    Verneulen, M.3
  • 50
    • 0025954793 scopus 로고
    • Clinical aspects of the use of calcium antagonists in cerebrovascular disease
    • Grotta JC Clinical aspects of the use of calcium antagonists in cerebrovascular disease. Clin Neuropharmacol 1991, 14:373.
    • (1991) Clin Neuropharmacol , vol.14 , pp. 373
    • Grotta, J.C.1
  • 51
    • 0035134235 scopus 로고    scopus 로고
    • Calcium antagonists for ischemic stroke: A systematic review
    • Horn J, Limburg M Calcium antagonists for ischemic stroke: A systematic review. Stroke 2001, 32:570.
    • (2001) Stroke , vol.32 , pp. 570
    • Horn, J.1    Limburg, M.2
  • 52
    • 0023927693 scopus 로고
    • Nimodipine treatment in poor-grade aneurysm patients: Results of a multicenter double-blind placebo-controlled trial
    • Petruk KC, West M, Mohr G, et al. Nimodipine treatment in poor-grade aneurysm patients: Results of a multicenter double-blind placebo-controlled trial. J Neurosurg 1988, 68:505.
    • (1988) J Neurosurg , vol.68 , pp. 505
    • Petruk, K.C.1    West, M.2    Mohr, G.3
  • 53
    • 0024515530 scopus 로고
    • Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British Aneurysm Nimodipine Trial
    • Pickard JD, Murray GD, Illingworth R, et al. Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British Aneurysm Nimodipine Trial. BMJ 1989, 298:636.
    • (1989) BMJ , vol.298 , pp. 636
    • Pickard, J.D.1    Murray, G.D.2    Illingworth, R.3
  • 54
    • 0026098394 scopus 로고
    • Long-term effects of nimodipine on cerebral infarcts and outcome after aneurysmal subarachnoid hemorrhage and surgery
    • Ohman J, Servo A, Heiskanen O Long-term effects of nimodipine on cerebral infarcts and outcome after aneurysmal subarachnoid hemorrhage and surgery. J Neurosurg 1991, 74:8.
    • (1991) J Neurosurg , vol.74 , pp. 8
    • Ohman, J.1    Servo, A.2    Heiskanen, O.3
  • 55
    • 0030030221 scopus 로고    scopus 로고
    • Efficacy of prophylactic nimodipine for delayed ischemic deficit after subarachnoid hemorrhage: A meta-analysis
    • Barker FG, Ogilvy CS Efficacy of prophylactic nimodipine for delayed ischemic deficit after subarachnoid hemorrhage: A meta-analysis. J Neurosurg 1996, 84:405.
    • (1996) J Neurosurg , vol.84 , pp. 405
    • Barker, F.G.1    Ogilvy, C.S.2
  • 57
    • 0025603119 scopus 로고
    • Nimodipine after resuscitation from out-of-hospital ventricular fibrillation: A placebo-controlled, double-blind, randomized trial
    • Roine RO, Kaste M, Kinnunen A, et al. Nimodipine after resuscitation from out-of-hospital ventricular fibrillation: A placebo-controlled, double-blind, randomized trial. JAMA 1990, 264:3171.
    • (1990) JAMA , vol.264 , pp. 3171
    • Roine, R.O.1    Kaste, M.2    Kinnunen, A.3
  • 58
    • 0021257790 scopus 로고
    • The effects of nimodipine on the clinical course of patients with acute ischemic stroke
    • Gelmers HJ The effects of nimodipine on the clinical course of patients with acute ischemic stroke. Acta Neurol Scand 1984, 69:232.
    • (1984) Acta Neurol Scand , vol.69 , pp. 232
    • Gelmers, H.J.1
  • 60
    • 20244370977 scopus 로고
    • Nimodipine in acute ischemic stroke: A double-blind controlled study
    • Paci A, Ottaviano P, Trenta A, et al. Nimodipine in acute ischemic stroke: A double-blind controlled study. Acta Neurol Scand 1989, 80:282.
    • (1989) Acta Neurol Scand , vol.80 , pp. 282
    • Paci, A.1    Ottaviano, P.2    Trenta, A.3
  • 61
    • 0025602265 scopus 로고
    • Effect of nimodipine on acute ischemic stroke: Pooled results from 5 randomized trials
    • Gelmers HJ, Hennerici M Effect of nimodipine on acute ischemic stroke: Pooled results from 5 randomized trials. Stroke 1990, 21(Suppl):IV81.
    • (1990) Stroke , vol.21 , Issue.SUPPL , pp. IV81
    • Gelmers, H.J.1    Hennerici, M.2
  • 62
    • 0031794687 scopus 로고    scopus 로고
    • A randomized double-blind controlled study of nimodipine in acute cerebral ischemic stroke
    • Nag D, Garg RK, Varma M A randomized double-blind controlled study of nimodipine in acute cerebral ischemic stroke. Indian J Physiol Pharmacol 1998, 42:555.
    • (1998) Indian J Physiol Pharmacol , vol.42 , pp. 555
    • Nag, D.1    Garg, R.K.2    Varma, M.3
  • 63
    • 0026544260 scopus 로고
    • Clinical trial of nimodipine in acute ischemic stroke
    • Clinical trial of nimodipine in acute ischemic stroke The American Nimodipine Study Group. Stroke 1992, 23:3.
    • (1992) Stroke , vol.23 , pp. 3
  • 64
    • 0001694755 scopus 로고
    • Intravenous Nimodipine West European Stroke Trial (INWEST) of nimodipine in the treatment of acute ischemic stroke. The INWEST Study Group
    • Wahlgren N, MacMahon D, De Keyser J, et al. Intravenous Nimodipine West European Stroke Trial (INWEST) of nimodipine in the treatment of acute ischemic stroke. The INWEST Study Group. Cerebrovasc Dis 1994, 4:204.
    • (1994) Cerebrovasc Dis , vol.4 , pp. 204
    • Wahlgren, N.1    MacMahon, D.2    De Keyser, J.3
  • 65
    • 0028243698 scopus 로고
    • A randomized, double-blind, placebo-controlled trial of nimodipine in acute ischemic hemispheric stroke
    • Kaste M, Fogelholm R, Erila T, et al. A randomized, double-blind, placebo-controlled trial of nimodipine in acute ischemic hemispheric stroke. Stroke 1994, 25:1348.
    • (1994) Stroke , vol.25 , pp. 1348
    • Kaste, M.1    Fogelholm, R.2    Erila, T.3
  • 66
    • 0343963044 scopus 로고    scopus 로고
    • Effect of intravenous nimodipine on blood pressure and outcome after acute stroke
    • Ahmed N, Nasman P, Wahlgren NG Effect of intravenous nimodipine on blood pressure and outcome after acute stroke. Stroke 2000, 31:1250.
    • (2000) Stroke , vol.31 , pp. 1250
    • Ahmed, N.1    Nasman, P.2    Wahlgren, N.G.3
  • 67
    • 84939677173 scopus 로고
    • Meta-analysis of oral nimodipine trials in acute ischemic stroke
    • Mohr J, Orgogozo J, Harrison M, et al. Meta-analysis of oral nimodipine trials in acute ischemic stroke. Cerebrovasc Dis 1994, 4:197.
    • (1994) Cerebrovasc Dis , vol.4 , pp. 197
    • Mohr, J.1    Orgogozo, J.2    Harrison, M.3
  • 68
    • 0035134255 scopus 로고    scopus 로고
    • Very Early Nimodipine Use in Stroke (VENUS): A randomized, double-blind, placebo-controlled trial
    • Horn J, de Haan RJ, Verneulen M, Limburg M Very Early Nimodipine Use in Stroke (VENUS): A randomized, double-blind, placebo-controlled trial. Stroke 2001, 32:461.
    • (2001) Stroke , vol.32 , pp. 461
    • Horn, J.1    de Haan, R.J.2    Verneulen, M.3    Limburg, M.4
  • 69
    • 0027417278 scopus 로고
    • A randomized controlled trial of high dose intravenous nicardipine in aneurysmal subarachnoid hemorrhage-a report of the Cooperative Aneurysm Study
    • Haley C, Kassel N, Torner J, et al. A randomized controlled trial of high dose intravenous nicardipine in aneurysmal subarachnoid hemorrhage-a report of the Cooperative Aneurysm Study. J Neurosurg 1993, 78:537.
    • (1993) J Neurosurg , vol.78 , pp. 537
    • Haley, C.1    Kassel, N.2    Torner, J.3
  • 70
    • 0025736192 scopus 로고
    • Early treatment of ischemic stroke with a calcium antagonist
    • Rosenbaum D, Zabramski J, Frey J, et al. Early treatment of ischemic stroke with a calcium antagonist. Stroke 1991, 22:437.
    • (1991) Stroke , vol.22 , pp. 437
    • Rosenbaum, D.1    Zabramski, J.2    Frey, J.3
  • 71
    • 84920304769 scopus 로고    scopus 로고
    • Ca channel antagonists and neuroprotection from cerebral ischemia
    • Kobayashi T, Mori Y Ca channel antagonists and neuroprotection from cerebral ischemia. Eur J Pharmacol 1998, 363:1.
    • (1998) Eur J Pharmacol , vol.363 , pp. 1
    • Kobayashi, T.1    Mori, Y.2
  • 72
    • 0026713642 scopus 로고
    • Programmed cell death: Its possible contribution to neurotoxicity mediated by calcium channel antagonists
    • Koh JY, Cotman CW Programmed cell death: Its possible contribution to neurotoxicity mediated by calcium channel antagonists. Brain Res 1992, 587:233.
    • (1992) Brain Res , vol.587 , pp. 233
    • Koh, J.Y.1    Cotman, C.W.2
  • 73
    • 0028171089 scopus 로고
    • A selective N-type Ca channel blocker prevents CA1 injury 24h following severe forebrain ischemia and reduces infarction following focal ischemia
    • Buchan AM, Gertler SZ, Li H, et al. A selective N-type Ca channel blocker prevents CA1 injury 24h following severe forebrain ischemia and reduces infarction following focal ischemia. J Cereb Blood Flow Metab 1994, 14:903.
    • (1994) J Cereb Blood Flow Metab , vol.14 , pp. 903
    • Buchan, A.M.1    Gertler, S.Z.2    Li, H.3
  • 74
    • 0025351198 scopus 로고
    • CGS-19755, a competitive NMDA receptor antagonist, reduces calcium-calmodulin binding and improves outcome after global cerebral ischemia
    • Grotta JC, Picone CM, Ostrow PT, et al. CGS-19755, a competitive NMDA receptor antagonist, reduces calcium-calmodulin binding and improves outcome after global cerebral ischemia. Ann Neurol 1990, 27:612.
    • (1990) Ann Neurol , vol.27 , pp. 612
    • Grotta, J.C.1    Picone, C.M.2    Ostrow, P.T.3
  • 75
    • 0025309389 scopus 로고
    • N-methyl- d-aspartate antagonist reduces stroke size and regional glucose metabolism
    • Simon R, Shiraishi K N-methyl- d-aspartate antagonist reduces stroke size and regional glucose metabolism. Ann Neurol 1990, 27:606.
    • (1990) Ann Neurol , vol.27 , pp. 606
    • Simon, R.1    Shiraishi, K.2
  • 76
    • 0343843198 scopus 로고
    • The effects of CGS-19755 in rat focal cerebral ischemia produced by tandem ipsilateral common carotid artery and middle cerebral artery occlusion [abstract]
    • Simmonds J, Sailer T, Moyer J The effects of CGS-19755 in rat focal cerebral ischemia produced by tandem ipsilateral common carotid artery and middle cerebral artery occlusion [abstract]. Soc Neurosci Abstr 1993, 19:1647.
    • (1993) Soc Neurosci Abstr , vol.19 , pp. 1647
    • Simmonds, J.1    Sailer, T.2    Moyer, J.3
  • 77
    • 0028921447 scopus 로고
    • Safety and tolerability of the glutamate antagonist CGS 1975 (selfotel) in patients with acute ischemic stroke: Results of a phase IIa randomized trial
    • Grotta J, Clark W, Coull B, et al. Safety and tolerability of the glutamate antagonist CGS 1975 (selfotel) in patients with acute ischemic stroke: Results of a phase IIa randomized trial. Stroke 1995, 26:602.
    • (1995) Stroke , vol.26 , pp. 602
    • Grotta, J.1    Clark, W.2    Coull, B.3
  • 78
    • 0033951941 scopus 로고    scopus 로고
    • Selfotel in acute ischemic stroke: Possible neurotoxic effects of an NMDA antagonist. The ASSIST Investigators
    • Davis SM, Lees KR, Albers GW, et al. selfotel in acute ischemic stroke: Possible neurotoxic effects of an NMDA antagonist. The ASSIST Investigators. Stroke 2000, 31:347.
    • (2000) Stroke , vol.31 , pp. 347
    • Davis, S.M.1    Lees, K.R.2    Albers, G.W.3
  • 79
    • 0345429802 scopus 로고    scopus 로고
    • CGS-19755: Correlation of in vitro neuroprotection, protection against experimental ischemia and CSF levels in cerebrovascular surgery patients [abstract].
    • July 20-22, 1994, Marburg, Germany.
    • Steinberg GK, Perez-Pinzon MA, Maier CM, et al: CGS-19755: Correlation of in vitro neuroprotection, protection against experimental ischemia and CSF levels in cerebrovascular surgery patients [abstract]. In Proceedings of the 5th International Symposium on Pharmacology of Cerebral Ischemia, July 20-22, 1994, Marburg, Germany.
    • Proceedings of the 5th International Symposium on Pharmacology of Cerebral Ischemia
    • Steinberg, G.K.1    Perez-Pinzon, M.A.2    Maier, C.M.3
  • 80
    • 0028870990 scopus 로고
    • Safety, tolerability, and pharmacokinetics of the N-methyl-B aspartate antagonist dextrorphan in patients with acute stroke
    • Albers GW, Atkinson RP, Kelley RE, et al. Safety, tolerability, and pharmacokinetics of the N-methyl-B aspartate antagonist dextrorphan in patients with acute stroke. Stroke 1995, 26:254.
    • (1995) Stroke , vol.26 , pp. 254
    • Albers, G.W.1    Atkinson, R.P.2    Kelley, R.E.3
  • 81
    • 0027474565 scopus 로고
    • Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI
    • Minematsu K, Fisher M, Li L, et al. Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI. Neurology 1993, 43:397.
    • (1993) Neurology , vol.43 , pp. 397
    • Minematsu, K.1    Fisher, M.2    Li, L.3
  • 82
    • 0032824132 scopus 로고    scopus 로고
    • Safety and tolerability study of aptiganel hydrochloride in patients with an acute ischemic stroke
    • Dyker AG, Edwards KR, Fayad PB, et al. Safety and tolerability study of aptiganel hydrochloride in patients with an acute ischemic stroke. Stroke 1999, 30:2038.
