Effects of mild hypothermia on cerebral blood flow-independent changes in cortical extracellular levels of amino acids following contusion trauma in the rat

Brain Research

Volumn 747, Issue 2, 1997, Pages 304-312

  Koizumi, Hiroyasu ^a   Fujisawa, Hirosuke ^a   Ito, Haruhide ^a   Maekawa, Tsuyoshi ^a   Di, Xiao ^b   Bullock, Ross ^b  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

autoradiography; cerebral blood flow; cerebral contusion; excitatory amino acid; extravasation; microdialysis; rat

Indexed keywords

ASPARTIC ACID; GLUTAMIC ACID; GLYCINE; TAURINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN BLOOD FLOW; BRAIN INJURY; CONTROLLED STUDY; HYPOTHERMIA; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINO ACIDS; ANALYSIS OF VARIANCE; ANIMALS; BODY TEMPERATURE REGULATION; BRAIN CONCUSSION; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; EXTRAVASATION OF DIAGNOSTIC AND THERAPEUTIC MATERIALS; GLUTAMIC ACID; MALE; RATS; RATS, WISTAR;

EID: 0031046699     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01240-1     Document Type: Article

References (51)

1. Baethmann, A., Maier-Hauff, K., Schürer, L., Lange, M., Guggenbichler, C., Vogt, W., Jacob, K. and Kempski, O., Release of glutamate and of free fatty acids in vasogenic brain edema, J. Neurosurg., 70 (1989) 578-591.
2. Benveniste, H., Brain Microdialysis, J. Neurochem., 52 (1989) 1667-1679.
3. Benveniste, H., Drejer, J., Schousboe, A. and Diemer, N.H., Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis, J. Neurochem., 43 (1984) 1369-1374.
4. Betz, A.L. and Goldstein, G.W., Polarity of the blood-brain barrier: neutral amino acid transport into isolated brain capillaries, Science, 202 (1978) 225-227.
5. Bouma, G.J., Muizelaar, J.P., Choi, S.C., Newlon, P.G. and Young, H.F., Cerebral circulation and metabolism after severe traumatic brain injury: the elusive role of ischemia, J. Neurosurg., 75 (1991) 685-693.
6. Bouma, G.J., Muizelaar, J.P., Stringer, W.A., Choi, S.C., Fatouros, P. and Young, H.F., Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using xenon-enhanced computerized tomography, J. Neurosurg., 77 (1992) 360-368.
7. Bullock, R. and Fujisawa, H., The role of glutamate antagonists for the treatment of CNS injury, J. Neurotrauma, 9 (1992) S443-S461.
8. Busto, R., Globus, M.Y.T., Dietrich, W.D., Martinez, E., Valdés, I. and Ginsberg, M.D., Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain, Stroke, 20 (1989) 904-910.
9. Butcher, S.P., Bullock, R., Graham, D.I. and McCulloch, J., Correlation between amino acid release and neuropathologic outcome in rat brain following middle cerebral artery occlusion, Stroke, 21 (1990) 1727-1733.
10. Choi, D.W., Ionic dependence of glutamate neurotoxicity, J. Neurosci., 7 (1987) 369-379.
11. Clifton, G.L., Jiang, J.Y., Lyeth, B.G., Jenkins, L.W., Hamm, R.J. and Hayes, R.L., Marked protection by moderate hypothermia after experimental traumatic brain injury, J. Cereb. Blood Flow Metab., 11 (1991) 114-121.
12. Corbett, D., Evans, S., Thomas, C., Wang, D. and Jonas, R.A., MK-801 reduced cerebral ischemic injury by inducing hypothermia, Brain Res., 514 (1990) 300-304.
13. Dewitt, D.S., Jenkins, L.W., Wei, E.P., Lutz, H., Becker, D.P. and Kontos, H.A., Effects of fluid-percussion brain injury on regional cerebral blood flow and pial arteriolar diameter, J. Neurosurg. 64 (1986) 787-794.
