Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo

Molecular Endocrinology

Volumn 11, Issue 9, 1997, Pages 1245-1255

  Vayssière, Béatrice M ^a,c   Dupont, Sonia ^a,d   Choquart, Agnès ^a   Petit, Francis ^a   Garcia, Teresa ^a   Marchandeau, Christian ^a   Gronemeyer, Hinrich ^b   Resche Rigon, Michèle ^a  

^a SANOFI   (France)

^b INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c INSTITUT CURIE   (France)

^d Inst Genet Biol Molec et Cell

Author keywords

[No Author keywords available]

Indexed keywords

CROTON OIL; DEXAMETHASONE; GLUCOCORTICOID; INTERLEUKIN 1BETA; LIGAND; PREDNISOLONE; RU 24782; RU 24858; RU 40066; TRANSCRIPTION FACTOR AP 1; TYROSINE AMINOTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; EDEMA; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE; GLUCONEOGENESIS; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TOPICAL DRUG ADMINISTRATION; TRANSACTIVATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARCINOMA, HEPATOCELLULAR; COLLAGENASES; DOSE-RESPONSE RELATIONSHIP, DRUG; GENES, REPORTER; GLUCOCORTICOIDS; HELA CELLS; HUMANS; HYDROXYCORTICOSTEROIDS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-1; MALE; MICE; MICE, INBRED STRAINS; MONOCYTES; PROMOTER REGIONS (GENETICS); RATS; RECEPTORS, GLUCOCORTICOID; THYMUS GLAND; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-1; TRANSFECTION; TYROSINE TRANSAMINASE;

EID: 0031474156     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.11.9.1245     Document Type: Article

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