    • (1999) Stroke , vol.30 , pp. 2038
    • Dyker, A.G.1    Edwards, K.R.2    Fayad, P.B.3
  • 83
    • 0035814418 scopus 로고    scopus 로고
    • Aptiganel hydrochloride in acute ischemic stroke: A randomized controlled trial. Aptiganel Acute Stroke Investigators
    • Albers GW, Goldstein LB, Hall D, et al. Aptiganel hydrochloride in acute ischemic stroke: A randomized controlled trial. Aptiganel Acute Stroke Investigators. JAMA 2001, 21:2673.
    • (2001) JAMA , vol.21 , pp. 2673
    • Albers, G.W.1    Goldstein, L.B.2    Hall, D.3
  • 84
    • 0036249910 scopus 로고    scopus 로고
    • Treatment of acute ischaemic stroke with the low affinity, use-dependent NMDA antagonist AR-R15896AR: A safety and tolerability study
    • Diener HC, AlKhedr A, Busse O, et al. Treatment of acute ischaemic stroke with the low affinity, use-dependent NMDA antagonist AR-R15896AR: A safety and tolerability study. J Neurol 2002, 249:561.
    • (2002) J Neurol , vol.249 , pp. 561
    • Diener, H.C.1    AlKhedr, A.2    Busse, O.3
  • 85
    • 0036871758 scopus 로고    scopus 로고
    • Magnesium in stroke treatment
    • Muir KW Magnesium in stroke treatment. Postgrad Med J 2002, 78:641.
    • (2002) Postgrad Med J , vol.78 , pp. 641
    • Muir, K.W.1
  • 86
    • 0029067191 scopus 로고
    • A randomized, double-blind, placebo-controlled pilot trial of intravenous magnesium sulfate in acute stroke
    • Muir KW, Lees DR A randomized, double-blind, placebo-controlled pilot trial of intravenous magnesium sulfate in acute stroke. Stroke 1995, 126:1183.
    • (1995) Stroke , vol.126 , pp. 1183
    • Muir, K.W.1    Lees, D.R.2
  • 87
    • 0026733499 scopus 로고
    • Pathobiology of magnesium deficiency: A cytokine/neurogenic inflammation hypothesis
    • Weglicki WB, Phillips TM Pathobiology of magnesium deficiency: A cytokine/neurogenic inflammation hypothesis. Am J Physiol 1992, 263:R734.
    • (1992) Am J Physiol , vol.263 , pp. R734
    • Weglicki, W.B.1    Phillips, T.M.2
  • 88
    • 0034640147 scopus 로고    scopus 로고
    • Survival and histological evaluation of therapeutic window of post-ischemia treatment with magnesium sulfate in embolic stroke model of rat
    • Yang Y, Li Q, Ahmad F, Shuaib A Survival and histological evaluation of therapeutic window of post-ischemia treatment with magnesium sulfate in embolic stroke model of rat. Neurosci Lett 2000, 285:119.
    • (2000) Neurosci Lett , vol.285 , pp. 119
    • Yang, Y.1    Li, Q.2    Ahmad, F.3    Shuaib, A.4
  • 89
    • 0031564829 scopus 로고    scopus 로고
    • Low levels of serum ionized magnesium are found in patients early after stroke which result in rapid elevation in cytosolic free calcium and spasm in cerebral vascular muscle cells
    • Altura BT, Memon ZI, Zhang A, et al. Low levels of serum ionized magnesium are found in patients early after stroke which result in rapid elevation in cytosolic free calcium and spasm in cerebral vascular muscle cells. Neurosci Lett 1997, 230:37.
    • (1997) Neurosci Lett , vol.230 , pp. 37
    • Altura, B.T.1    Memon, Z.I.2    Zhang, A.3
  • 90
    • 0031705667 scopus 로고    scopus 로고
    • Cerebrospinal fluid magnesium level as a prognostic factor in ischaemic stroke
    • Lampl Y, Geva D, Gilad R, et al. Cerebrospinal fluid magnesium level as a prognostic factor in ischaemic stroke. J Neurol 1998, 245:584.
    • (1998) J Neurol , vol.245 , pp. 584
    • Lampl, Y.1    Geva, D.2    Gilad, R.3
  • 91
    • 0031970836 scopus 로고    scopus 로고
    • Dose optimization of intravenous magnesium sulfate after acute stroke
    • Muir KW, Lees KR Dose optimization of intravenous magnesium sulfate after acute stroke. Stroke 1998, 29:918.
    • (1998) Stroke , vol.29 , pp. 918
    • Muir, K.W.1    Lees, K.R.2
  • 92
    • 0026091467 scopus 로고
    • Reduction of infarct volume by magnesium after middle cerebral artery occlusion in rates
    • Izumi Y, Roussl S, Pinard E, Seylaz J Reduction of infarct volume by magnesium after middle cerebral artery occlusion in rates. J Cereb Blood Flow Metab 1991, 11:1025.
    • (1991) J Cereb Blood Flow Metab , vol.11 , pp. 1025
    • Izumi, Y.1    Roussl, S.2    Pinard, E.3    Seylaz, J.4
  • 93
    • 84912029077 scopus 로고    scopus 로고
    • The Field Administration of Stroke Therapy-Magnesium (FAST-MAG) Phase 3 Trial.
    • Abstract presented at the Ongoing Clinical Trials Session, 27th International Stroke Conference, February 7-9, 2002, San Antonio, Texas
    • Saver JL, Kidwell CS, Hamilton S, et al: The Field Administration of Stroke Therapy-Magnesium (FAST-MAG) Phase 3 Trial. Abstract presented at the Ongoing Clinical Trials Session, 27th International Stroke Conference, February 7-9, 2002, San Antonio, Texas.
    • Saver, J.L.1    Kidwell, C.S.2    Hamilton, S.3
  • 94
    • 84942628126 scopus 로고    scopus 로고
    • Intravenous Magnesium Efficacy in Stroke Stroke Center Clinical Trials Directory.
    • Available at Updated 07/30/2002
    • Intravenous Magnesium Efficacy in Stroke Stroke Center Clinical Trials Directory. Available at Updated 07/30/2002 . http://www.mtsinai.org/pulmonary/books/house/legal.html.
  • 95
    • 0024338054 scopus 로고
    • Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs
    • Olney JW, Labruyere J, Price MT Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 1989, 244:1360.
    • (1989) Science , vol.244 , pp. 1360
    • Olney, J.W.1    Labruyere, J.2    Price, M.T.3
  • 96
    • 0031564609 scopus 로고    scopus 로고
    • MK-801-induced neuronal damage in rats
    • Horvath ZC, Czopf J, Buzsaki G MK-801-induced neuronal damage in rats. Brain Res 1997, 753:181.
    • (1997) Brain Res , vol.753 , pp. 181
    • Horvath, Z.C.1    Czopf, J.2    Buzsaki, G.3
  • 97
    • 85047700000 scopus 로고    scopus 로고
    • Receptor mechanisms and circuitry underlying NMDA antagonist neurotoxicity
    • Farber NB, Kim SH, Dikranian K, et al. Receptor mechanisms and circuitry underlying NMDA antagonist neurotoxicity. Mol Psychiatry 2002, 7:32.
    • (2002) Mol Psychiatry , vol.7 , pp. 32
    • Farber, N.B.1    Kim, S.H.2    Dikranian, K.3
  • 98
    • 0032846330 scopus 로고    scopus 로고
    • Excessive cerebrocortical release of acetylcholine induced by NMDA antagonists is reduced by GABAergic and alpha2-adrenergic agonists
    • Kim SH, Price MT, Olney JW, Farber NB Excessive cerebrocortical release of acetylcholine induced by NMDA antagonists is reduced by GABAergic and alpha2-adrenergic agonists. Mol Psychiatry 1999, 4:344.
    • (1999) Mol Psychiatry , vol.4 , pp. 344
    • Kim, S.H.1    Price, M.T.2    Olney, J.W.3    Farber, N.B.4
  • 99
    • 0036795176 scopus 로고    scopus 로고
    • Drug-induced apoptotic neurodegeneration in the developing brain
    • Olney JW, Wozniak DF, Jevtovic-Todorovic V, et al. Drug-induced apoptotic neurodegeneration in the developing brain. Brain Pathol 2002, 12:488.
    • (2002) Brain Pathol , vol.12 , pp. 488
    • Olney, J.W.1    Wozniak, D.F.2    Jevtovic-Todorovic, V.3
  • 100
    • 0030666876 scopus 로고    scopus 로고
    • Cerestat and other NMDA antagonists in ischemic stroie
    • Lees KR Cerestat and other NMDA antagonists in ischemic stroie. Neurology 1997, 49(Suppl 4):S66.
    • (1997) Neurology , vol.49 , Issue.SUPPL.4 , pp. S66
    • Lees, K.R.1
  • 101
    • 0030739272 scopus 로고    scopus 로고
    • The glycine antagonist GV150526 protects somatosensory evoked potentials and reduces the infarct area in the MCAO model of focal ischemia in the rat
    • Bordi F, Pietra C, Ziviani L, Reggiani A The glycine antagonist GV150526 protects somatosensory evoked potentials and reduces the infarct area in the MCAO model of focal ischemia in the rat. Exp Neurol 1997, 145:425.
    • (1997) Exp Neurol , vol.145 , pp. 425
    • Bordi, F.1    Pietra, C.2    Ziviani, L.3    Reggiani, A.4
  • 102
    • 0032925354 scopus 로고    scopus 로고
    • Safety and tolerability of GV150526 (a glycine site antagonist at the N-methyl- d-aspartate receptor) in patients with acute stroke
    • Dyker AG, Lees KR Safety and tolerability of GV150526 (a glycine site antagonist at the N-methyl- d-aspartate receptor) in patients with acute stroke. Stroke 1999, 30:986.
    • (1999) Stroke , vol.30 , pp. 986
    • Dyker, A.G.1    Lees, K.R.2
  • 103
    • 0343415042 scopus 로고    scopus 로고
    • Phase II studies of the glycine antagonist GV150526 in acute stroke. The North American experience. The North American Glycine Antagonist in Neuroprotection (GAIN) Investigators
    • Phase II studies of the glycine antagonist GV150526 in acute stroke The North American experience. The North American Glycine Antagonist in Neuroprotection (GAIN) Investigators. Stroke 2000, 31:358.
    • (2000) Stroke , vol.31 , pp. 358
  • 104
    • 0035137210 scopus 로고    scopus 로고
    • Glycine antagonist (GV150526) in acute stroke: A multicentre, double-blind placebo-controlled phase II trial. The GAIN Phase II European Study Group
    • Lees KR, Lavelle JF, Cunha L, et al. Glycine antagonist (GV150526) in acute stroke: A multicentre, double-blind placebo-controlled phase II trial. The GAIN Phase II European Study Group. Cerebrovasc Dis 2001, 11:20.
    • (2001) Cerebrovasc Dis , vol.11 , pp. 20
    • Lees, K.R.1    Lavelle, J.F.2    Cunha, L.3
  • 105
    • 0035804844 scopus 로고    scopus 로고
    • Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: A randomized controlled trial. The GAIN Americas Investigators
    • Sacco RL, DeRosa JT, Haley C, et al. Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: A randomized controlled trial. The GAIN Americas Investigators. JAMA 2001, 285:1719.
    • (2001) JAMA , vol.285 , pp. 1719
    • Sacco, R.L.1    DeRosa, J.T.2    Haley, C.3
  • 106
    • 0036362716 scopus 로고    scopus 로고
    • Glutamate AMPA receptor antagonist treatment for ischaemic stroke
    • Akins PT, Atkinson RP Glutamate AMPA receptor antagonist treatment for ischaemic stroke. Curr Med Res Opin 2002, 18(Suppl 2):S9.
    • (2002) Curr Med Res Opin , vol.18 , Issue.SUPPL.2 , pp. S9
    • Akins, P.T.1    Atkinson, R.P.2
  • 107
    • 0033988426 scopus 로고    scopus 로고
    • Neuroprotective effects of an AMPA receptor antagonist YM872 in a rat transient middle cerebral artery occlusion model
    • Kawasaki-Yatsugi S, Ichiki C, Yatsugi S, et al. Neuroprotective effects of an AMPA receptor antagonist YM872 in a rat transient middle cerebral artery occlusion model. Neuropharmacology 2000, 39:211.
    • (2000) Neuropharmacology , vol.39 , pp. 211
    • Kawasaki-Yatsugi, S.1    Ichiki, C.2    Yatsugi, S.3
  • 108
    • 0038706172 scopus 로고    scopus 로고
    • Clinical experience with YM872, a novel AMPA receptor antagonist for acute ischemic stroke [abstract]
    • Van Hoogdalem E, de Vos R, Hefting NR, Napoliello MJ Clinical experience with YM872, a novel AMPA receptor antagonist for acute ischemic stroke [abstract]. Stroke 1999, 30:264.
    • (1999) Stroke , vol.30 , pp. 264
    • Van Hoogdalem, E.1    de Vos, R.2    Hefting, N.R.3    Napoliello, M.J.4
  • 109
    • 0037414703 scopus 로고    scopus 로고
    • Neuroprotective effects of YM872.coadministered with t-PA in a rat embolic stroke model
    • Suzuki M, Sasamata M, Miyata K Neuroprotective effects of YM872.coadministered with t-PA in a rat embolic stroke model. Brain Res 2003, 959:169.
    • (2003) Brain Res , vol.959 , pp. 169
    • Suzuki, M.1    Sasamata, M.2    Miyata, K.3
  • 110
    • 0036904876 scopus 로고    scopus 로고
    • AMPA antagonist ZK200775 in patients with acute ischemic stroke: Possible glial cell toxicity detected by monitoring of S-100B serum levels
    • Elting JW, Sulter GA, Kaste M, et al. AMPA antagonist ZK200775 in patients with acute ischemic stroke: Possible glial cell toxicity detected by monitoring of S-100B serum levels. Stroke 2002, 33:2813.
    • (2002) Stroke , vol.33 , pp. 2813
    • Elting, J.W.1    Sulter, G.A.2    Kaste, M.3
  • 111
    • 0028959228 scopus 로고
    • Cerebroprotective effect of lamotrigine after focal ischemia in rats
    • Smith SE, Meldrum BS Cerebroprotective effect of lamotrigine after focal ischemia in rats. Stroke 1995, 26:117.
    • (1995) Stroke , vol.26 , pp. 117
    • Smith, S.E.1    Meldrum, B.S.2
  • 112
    • 0034745250 scopus 로고    scopus 로고
    • Anticonvulsant lamotrigine administered on reperfusion fails to improve experimental stroke outcomes
    • Traystman RJ, Klaus JA, DeVries AC, et al. Anticonvulsant lamotrigine administered on reperfusion fails to improve experimental stroke outcomes. Stroke 2001, 32:783.
    • (2001) Stroke , vol.32 , pp. 783
    • Traystman, R.J.1    Klaus, J.A.2    DeVries, A.C.3
  • 113
    • 0027287896 scopus 로고
    • BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage
    • Leach MJ, Swan JH, Eisenthal D, et al. BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. Stroke 1993, 24:1063.