14. Dhillon, H.S., Donaldson, D., Dempsey, R.J. and Prasad, M.R., Regional levels of free fatty acids and Evans blue extravasation after experimental brain injury, J. Neurotrauma, 11 (1994) 405-415.
15. Dietrich, W.D., Alonso, O. and Halley, M., Early microvascular and neuronal consequences of traumatic brain injury: A light and electron microscopic study in rats, J. Neurotrauma, 11 (1994) 289-301.
16. Faden, A.I., Demediuk, P., Panter, S.S. and Vink, R., The role of excitatory amino acids and NMDA receptors in traumatic brain injury, Science, 244 (1988) 798-800.
17. Fonnum, F., Glutamate: a neurotransmitter in mammalian brain, J. Neurochem., 42 (1984) 1-11.
18. Graham, D.I. and Adams, J.H., Ischaemic brain damage in fatal head injuries, Lancet, 6 (1971) 265-266.
19. Graham, D.I., Adams, J.H. and Doyle, D., Ischaemic brain damage in fatal non-missile head injuries, J. Neurol. Sci., 39 (1978) 213-234.
20. Graham, D.I., Ford, I., Adams, J.H., Doyle, D., Teasdale, G.M., Lawrence, A.E. and McLellan, D.R., Ischaemic brain damage is still common in fatal non-missile head injury, J. Neurol. Neurosurg. Psychiat., 52 (1989) 346-350.
21. Graham, S.H., Shiraishi, K., Panter, S.S., Simon, R.P. and Faden, A.I., Changes in extracellular amino acid neurotransmitters produced by focal cerebral ischemia, Neurosci. Lett., 110 (1990) 124-130.
22. Grundl, P.D., Biagas, K.V., Kochanek, P.M., Schiding, J.K., Barmada, M.A. and Nemoto, E.M., Early cerebrovascular response to head injury in immature and mature rats, J. Neurotrauma, 11 (1994) 135-148.
23. Hagberg, H., Lehman, A., Sandberg, M., Nyström, B. and Jacobson, I., Hamberger to extracellular compartments, J. Cereb. Blood. Flow Metab., 5 (1985) 413-419.
24. Hutchison, H.T., Eisenberg, H.M. and Haber, B., High-affinity transport of glutamate in rat brain microvessels, Exp. Neurol., 87 (1985) 260-269.
25. Jones, T.J., Morawetz, R.B., Crowell, R.M., Marcoux, F.W., Fitzgibbon, S.J., Degirolami, U. and Ojemann, R.G., Thresholds of focal cerebral ischemia in awake monkeys, J. Neurosurg., 54 (1981) 773-782.
26. Katayama, Y., Becker, D.P., Tamura, T. and Hovda, D.A., Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury, J. Neurosurg., 73 (1990) 889-900.
27. +, Brain Res., 590 (1992) 6-12.
28. + in primary astrocyte cultures, J. Neurosci., 9 (1989) 1141-1149.
29. Krantis, A., Hypothermia-induced reduction in the permeation of radiolabelled tracer substances across the blood-brain barrier, Acta Neuropathol. (Berl.00), 60 (1983) 61-69.
30. Kristián, T., Katsura, K., Siesjö, B.K., The influence of moderate hypothermia on cellular calcium uptake in complete ischaemia: implication for the excitotoxic hypothesis, Acta Physiol. Scand., 146 (1992) 531-532.
31. Marion, D.W., Obrist, W.D., Carlier, P.M., Penrod, L.E. and Darby, J., The use of moderate therapeutic hypothermia for patients with severe head injuries: a preliminary report, J. Neurosurg., 79 (1993) 354-362.
32. McCulloch, J., Bullock, R. and Teasdale, G.M., Excitatory amino acid antagonists: opportunities for the treatment of ischaemic brain damage in man. In B. Meldrum (Ed.), Excitatory Amino Acid Antagonists, Blackwell Scientific, 1991, pp. 287-326.
33. Minamisawa, H., Mellergård, P., Smith, M.L., Bengtsson, F., Theander, S., Boris-Möller, F. and Siesjö, B.K., Preservation of brain temperature during ischemia in rats, Stroke, 21 (1990) 758-764.
