Excessive cerebrocortical release of acetylcholine induced by NMDA antagonists is reduced by GABAergic and α2-adrenergic agonists

Molecular Psychiatry

Volumn 4, Issue 4, 1999, Pages 344-352

  Kim, S H ^a   Price, M T ^b   Olney, J W ^b   Farber, N B ^b  

^a Korea University College of Medicine   (South Korea)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Ketamine; Microdialysis; MK 801; Neurotoxicity; NMDA antagonists; Posterior cingulate; Retrosplenial cortex; Schizophrenia

Indexed keywords

ACETYLCHOLINE; ALPHA 2 ADRENERGIC RECEPTOR; CLONIDINE; DIAZEPAM; DIZOCILPINE; GABAERGIC RECEPTOR AFFECTING AGENT; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PENTOBARBITAL; PHENCYCLIDINE;

ACETYLCHOLINE BRAIN LEVEL; ANIMAL EXPERIMENT; ARTICLE; BRAIN CELL; CONTROLLED STUDY; FEMALE; MICRODIALYSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0032846330     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000529     Document Type: Article

References (49)

1. Olney JW, Labruyere J, Price MT. Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 1989; 244: 1360-1362.
2. Allen HL, Iversen LL. Phencyclidine, dizocilpine, and cerebrocortical neurons. Science 1990; 247: 221.
3. Fix AS, Horn JW, Wightman KA, Johnson CA, Long GG, Storts RW et al. Neuronal vacuolization and necrosis induced by the noncompetitive N-methyl-D-aspartate (NMDA) antagonist MK(+)801 (dizocilpine maleate): a light and electron microscopic evaluation of the rat retrosplenial cortex. Exp Neurol 1993; 123: 204-215.
4. Corso TD, Sesma MA, Tenkova TI, Der TC, Wozniak DF, Farber NB et al. Multifocal brain damage induced by phencyclidine is augmented by pilocarpine. Brain Res 1997; 752: 1-14.
5. Ellison G, Switzer RC. Dissimilar patterns of degeneration in brain following four different addictive stimulants. Neuroreport 1993; 5: 17-20.
6. Ellison G. Competitive and non-competitive NMDA antagonists induce similar limbic degeneration. Neuroreport 1994; 5: 2688-2692.
7. Horvath ZC, Czopf J, Buzsaki G. MK-801-induced neuronal damage in rats. Brain Res 1997; 753: 181-195.
8. Wozniak DF, Dikranian K, Ishimaru M, Nardi A, Corso TD, Tenkova TI et al. Disseminated corticolimbic neuronal degeneration induced in rat brain by MK-801: potential relevance to Alzheimer's disease. Neurobiol Dis 1998; 5: 305-322.
9. Sharp FR, Jasper P, Hall J, Noble L, Sagar SM. MK-801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex. Ann Neurol 1991; 30: 801-809.
10. Olney JW, Labruyere J, Wang G, Wozniak DF, Price MT, Sesma MA. NMDA antagonist neurotoxicity: mechanism and prevention. Science 1991; 254: 1515-1518.
11. Olney JW, Wozniak DF, Farber NB. Excitotoxic neurodegeneration in Alzheimer disease; new hypothesis and new therapeutic strategies. Arch Neurol 1997; 54: 1234-1240.
12. Gonzales RA, Brown LM, Jones TW, Trent RD, Westbrook SL, Leslie SW. N-methyl-D-aspartate mediated responses decrease with age in Fischer 344 rat brain. Neurobiol Aging 1991; 12: 219-225.
13. Wenk GL, Walker LC, Price DL, Cork LC, Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys. Neurobiol Aging 1991; 12: 93-98.
14. Magnusson KR, Cotman CW. Age-related changes in excitatory amino acid receptors in two mouse strains. Neurobiol Aging 1993; 14: 197-206.
15. Saransaari P, Oja SS. Dizocilpine binding to cerebral cortical membranes from developing and ageing mice. Mech Ageing Develop 1995; 85: 171-181.
16. Ulas J, Cotman CW. Decreased expression of N-methyl-D-aspartate receptor 1 messenger RNA in select regions of Alzheimer brain. Neuroscience 1997; 79: 973-982.
17. Olney JW, Farber NB. Excitatory transmitter neurotoxicity and Alzheimer's disease. In: Giacobini E, Becker R (eds). Alzheimer Disease: Therapeutic Strategies. Birkhauser: Boston, 1994, pp 293-298.
18. Farber NB, Newcomer JW, Olney JW. The glutamate synapse in neuropsychiatric disorders: focus on schizophrenia and Alzheimer's disease. In: Ottersen OP, Langmoen I, Gjerstad L (eds). The Glutamate Synapse as a Therapeutical Target: Molecular Organization and Pathology of the Glutamate Synapse. Elsevier: Amsterdam, 1988, pp 421-437.
19. Javitt DC, Zukin SR. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 1991; 148: 1301-1308.
20. Krystal JH, Karper LP, Seibyl JP, Freeman GK, Delaney R, Bremner JD et al. Subanesthetic effects of the noncompetitive MDA antagonist ketamine, in humans. Psychotomimetic, parceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry 1994; 51: 199-214.
21. Olney JW, Farber NB. Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry 1995; 52: 998-1007.
22. Lahti AC, Koffel B, LaPorte DJ, Tamminga CA. Subanesthetic doses of ketamine stimulate psychosis in schizophrenia. Neurapsychopharmacology 1995; 13: 9-19.