    • (1993) Stroke , vol.24 , pp. 1063
    • Leach, M.J.1    Swan, J.H.2    Eisenthal, D.3
  • 114
    • 0031037335 scopus 로고
    • Neuroprotective effects of the glutamate release inhibitor 619C89 in temporary middle cerebral artery occlusion
    • Kawaguchi K, Graham SH Neuroprotective effects of the glutamate release inhibitor 619C89 in temporary middle cerebral artery occlusion. Brain Res 1991, 749:131.
    • (1991) Brain Res , vol.749 , pp. 131
    • Kawaguchi, K.1    Graham, S.H.2
  • 115
    • 0033777534 scopus 로고    scopus 로고
    • Phase II clinical trial of sipatrigine (619C89) by continuous infusion in acute stroke
    • Muir KW, Holzapfel L, Lees KR Phase II clinical trial of sipatrigine (619C89) by continuous infusion in acute stroke. Cerebrovasc Dis 2000, 10:431.
    • (2000) Cerebrovasc Dis , vol.10 , pp. 431
    • Muir, K.W.1    Holzapfel, L.2    Lees, K.R.3
  • 116
    • 84942572040 scopus 로고    scopus 로고
    • Stroke Center Clinical Trials Directory
    • Available at
    • Sipatrigine in Stroke (SIS). Stroke Center Clinical Trials Directory. Available at . http://www.mtsinai.org/pulmonary/books/house/legal.html.
  • 117
    • 84942628127 scopus 로고    scopus 로고
    • Fosphenytoin Phase 3 Stroke Center Clinical Trials Directory. Available at Updated 8/3/2000
    • Fosphenytoin Phase 3 Stroke Center Clinical Trials Directory. Available at Updated 8/3/2000 . http://www.mtsinai.org/pulmonary/books/house/legal.html.
  • 118
    • 0009646906 scopus 로고    scopus 로고
    • The pharmacology and molecular biology of large-conductance calcium-activated (BK) potassium channels
    • Gribkoff VK, Starrett JE, Dworetzky SI The pharmacology and molecular biology of large-conductance calcium-activated (BK) potassium channels. Adv Pharmacol 1997, 37:319.
    • (1997) Adv Pharmacol , vol.37 , pp. 319
    • Gribkoff, V.K.1    Starrett, J.E.2    Dworetzky, S.I.3
  • 119
    • 0006089538 scopus 로고    scopus 로고
    • Efficacy and safety of Maxi-Post TM in patients with acute stroke [abstract]
    • Bozik M, Hommel M, Grotta J, et al. Efficacy and safety of Maxi-Post TM in patients with acute stroke [abstract]. J Neurol Sci 2001, 187:s252.
    • (2001) J Neurol Sci , vol.187 , pp. s252
    • Bozik, M.1    Hommel, M.2    Grotta, J.3
  • 120
    • 0029873354 scopus 로고    scopus 로고
    • The effects of lifarizine in acute cerebral infarction: A pilot safety study. The Lifarizine Study Group
    • Squire I, Lees K, Pryse-Phillips W, et al. The effects of lifarizine in acute cerebral infarction: A pilot safety study. The Lifarizine Study Group. Cerebrovasc Dis 1996, 6:156.
    • (1996) Cerebrovasc Dis , vol.6 , pp. 156
    • Squire, I.1    Lees, K.2    Pryse-Phillips, W.3
  • 121
    • 0011848966 scopus 로고
    • Lubeluzole, a novel benzothiazole, protects neurologic function after cerebral thrombotic stroke in rats: An apparent stereospecific effect [abstract]
    • DeRyck M, Keersmaekers R, Clincke G, et al. Lubeluzole, a novel benzothiazole, protects neurologic function after cerebral thrombotic stroke in rats: An apparent stereospecific effect [abstract]. Soc Neurosci Abstr 1994, 20:185.
    • (1994) Soc Neurosci Abstr , vol.20 , pp. 185
    • DeRyck, M.1    Keersmaekers, R.2    Clincke, G.3
  • 122
    • 0030175245 scopus 로고    scopus 로고
    • Treatment of experimental focal ischemia in rats with lubeluzole
    • Aronowski J, Strong R, Grotta JC Treatment of experimental focal ischemia in rats with lubeluzole. Neuropharmacology 1996, 35:689.
    • (1996) Neuropharmacology , vol.35 , pp. 689
    • Aronowski, J.1    Strong, R.2    Grotta, J.C.3
  • 123
    • 0033975565 scopus 로고    scopus 로고
    • Diffusion-weighted MRI of infarct growth in a rat photochemical stroke model: Effect of lubeluzole
    • DeRyck M, Verhoye M, Van der Linden AM Diffusion-weighted MRI of infarct growth in a rat photochemical stroke model: Effect of lubeluzole. Neuropharmacology 2000, 39:691.
    • (2000) Neuropharmacology , vol.39 , pp. 691
    • DeRyck, M.1    Verhoye, M.2    Van der Linden, A.M.3
  • 124
    • 0030777379 scopus 로고    scopus 로고
    • Differential effects of the neuroprotectant lubeluzole on bovine and mouse chromaffin cell calcium channel subtypes
    • Hernandez-Guijo JM, Gandia L, de Pascual R, Garcia AG Differential effects of the neuroprotectant lubeluzole on bovine and mouse chromaffin cell calcium channel subtypes. Br J Pharmacol 1997, 122:275.
    • (1997) Br J Pharmacol , vol.122 , pp. 275
    • Hernandez-Guijo, J.M.1    Gandia, L.2    de Pascual, R.3    Garcia, A.G.4
  • 125
    • 0030725633 scopus 로고    scopus 로고
    • Lubeluzole blocks increases in extracellular glutamate and taurine in the peri-infarct zone in rats
    • Scheller DKA, DeRyck M, Kolb J, et al. Lubeluzole blocks increases in extracellular glutamate and taurine in the peri-infarct zone in rats. Eur J Pharmacol 1997, 338:243.
    • (1997) Eur J Pharmacol , vol.338 , pp. 243
    • Scheller, D.K.A.1    DeRyck, M.2    Kolb, J.3
  • 126
    • 0030426710 scopus 로고    scopus 로고
    • Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway
    • Lesage AS, Peeters L, Leysen JE Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway. J Pharmacol Exp Ther 1996, 279:759.
    • (1996) J Pharmacol Exp Ther , vol.279 , pp. 759
    • Lesage, A.S.1    Peeters, L.2    Leysen, J.E.3
  • 127
    • 0030069170 scopus 로고    scopus 로고
    • Lubeluzole in acute ischemic stroke: A double blind placebo controlled phase II trial. The Lubeluzole International Study Group
    • Diener H, Hacke W, Hennerici M, et al. Lubeluzole in acute ischemic stroke: A double blind placebo controlled phase II trial. The Lubeluzole International Study Group. Stroke 1996, 27:76.
    • (1996) Stroke , vol.27 , pp. 76
    • Diener, H.1    Hacke, W.2    Hennerici, M.3
  • 128
    • 0030426259 scopus 로고    scopus 로고
    • Lubeluzole protects sensorimotor function and reduces infarct size in a photochemical stroke model
    • DeRyck M, Keersmackers R, Duytschaever H, et al. Lubeluzole protects sensorimotor function and reduces infarct size in a photochemical stroke model. J Pharmacol Exp Ther 1996, 35:748.
    • (1996) J Pharmacol Exp Ther , vol.35 , pp. 748
    • DeRyck, M.1    Keersmackers, R.2    Duytschaever, H.3
  • 129
    • 0031923952 scopus 로고    scopus 로고
    • Multinational randomized controlled trial of lubeluzole in acute ischaemic stroke: European and Australian Lubeluzole Ischaemic Stroke Study Group
    • Diener HC Multinational randomized controlled trial of lubeluzole in acute ischaemic stroke: European and Australian Lubeluzole Ischaemic Stroke Study Group. Cerebrovasc Dis 1998, 8:172.
    • (1998) Cerebrovasc Dis , vol.8 , pp. 172
    • Diener, H.C.1
  • 130
    • 0031438509 scopus 로고    scopus 로고
    • Lubeluzole treatment of acute ischemic stroke. The US and Canadian Lubeluzole Ischemic Stroke Study Group
    • Grotta J Lubeluzole treatment of acute ischemic stroke. The US and Canadian Lubeluzole Ischemic Stroke Study Group. Stroke 1997, 28:2338.
    • (1997) Stroke , vol.28 , pp. 2338
    • Grotta, J.1
  • 131
    • 0033766740 scopus 로고    scopus 로고
    • Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-hour inclusion window comparing a 10-mg daily dose of lubeluzole with placebo. The LUB-INT-13 Investigators
    • Diener HC, Cortens M, Ford G, et al. Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-hour inclusion window comparing a 10-mg daily dose of lubeluzole with placebo. The LUB-INT-13 Investigators. Stroke 2000, 31:2543.
    • (2000) Stroke , vol.31 , pp. 2543
    • Diener, H.C.1    Cortens, M.2    Ford, G.3
  • 133
    • 0023233048 scopus 로고
    • Two distinct effects of 5-hydroxytryptamine on single cortical neurons
    • Davies MF, Deisz RA, Prince DA, Peroutka SJ Two distinct effects of 5-hydroxytryptamine on single cortical neurons. Brain Res 1987, 423:347.
    • (1987) Brain Res , vol.423 , pp. 347
    • Davies, M.F.1    Deisz, R.A.2    Prince, D.A.3    Peroutka, S.J.4
  • 134
    • 0030605850 scopus 로고    scopus 로고
    • Regulation of glutamate release via NMDA and 5-HT1A receptors in guinea pig dentate gyrus
    • Matsuyama S, Nei K, Tanaka C Regulation of glutamate release via NMDA and 5-HT1A receptors in guinea pig dentate gyrus. Brain Res 1996, 728:175.
    • (1996) Brain Res , vol.728 , pp. 175
    • Matsuyama, S.1    Nei, K.2    Tanaka, C.3
  • 135
    • 0034634432 scopus 로고    scopus 로고
    • Stimulation of 5-HT1A receptors reduces apoptosis after transient forebrain ischemia in the rat
    • Schaper C, Zhu Y, Kouklei M, et al. Stimulation of 5-HT1A receptors reduces apoptosis after transient forebrain ischemia in the rat. Brain Res 2000, 883:41.
    • (2000) Brain Res , vol.883 , pp. 41
    • Schaper, C.1    Zhu, Y.2    Kouklei, M.3
  • 136
    • 0022452686 scopus 로고
    • Failure of central nervous system serotonin blockage to influence outcome in acute cerebral infarction: A double blind randomized trial
    • Ramirez-Lessepas M, Patrick BK, Snyder BD, Lakatua DJ Failure of central nervous system serotonin blockage to influence outcome in acute cerebral infarction: A double blind randomized trial. Stroke 1986, 17:953.
    • (1986) Stroke , vol.17 , pp. 953
    • Ramirez-Lessepas, M.1    Patrick, B.K.2    Snyder, B.D.3    Lakatua, D.J.4
  • 137
    • 0032561474 scopus 로고    scopus 로고
    • Neuroprotective effect of 5-HT1A receptor agonist, BAY × 3702, demonstrated in vitro and in vivo
    • Semkova I, Wolz P, Krieglstein J Neuroprotective effect of 5-HT1A receptor agonist, BAY × 3702, demonstrated in vitro and in vivo. Eur J Pharmacol 1998, 359:251.
    • (1998) Eur J Pharmacol , vol.359 , pp. 251
    • Semkova, I.1    Wolz, P.2    Krieglstein, J.3
  • 138
    • 0346822699 scopus 로고    scopus 로고
    • Bayer Randomized Acute Ischemia Neuroprotectant Study (BRAINS). Abstracts from the 4th World Stroke Congress
    • Bayer Randomized Acute Ischemia Neuroprotectant Study (BRAINS). Abstracts from the 4th World Stroke Congress. Stroke 2000, 31:2768.
    • (2000) Stroke , vol.31 , pp. 2768
  • 139
    • 84942628128 scopus 로고    scopus 로고
    • Repinotan (BAY × 3702) in acute ischemic stroke: A randomized exposure controlled trial. Abstract presented in the Ongoing Clinical Trials Session, 26th International Stroke Conference, February 13-15, 2001, Fort Lauderdale, FL
    • Teal P, Rombout F, Weber H, et al: Repinotan (BAY × 3702) in acute ischemic stroke: A randomized exposure controlled trial. Abstract presented in the Ongoing Clinical Trials Session, 26th International Stroke Conference, February 13-15, 2001, Fort Lauderdale, FL.
    • Teal, P.1    Rombout, F.2    Weber, H.3
  • 140
    • 84942628129 scopus 로고    scopus 로고
    • ONO-2506 in Acute Ischemic Stroke. In Stroke Center Clinical Trials Directory. Available at Updated 11/14/2002
    • ONO-2506 in Acute Ischemic Stroke. In Stroke Center Clinical Trials Directory. Available at Updated 11/14/2002 . http://www.mtsinai.org/pulmonary/books/house/legal.html.
  • 141
    • 0022628379 scopus 로고
    • Effect of naloxone on cerebral perfusion and cardiac performance during experimental cerebral ischemia
    • Harini RJ, Supra EL, Roberts JP, Lavyne MH Effect of naloxone on cerebral perfusion and cardiac performance during experimental cerebral ischemia. J Neurosurg 1986, 64:780.
    • (1986) J Neurosurg , vol.64 , pp. 780
    • Harini, R.J.1    Supra, E.L.2    Roberts, J.P.3    Lavyne, M.H.4
  • 142
    • 0022449111 scopus 로고
    • Opiate-antagonist reversal of neurological deficits: Experimental and clinical studies
    • Namba S, Nishigaki S, Fujiwara N, et al. Opiate-antagonist reversal of neurological deficits: Experimental and clinical studies. Jpn J Psych Neurol 1986, 40:61.
    • (1986) Jpn J Psych Neurol , vol.40 , pp. 61
    • Namba, S.1    Nishigaki, S.2    Fujiwara, N.3
  • 143
    • 0021969418 scopus 로고
    • Treatment of stroke with opiate antagonists: Effects of exogenous antagonist and dynorphin 1-13
    • Baskin DS, Juroda H, Hosobuchi Y, Lee NM Treatment of stroke with opiate antagonists: Effects of exogenous antagonist and dynorphin 1-13. Neuropeptides 1985, 5:307.
    • (1985) Neuropeptides , vol.5 , pp. 307
    • Baskin, D.S.1    Juroda, H.2    Hosobuchi, Y.3    Lee, N.M.4
  • 144
    • 0021275287 scopus 로고
    • A double blind trial of naloxone in the treatment of acute stroke
    • Fallis RF, Fisher M, Lobo RA A double blind trial of naloxone in the treatment of acute stroke. Stroke 1984, 15:627.
    • (1984) Stroke , vol.15 , pp. 627
    • Fallis, R.F.1    Fisher, M.2    Lobo, R.A.3
  • 145
    • 0021322456 scopus 로고
    • Naloxone administration to patients with acute stroke
    • Jabaily J, Davis JN Naloxone administration to patients with acute stroke. Stroke 1984, 15:36.
