A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients

Neurology

Volumn 57, Issue 9, 2001, Pages 1595-1602

  Clark, W M ^a   Wechsler, L R ^b   Sabounjian, L A ^c   Schwiderski, U E ^c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c Interneuron Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CITICOLINE; FREE RADICAL; PLACEBO;

ADULT; AGED; ARTICLE; CELL MEMBRANE; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE CEREBRAL ARTERY; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TREATMENT OUTCOME;

EID: 0035856456     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.57.9.1595     Document Type: Article

References (30)

1. The metabolism and function of complex liquids
2. Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain
3. Brain lipid changes following hypoxia
4. Effect of ischemic anoxia and barbiturate anesthesia on free radical oxidation of mitochondrial phospholipids
5. Effect of cytidine diphosphate choline (CDP-choline) on ischemia-induced alterations of brain lipid in the gerbil
6. Control of lipid metabolism in ischemic brain CDPamines
7. Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline
8. Effects of CDP-choline on neurologic deficits and cerebral glucose metabolism in a rat model of cerebral ischemia
9. Effects of CDP choline and CDP ethanolamine on the alterations in rat brain lipid metabolism induced by global ischemia
10. Pharmacological actions of a new TRH analogue, YM-14673, in rats subjected to cerebral ischemia and anoxia
11. Hemodynamic, functional, and biochemical effects of hypobaric hypoxia in rats treated with cytidine diphosphocholine
12. Study of the effects of oral administration of CDP-choline on open-field behaviour under conditions of chronic hypoxia
13. Phospholipid metabolism during central and peripheral damage and recovery in nervous tissue
14. Effect of CDP-choline on hypocampic neurons in culture
15. Citicoline for treatment of experimental focal ischemia: Histologic and behavioral outcome
16. Citicoline treatment for experimental intracerebral hemorrhage in mice
17. Results after 90 days of stroke treatment with CDP-choline, concerning a double blind test
18. Therapeutic conduct in light of a cerebral vascular accident and the use of CDP-choline
19. Treatment of acute cerebral infarction with a choline precursor in a multicenter double-blind placebo-controlled study
20. A randomized dose response trial of citicoline in acute ischemic stroke patients
21. A randomized efficacy trial of citicoline in patients with acute ischemic stroke
22. Measurements of acute cerebral infarction: A clinical examination scale
23. Functional evaluation: The Barthel index
24. Interobserver agreement for the assessment of handicap in stroke patients
25. Tissue plasminogen activator for acute ischemic stroke
26. Randomized double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASSII)
27. Progression in acute stroke: Value of the initial NIH stroke scale score on patient stratification in future trials
28. Classification of subtype of acute ischemic stroke