An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell- permeable calpain inhibitor and is neuroprotective

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 13, 1996, Pages 6687-6692

  Wang, K K W ^a   Nath, R ^a   Posner, A ^a   Raser, K J ^a   Buroker Kilgore, M ^a   Hajimohammadreza, I ^a   Probert A W , Jr ^a   Marcoux, F W ^a   Ye, Q ^a   Takano, E ^a   Hatanaka, M ^a   Maki, M ^a   Caner, H ^a   Collins, J L ^a   Fergus, A ^a   Lee, K S ^a   Lunney, E A ^a   Hays, S J ^a   Yuen, P W ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

calcium binding protein; calpain; excitotoxicity; protease; protease inhibitor

Indexed keywords

ACRYLIC ACID DERIVATIVE; CALPAIN; CALPASTATIN;

ANIMAL CELL; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN PROTECTION; CALCIUM TRANSPORT; CATARACT; HEART MUSCLE ISCHEMIA; NERVE DEGENERATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PURKINJE CELL; STROKE;

ACRYLATES; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CELL HYPOXIA; CELL LINE; CEREBRAL CORTEX; CYSTEINE PROTEINASE INHIBITORS; GLYCOPROTEINS; HYPOGLYCEMIA; MOLECULAR SEQUENCE DATA; NEURONS; NEUROPROTECTIVE AGENTS; PURKINJE CELLS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0029987453     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.13.6687     Document Type: Article

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