    • (1984) Stroke , vol.15 , pp. 36
    • Jabaily, J.1    Davis, J.N.2
  • 146
    • 0022512423 scopus 로고
    • A dose-escalation study of large doses of naloxone for treatment of patients with acute cerebral ischemia
    • Adams HP, Olinger CP, Barsan WG, et al. A dose-escalation study of large doses of naloxone for treatment of patients with acute cerebral ischemia. Stroke 1986, 17:404.
    • (1986) Stroke , vol.17 , pp. 404
    • Adams, H.P.1    Olinger, C.P.2    Barsan, W.G.3
  • 147
    • 0025311274 scopus 로고
    • High-dose intravenous naloxone for the treatment of acute ischemic stroke
    • Olinger CP, Adams HP, Brott TG, et al. High-dose intravenous naloxone for the treatment of acute ischemic stroke. Stroke 1990, 21:721.
    • (1990) Stroke , vol.21 , pp. 721
    • Olinger, C.P.1    Adams, H.P.2    Brott, T.G.3
  • 148
    • 0026349465 scopus 로고
    • A double blind randomized pilot trial of naloxone in the treatment of acute ischemic stroke
    • Federico F, Lucivero V, Lamberti P, et al. A double blind randomized pilot trial of naloxone in the treatment of acute ischemic stroke. Ital J Neurol Sci 1991, 12:557.
    • (1991) Ital J Neurol Sci , vol.12 , pp. 557
    • Federico, F.1    Lucivero, V.2    Lamberti, P.3
  • 149
    • 0005489840 scopus 로고    scopus 로고
    • Randomized trial of Cervene, a κ receptor-selective opioid antagonist, in acute ischemic stroke
    • Clark W, Coull B, Karukin M, et al. Randomized trial of Cervene, a κ receptor-selective opioid antagonist, in acute ischemic stroke. J Stroke Cerebrovasc Dis 1996, 6:35.
    • (1996) J Stroke Cerebrovasc Dis , vol.6 , pp. 35
    • Clark, W.1    Coull, B.2    Karukin, M.3
  • 150
    • 0001223098 scopus 로고    scopus 로고
    • Cervene in acute ischemic stroke: Results of a double-blind, placebo-controlled, dose-comparison study
    • Clark W, Ertag W, Orecchio E, Raps E Cervene in acute ischemic stroke: Results of a double-blind, placebo-controlled, dose-comparison study. J Stroke Cerebrovasc Dis 1999, 8:224.
    • (1999) J Stroke Cerebrovasc Dis , vol.8 , pp. 224
    • Clark, W.1    Ertag, W.2    Orecchio, E.3    Raps, E.4
  • 151
    • 0034034434 scopus 로고    scopus 로고
    • Cervene (nalmefene) in acute ischemic stroke: Final results of a phase III efficacy study. The Cervene Stroke Study Investigators
    • Clark WM, Raps EC, Tong DC, Kelly RE Cervene (nalmefene) in acute ischemic stroke: Final results of a phase III efficacy study. The Cervene Stroke Study Investigators. Stroke 2000, 31:1234.
    • (2000) Stroke , vol.31 , pp. 1234
    • Clark, W.M.1    Raps, E.C.2    Tong, D.C.3    Kelly, R.E.4
  • 152
    • 0034078117 scopus 로고    scopus 로고
    • GABA potentiation: A logical pharmacological approach for the treatment of acute ischaemic stroke
    • Green AR, Hainsworth AH, Jackson DM GABA potentiation: A logical pharmacological approach for the treatment of acute ischaemic stroke. Neuropharmacology 2000, 39:1483.
    • (2000) Neuropharmacology , vol.39 , pp. 1483
    • Green, A.R.1    Hainsworth, A.H.2    Jackson, D.M.3
  • 153
    • 0024517681 scopus 로고
    • Clomethiazole: Neurochemical actions at the gamma-aminobutyric acid complex
    • Moody IF, Skolnick P Clomethiazole: Neurochemical actions at the gamma-aminobutyric acid complex. Br J Pharmacol 1989, 164:153.
    • (1989) Br J Pharmacol , vol.164 , pp. 153
    • Moody, I.F.1    Skolnick, P.2
  • 154
    • 0026094214 scopus 로고
    • Neuroprotective activity of clomethiazole following transient forebrain ischemia in the gerbil
    • Cross AF, Jones JA, Snares M, et al. Neuroprotective activity of clomethiazole following transient forebrain ischemia in the gerbil. Br J Pharmacol 1991, 104:406.
    • (1991) Br J Pharmacol , vol.104 , pp. 406
    • Cross, A.F.1    Jones, J.A.2    Snares, M.3
  • 155
    • 0345452000 scopus 로고    scopus 로고
    • Functional benefit from clomethiazole treatment after focal cerebral ischaemia in a non-human primate species [abstract]
    • Marshall JWB, Cross AF, Murray TK, Ridley RM Functional benefit from clomethiazole treatment after focal cerebral ischaemia in a non-human primate species [abstract]. Stroke 1998, 29:330.
    • (1998) Stroke , vol.29 , pp. 330
    • Marshall, J.W.B.1    Cross, A.F.2    Murray, T.K.3    Ridley, R.M.4
  • 156
    • 0031923216 scopus 로고    scopus 로고
    • An open study of clomethiazole in patients with acute cerebral infarction
    • Wester P, Strand T, Wahlgren NG, et al. An open study of clomethiazole in patients with acute cerebral infarction. Cerebrovasc Dis 1998, 8:188.
    • (1998) Cerebrovasc Dis , vol.8 , pp. 188
    • Wester, P.1    Strand, T.2    Wahlgren, N.G.3
  • 157
    • 0034678869 scopus 로고    scopus 로고
    • Clomethiazole is neuroprotective in models of global and focal cerebral ischemia when infused at doses producing clinically relevant plasma concentrations
    • Sydserff SG, Cross AJ, Murray TK, et al. Clomethiazole is neuroprotective in models of global and focal cerebral ischemia when infused at doses producing clinically relevant plasma concentrations. Brain Res 2000, 862:59.
    • (2000) Brain Res , vol.862 , pp. 59
    • Sydserff, S.G.1    Cross, A.J.2    Murray, T.K.3
  • 158
    • 0032953495 scopus 로고    scopus 로고
    • Clomethiazole Acute Stroke Study (CLASS): Results of a randomized, controlled trial of clomethiazole versus placebo in 1360 acute stroke patients. The CLASS Study Group
    • Wahlgren NG, Ranasinha KW, Rosolacci T, et al. Clomethiazole Acute Stroke Study (CLASS): Results of a randomized, controlled trial of clomethiazole versus placebo in 1360 acute stroke patients. The CLASS Study Group. Stroke 1999, 30:21.
    • (1999) Stroke , vol.30 , pp. 21
    • Wahlgren, N.G.1    Ranasinha, K.W.2    Rosolacci, T.3
  • 159
    • 0033971797 scopus 로고    scopus 로고
    • Results in 95 hemorrhagic stroke patients included in CLASS, a controlled trial of clomethiazole versus placebo in acute stroke patients. The CLASS Study Group
    • Wahlgren NG, Diez-Tejedor E, Teitelbaum J, et al. Results in 95 hemorrhagic stroke patients included in CLASS, a controlled trial of clomethiazole versus placebo in acute stroke patients. The CLASS Study Group. Stroke 2000, 31:82.
    • (2000) Stroke , vol.31 , pp. 82
    • Wahlgren, N.G.1    Diez-Tejedor, E.2    Teitelbaum, J.3
  • 160
    • 18244392468 scopus 로고    scopus 로고
    • Clomethiazole Acute Stroke Study in ischemic stroke (CLASS-I): Final results. The CLASS-I/H/T Investigators
    • Lyden P, Shuaib A, Ng K, et al. Clomethiazole Acute Stroke Study in ischemic stroke (CLASS-I): Final results. The CLASS-I/H/T Investigators. Stroke 2002, 33:122.
    • (2002) Stroke , vol.33 , pp. 122
    • Lyden, P.1    Shuaib, A.2    Ng, K.3
  • 161
    • 84942628130 scopus 로고    scopus 로고
    • Early GABA-ergic activation study in stroke. Abstract presented at the Ongoing Clinical Trials Session
    • 26th International Stroke Conference, February 13-15, 2001, Fort Lauderdale, FL
    • Lodder J, Raak van EPM, Kessels F: Early GABA-ergic activation study in stroke. Abstract presented at the Ongoing Clinical Trials Session, 26th International Stroke Conference, February 13-15, 2001, Fort Lauderdale, FL.
    • Lodder, J.1    Raak van, E.P.M.2    Kessels, F.3
  • 162
    • 0023785218 scopus 로고
    • 21-Aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils
    • Hall ED, Pazara KE, Braughler JM 21-Aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils. Stroke 1988, 19:997.
    • (1988) Stroke , vol.19 , pp. 997
    • Hall, E.D.1    Pazara, K.E.2    Braughler, J.M.3
  • 163
    • 0024336859 scopus 로고
    • Effect of the 21-aminosteroid U-74006 on cerebra vasospasm following subarachnoid hemorrhage
    • Zuccarello M, Marsch JT, Schmitt G, et al. Effect of the 21-aminosteroid U-74006 on cerebra vasospasm following subarachnoid hemorrhage. J Neurosurg 1989, 71:98.
    • (1989) J Neurosurg , vol.71 , pp. 98
    • Zuccarello, M.1    Marsch, J.T.2    Schmitt, G.3
  • 164
    • 0029688435 scopus 로고    scopus 로고
    • Neuroprotective efficacy of microvascularly-localized versus brain-penetrating antioxidants
    • Hall ED, Andrus PK, Smith SL, et al. Neuroprotective efficacy of microvascularly-localized versus brain-penetrating antioxidants. Acta Neurochir Suppl (Wien) 1996, 66:107.
    • (1996) Acta Neurochir Suppl (Wien) , vol.66 , pp. 107
    • Hall, E.D.1    Andrus, P.K.2    Smith, S.L.3
  • 165
    • 0028036213 scopus 로고
    • Safety study of tirilazad mesylate in patients with acute ischemia stroke (STIPAS). The STIPAS Investigators
    • Safety study of tirilazad mesylate in patients with acute ischemia stroke (STIPAS). The STIPAS Investigators. Stroke 1994, 25:418.
    • (1994) Stroke , vol.25 , pp. 418
  • 166
    • 0043204506 scopus 로고    scopus 로고
    • A randomized trial of tirilazad mesylate in patients with acute stroke (RANTTAS). The RANTTAS Investigators
    • A randomized trial of tirilazad mesylate in patients with acute stroke (RANTTAS). The RANTTAS Investigators. Stroke 1996, 27:1453.
    • (1996) Stroke , vol.27 , pp. 1453
  • 167
    • 0031781078 scopus 로고    scopus 로고
    • High-dose tirilazad for acute stroke (RANTTAS II). The RANTTAS II Investigators
    • Haley EC High-dose tirilazad for acute stroke (RANTTAS II). The RANTTAS II Investigators. Stroke 1998, 29:1256.
    • (1998) Stroke , vol.29 , pp. 1256
    • Haley, E.C.1
  • 168
    • 0033816426 scopus 로고    scopus 로고
    • Tirilazad mesylate in acute ischemic stroke. A systematic review.
    • Tirilazad mesylate in acute ischemic stroke A systematic review. Tirilazad International Steering Committee. Stroke 2000, 32:2257.
    • (2000) Stroke , vol.32 , pp. 2257
  • 169
    • 0037039233 scopus 로고    scopus 로고
    • The effect of tirilazad mesylate on infarct volume of patients with acute ischemic stroke. The TESS and TESS II Investigators
    • Van der Worp HB, Kappelle LJ, Algra A, et al. The effect of tirilazad mesylate on infarct volume of patients with acute ischemic stroke. The TESS and TESS II Investigators. Neurology 2002, 58:133.
    • (2002) Neurology , vol.58 , pp. 133
    • Van der Worp, H.B.1    Kappelle, L.J.2    Algra, A.3
  • 170
    • 0025183728 scopus 로고
    • Failure of the lipid peroxidation inhibitor U74006F to improve neurological outcome after transient forebrain ischemia in the rat
    • Beck T, Bielenberg GW Failure of the lipid peroxidation inhibitor U74006F to improve neurological outcome after transient forebrain ischemia in the rat. Brain Res 1990, 532:336.
    • (1990) Brain Res , vol.532 , pp. 336
    • Beck, T.1    Bielenberg, G.W.2
  • 171
    • 0023601670 scopus 로고
    • Inhibition of superoxide anion production in guinea pig polymorphonuclear leukocytes by a seleno-organic compound, ebselen
    • Ichikawa S, Omura K, Katayama T, et al. Inhibition of superoxide anion production in guinea pig polymorphonuclear leukocytes by a seleno-organic compound, ebselen. J Pharmacobio-Dyn 1987, 10:595.
    • (1987) J Pharmacobio-Dyn , vol.10 , pp. 595
    • Ichikawa, S.1    Omura, K.2    Katayama, T.3
  • 172
    • 0028180046 scopus 로고
    • Preferential inhibition of inducible nitric oxide synthase by ebselen
    • Hattori R, Inoue R, Sase K, et al. Preferential inhibition of inducible nitric oxide synthase by ebselen. Eur J Pharmacol 1994, 267:R1.
    • (1994) Eur J Pharmacol , vol.267 , pp. R1
    • Hattori, R.1    Inoue, R.2    Sase, K.3
  • 173
    • 0023891447 scopus 로고
    • Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51)
    • Maiorino M, Roveri A, Coassin M, Ursini F Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51). Biochem Pharmacol 1988, 37:2267.
    • (1988) Biochem Pharmacol , vol.37 , pp. 2267
    • Maiorino, M.1    Roveri, A.2    Coassin, M.3    Ursini, F.4
  • 174
    • 0030734080 scopus 로고    scopus 로고
    • Neuroprotective efficacy of ebselen, an anti-oxidant with anti-inflammatory actions, in a rodent model of permanent middle cerebral artery occlusion
    • Takasago T, Peters EE, Graham DI, et al. Neuroprotective efficacy of ebselen, an anti-oxidant with anti-inflammatory actions, in a rodent model of permanent middle cerebral artery occlusion. Br J Pharmacol 1997, 122:1251.
    • (1997) Br J Pharmacol , vol.122 , pp. 1251
    • Takasago, T.1    Peters, E.E.2    Graham, D.I.3
  • 175
    • 0031963836 scopus 로고    scopus 로고
    • Ebselen in acute ischemic stroke: A placebo-controlled, double-blind clinical trial. The Ebselen Study Group
    • Yamaguchi T, Sano K, Takakura K, et al. Ebselen in acute ischemic stroke: A placebo-controlled, double-blind clinical trial. The Ebselen Study Group. Stroke 1998, 29:12.