23. Malhotra AK, Pinals DA, Weingartner H, Sirocco K, Missar CD, Picker D et al. NMDA receptor funtion and human cognition: the effects of ketamine in healthy volunteers. Neuropsychopharmacology 1996; 14: 301-307.
24. Newcomer JW, Farber NB, Jevtovic-Todorovic V, Selke G, Kelly Melson A, Hershey T et al. Ketamine-induced NMDA receptor hypofunction as a model of memory impairment in schizophrenia. Neuropsychopharmacology 1999; 20: 106-118.
25. Farber NB, Newcomer JW, Olney JW. Glycine agonists: what can they teach us about schizopherenia? Arch Gen Psychiatry 1999; 56: 13-17.
26. Adams B, Moghaddam B. Corticolimbic dopamine neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine. J Neurosci 1998; 18: 5545-5554.
27. 2 adrenergic agonists prevent MK-801 neurotoxicity. Neuropsychopharmacology 1995; 12: 347-349.
28. Sharp JW, Petersen DL, Langford MT. DNQX inhibits phencyclidine (PCP) and ketamine induction of the hsp70 heat shock gene in the rat cingulate and retrosplenial cortex. Brain Res 1995; 687: 114-124.
29. Farber NB, Kim SH, Olney JW. Costimulation of muscarinic and non-NMDA glutamate receptors reproduces NMDA antagonist neurotoxicity. Soc Neurosci Abstr 1997; 23: 2308.
30. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. 2nd Edn. Academic Press: New York, 1986.
31. Robinson TE, Whishaw IQ. Normalization of extracellular dopamine in striatum following recovery from a partial unilateral 6-OHDA lesion of the substantia nigra: a microdialysis study in freely moving rats. Brain Res 1988; 450: 209-224.
32. Wozniak DF, Nardi A, Corso TD, Olney JW. Scopolamine and pentobarbital attenuate MK-801-induced neuronal necrosis. Soc Neurosci Abstr 1995; 21: 73.
33. Bigl V, Woolf NJ, Butcher LL. Cholinergic projections from the basal forebrain to frontal, parietal, temporal, occipital, and cingulate cortices: a combined fluorescent tracer and acetylcholinesterase analysis. Res Bull 1982; 8: 727-749.
34. Woolf NJ, Eckenstein F, Butcher LL. Cholinergic systems in the rat brain: I. Projections to the limbic telencephalon. Brain Res Bull 1984; 13: 751-784.
35. Woolf NJ. Cholinergic systems in mammalian brain and spinal cord. Prog Neurobiol 1991; 37: 475-524.
36. z adrenergic receptors in the diagonal band. Soc Neurosci Abstr 1998; 24: 462.
37. Brashear HR, Zaborszky L, Heimer L. Distribution of GABAergic and cholinergic neurons in the rat diagonal band. Neuroscience, 1986; 17: 439-451.
38. Gritti I, Mainville L, Jones BE. Codistribution of GABA- with acetylcholine-synthesizing neurons in the basal forebrain of the rat. J Comp Neurol 1993; 329: 438-457.
39. Giovannini MG, Mutolo D, Bianchi L, Michelassi A, Pepeu G. NMDA receptor antagonists decrease GABA outflow from the septum and increase acetylcholine outflow from the hippocampus: a microdialysis study. J Neurosci 1994; 14: 1358-1365.
40. Jevtovic-Todorovic V, Todorvic SM, Mennerick S, Powell S, Dikranian K, Benshoff N et al. Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin. Nature Med 1998; 4: 460-463.
41. Mennerick S, Jevtovic-Todorovic V, Todorvic SM, Shen W, Olney JW, Zorumski CF. Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures. J Neurosci 1998; 18: 9716-9726.
42. Hasegawa M, Kinoshita H, Amano M, Hasegawa T, Kameyama T, Nabeshima T. MK-801 increases endogenous acetylcholine release in the rat parietal cortex: a study using brain microdialysis. Neurosci Lett 1993; 150: 53-56.
43. Giovannini MG, Giovannelli L, Bianchi L, Kalfin R, Pepeu G. Glutamatergic modulation of cortical acetylcholine release in the rat: a combined in vivo microdialysis, retrograde tracing and immunohistochemical study. Eur J Neurosci 1997; 9: 1678-1689.
44. Zhelyazkova-Savova M, Giovannini MG, Pepeu G. Increase of cortical acetylcholine release after systemic administration of chlorophenylpiperazine in the rat: an in vivo microdialysis study. Neurosci Lett 1997; 236: 151-154.
45. Shichino T, Murakawa M, Adachi T, Arai T, Miyazaki Y, Mori K. Effects of inhalation anaesthetics on the release of acetylcholine in the rat cerebral cortex in vivo. Br J Anaesth 1998; 80: 365-370.
46. Noguchi K, Johnson R, Ellison G. The effects of MK-801 on aspartate and glutamate levels in the anterior cingulate and retrosplenial cortices: an in vivo microdialysis study. Soc Neurosci Abstr 1998; 24: 233.
47. Moghaddam B, Adams B. Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science 1998; 281: 1349-1352.
48. Olney JW, Wozniak DF, Ishimaru M, Farber NB. NMDA receptor dysfunction in Alzheimer's disease. In: Becker R, Giacobini E. (eds). Alzheimer disease: from molecular biology to therapy. Birkhauser: Boston; 1997, pp 107-112.
49. Farber NB, Newcomer JW, Wozniak DF, Olney JW. Neurodegeneration induced by NMDA glutamate receptor hypofunction: implications for Alzheimer's disease. In: Vellas B, Fitten JL, (eds). Research and Practice in Alzheimer's Disease and Other Dementias. Paris: Serdi: PaMS, 1999 (in press).