메뉴 건너뛰기




Volumn 31, Issue 2, 2000, Pages 358-365

Phase II studies of the glycine antagonist GV150526 in acute stroke: The North American Experience

Author keywords

Cerebral infarction; Glutamate antagonists; Neuroprotection; Stroke therapy; Stroke, acute

Indexed keywords

GAVESTINEL; GLYCINE RECEPTOR ANTAGONIST;

EID: 0343415042     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.31.2.358     Document Type: Article
Times cited : (40)

References (18)
  • 1
    • 0025438029 scopus 로고
    • Methods for antagonizing glutamate neurotoxicity
    • Choi D. Methods for antagonizing glutamate neurotoxicity. Cerebrovasc Brain Metab Rev. 1990;2:105-147.
    • (1990) Cerebrovasc Brain Metab Rev. , vol.2 , pp. 105-147
    • Choi, D.1
  • 2
    • 0028870990 scopus 로고
    • Safety, tolerability and pharmacokinetics of the N-methyl-D-aspartate antagonist dextrorphan in patients with acute stroke
    • Albers GW, Atkinson RP, Kelley RE, Rosenbaum MD, on behalf of the Dextrorphan Study Group. Safety, tolerability and pharmacokinetics of the N-methyl-D-aspartate antagonist dextrorphan in patients with acute stroke. Stroke. 1995;26:254-258.
    • (1995) Stroke , vol.26 , pp. 254-258
    • Albers, G.W.1    Atkinson, R.P.2    Kelley, R.E.3    Rosenbaum, M.D.4
  • 3
    • 0343472092 scopus 로고    scopus 로고
    • Termination of acute stroke studies involving selfotel treatment
    • Letter
    • Davis SM, Albers GW, Diener HC, Lees KR, Morris J. Termination of acute stroke studies involving selfotel treatment. Lancet. 1997;349:32. Letter.
    • (1997) Lancet , vol.349 , pp. 32
    • Davis, S.M.1    Albers, G.W.2    Diener, H.C.3    Lees, K.R.4    Morris, J.5
  • 4
    • 0030666876 scopus 로고    scopus 로고
    • Cerestat and other NMDA antagonists in ischemic stroke
    • Lees KR. Cerestat and other NMDA antagonists in ischemic stroke. Neurology. 1997;49(suppl 4):S66-S69.
    • (1997) Neurology , vol.49 , Issue.SUPPL. 4
    • Lees, K.R.1
  • 6
    • 0030739272 scopus 로고    scopus 로고
    • The glycine antagonist GV150526 protects somatosensory evoked potentials and reduces the infarct area in the MCAo model of focal ischemia in the rat
    • Bordi F, Pietra C, Ziviani L, Reggiani A. The glycine antagonist GV150526 protects somatosensory evoked potentials and reduces the infarct area in the MCAo model of focal ischemia in the rat. Exp Neurol. 1997;145:1-10.
    • (1997) Exp Neurol. , vol.145 , pp. 1-10
    • Bordi, F.1    Pietra, C.2    Ziviani, L.3    Reggiani, A.4
  • 7
    • 0032925354 scopus 로고    scopus 로고
    • Safety and tolerability of GV150526 (a glycine site antagonist at the N-methyl-D-aspartate receptor) in patients with acute stroke
    • Dyker AG, Lees KR. Safety and tolerability of GV150526 (a glycine site antagonist at the N-methyl-D-aspartate receptor) in patients with acute stroke. Stroke. 1999;30:986-992.
    • (1999) Stroke , vol.30 , pp. 986-992
    • Dyker, A.G.1    Lees, K.R.2
  • 8
    • 0000471174 scopus 로고    scopus 로고
    • Safety and tolerability of GV150526 in acute stroke (GLYB2002)
    • Abstract