    • (1998) Stroke , vol.29 , pp. 12
    • Yamaguchi, T.1    Sano, K.2    Takakura, K.3
  • 176
    • 0035800578 scopus 로고    scopus 로고
    • NXY-059, a novel free radical trapping compound, reduces cortical infarction after permanent focal cerebral ischemia in the rat
    • Zhao Z, Cheng M, Maples KR, et al. NXY-059, a novel free radical trapping compound, reduces cortical infarction after permanent focal cerebral ischemia in the rat. Brain Res 2001, 909:46.
    • (2001) Brain Res , vol.909 , pp. 46
    • Zhao, Z.1    Cheng, M.2    Maples, K.R.3
  • 177
    • 0036152938 scopus 로고    scopus 로고
    • Effect of NSY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat: Studies on dose, plasma concentration and therapeutic time window
    • Sydserff SG, Borelli AR, Green AR, Cross AJ Effect of NSY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat: Studies on dose, plasma concentration and therapeutic time window. Br J Pharmacol 2002, 135:103.
    • (2002) Br J Pharmacol , vol.135 , pp. 103
    • Sydserff, S.G.1    Borelli, A.R.2    Green, A.R.3    Cross, A.J.4
  • 178
    • 0033502692 scopus 로고    scopus 로고
    • Neuroprotective effects of a novel nitrone, NCY-059, after transient focal cerebral ischemia in the rat
    • Kuroda S, Tsuchidate R, Smith ML, et al. Neuroprotective effects of a novel nitrone, NCY-059, after transient focal cerebral ischemia in the rat. J Cereb Blood Flow Metab 1999, 19:778.
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 778
    • Kuroda, S.1    Tsuchidate, R.2    Smith, M.L.3
  • 179
    • 0035154631 scopus 로고    scopus 로고
    • NXY-059, a free radical-trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species
    • Marshall JWB, Duffin KJ, Green AR, Ridley RM NXY-059, a free radical-trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species. Stroke 2001, 32:190.
    • (2001) Stroke , vol.32 , pp. 190
    • Marshall, J.W.B.1    Duffin, K.J.2    Green, A.R.3    Ridley, R.M.4
  • 180
    • 84942628131 scopus 로고    scopus 로고
    • The effect of increasing doses of NXY-059 on infarct size following permanent middle cerebral artery occlusion in the rat.
    • Cross AJ: The effect of increasing doses of NXY-059 on infarct size following permanent middle cerebral artery occlusion in the rat. AstraZeneca Report 805-61 AN 062-01, 2000-06-09.
    • Cross, A.J.1
  • 181
    • 0034745231 scopus 로고    scopus 로고
    • Tolerability and pharmacokinetics of the nitrone NXY-059 in patients with acute stroke. The SANXY-0003 Investigators
    • Lees KR, Sharma AK, Barer D, et al. Tolerability and pharmacokinetics of the nitrone NXY-059 in patients with acute stroke. The SANXY-0003 Investigators. Stroke 2001, 32:675.
    • (2001) Stroke , vol.32 , pp. 675
    • Lees, K.R.1    Sharma, A.K.2    Barer, D.3
  • 182
    • 0028147428 scopus 로고
    • P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion
    • Okada Y, Copeland BR, More E, et al. P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion. Stroke 1994, 25:202.
    • (1994) Stroke , vol.25 , pp. 202
    • Okada, Y.1    Copeland, B.R.2    More, E.3
  • 183
    • 0029006577 scopus 로고
    • The temporal profiles of ICAM-1 protein and mRNA expression after transient MCA occlusion in the rat
    • Zhang RL, Chopp M, Zaloga C, et al. The temporal profiles of ICAM-1 protein and mRNA expression after transient MCA occlusion in the rat. Brain Res 1995, 682:182.
    • (1995) Brain Res , vol.682 , pp. 182
    • Zhang, R.L.1    Chopp, M.2    Zaloga, C.3
  • 184
    • 0032930869 scopus 로고    scopus 로고
    • Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury
    • Soriano SG, Coxon A, Wang YF, et al. Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury. Stroke 1999, 30:134.
    • (1999) Stroke , vol.30 , pp. 134
    • Soriano, S.G.1    Coxon, A.2    Wang, Y.F.3
  • 185
    • 0031742806 scopus 로고    scopus 로고
    • Deficiency of intercellular adhesion molecule-1 attenuates microcirculatory disturbance and infarction size in focal cerebral ischemia
    • Kitagawa K, Matsumoto M, Mabuchi T, et al. Deficiency of intercellular adhesion molecule-1 attenuates microcirculatory disturbance and infarction size in focal cerebral ischemia. J Cereb Blood Flow Metab 1998, 18:1336.
    • (1998) J Cereb Blood Flow Metab , vol.18 , pp. 1336
    • Kitagawa, K.1    Matsumoto, M.2    Mabuchi, T.3
  • 186
    • 0025768180 scopus 로고
    • Reduction of central nervous system ischemic injury in rabbits using leukocyte adhesion antibody treatment
    • Clark WM, Madden KP, Rothlein R, Zivin JA Reduction of central nervous system ischemic injury in rabbits using leukocyte adhesion antibody treatment. Stroke 1991, 22:877.
    • (1991) Stroke , vol.22 , pp. 877
    • Clark, W.M.1    Madden, K.P.2    Rothlein, R.3    Zivin, J.A.4
  • 187
    • 0029096735 scopus 로고
    • Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat
    • Zhang RL, Chopp M, Jiang N, et al. Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat. Stroke 1995, 26:1438.
    • (1995) Stroke , vol.26 , pp. 1438
    • Zhang, R.L.1    Chopp, M.2    Jiang, N.3
  • 188
    • 0001373003 scopus 로고    scopus 로고
    • Thrombolysis with tissue plasminogen activator alters adhesion molecule expression in the ischemic rat brain
    • Zhang RL, Zhang ZG, Chopp M, Zivin JA Thrombolysis with tissue plasminogen activator alters adhesion molecule expression in the ischemic rat brain. Stroke 1999, 30:624.
    • (1999) Stroke , vol.30 , pp. 624
    • Zhang, R.L.1    Zhang, Z.G.2    Chopp, M.3    Zivin, J.A.4
  • 189
    • 0029100108 scopus 로고
    • Circulating selectin- and immunoglobulin-type adhesion molecules in acute ischemic stroke
    • Fassbender K, Mossner R, Motsch L, et al. Circulating selectin- and immunoglobulin-type adhesion molecules in acute ischemic stroke. Stroke 1995, 26:1361.
    • (1995) Stroke , vol.26 , pp. 1361
    • Fassbender, K.1    Mossner, R.2    Motsch, L.3
  • 190
    • 0031681362 scopus 로고    scopus 로고
    • A longitudinal prospective study of soluble adhesion molecules in acute stroke
    • Bitsch A, Klene W, Murtada L, et al. A longitudinal prospective study of soluble adhesion molecules in acute stroke. Stroke 1998, 29:2129.
    • (1998) Stroke , vol.29 , pp. 2129
    • Bitsch, A.1    Klene, W.2    Murtada, L.3
  • 191
    • 0030665650 scopus 로고    scopus 로고
    • Soluble adhesion molecules reflect endothelial cell activation in ischemic stroke and in carotid atherosclerosis
    • Frijns CJ, Kappelle LJ, van Ijn J, et al. Soluble adhesion molecules reflect endothelial cell activation in ischemic stroke and in carotid atherosclerosis. Stroke 1997, 28:2214.
    • (1997) Stroke , vol.28 , pp. 2214
    • Frijns, C.J.1    Kappelle, L.J.2    van Ijn, J.3
  • 192
    • 0029808409 scopus 로고    scopus 로고
    • Endothelial ICAM-1 expression associated with inflammatory cell response in human ischemic stroke
    • Lindsberg PJ, Carpen O, Paetau A, et al. Endothelial ICAM-1 expression associated with inflammatory cell response in human ischemic stroke. Circulation 1996, 94:939.
    • (1996) Circulation , vol.94 , pp. 939
    • Lindsberg, P.J.1    Carpen, O.2    Paetau, A.3
  • 193
    • 0031848946 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and biological activity of enlimomab (anti-ICAM-1. antibody): An open-label, dose escalation study in patients hospitalized for acute stroke
    • Schneider D, Berrouschot J, Brandt T, et al. Safety, pharmacokinetics and biological activity of enlimomab (anti-ICAM-1. antibody): An open-label, dose escalation study in patients hospitalized for acute stroke. European Neurol 1998, 40:78.
    • (1998) European Neurol , vol.40 , pp. 78
    • Schneider, D.1    Berrouschot, J.2    Brandt, T.3
  • 194
    • 0035940577 scopus 로고    scopus 로고
    • Use of anti-ICAM-1 therapy in ischemic stroke: Results of the Enlimomab Acute Stroke Trial. Enlimomab Acute Stroke Trial Investigators
    • Use of anti-ICAM-1 therapy in ischemic stroke: Results of the Enlimomab Acute Stroke Trial. Enlimomab Acute Stroke Trial Investigators. Neurology 2001, 57:1428.
    • (2001) Neurology , vol.57 , pp. 1428
  • 195
    • 0035164475 scopus 로고    scopus 로고
    • Examination of several potential mechanisms for the negative outcome in a clinical stroke trial of enlimomab, a murine anti-human intercellular adhesion molecule-1 antibody: A bedside-to-bench study
    • Furuya K, Takeda H, Axhar S, et al. Examination of several potential mechanisms for the negative outcome in a clinical stroke trial of enlimomab, a murine anti-human intercellular adhesion molecule-1 antibody: A bedside-to-bench study. Stroke 2001, 32:2665.
    • (2001) Stroke , vol.32 , pp. 2665
    • Furuya, K.1    Takeda, H.2    Axhar, S.3
  • 196
    • 84942628132 scopus 로고    scopus 로고
    • ICOS halts trial of stroke drug, reports Q1 net loss. April 20th, 2000. Available at
    • ICOS halts trial of stroke drug, reports Q1 net loss. April 20th, 2000. Available at . http://www.mtsinai.org/pulmonary/books/house/legal.html.
  • 197
    • 0032579788 scopus 로고    scopus 로고
    • Neutrophil inhibitory factor treatment of focal cerebral ischemia in the rat
    • Jiang N, Chopp M, Chahwala S Neutrophil inhibitory factor treatment of focal cerebral ischemia in the rat. Brain Res 1998, 788:25.
    • (1998) Brain Res , vol.788 , pp. 25
    • Jiang, N.1    Chopp, M.2    Chahwala, S.3
  • 198
    • 84942628133 scopus 로고    scopus 로고
    • UK-279,276 Stroke Center Clinical Trials Directory. Available at Updated 5/9/2002.
    • UK-279,276 Stroke Center Clinical Trials Directory. Available at Updated 5/9/2002. http://www.mtsinai.org/pulmonary/books/house/legal.html.
  • 199
    • 0037227092 scopus 로고    scopus 로고
    • Reperfusion differentially induces caspases-3 activation in ischemic core and penumbra after stroke in immature brain
    • Manabat C, Han BH, Wendland M, et al. Reperfusion differentially induces caspases-3 activation in ischemic core and penumbra after stroke in immature brain. Stroke 2003, 34:207.
    • (2003) Stroke , vol.34 , pp. 207
    • Manabat, C.1    Han, B.H.2    Wendland, M.3
  • 201
    • 0029956924 scopus 로고    scopus 로고
    • Neuroprotective properties of a protein kinase inhibitor against ischaemia-induced neuronal damage in rats and gerbils
    • Satoh S, Ikegaki I, Suzuki Y, et al. Neuroprotective properties of a protein kinase inhibitor against ischaemia-induced neuronal damage in rats and gerbils. Br J Pharmacol 1996, 118:1592.
    • (1996) Br J Pharmacol , vol.118 , pp. 1592
    • Satoh, S.1    Ikegaki, I.2    Suzuki, Y.3
  • 202
    • 0029987453 scopus 로고    scopus 로고
    • An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective
    • Wang KKW, Nath R, Rosner A, et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc Natl Acad Sci U S A 1996, 93:6687.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 6687
    • Wang, K.K.W.1    Nath, R.2    Rosner, A.3
  • 203
    • 0035142857 scopus 로고    scopus 로고
    • SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia
    • Barone FC, Irving EA, Ray AM, et al. SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia. J Pharmacol Exp Ther 2001, 296:312.
    • (2001) J Pharmacol Exp Ther , vol.296 , pp. 312
    • Barone, F.C.1    Irving, E.A.2    Ray, A.M.3
  • 204
    • 0031984802 scopus 로고    scopus 로고
    • Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats
    • Markgraf CG, Velayo NL, Johnson MP, et al. Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats. Stroke 1998, 29:152.
    • (1998) Stroke , vol.29 , pp. 152
    • Markgraf, C.G.1    Velayo, N.L.2    Johnson, M.P.3
  • 205
    • 0032442475 scopus 로고    scopus 로고
    • Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
    • Yrjanheikki J, Keinanen R, Pellikka M, et al. Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci U S A 1998, 95:15769.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 15769
    • Yrjanheikki, J.1    Keinanen, R.2    Pellikka, M.3
  • 206
    • 0033539522 scopus 로고    scopus 로고
    • A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
    • Yrjanheikki J, Tikka T, Keinanen R, et al. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci U S A 1999, 96:13496.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 13496
    • Yrjanheikki, J.1    Tikka, T.2    Keinanen, R.3
  • 207
    • 0013071212 scopus 로고    scopus 로고
    • Delayed minocycline but not delayed mild hypothermia protects against embolic stroke
    • Wang C, Yang T, Noor R, Shuaib A Delayed minocycline but not delayed mild hypothermia protects against embolic stroke. BMC Neurol 2002, 2(1).
    • (2002) BMC Neurol , vol.2 , Issue.1
    • Wang, C.1    Yang, T.2    Noor, R.3    Shuaib, A.4
  • 208
    • 0033607543 scopus 로고    scopus 로고
    • High level calcineurin activity predisposes neuronal cells to apoptosis
    • Asai A, Qiu J, Narita Y, et al. High level calcineurin activity predisposes neuronal cells to apoptosis. J Biol Chem 1999, 274:34450.
    • (1999) J Biol Chem , vol.274 , pp. 34450
    • Asai, A.1    Qiu, J.2    Narita, Y.3
  • 209
    • 0033135379 scopus 로고    scopus 로고
    • FK506 prevents stroke-induced generation of ceramide and apoptosis signaling
    • Herr I, Martin-Villalba A, Kurz E, et al. FK506 prevents stroke-induced generation of ceramide and apoptosis signaling. Brain Res 1999, 826:210.
    • (1999) Brain Res , vol.826 , pp. 210
    • Herr, I.1    Martin-Villalba, A.2    Kurz, E.3
  • 210
    • 0033019790 scopus 로고    scopus 로고
    • Calcineurin inhibitors FK506 and SDZ ASM 981 alleviate the outcome of focal cerebral ischemic/reperfusion injury
    • Bochelen D, Rudin M, Sauter A Calcineurin inhibitors FK506 and SDZ ASM 981 alleviate the outcome of focal cerebral ischemic/reperfusion injury. J Pharmacol Exp Ther 1999, 288:653.
