Synergistic protective effect of caspase inhibitors and bFGF against brain injury induced by transient focal ischaemia

British Journal of Pharmacology

Volumn 133, Issue 3, 2001, Pages 345-350

  Ma, Jianya ^a   Qiu, Jianhua ^a   Hirt, Lorenz ^a   Dalkara, Turgay ^b   Moskowitz, Michael A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HACETTEPE UNIVERSITY   (Turkey)

Author keywords

bFGF; Caspase inhibitors; Focal cerebral ischaemia; Growth factors; Neuroprotection

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; REPERFUSION;

EID: 0034753649     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704075     Document Type: Article

References (36)

1. Both FGF1 and bcl-x synthesis are necessary for the reduction of apoptosis in retinal pigmented epithelial cells by FGF2: Role of the extracellular signal-regulated kinase 2
2. Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons
3. Mechanisms of nerve cell death: Apoptosis or necrosis after cerebral ischaemia
4. Antagonizing excitotoxicity: A therapeutic strategy for stroke?
5. Cellular survival: A play in three Akts
6. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
7. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family
8. The role of polypeptide growth factors in human carcinomas: New targets for a novel pharmacological approach
9. Prolonged therapeutic window for ischemic brain damage caused by delayed caspase activation
10. CREB couples neurotrophin signals to survival messages
11. Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats
12. Altered expression of Bcl-2, Bcl-X, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats
13. Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein
14. Inhibition of interleukin 1 beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage
15. Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion
16. Disturbances of cerebral protein synthesis and ischemic cell death
17. bFGF ameliorates focal ischemic injury by blood flow-independent mechanisms in eNOS mutant mice
18. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase
19. Differential regulation of Bax, Bcl-2, and Bcl-X proteins in focal cortical ischemia in the rat
20. Delayed intravenous administration of basic fibroblast growth factor (bFGF) reduces infarct volume in a model of focal cerebral ischemia/reperfusion in the rat
21. Signal transduction by the neurotrophin receptors
22. Pretreatment with intraventricular basic fibroblast growth factor decreases infarct size following focal cerebral ischemia in rats
23. Increased expression and nuclear accumulation of basic fibroblast growth factor in primary cultured astrocytes following ischemic-like insults
24. Roles of p53, c-Myc, Bcl-2, Bax and caspases in glutamate-induced neuronal apoptosis and the possible neuroprotective mechanism of basic fibroblast growth factor
25. Synergistic effects of caspase inhibitors and MK-801 in brain injury after transient focal cerebral ischaemia in mice
26. Gene expression induced by cerebral ischemia: An apoptotic perspective
27. Evidence for synaptic apoptosis
28. Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons
29. Endogenous neuroprotection factors and traumatic brain injury: Mechanisms of action and implications for therapy
30. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia
31. Neuronal cell death
32. The role of interleukin 1 in acute neurodegeneration and stroke: Pathophysiological and therapeutic implications
33. Proteasome inhibitors induce cytochrome c-caspase-3-like protease-mediated apoptosis in cultured cortical neurons
34. Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia
35. Growth factors prevent changes in Bcl-2 and Bax expression and neuronal apoptosis induced by nitric oxide
36. Roles of Bcl-2 and caspases in hypoxia-induced neuronal cell death: A possible neuroprotective mechanism of peptide growth factors