A randomized double-blind controlled study of nimodipine in acute cerebral ischemic stroke

Indian Journal of Physiology and Pharmacology

Volumn 42, Issue 4, 1998, Pages 555-558

  Nag, Devika ^a   Garg, R K ^a,b   Varma, M ^a  

^a KING GEORGE'S MEDICAL UNIVERSITY   (India)

^b BANARAS HINDU UNIVERSITY   (India)

Author keywords

Calcium antagonists; Calcium channel blockers; Cerebral infarction; Nimodipine; Stroke

Indexed keywords

CALCIUM ANTAGONIST; CALCIUM CHANNEL BLOCKING AGENT; NIMODIPINE; PLACEBO;

ADULT; AGED; ARTICLE; BLOOD BRAIN BARRIER; BRAIN INFARCTION; BRAIN ISCHEMIA; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDIATOR RELEASE; NEUROTOXICITY; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; STROKE;

ADULT; AGED; BRAIN ISCHEMIA; CALCIUM CHANNEL BLOCKERS; CEREBRAL INFARCTION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; NIMODIPINE;

EID: 0031794687     PISSN: 00195499     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Giroux C, Scatton B. Ischaemic stroke : treatment on the horizon. Eur Neurol 1996; 36 : 61-64.
2. McCalden TA, Nath RO, Thiele K. The effects of a calcium antagonist (nimodipine) on basal cerebral blood flow and reactivity to various agonists. Stroke 1984; 15. 527-530.
3. Pozzilli C. Di Piero V, Pantano P, Rasura M, Lenzi GL. Influence of nimodipine on cerebral blood flow in human ischaemia. J Neurol 1989; 236: 199-202.
4. Pickard JD, Murray CD, Illingworth R et al. Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage. British Aneurysm Nimodipine Trial. Br Med J 1989; 298: 636-642.
5. Glemers HJ, Gorter K, De Weerdt CJ, Weizer HJA. A controlled trial of nimodipine in acute ischaemic stroke. N Engl J Med 1998; 318: 203-207.
6. Mathew NT, Meyer JS, Rivera VM, Charney JZ, Hartmann A. Double blind evaluation of glycerol therapy in acute cerebral infarction. Lancet 1972; 2: 1327-1329.
7. The American nimodipine study group: Clinical Trial of nimodipine in acute ischaemic stroke. Stroke 1992; 23: 3-8.
8. Trust Study Group. Randomized, double blind placebo controlled trial of nimodipine in acute stroke. Lancet 1990; 2: 1205-1209.
9. Roda JM, Carceller F, Diez-Tejedor E, Avendano C. Reduction of infarct size by intra-arterial nimodipine administered at reperfusion in a rat model of partially reversible brain focal ischemia. Stroke 1995; 26: 1888-1892.
10. Kakarieka A, Schakel EH, Fritze J. Clinical experiences with nimodipine in cerebral ischaemia. J Neural Transm (Suppl) 1994; 43: 13-21.