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 653
    • Bochelen, D.1    Rudin, M.2    Sauter, A.3
  • 211
    • 0034996767 scopus 로고    scopus 로고
    • Early and delayed neuroprotective effects of FK506 on experimental focal ischemia quantitatively assessed by diffusion-weighted MRI
    • Ebisu T, Katsuta K, Fujikawa A, et al. Early and delayed neuroprotective effects of FK506 on experimental focal ischemia quantitatively assessed by diffusion-weighted MRI. Magn Reson Imaging 2001, 19:153.
    • (2001) Magn Reson Imaging , vol.19 , pp. 153
    • Ebisu, T.1    Katsuta, K.2    Fujikawa, A.3
  • 213
    • 0034791043 scopus 로고    scopus 로고
    • Neuroprotective effect of immunosuppressant FK506 in transient focal ischemia in rat: Therapeutic time window for FK506 in transient focal ischemia
    • Arii T, Kamiya T, Arii K, et al. Neuroprotective effect of immunosuppressant FK506 in transient focal ischemia in rat: Therapeutic time window for FK506 in transient focal ischemia. Neurol Res 2001, 23:755.
    • (2001) Neurol Res , vol.23 , pp. 755
    • Arii, T.1    Kamiya, T.2    Arii, K.3
  • 214
    • 0035662825 scopus 로고    scopus 로고
    • FK506 attenuates early ischemic neuronal death in a monkey model of stroke
    • Takamatsu H, Tsukada H, Noda A, et al. FK506 attenuates early ischemic neuronal death in a monkey model of stroke. J Nucl Med 2001, 42:1833.
    • (2001) J Nucl Med , vol.42 , pp. 1833
    • Takamatsu, H.1    Tsukada, H.2    Noda, A.3
  • 215
    • 0036897343 scopus 로고    scopus 로고
    • Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids
    • Limbourg FP, Huang Z, Plumier JC, et al. Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids. J Clin Invest 2002, 110:1729.
    • (2002) J Clin Invest , vol.110 , pp. 1729
    • Limbourg, F.P.1    Huang, Z.2    Plumier, J.C.3
  • 217
    • 0022645283 scopus 로고
    • High dose steroid treatment in cerebral infarction
    • Norris JW, Hachinski VC High dose steroid treatment in cerebral infarction. BMJ 1986, 292:21.
    • (1986) BMJ , vol.292 , pp. 21
    • Norris, J.W.1    Hachinski, V.C.2
  • 219
    • 0031474156 scopus 로고    scopus 로고
    • Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit anti-inflammatory activity in vivo
    • Vayssiere BM, Dupont S, Choquart A, et al. Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit anti-inflammatory activity in vivo. Mol Endocrinol 1997, 11:1245.
    • (1997) Mol Endocrinol , vol.11 , pp. 1245
    • Vayssiere, B.M.1    Dupont, S.2    Choquart, A.3
  • 220
    • 0035073930 scopus 로고    scopus 로고
    • Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice
    • Amin-Hanjani S, Stagliano NE, Yamada M, et al. Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice. Stroke 2001, 32:980.
    • (2001) Stroke , vol.32 , pp. 980
    • Amin-Hanjani, S.1    Stagliano, N.E.2    Yamada, M.3
  • 221
    • 0031005723 scopus 로고    scopus 로고
    • Stroke, statins, and cholesterol: A meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors
    • Blauw GJ, Lagaay AM, Smelt AHM, Westendorp RGJ Stroke, statins, and cholesterol: A meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors. Stroke 1997, 28:946.
    • (1997) Stroke , vol.28 , pp. 946
    • Blauw, G.J.1    Lagaay, A.M.2    Smelt, A.H.M.3    Westendorp, R.G.J.4
  • 222
    • 0035133027 scopus 로고    scopus 로고
    • Human albumin therapy of acute ischemic stroke: Marked neuroprotective efficacy at moderate doses and with a broad therapeutic window
    • Belayev L, Liu Y, Zhao W, et al. Human albumin therapy of acute ischemic stroke: Marked neuroprotective efficacy at moderate doses and with a broad therapeutic window. Stroke 2001, 32:553.
    • (2001) Stroke , vol.32 , pp. 553
    • Belayev, L.1    Liu, Y.2    Zhao, W.3
  • 223
    • 10344266010 scopus 로고    scopus 로고
    • Serum albumin is a specific inhibitor of apoptosis in human endothelial cells
    • Zoellner H, Hofler M, Beckmann R, et al. Serum albumin is a specific inhibitor of apoptosis in human endothelial cells. J Cell Sci 1996, 109:2571.
    • (1996) J Cell Sci , vol.109 , pp. 2571
    • Zoellner, H.1    Hofler, M.2    Beckmann, R.3
  • 224
    • 0036828345 scopus 로고    scopus 로고
    • Systemic fatty acid responses to transient focal cerebral ischemia: Influence of neuroprotectant therapy with human albumin
    • Rodriguez de Turco IB, Belayev L, Liu Y, et al. Systemic fatty acid responses to transient focal cerebral ischemia: Influence of neuroprotectant therapy with human albumin. J Neurochem 2002, 83:515.
    • (2002) J Neurochem , vol.83 , pp. 515
    • Rodriguez de Turco, I.B.1    Belayev, L.2    Liu, Y.3
  • 225
    • 0027936299 scopus 로고
    • Early treatment of stroke with monosialoganglioside GM-1: Efficacy and safety results of the early stroke trial. The Early Stroke Trial Group
    • Lenzi GL, Grigoletto F, Gent M, et al. Early treatment of stroke with monosialoganglioside GM-1: Efficacy and safety results of the early stroke trial. The Early Stroke Trial Group. Stroke 1994, 25:1552.
    • (1994) Stroke , vol.25 , pp. 1552
    • Lenzi, G.L.1    Grigoletto, F.2    Gent, M.3
  • 226
    • 0031596276 scopus 로고    scopus 로고
    • Brain-derived peptides reduce the size of cerebral infarction and loss of MAP2 immunoreactivity after focal ischemia in rats
    • Schwab M, Antonow-Schorke I, Zwiener U, Bauer R Brain-derived peptides reduce the size of cerebral infarction and loss of MAP2 immunoreactivity after focal ischemia in rats. J Neural Transm Suppl 1998, 53:299.
    • (1998) J Neural Transm Suppl , vol.53 , pp. 299
    • Schwab, M.1    Antonow-Schorke, I.2    Zwiener, U.3    Bauer, R.4
  • 227
    • 26744478852 scopus 로고    scopus 로고
    • Neuroprotection in acute ischaemic stroke [abstract]
    • Ladurner F Neuroprotection in acute ischaemic stroke [abstract]. Stroke 2001, 32:323.
    • (2001) Stroke , vol.32 , pp. 323
    • Ladurner, F.1
  • 228
    • 0344240113 scopus 로고    scopus 로고
    • CDP-choline: Neuroprotection in transient forebrain ischemia of gerbils
    • Rao AM, Hatcher JF, Dempsey RJ CDP-choline: Neuroprotection in transient forebrain ischemia of gerbils. J Neurosci Res 1999, 58:697.
    • (1999) J Neurosci Res , vol.58 , pp. 697
    • Rao, A.M.1    Hatcher, J.F.2    Dempsey, R.J.3
  • 229
    • 0036270432 scopus 로고    scopus 로고
    • Citicoline: Neuroprotective mechanisms in cerebral ischemia
    • Adibhatla RM, Hatcher JF, Dempsey RJ Citicoline: Neuroprotective mechanisms in cerebral ischemia. J Neurochem 2002, 80:12.
    • (2002) J Neurochem , vol.80 , pp. 12
    • Adibhatla, R.M.1    Hatcher, J.F.2    Dempsey, R.J.3
  • 230
    • 0036098560 scopus 로고    scopus 로고
    • CDP-choline reduces procaspase and cleaved caspae-3 expression, nuclear DNA fragmentation, and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat
    • Krupinski J, Ferrer I, Barrachina M, et al. CDP-choline reduces procaspase and cleaved caspae-3 expression, nuclear DNA fragmentation, and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat. Neuropharmacology 2002, 42:846.
    • (2002) Neuropharmacology , vol.42 , pp. 846
    • Krupinski, J.1    Ferrer, I.2    Barrachina, M.3
  • 231
    • 0025912472 scopus 로고
    • Biochemical rationale for the use of CDP-choline in traumatic brain injury: Pharmacokinetics of the orally administered drug
    • Galleti P, DeRosa M, Cotticelli MG, et al. Biochemical rationale for the use of CDP-choline in traumatic brain injury: Pharmacokinetics of the orally administered drug. J Neurol Sci 1991, 103:S19.
    • (1991) J Neurol Sci , vol.103 , pp. S19
    • Galleti, P.1    DeRosa, M.2    Cotticelli, M.G.3
  • 232
    • 0030760430 scopus 로고    scopus 로고
    • A randomized dose-response trial of citicoline in acute ischemic stroke patients. The Citicoline Study Group
    • Clark W, Warach S A randomized dose-response trial of citicoline in acute ischemic stroke patients. The Citicoline Study Group. Neurology 1997, 49:671.
    • (1997) Neurology , vol.49 , pp. 671
    • Clark, W.1    Warach, S.2
  • 233
    • 0032709479 scopus 로고    scopus 로고
    • A randomized efficacy trial of citicoline in patients with acute ischemic stroke. The Citicoline Stroke Study Group
    • Clark WM, Williams BJ, Selzer KA, et al. A randomized efficacy trial of citicoline in patients with acute ischemic stroke. The Citicoline Stroke Study Group. Stroke 1999, 30:2592.
    • (1999) Stroke , vol.30 , pp. 2592
    • Clark, W.M.1    Williams, B.J.2    Selzer, K.A.3
  • 234
    • 0035856456 scopus 로고    scopus 로고
    • A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients. The Citicoline Stroke Study Group
    • Clark WM, Wechsler LR, Sabounjian LA, Schwiderski UE A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients. The Citicoline Stroke Study Group. Neurology 2001, 57:1595.
    • (2001) Neurology , vol.57 , pp. 1595
    • Clark, W.M.1    Wechsler, L.R.2    Sabounjian, L.A.3    Schwiderski, U.E.4
  • 235
    • 84942595389 scopus 로고
    • CDP-choline for cerebrovascular disorders: Clinical evaluation and evaluation of electrophysiological symptomology
    • Corso A, Arena M, Ventimiglia A, et al. CDP-choline for cerebrovascular disorders: Clinical evaluation and evaluation of electrophysiological symptomology. Clin Ter 1982, 102:370.
    • (1982) Clin Ter , vol.102 , pp. 370
    • Corso, A.1    Arena, M.2    Ventimiglia, A.3
  • 236
    • 0023860168 scopus 로고
    • Treatment of acute cerebral infarction with a choline precursor in a multicenter double-blind placebo-controlled study
    • Tazaki Y, Sakai F, Otomo E, et al. Treatment of acute cerebral infarction with a choline precursor in a multicenter double-blind placebo-controlled study. Stroke 1988, 19:211-216.
    • (1988) Stroke , vol.19 , pp. 211-216
    • Tazaki, Y.1    Sakai, F.2    Otomo, E.3
  • 237
    • 84882910153 scopus 로고    scopus 로고
    • Choline precursors in acute and subacute stroke: A meta-analysis
    • Saver J, Wilterdink J Choline precursors in acute and subacute stroke: A meta-analysis. Stroke 2002, 32:1598.
    • (2002) Stroke , vol.32 , pp. 1598
    • Saver, J.1    Wilterdink, J.2
  • 238
    • 0032985429 scopus 로고    scopus 로고
    • Effects of citicoline combined with thrombolytic therapy in a rat embolic stroke model
    • Andersen M, Overgaard K, Meden P, Boysen G Effects of citicoline combined with thrombolytic therapy in a rat embolic stroke model. Stroke 1999, 30:1464.
    • (1999) Stroke , vol.30 , pp. 1464
    • Andersen, M.1    Overgaard, K.2    Meden, P.3    Boysen, G.4
  • 239
    • 0031904678 scopus 로고    scopus 로고
    • Estrogen-mediated neuroprotection after experimental stroke in male rates
    • Toung TJK, Traystman RJ, Hurn PD Estrogen-mediated neuroprotection after experimental stroke in male rates. Stroke 1998, 29:1666.
    • (1998) Stroke , vol.29 , pp. 1666
    • Toung, T.J.K.1    Traystman, R.J.2    Hurn, P.D.3
  • 240
    • 0030700217 scopus 로고    scopus 로고
    • Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat
    • Simpkins JW, Rajakumar G, Zhang YQ, et al. Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. J Neurosurg 1997, 87:724.
    • (1997) J Neurosurg , vol.87 , pp. 724
    • Simpkins, J.W.1    Rajakumar, G.2    Zhang, Y.Q.3
  • 241
    • 0033178294 scopus 로고    scopus 로고
    • Estradiol modulates bcl-2 in cerebral ischemia: A potential role for estrogen receptors
    • Dubal DB, Shughrue PJ, Wilson ME, et al. Estradiol modulates bcl-2 in cerebral ischemia: A potential role for estrogen receptors. J Neurosci 1999, 19:6385.
    • (1999) J Neurosci , vol.19 , pp. 6385
    • Dubal, D.B.1    Shughrue, P.J.2    Wilson, M.E.3
  • 242
    • 0034237128 scopus 로고    scopus 로고
    • Neuroprotective effects of estrogens: Potential mechanisms of action
    • Green PS, Simpkins JW Neuroprotective effects of estrogens: Potential mechanisms of action. Int J Dev Neurosci 2000, 8:347.
    • (2000) Int J Dev Neurosci , vol.8 , pp. 347
    • Green, P.S.1    Simpkins, J.W.2
  • 243
    • 0023808893 scopus 로고
    • Postmenopausal oestrogen treatment and stroke: A prospective study
    • Paganini-Hill A, Ross RK, Henderson BE Postmenopausal oestrogen treatment and stroke: A prospective study. BMJ 1988, 297:519.
    • (1988) BMJ , vol.297 , pp. 519
    • Paganini-Hill, A.1    Ross, R.K.2    Henderson, B.E.3
  • 244
    • 0033520748 scopus 로고    scopus 로고
    • Weighing the risks and benefits of tamoxifen treatment for preventing breast cancer
    • Gail MH, Costantino JP, Bryant J, et al. Weighing the risks and benefits of tamoxifen treatment for preventing breast cancer. J Natl Cancer Inst 1999, 91:1829.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1829
    • Gail, M.H.1    Costantino, J.P.2    Bryant, J.3
  • 247
    • 0032516086 scopus 로고    scopus 로고
    • In vitro evidence that erythropoietin protects neurons from ischemic damage
    • Sakanaka M, Wen TC, Matsuda S, et al. In vitro evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci U S A 1998, 95:4635.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 4635
    • Sakanaka, M.1    Wen, T.C.2    Matsuda, S.3
  • 248
    • 0030636320 scopus 로고    scopus 로고
    • Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death
    • Morishita E, Masuda S, Nagao M, et al. Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death. Neuroscience 1997, 76:105.