    • GAIN European Study Group. Safety and tolerability of GV150526 in acute stroke (GLYB2002). Cerebrovasc Dis. 1998;6(suppl. 4):20. Abstract.
    • (1998) Cerebrovasc Dis. , vol.6 , Issue.SUPPL. 4 , pp. 20
  • 10
    • 70450195021 scopus 로고
    • Functional evaluation: The Barthel Index
    • Mahoney FI, Barthel DW. Functional evaluation: the Barthel Index. Md State Med J. 1965;14:61-65.
    • (1965) Md State Med J. , vol.14 , pp. 61-65
    • Mahoney, F.I.1    Barthel, D.W.2
  • 12
    • 0027514354 scopus 로고
    • Classification of subtype of acute ischemic stroke: Definitions for use in a multicenter clinical trial
    • Adams HP Jr, Bendixen BH, Kappelle J, Biller J, Love BB, Gordon DL, Marsh EE, and the TOAST Investigators. Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial. Stroke. 1993;24:35-41.
    • (1993) Stroke , vol.24 , pp. 35-41
    • Adams H.P., Jr.1    Bendixen, B.H.2    Kappelle, J.3    Biller, J.4    Love, B.B.5    Gordon, D.L.6    Marsh, E.E.7
  • 13
    • 0003747347 scopus 로고
    • San Francisco, Calif: University of California at San Francisco, Division of Clinical Pharmacology
    • Beal SL, Sheiner LB. NONMEM Users Guide. San Francisco, Calif: University of California at San Francisco, Division of Clinical Pharmacology; 1979-1998.
    • (1979) NONMEM Users Guide
    • Beal, S.L.1    Sheiner, L.B.2
  • 14
    • 0342971942 scopus 로고    scopus 로고
    • Results of the GAIN 2 MRI feasibility study: A substudy of the phase II 2005 safety trial of GV150526
    • Abstract
    • Warach S. Results of the GAIN 2 MRI feasibility study: a substudy of the phase II 2005 safety trial of GV150526. Cerebrovasc Dis. 1999;9(suppl 1):128. Abstract.
    • (1999) Cerebrovasc Dis. , vol.9 , Issue.SUPPL. 1 , pp. 128
    • Warach, S.1
  • 15
    • 0001863422 scopus 로고    scopus 로고
    • Epidemiology of stroke
    • : Barnett HJM, Mohr JP, Stein BM, Yatsu FM, eds. New York, NY: Churchill Livingstone
    • Wolf PA, D'Agostino RB. Epidemiology of stroke. In: Barnett HJM, Mohr JP, Stein BM, Yatsu FM, eds. Stroke: Pathophysiology, Diagnosis, and Management. New York, NY: Churchill Livingstone; 1998:3-28.
    • (1998) Stroke: Pathophysiology, Diagnosis, and Management , pp. 3-28
    • Wolf, P.A.1    D'Agostino, R.B.2
  • 16
    • 0020211722 scopus 로고
    • Moderate hyperglycemia augments ischemic brain damage: A neuropathologic study in the rat
    • Pulsinelli WA, Waldman S, Rawlinson D, Plum F. Moderate hyperglycemia augments ischemic brain damage: a neuropathologic study in the rat. Neurology. 1982;32:1239-1246.
    • (1982) Neurology , vol.32 , pp. 1239-1246
    • Pulsinelli, W.A.1    Waldman, S.2    Rawlinson, D.3    Plum, F.4
  • 17
    • 0030966075 scopus 로고    scopus 로고
    • Is hyperglycaemia an independent predictor of poor outcome after acute stroke? Results of a long term follow up study
    • Weir CJ, Murray GD, Dyker AG, Lees KR. Is hyperglycaemia an independent predictor of poor outcome after acute stroke? Results of a long term follow up study. BMJ. 1997;314:1303-1306.
    • (1997) BMJ , vol.314 , pp. 1303-1306
    • Weir, C.J.1    Murray, G.D.2    Dyker, A.G.3    Lees, K.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.