Treatment of experimental focal ischemia in rats with lubeluzole

Neuropharmacology

Volumn 35, Issue 6, 1996, Pages 689-693

  Aronowski, J ^a   Strong, R ^a   Grotta, J C ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Edema; Focal ischemia; Infarct volume; Lubeloze; Neuroprotection; Reperfusion

Indexed keywords

LUBELUZOLE; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; BRAIN ISCHEMIA; CONTROLLED STUDY; HISTOLOGY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030175245     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(96)84640-5     Document Type: Article

References (15)

1. Aronowski J., Waxham M. N. and Grotta J. C. (1992) Neuronal protection and preservation of calcium/calmodulin-dependent protein kinase II and protein kinase C activity by dextrorphan treatment in global ischemia. J. Cereb. Blood Flow Metab. 13: 550-557.
2. Aronowski J., Samways E., Strong R. and Grotta J. C. (1994) A graded bioassay for demonstration of brain rescue from experimental acute ischemia. Stroke 25: 2235-2240.
3. Aronowski J., Samways E., Strong R., Rhoades H. M. and Grotta J. C. An alternative method for the quantitation of neuronal damage after experimental middle cerebral artery occlusion in rats; Analysis of behavioral deficit. J. Cereb. Blood Flow Metab. (in press).
4. De Ryck M., Keersmaekers R., Clincke G., Janssen M. and Van Reet S. (1994) Lubeluzole, a novel benzothiazole, protects neurologic function after cerebral thrombotic stroke in rats: An apparent stereospecific effect. Soc. Neurosci. Abstr. 20: 185.
5. De Ryck M., Scheller D., Clincke G., Janssen M. and Van Reet S. (1995) Lubeluzole, a novel benzothiazole, protects neurologic function, reduces infarct size, and blocks peri-infarct glutamate rise after cerebral thrombotic stroke in rats. Cerebrovasc. Res. Abstr. 5: 264.
6. Deshpande J. K. and Wieloch T. (1986) Flunarizine a calcium entry blocker, ameliorates ischemia brain damage in the rats. Anesthesiology 64: 215-224.
7. Diener H.-C., Hacke W., Hennerici M., Radberg J., Hantson L. and De Keyser J. (1996) Lubeluzole in acute ischemic stroke: A double-blind, placebo-controlled phase II trial. Stroke 27: 76-81.
8. Grotta J. C., Pettigrew L. C., Rosenbaum D., Reid C., Rhoades H. and McCandless D. (1988) Efficacy and mechanism of action of calcium channel blocker after global cerebral ischemia in rats. Stroke 19: 447-454.
9. Grotta J. C., Picone C. M., Ostrow P. T., Strong R. A., Earls R. M., Yao L. P., Rhoades H. M. and Dedman J. R. (1990) CGS-19755, a competitive NMDA receptor antagonist, reduces calcium-calmodulin binding and improves outcome after global cerebral ischemia. Ann. Neurol. 27: 612-619.
10. Hara H., Onodera H., Yoshidomi M., Matsuda Y. and Kyuya K. (1990) Staurosporine, a novel protein kinase C inhibitor, prevents post-ischemic neuronal damage in the gerbil and rat. J. Cereb. Blood Flow Metab. 10: 646-653.
11. Lee K. S., Frank S., Vanderklish P., Arai A. and Lynch G. (1991) Inhibition of proteolysis protects hippocampal neurons from ischemia. Proc. natn. Acad. Sci. U.S.A. 88: 7233-7237.
12. Madden K. P., Clark W. M., Kochhar A. and Zivin J. A. (1991) Effect of protein kinase C modulation on outcome of experimental CNS ischemia. Brain Res. 547: 193-198.
13. Ozyurt E., Graham D. I., Woodruff G. N. and McCulloch J. (1988) Protective effect of the glutamate antagonist, MK-801 in focal cerebral ischemia in the cat. J. Cereb. Blood Flow Metab. 8: 138-143.
14. Simon R. P., Swan J. H., Griffiths T. and Meldrum B. S. (1984) Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain. Science 226: 850-852.
15. Steinberg G. K., George C. P., DeLaPaz R., Shibata D. and Gross T. (1988) Dextromethorphan protects against cerebral injury following transient focal ischemia in rabbits. Stroke 19: 1112-1118.