    • (1997) Neuroscience , vol.76 , pp. 105
    • Morishita, E.1    Masuda, S.2    Nagao, M.3
  • 249
    • 0034641710 scopus 로고    scopus 로고
    • Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury
    • Brines ML, Ghezzi P, Keenan S, et al. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci U S A 2000, 97:10526.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 10526
    • Brines, M.L.1    Ghezzi, P.2    Keenan, S.3
  • 250
    • 0035957426 scopus 로고    scopus 로고
    • Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
    • Siren AL, Fratelli M, Brines M, et al. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci U S A 2000, 98:4044.
    • (2000) Proc Natl Acad Sci U S A , vol.98 , pp. 4044
    • Siren, A.L.1    Fratelli, M.2    Brines, M.3
  • 251
    • 0035910918 scopus 로고    scopus 로고
    • Intravenous basic fibroblast growth factor (bFGF) decreases DNA fragmentation and prevents downregulation of Bcl-2 expression in the ischemic brain following middle cerebral artery occlusion in rats
    • Ay I, Sugimori H, Finklestein SP Intravenous basic fibroblast growth factor (bFGF) decreases DNA fragmentation and prevents downregulation of Bcl-2 expression in the ischemic brain following middle cerebral artery occlusion in rats. Mol Brain Res 2001, 87:71.
    • (2001) Mol Brain Res , vol.87 , pp. 71
    • Ay, I.1    Sugimori, H.2    Finklestein, S.P.3
  • 252
    • 0030760175 scopus 로고    scopus 로고
    • Intracisternal basic fibroblast growth factor enhances functional recovery and upregulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction
    • Kawamata T, Kietrich WD, Schallert T, et al. Intracisternal basic fibroblast growth factor enhances functional recovery and upregulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction. Proc Natl Acad Sci U S A 1997, 94:8179.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 8179
    • Kawamata, T.1    Kietrich, W.D.2    Schallert, T.3
  • 253
    • 0036433581 scopus 로고    scopus 로고
    • Postischemic administration of basic fibroblast growth factor improves sensorimotor function and reduces infarct size following permanent focal cerebral ischemia in the rat
    • Li Q, Stephenson D Postischemic administration of basic fibroblast growth factor improves sensorimotor function and reduces infarct size following permanent focal cerebral ischemia in the rat. Exp Neurol 2002, 177:531.
    • (2002) Exp Neurol , vol.177 , pp. 531
    • Li, Q.1    Stephenson, D.2
  • 254
    • 0345561549 scopus 로고    scopus 로고
    • Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia
    • Schabitz WR, Li F, Irie K, et al. Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia. Stroke 1999, 30:427.
    • (1999) Stroke , vol.30 , pp. 427
    • Schabitz, W.R.1    Li, F.2    Irie, K.3
  • 255
    • 0034753649 scopus 로고    scopus 로고
    • Synergistic protective effect of caspases inhibitors and bFGF against brain injury induced by transient focal ischaemia
    • Ma J, Aui J, Hirt L, et al. Synergistic protective effect of caspases inhibitors and bFGF against brain injury induced by transient focal ischaemia. Br J Pharmacol 2001, 133:345.
    • (2001) Br J Pharmacol , vol.133 , pp. 345
    • Ma, J.1    Aui, J.2    Hirt, L.3
  • 256
    • 0036968150 scopus 로고    scopus 로고
    • Fiblast (trafermin) in acute stroke: Results of the European-Australian phase II/III safety and efficacy trial. The European-Australian Fiblast in Acute Stroke Group
    • Bogousslavsky J, Victor SJ, Salinas EO, et al. Fiblast (trafermin) in acute stroke: Results of the European-Australian phase II/III safety and efficacy trial. The European-Australian Fiblast in Acute Stroke Group. Cerebrovasc Dis 2002, 14:239.
    • (2002) Cerebrovasc Dis , vol.14 , pp. 239
    • Bogousslavsky, J.1    Victor, S.J.2    Salinas, E.O.3
  • 257
    • 0036228917 scopus 로고    scopus 로고
    • Enhanced neuroprotective effects of basic fibroblast growth factor in regional brain ischemia after conjugation to a blood-brain barrier delivery vector
    • Song BW, Vinters HV, Wu D, Pardridge WM Enhanced neuroprotective effects of basic fibroblast growth factor in regional brain ischemia after conjugation to a blood-brain barrier delivery vector. J Pharmacol Exp Ther 2002, 301:605.
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 605
    • Song, B.W.1    Vinters, H.V.2    Wu, D.3    Pardridge, W.M.4
  • 258
    • 0030934491 scopus 로고    scopus 로고
    • A putative role for platelet-derived growth factor in angiogenesis and neuroprotection after ischemic stroke in humans
    • Krupinski J, Issa R, Bujny T, et al. A putative role for platelet-derived growth factor in angiogenesis and neuroprotection after ischemic stroke in humans. Stroke 1997, 28:564.
    • (1997) Stroke , vol.28 , pp. 564
    • Krupinski, J.1    Issa, R.2    Bujny, T.3
  • 259
    • 0032873417 scopus 로고    scopus 로고
    • Neuroprotection mediated via neurotrophic factors and induction of neurotrophic factors
    • Semkova I, Krieglstein J Neuroprotection mediated via neurotrophic factors and induction of neurotrophic factors. Brain Res Rev 1999, 30:176.
    • (1999) Brain Res Rev , vol.30 , pp. 176
    • Semkova, I.1    Krieglstein, J.2
  • 260
    • 0036275026 scopus 로고    scopus 로고
    • Protective effects of glial cell line-derived neurotrophic factor in ischemic brain injury
    • Wang Y, Chang CF, Morales M, et al. Protective effects of glial cell line-derived neurotrophic factor in ischemic brain injury. Ann N Y Acad Sci 2002, 962:423.
    • (2002) Ann N Y Acad Sci , vol.962 , pp. 423
    • Wang, Y.1    Chang, C.F.2    Morales, M.3
  • 261
    • 0036829818 scopus 로고    scopus 로고
    • Intravenous TAT-Bcl-XL is protective after middle cerebral artery occlusion in mice
    • Kilic E, Dietz GPH, Hermann DM, Bahr M Intravenous TAT-Bcl-XL is protective after middle cerebral artery occlusion in mice. Ann Neurol 2002, 52:617.
    • (2002) Ann Neurol , vol.52 , pp. 617
    • Kilic, E.1    Dietz, G.P.H.2    Hermann, D.M.3    Bahr, M.4
  • 262
    • 0023554153 scopus 로고
    • Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury
    • Busto R, Dietrich WD, Globus MYT, et al. Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab 1987, 7:729.
    • (1987) J Cereb Blood Flow Metab , vol.7 , pp. 729
    • Busto, R.1    Dietrich, W.D.2    Globus, M.Y.T.3
  • 263
    • 0025012714 scopus 로고
    • Hypothermia but not N-methyl-D-aspartate antagonist MK-801 attenuates neuronal damage in gerbils subjected to transient global ischemia
    • Buchan A, Pulsinell WA Hypothermia but not N-methyl-D-aspartate antagonist MK-801 attenuates neuronal damage in gerbils subjected to transient global ischemia. J Neurosci 1990, 10:311.
    • (1990) J Neurosci , vol.10 , pp. 311
    • Buchan, A.1    Pulsinell, W.A.2
  • 265
    • 0026621037 scopus 로고
    • Hypothermia ameliorates neuronal survival when induced 2 hours after ischemia in the rat
    • Coimbra C, Wielock T Hypothermia ameliorates neuronal survival when induced 2 hours after ischemia in the rat. Acta Physiol Scand 1992, 146:543.
    • (1992) Acta Physiol Scand , vol.146 , pp. 543
    • Coimbra, C.1    Wielock, T.2
  • 266
    • 0028356643 scopus 로고
    • The influence of body temperature on infarct volume and thrombolytic therapy in a rat embolic stroke model
    • Meden P, Overguard K, Pedersen H, Boysen G The influence of body temperature on infarct volume and thrombolytic therapy in a rat embolic stroke model. Brain Res 1994, 647:131.
    • (1994) Brain Res , vol.647 , pp. 131
    • Meden, P.1    Overguard, K.2    Pedersen, H.3    Boysen, G.4
  • 267
    • 0030664030 scopus 로고    scopus 로고
    • Hypothermic neuroprotection: A global ischemia study using 18- to 20-month-old gerbils
    • Corbett D, Nurse S, Colbourne F Hypothermic neuroprotection: A global ischemia study using 18- to 20-month-old gerbils. Stroke 1997, 28:2238.
    • (1997) Stroke , vol.28 , pp. 2238
    • Corbett, D.1    Nurse, S.2    Colbourne, F.3
  • 268
    • 0031046512 scopus 로고    scopus 로고
    • Brain cooling during transient focal ischemia provides complete neuroprotection
    • Barone FC, Feuerstein GZ, White RF Brain cooling during transient focal ischemia provides complete neuroprotection. Neurosci Biobehav Rev 1997, 21:31.
    • (1997) Neurosci Biobehav Rev , vol.21 , pp. 31
    • Barone, F.C.1    Feuerstein, G.Z.2    White, R.F.3
  • 269
    • 0345563285 scopus 로고    scopus 로고
    • Optimal depth and duration of mild hypothermia in a focal model of transient cerebral ischemia: Effects of neurologic outcome, infarct size, apoptosis, and inflammation
    • Maier CM, Ahern KB, Cheng MD, et al. Optimal depth and duration of mild hypothermia in a focal model of transient cerebral ischemia: Effects of neurologic outcome, infarct size, apoptosis, and inflammation. Stroke 1998, 29:2191.
    • (1998) Stroke , vol.29 , pp. 2191
    • Maier, C.M.1    Ahern, K.B.2    Cheng, M.D.3
  • 270
    • 0034025375 scopus 로고    scopus 로고
    • Persistent neuroprotection with prolonged postischemic hypothermia in adult rats subjected to transient middle cerebral artery occlusion
    • Corbett D, Hamilton M, Colbourne F Persistent neuroprotection with prolonged postischemic hypothermia in adult rats subjected to transient middle cerebral artery occlusion. Exp Neurol 2000, 163:200.
    • (2000) Exp Neurol , vol.163 , pp. 200
    • Corbett, D.1    Hamilton, M.2    Colbourne, F.3
  • 271
    • 0033855476 scopus 로고    scopus 로고
    • Effects of delayed intraischemic and postischemic hypothermia on a focal model of transient cerebral ischemia in rats
    • Kawai N, Okauchi M, Morisaki K, Nagao S Effects of delayed intraischemic and postischemic hypothermia on a focal model of transient cerebral ischemia in rats. Stroke 2000, 31:1982.
    • (2000) Stroke , vol.31 , pp. 1982
    • Kawai, N.1    Okauchi, M.2    Morisaki, K.3    Nagao, S.4
  • 272
    • 0029927772 scopus 로고    scopus 로고
    • Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization
    • Nakashima K, Todd MM Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization. Stroke 1996, 27:913.
    • (1996) Stroke , vol.27 , pp. 913
    • Nakashima, K.1    Todd, M.M.2
  • 273
    • 0031046699 scopus 로고    scopus 로고
    • Effects of mild hypothermia on cerebral blood flow-independent changes in cortical extracellular levels of amino acids following contusion trauma in the rat
    • Koizumi H, Fujisawa H, Ito H, et al. Effects of mild hypothermia on cerebral blood flow-independent changes in cortical extracellular levels of amino acids following contusion trauma in the rat. Brain Res 1997, 747:304.
    • (1997) Brain Res , vol.747 , pp. 304
    • Koizumi, H.1    Fujisawa, H.2    Ito, H.3
  • 274
    • 0032751371 scopus 로고    scopus 로고
    • Mild hypothermia improves recovery of cortical extracellular potassium ion activity and excitability after middle cerebral artery occlusion in the rat
    • Sick TJ, Xu G, Perez-Pinzon AM Mild hypothermia improves recovery of cortical extracellular potassium ion activity and excitability after middle cerebral artery occlusion in the rat. Stroke 1999, 30:2416.
    • (1999) Stroke , vol.30 , pp. 2416
    • Sick, T.J.1    Xu, G.2    Perez-Pinzon, A.M.3
  • 275
    • 0034703589 scopus 로고    scopus 로고
    • Immunohistochemical expression of Bcl-2, Bax and cytochrome c following focal cerebral ischemia and effect of hypothermia in rat
    • Babu PP, Yoshida Y, Su M, et al. Immunohistochemical expression of Bcl-2, Bax and cytochrome c following focal cerebral ischemia and effect of hypothermia in rat. Neurosci Lett 2000, 291:196.
    • (2000) Neurosci Lett , vol.291 , pp. 196
    • Babu, P.P.1    Yoshida, Y.2    Su, M.3
  • 276
    • 0032776401 scopus 로고    scopus 로고
    • Effects of moderate hypothermia on leukocyte-endothelium interaction in the rat pial microvasculature after transient middle cerebral artery occlusion
    • Ishikawa M, Sekizuka E, Sato S, et al. Effects of moderate hypothermia on leukocyte-endothelium interaction in the rat pial microvasculature after transient middle cerebral artery occlusion. Stroke 1999, 30:1679.
    • (1999) Stroke , vol.30 , pp. 1679
    • Ishikawa, M.1    Sekizuka, E.2    Sato, S.3
  • 277
    • 0034703331 scopus 로고    scopus 로고
    • Post-ischemic hypothermia delayed neutrophil accumulation and microglial activation following transient focal cerebral ischemia in rats
    • Inamasu J, Suga S, Sato S, et al. Post-ischemic hypothermia delayed neutrophil accumulation and microglial activation following transient focal cerebral ischemia in rats. J Neuroimmunol 2000, 109:66.
    • (2000) J Neuroimmunol , vol.109 , pp. 66
    • Inamasu, J.1    Suga, S.2    Sato, S.3
  • 278
    • 19244380799 scopus 로고    scopus 로고
    • Mild resuscitative hypothermia to improve neurological outcome after cardiac arrest. The Hypothermia After Cardiac Arrest (HACA) Study Group
    • Zeiner A, Holzer M, Sterz F, et al. Mild resuscitative hypothermia to improve neurological outcome after cardiac arrest. The Hypothermia After Cardiac Arrest (HACA) Study Group. Stroke 2000, 31:86.
    • (2000) Stroke , vol.31 , pp. 86
    • Zeiner, A.1    Holzer, M.2    Sterz, F.3
  • 279
    • 0035834154 scopus 로고    scopus 로고
    • Hypothermia after cardiac arrest: Feasibility and safety of an external cooling protocol
    • Felberg RA, Krieger DW, Chuang R, et al. Hypothermia after cardiac arrest: Feasibility and safety of an external cooling protocol. Circulation 2001, 104:1799.
    • (2001) Circulation , vol.104 , pp. 1799
    • Felberg, R.A.1    Krieger, D.W.2    Chuang, R.3
  • 280
    • 0028879709 scopus 로고
    • Fever in acute stroke worsens prognosis
    • Azzimondi G, Bassein L, Nonino F, et al. Fever in acute stroke worsens prognosis. Stroke 1995, 26:2040.
