CDP-choline reduces pro-caspase and cleaved caspase-3 expression, nuclear DNA fragmentation, and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat

Neuropharmacology

Volumn 42, Issue 6, 2002, Pages 846-854

  Krupinski, J ^a,b   Ferrer, I ^a,b   Barrachina, M ^a   Secades, J J ^c   Mercadal, J ^c   Lozano, R ^c  

^a UNIVERSITY OF BARCELONA   (Spain)

^b HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^c Ferrer Group SA Medical Department   (Spain)

Author keywords

Caspase; Citicoline; Ischaemia; PARP; Stroke

Indexed keywords

CASPASE; CASPASE 3; CITICOLINE; DNA FRAGMENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCASPASE 1; PROCASPASE 2; PROCASPASE 3; PROCASPASE 6; PROCASPASE 8; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME SUBSTRATE; FEMALE; GEL ELECTROPHORESIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CASPASE 3; CASPASES; CELL NUCLEUS; CYTIDINE DIPHOSPHATE CHOLINE; DNA FRAGMENTATION; ENZYME PRECURSORS; FEMALE; HYDROLYSIS; INFARCTION, MIDDLE CEREBRAL ARTERY; INJECTIONS, INTRAPERITONEAL; NOOTROPIC AGENTS; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY; SUBSTRATE SPECIFICITY;

EID: 0036098560     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(02)00032-1     Document Type: Article

References (34)

1. Choline-deficiency induced apoptosis in SV40-immortalized CWSV-1 rat hepatocytes in culture
2. Effects of citicoline combined with thrombolytic therapy in a rat embolic stroke model
3. Inhibition of phosphatidylcholine biosynthesis following induction of apoptosis in HL-60 cells
4. Citicoline for treatment of experimental focal ischaemia: Histologic and behavioral outcome
5. Expression of interleukin-1βconverting enzyme gene family and bcl-2 gene family in the rat brain following permanent occlusion of the middle cerebral artery
6. Apoptosis triggered by 1-0-octadecyl-2-0-methyl-rac-glycero-3-phosphocholine is prevented by increased expression of CTP: Phosphocholine cytidytyltransferase
7. Stroke-damaged neurons may commit cellular suicide
8. Multicentric open label study of the efficacy and tolerability of citicoline in the treatment of acute cerebral infarction
9. A randomized dose-response trial of citicoline in acute ischaemic stroke patients
10. At the scene of ischemic brain injury: Is PARP a perp?
11. Caspases: The executioners of apoptosis
12. A genetic defect in phosphatidylcholine biosynthesis triggers apoptosis in Chinese hamster ovary cells
13. Attenuation of delayed neuronal death after mild focal ischaemia in mice by inhibition of the caspase family
14. ICE, neuronal apoptosis and neurodegeneration
15. The reverse reactions of cholinephosphotransferase in rat brain microsomes. A new pathway for degeneration of phosphatidylcholine
16. Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein
17. Inhibition of ICE family proteases reduces ischemic and excitotoxic neuronal damage
18. Ceramide induced apoptosis in PC12 cells
19. Apoptosis is induced by choline deficiency in fetal brain and PC12 cells
20. Effects of CDP-choline on neurologic deficits and cerebral glucose metabolism in a rat model of cerebral ischemia
21. The function of cytidine coenzymes in the biosynthesis of phospholipids
22. Up-regulation of teh Nedd2 gene encoding an ICE/Ced-3-like cysteine protease in the gerbil brain after transient forebrain ischemia
23. Expression of caspases and their substrates in the rat model of focal cerebral ischaemia
24. Enhancement by cytidine of membrane phospholipid synthesis
25. Neuronal accumulation of poly(ADP-ribose) after brain ischemia
26. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia
27. Caspases: The proteases of the apoptotic pathway
28. Synergestic effects of citicoline and MK-801 in temporary experimental focal ischaemia in rats
29. The effects of prolonged treatment with citicoline in temporary experimental focal ischaemia
30. CDP-choline. Update and review of its pharmacology and clinical use
31. Focal cerebral ischaemia in the rat: 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion
32. Effects of cytidine diphosphate choline (CDP-choline) on ischaemia-induced alteration of brain lipid in the gerbil
33. Minireview, metabolism and action of CDP-choline as an endogenous compound and administered exogenously as citicoline
34. Choline deficiency-induced apoptosis in PC12 cells is associated with dimnished membrane phosphatidylcholine and sphingomyelin, accumulation of ceramide and diacylglycerol, and activation of a caspase