34. Nicholls, D. and Attwell, D., The release and uptake of excitatory amino acids, Trends Pharmacol. Sci., 11 (1990) 462-468.
35. Nilsson, B. and Nordström, C.H., Experimental head injury in the rat. Part 3: Cerebral blood flow and oxygen consumption after concussive impact acceleration, J. Neurosurg., 47 (1977) 262-273.
36. Nilsson, P., Hillered, L., Pontén, U. and Ungerstedt, U., Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats, J. Cereb. Blood. Flow Metab., 10 (1990) 631-637.
37. Norwood, W.I. and Norwood, C.R., Influence of hypothermia on intracellular pH during anoxia, Am. J. Physiol., 243 (1982) C62-C65.
38. Oldendorf, W.H. and Szabo, J., Amino acid assignment to one of the three blood-brain barrier amino acid carriers, Am. J. Physiol., 230 (1976) 94-98.
39. Palmer, A.M., Marion, D.W., Botscheller, M.L. and Redd, E.E., Therapeutic hypothermia is cytoprotective without attenuating the traumatic brain injury-induced elevations in interstitial concentrations of aspartate and glutamate, J. Neurotrauma, 10 (1994) 363-372.
40. Palmer, A.M., Marion, D.W., Botscheller, M.L., Swedlow, P.E., Styren, S.D. and DeKosky, S.T., Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model, J. Neurochem., 61 (1993) 2015-2024.
41. Rothman, S.M. and Olney, J.W., Excitotoxicity and the NMDA receptor, Trends Neurosci., 10 (1987) 299-302.
42. Shimada, N., Graf, R., Rosner, G., Wakayama, A., George, C.P. and Heiss, W.-D., Ischemic flow threshold for extracellular glutamate increase in cat cortex, J. Cereb. Blood. Flow Metab., 9 (1989) 603-606.
43. Siesjö, B.K., Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology, J. Neurosurg., 77 (1992) 169-184.
44. Siesjö, B.K., Pathophysiology and treatment of focal cerebral ischemia. Part II: Mechanisms of damage and treatment, J. Neurosurg., 77 (1992) 337-354.
45. Smith, S.L., Andrus, P.K., Zhang, J.R. and Hall, E.D., Direct measurement of hydroxyl radicals, lipid peroxidation, and blood-brain barrier disruption following unilateral cortical impact head injury in the rat, J. Neurotrauma, 11 (1994) 393-404.
46. Taft, W.C., Yang, K., Dixon, C.E., Clifton, G.L. and Hayes, R.L., Hypothermia attenuates the loss of hippocampal microtubule-associated protein 2 (MAP2) following traumatic brain injury, J. Cereb. Blood. Flow Metab., 13 (1993) 796-802.
47. Takagi, K., Ginsberg, M.D., Globus, M.Y.T., Dietrich, W.D., Martinez, E., Kraydieh, S. and Busto, R., Changes in amino acid neurotransmitters and cerebral blood flow in the ischemic penumbral region following middle cerebral artery occlusion in the rat: Correlation with histopathology, J. Cereb. Blood. Flow Metab., 13 (1993) 575-585.
48. Tanno, H., Nockels, R.P., Pitts, L.H. and Noble, L.J., Breakdown of blood-brain barrier after fluid percussive brain injury in the rat. Part 1: Distribution and time course of protein extravasation, J. Neurotrauma, 9 (1992) 21-32.
49. Tossman, U. and Ungerstedt, U., Microdialysis in the study of extracellular levels of amino acids in the brain, Acta Physiol. Scand., 128 (1986) 9-14.
50. Yamakami, I. and McIntosh, T.K., Effects of traumatic brain injury on regional cerebral blood flow in rats as measured with radiolabeled microspheres, J. Cereb. Blood. Flow Metab., 9 (1989) 117-124.
51. Yuan, X.Q., Prough, D.S., Smith, T.L. and Dewitt, D.S., The effects of traumatic brain injury on regional cerebral blood flow in rats, J. Neurotrauma, 5 (1988) 289-301.