    • (1995) Stroke , vol.26 , pp. 2040
    • Azzimondi, G.1    Bassein, L.2    Nonino, F.3
  • 281
    • 0029886867 scopus 로고    scopus 로고
    • Body temperature and outcome in stroke patients [letter]
    • Jorgensen HS, Reith J, Pedersen PM, et al. Body temperature and outcome in stroke patients [letter]. Lancet 1996, 348:193.
    • (1996) Lancet , vol.348 , pp. 193
    • Jorgensen, H.S.1    Reith, J.2    Pedersen, P.M.3
  • 282
    • 0030039285 scopus 로고    scopus 로고
    • Body temperature in acute stroke: Relation to stroke severity, infarct size, mortality, and outcome
    • Reith J, Jorgensen HS, Pedersen PM, et al. Body temperature in acute stroke: Relation to stroke severity, infarct size, mortality, and outcome. Lancet 1996, 347:422.
    • (1996) Lancet , vol.347 , pp. 422
    • Reith, J.1    Jorgensen, H.S.2    Pedersen, P.M.3
  • 283
    • 0033951801 scopus 로고    scopus 로고
    • Influence of admission body temperature on stroke mortality
    • Wang Y, Lim LL, Levi C, et al. Influence of admission body temperature on stroke mortality. Stroke 2000, 31:404.
    • (2000) Stroke , vol.31 , pp. 404
    • Wang, Y.1    Lim, L.L.2    Levi, C.3
  • 284
    • 0031756859 scopus 로고    scopus 로고
    • Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction
    • Schwab S, Schwarz S, Spranger M, et al. Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction. Stroke 1998, 29:2461.
    • (1998) Stroke , vol.29 , pp. 2461
    • Schwab, S.1    Schwarz, S.2    Spranger, M.3
  • 285
    • 0033821072 scopus 로고    scopus 로고
    • Feasibility and safety of inducing modest hypothermia in awake patients with acute stroke through surface cooling: A case-control study
    • Kammersgaard LP, Rasmussen BH, Jorgensen HS, et al. Feasibility and safety of inducing modest hypothermia in awake patients with acute stroke through surface cooling: A case-control study. Stroke 2000, 31:2251.
    • (2000) Stroke , vol.31 , pp. 2251
    • Kammersgaard, L.P.1    Rasmussen, B.H.2    Jorgensen, H.S.3
  • 286
    • 0034835309 scopus 로고    scopus 로고
    • Feasibility and safety of moderate hypothermia after massive hemispheric infarction
    • Schwab S, Georgiadis D, Berrouschot J, et al. Feasibility and safety of moderate hypothermia after massive hemispheric infarction. Stroke 2001, 32:2033.
    • (2001) Stroke , vol.32 , pp. 2033
    • Schwab, S.1    Georgiadis, D.2    Berrouschot, J.3
  • 287
    • 0035207918 scopus 로고    scopus 로고
    • Effect and feasibility of controlled rewarming after moderate hypothermia in stroke patients with malignant infarction of the middle cerebral artery
    • Steiner T, Friede T, Aschoff A, et al. Effect and feasibility of controlled rewarming after moderate hypothermia in stroke patients with malignant infarction of the middle cerebral artery. Stroke 2001, 32:2833.
    • (2001) Stroke , vol.32 , pp. 2833
    • Steiner, T.1    Friede, T.2    Aschoff, A.3
  • 288
    • 0034889655 scopus 로고    scopus 로고
    • Cooling for Acute Ischemic Brain Damage (COOL AID): An open pilot study of induced hypothermia in acute ischemic stroke
    • Kreiger DW, DeGeorgia MA, Abou-Chebl A, et al. Cooling for Acute Ischemic Brain Damage (COOL AID): An open pilot study of induced hypothermia in acute ischemic stroke. Stroke 2001, 32:1847.
    • (2001) Stroke , vol.32 , pp. 1847
    • Kreiger, D.W.1    DeGeorgia, M.A.2    Abou-Chebl, A.3
  • 289
    • 0035172415 scopus 로고    scopus 로고
    • Endovascular cooling for moderate hypothermia in patients with acute stroke: First results of a novel approach
    • Georgiadis D, Schwarz S, Kollmar R, Schwab S Endovascular cooling for moderate hypothermia in patients with acute stroke: First results of a novel approach. Stroke 2001, 32:2550.
    • (2001) Stroke , vol.32 , pp. 2550
    • Georgiadis, D.1    Schwarz, S.2    Kollmar, R.3    Schwab, S.4
  • 290
    • 0033978741 scopus 로고    scopus 로고
    • Combination of low dose ethanol and caffeine protects brain from damage produced by focal ischemia in rats
    • Strong R, Grotta JC, Aronowski J Combination of low dose ethanol and caffeine protects brain from damage produced by focal ischemia in rats. Neuropharmacology 2000, 39:515.
    • (2000) Neuropharmacology , vol.39 , pp. 515
    • Strong, R.1    Grotta, J.C.2    Aronowski, J.3
  • 291
    • 0038222577 scopus 로고    scopus 로고
    • Ethanol plus caffeine (caffeinol) for treatment of ischemic stroke: preclinical experience
    • Aronowski J, Strong R, Shirzadi A, Grotta J Ethanol plus caffeine (caffeinol) for treatment of ischemic stroke: preclinical experience. Stroke 2003, 34:1246.
    • (2003) Stroke , vol.34 , pp. 1246
    • Aronowski, J.1    Strong, R.2    Shirzadi, A.3    Grotta, J.4
  • 292
    • 0038643447 scopus 로고    scopus 로고
    • Pilot dose-escalation study of caffeine plus ethanol (caffeinol) in acute ischemic stroke
    • Piriyawat P, Labiche LA, Burgin WS, et al. Pilot dose-escalation study of caffeine plus ethanol (caffeinol) in acute ischemic stroke. Stroke 2003, 34:1242.
    • (2003) Stroke , vol.34 , pp. 1242
    • Piriyawat, P.1    Labiche, L.A.2    Burgin, W.S.3
  • 293
    • 0028007097 scopus 로고
    • Diaspirin cross-linked hemoglobin improves neurological outcome following reversible but not irreversible CNS ischemia in rabbits
    • Bowes M, Burhop K, Zivin J Diaspirin cross-linked hemoglobin improves neurological outcome following reversible but not irreversible CNS ischemia in rabbits. Stroke 1994, 25:2253.
    • (1994) Stroke , vol.25 , pp. 2253
    • Bowes, M.1    Burhop, K.2    Zivin, J.3
  • 294
    • 0026667411 scopus 로고
    • Focal cerebral ischemia in rats: Effect of hemodilution with cross-linked hemoglobin on CBF
    • Cole D, Schell R, Przybelski R, et al. Focal cerebral ischemia in rats: Effect of hemodilution with cross-linked hemoglobin on CBF. J Cereb Blood Flow Metab 1992, 12:971.
    • (1992) J Cereb Blood Flow Metab , vol.12 , pp. 971
    • Cole, D.1    Schell, R.2    Przybelski, R.3
  • 295
    • 0027502466 scopus 로고
    • Focal cerebral ischemia in rats: Effect of hypervolemic hemodilution with diaspirin crossed-linked hemoglobin versus albumin on brain injury and edema
    • Cole D, Schell R, Drummond J, Reynolds L Focal cerebral ischemia in rats: Effect of hypervolemic hemodilution with diaspirin crossed-linked hemoglobin versus albumin on brain injury and edema. Anesthesiology 1993, 78:335.
    • (1993) Anesthesiology , vol.78 , pp. 335
    • Cole, D.1    Schell, R.2    Drummond, J.3    Reynolds, L.4
  • 296
    • 26444475060 scopus 로고    scopus 로고
    • DCLHb for focal ischemia and reperfusion
    • Grotta J, Aronowski J DCLHb for focal ischemia and reperfusion. Cerebrovasc Dis 1996, 6:189.
    • (1996) Cerebrovasc Dis , vol.6 , pp. 189
    • Grotta, J.1    Aronowski, J.2
  • 297
    • 0032921865 scopus 로고    scopus 로고
    • Controlled safety study of a hemoglobin-based oxygen carrier, DCLHb, in acute ischemic stroke
    • Saxena R, Wijnhoud AD, Carton H, et al. Controlled safety study of a hemoglobin-based oxygen carrier, DCLHb, in acute ischemic stroke. Stroke 1999, 30:993.
    • (1999) Stroke , vol.30 , pp. 993
    • Saxena, R.1    Wijnhoud, A.D.2    Carton, H.3
  • 298
    • 0037177102 scopus 로고    scopus 로고
    • Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke
    • Singhal AB, Dijkhuizen RM, Rosen B, Lo EH Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke. Neurology 2002, 58:945.
    • (2002) Neurology , vol.58 , pp. 945
    • Singhal, A.B.1    Dijkhuizen, R.M.2    Rosen, B.3    Lo, E.H.4
  • 299
    • 0034574703 scopus 로고    scopus 로고
    • Neutrophil sequestration and the effect of hyperbaric oxygen in a rat model of temporary middle cerebral artery occlusion
    • Atochin DN, Fisher D, Demchenko IT, Thom SR Neutrophil sequestration and the effect of hyperbaric oxygen in a rat model of temporary middle cerebral artery occlusion. Undersea Hyperb Med 2000, 27:185.
    • (2000) Undersea Hyperb Med , vol.27 , pp. 185
    • Atochin, D.N.1    Fisher, D.2    Demchenko, I.T.3    Thom, S.R.4
  • 300
    • 0035914182 scopus 로고    scopus 로고
    • Effect of hyperbaric oxygen on striatal metabolites: A microdialysis study in awake freely moving rats after MCA occlusion
    • Badr AE, Yin W, Mychaskiw G, Zhang JH Effect of hyperbaric oxygen on striatal metabolites: A microdialysis study in awake freely moving rats after MCA occlusion. Brain Res 2001, 916:85.
    • (2001) Brain Res , vol.916 , pp. 85
    • Badr, A.E.1    Yin, W.2    Mychaskiw, G.3    Zhang, J.H.4
  • 301
    • 0023223762 scopus 로고
    • Hyperbaric oxygen and cerebral infarction in the gerbil
    • Burt JT, Kapp JP, Smith RR Hyperbaric oxygen and cerebral infarction in the gerbil. Surg Neurol 1987, 28:265.
    • (1987) Surg Neurol , vol.28 , pp. 265
    • Burt, J.T.1    Kapp, J.P.2    Smith, R.R.3
  • 302
    • 0023264024 scopus 로고
    • Results of hyperbaric oxygen therapy during temporary middle cerebral artery occlusion in unanesthetized cats
    • Weinstein PR, Anderson GG, Telles DA Results of hyperbaric oxygen therapy during temporary middle cerebral artery occlusion in unanesthetized cats. Neurosurg 1987, 20:518.
    • (1987) Neurosurg , vol.20 , pp. 518
    • Weinstein, P.R.1    Anderson, G.G.2    Telles, D.A.3
  • 303
    • 0033957495 scopus 로고    scopus 로고
    • Hyperbaric oxygen decreases infarct size and behavioral deficit after transient focal cerebral ischemia in rats
    • Veltkamp R, Warner DS, Domoki F, et al. Hyperbaric oxygen decreases infarct size and behavioral deficit after transient focal cerebral ischemia in rats. Brain Res 2000, 853:68.
    • (2000) Brain Res , vol.853 , pp. 68
    • Veltkamp, R.1    Warner, D.S.2    Domoki, F.3
  • 304
    • 0033669963 scopus 로고    scopus 로고
    • Hyperbaric oxygen therapy for treatment of postischemic stroke in adult rats
    • Chang CF, Niu KC, Hoffer BJ, et al. Hyperbaric oxygen therapy for treatment of postischemic stroke in adult rats. Exp Neurol 2000, 166:298.
    • (2000) Exp Neurol , vol.166 , pp. 298
    • Chang, C.F.1    Niu, K.C.2    Hoffer, B.J.3
  • 305
    • 0033849294 scopus 로고    scopus 로고
    • Hyperbaric oxygen reduces infarct volume in rats by increasing oxygen supply to the ischemic periphery
    • Sunami K, Takeda Y, Hashimoto M, Hirakawa M Hyperbaric oxygen reduces infarct volume in rats by increasing oxygen supply to the ischemic periphery. Crit Care Med 2000, 28:2831.
    • (2000) Crit Care Med , vol.28 , pp. 2831
    • Sunami, K.1    Takeda, Y.2    Hashimoto, M.3    Hirakawa, M.4
  • 306
    • 0005228732 scopus 로고
    • The effect of hyperbaric oxygen on experimental cerebral infarction in the dog
    • Jacobson I, Lawson DD The effect of hyperbaric oxygen on experimental cerebral infarction in the dog. J Neurosurg 1963, 20:849.
    • (1963) J Neurosurg , vol.20 , pp. 849
    • Jacobson, I.1    Lawson, D.D.2
  • 307
    • 0031982958 scopus 로고    scopus 로고
    • Effects of hyperbaric oxygen on neurologic outcome for cerebral ischemia in rats
    • Roos JA, Jackson-Friedman C, Lyden P Effects of hyperbaric oxygen on neurologic outcome for cerebral ischemia in rats. Acad Emerg Med 1998, 5:18.
    • (1998) Acad Emerg Med , vol.5 , pp. 18
    • Roos, J.A.1    Jackson-Friedman, C.2    Lyden, P.3
  • 308
    • 0036514918 scopus 로고    scopus 로고
    • Hyperbaric oxygen and neutrophil accumulation/tissue damage during permanent focal cerebral ischaemia in rats
    • Hjelde A, Hjelstuen M, Haraldseth O, et al. Hyperbaric oxygen and neutrophil accumulation/tissue damage during permanent focal cerebral ischaemia in rats. Eur J Appl Physiol 2002, 86:401.
    • (2002) Eur J Appl Physiol , vol.86 , pp. 401
    • Hjelde, A.1    Hjelstuen, M.2    Haraldseth, O.3
  • 309
    • 0025871510 scopus 로고
    • A pilot study of hyperbaric oxygen in the treatment of human stroke
    • Anderson DC, Bottini AG, Jagiella WM, et al. A pilot study of hyperbaric oxygen in the treatment of human stroke. Stroke 1991, 22:1137.
    • (1991) Stroke , vol.22 , pp. 1137
    • Anderson, D.C.1    Bottini, A.G.2    Jagiella, W.M.3
  • 310
    • 0029100903 scopus 로고
    • Hyperbaric oxygen in the treatment of acute ischemic stroke: A double-blind pilot study
    • Nighoghossian N, Trouillas P, Adeleine P, Salord F Hyperbaric oxygen in the treatment of acute ischemic stroke: A double-blind pilot study. Stroke 1995, 26:1369.
    • (1995) Stroke , vol.26 , pp. 1369
    • Nighoghossian, N.1    Trouillas, P.2    Adeleine, P.3    Salord, F.4


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