Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat

Journal of Neurosurgery

Volumn 87, Issue 5, 1997, Pages 724-730

  Simpkins, James W ^a   Rajakumar, Gopal ^b   Zhang, Yu Qi ^b   Simpkins, Christopher E ^b   Greenwald, David ^b   Yu, Chun J ^b   Bodor, Nicholas ^b   Day, Arthur L ^b  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

^b NONE

Author keywords

17 estradiol; 17 estradiol; Estradiol chemical delivery system; Estrogen; Ischemia; Middle cerebral artery occlusion; Rat

Indexed keywords

17ALPHA ESTRADIOL; ESTRADIOL; ESTROGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN PROTECTION; CONTROLLED STUDY; DRUG EFFICACY; ESTROGEN THERAPY; FEMALE; HORMONAL REGULATION; MIDDLE CEREBRAL ARTERY OCCLUSION; MORTALITY; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RAT; STROKE; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030700217     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.1997.87.5.0724     Document Type: Article

References (38)

1. Bederson JB, Pitts LH, Germano IM, et al: Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke 17: 1304-1308, 1986
2. Behl C, Widmann M, Trapp T, et al: 17-β estradiol protects neurons from oxidative stress-induced cell death in vitro. Biochem Biophys Res Commun 216:473-482, 1995
3. Benveniste H, Drejer J, Schousboe A, et al: Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 43:1369-1374, 1984
4. Bishop J, Simpkins JW: Estradiol treatment increases viability of glioma and neuroblastoma cells in vitro. Mol Cell Neurosci 5:303-308, 1994
5. Brewster ME, Simpkins JW, Bodor N: Brain-targeted delivery of estrogens. Rev Neurosci 11:241-285, 1990
6. Brewster ME, Simpkins JW, Hara MS, et al: The potential use of cyclodextrins in parenteral formulations. J Parent Sci Technol 43:231-240, 1989
7. Chan PH: Oxygen radicals in focal cerebral ischemia. Brain Pathol 4:59-65, 1994
8. Choi DW: Excitotoxic cell death. J Neurobiol 23:1261-1276, 1992
9. Choi DW: Glutamate neurotoxicity and diseases of the nervous system. Neuron 1:623-634, 1988
10. Clark JH, Williams M, Upchurch S, et al: Effects of estradiol-17α on nuclear occupancy of the estrogen receptor, stimulation of nuclear type II sites and uterine growth. J Ster Biochem 16: 323-328, 1982
11. Dugan LL, Choi DW: Excitotoxicity, free radicals, and cell membrane changes. Am Neurol Assoc 35 (Suppl):S17-S21, 1994
12. Estes KS, Brewster ME, Simpkins JW, et al: A novel redox system for CNS-directed delivery of estradiol causes sustained LH suppression in castrate rats. Life Sci 40:1327-1334, 1987
13. Falkeborn M, Persson I, Terént A, et al: Hormone replacement therapy and the risk of stroke. Follow-up of a population-based cohort in Sweden. Arch Intern Med 153:1201-1209, 1993
14. Finucane FF, Madans JH, Bush TL, et al: Decreased risk of stroke among postmenopausal hormone users. Results from a national cohort. Arch Intern Med 153:73-79, 1993
15. Ginsberg MD, Busto R: Rodent models of cerebral ischemia. Stroke 20:1627-1642, 1989
16. Goodman Y, Bruce AJ, Cheng B: Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid β-peptide toxicity in hippocampal neurons. J Neurochem 66:1836-1844, 1996
17. Gotoh O, Mohamed AA, McCulloch J, et al: Nimodipine and the haemodynamic and histopathological consequences of middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 6:321-331, 1986
18. Green PS, Bishop J, Simpkins JW: 17α-estradiol exerts neuro-protective effects on SK-N-SH cells. J Neurosci 17:511-515, 1997
19. Green PS, Gridley KE, Simpkins JW: Estradiol protects against β-amyloid (25-35)-induced toxicity in SK-N-SH human neuroblastoma cells. Neurosci Lett 218:165-168, 1996
20. Huggins C, Jensen EV, Cleveland AS: Chemical structure of steroids in relation to promotion of growth of the vagina and uterus of the hypophysectomized rat. J Exp Med 100:225-241, 1954
21. Hum PD, Littleton-Kearney MT, Kirsch JR, et al: Postischemic cerebral blood flow recovery in the female: effect of 17β-estradiol. J Cereb Blood Flow Metab 15:666-672, 1995
22. Korenman SG: Comparative binding affinity of estrogens and its relation to estrogenic potency. Steroids 13:163-177, 1969
23. Manolio TA, Furberg CD, Shemanski L, et al: Associations of postmenopausal estrogen use with cardiovascular disease and its risk factors in older women. Circulation 88:2163-2171, 1993
24. Menzies SA, Hoff JT, Betz AL: Middle cerebral artery occlusion in rats: a neurological and pathological evaluation of a reproducible model. Neurosurgery 31:100-107, 1992
25. Mohamed AA, Gotoh O, Graham DI, et al: Effect of pretreatment with the calcium antagonist nimodipine on local cerebral blood flow and histopathology after middle cerebral artery occlusion. Ann Neurol 18:705-711, 1985
26. Morley P, Hogan MJ, Hakim AM: Calcium-mediated mechanisms of ischemic injury and protection. Brain Pathol 4: 37-47, 1994
27. Paganini-Hill A: Estrogen replacement therapy and stroke. Progr Cardiovasc Dis 38:223-242, 1995
28. Paganini-Hill A, Ross RK, Henderson BE: Postmenopausal oestrogen treatment and stroke: a prospective study. Br Med J 297:519-522, 1988
29. Rahimy MH, Anderson WR, Brewster ME, et al: The effects of a brain-enhanced estradiol delivery system on testosterone and androgen-dependent tissues: I. Dose-response and time-course evaluation. Endocrinology 129:717-725, 1991
30. Rahimy MH, Simpkins JW, Bodor N: Dose and time-course evaluation of a redox based estradiol-chemical delivery system for the brain. I. Tissue distribution. Pharmaceut Res 7: 1061-1067, 1990
31. Rahimy MH, Simpkins JW, Bodor N: Dose and time-course evaluation of a redox-based estradiol-chemical delivery system for the brain. II. Pharmacodynamic responses. Pharmaceut Res 7:1107-1112, 1990
32. Shamma FN, Fayan P, Brass L, et al: Middle cerebral artery blood velocity during controlled ovarian hyperstimulation. Fertil Steril 57:1022-1025, 1992
33. Simpkins JW, Green PS, Gridley KE, et al: Role of estrogen replacement therapy in memory enhancement and the prevention of neuronal loss associated with Alzheimer's disease. Am J Med (In press, 1997)
34. Simpkins JW, Singh M, Bishop J: The potential role for estrogen replacement therapy in the treatment of the cognitive decline and neurodegeneration associated with Alzheimer's disease. Neurobiol Aging 15 (Suppl 2):S195-S197, 1994
35. Singer CA, Strickland TM, Rogers KL, et al: Estrogen protects primary cortical neurons from glutamate neurotoxicity. Soc Neurosci Abstr 21:882, 1995
36. Singh M, Meyer EM, Millard WJ, et al: Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats. Brain Res 644:305-312, 1994
37. Stampfer MJ, Colditz GA, Willett WC, et al: Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurse's health study. N Engl J Med 325:756-762, 1991
38. Wren BG: The effect of oestrogen on the female cardiovascular system. Med J Aust 157:204-208, 1992