Reperfusion injury: Demonstration of brain damage produced by reperfusion after transient focal ischemia in rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 17, Issue 10, 1997, Pages 1048-1056

  Aronowski, Jaroslaw ^a   Strong, Roger ^a   Grotta, James C ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Cycloheximide; Focal ischemia; Model; PBN; Reperfusion injury; Stroke

Indexed keywords

CYCLOHEXIMIDE; N TERT BUTYL ALPHA PHENYLNITRONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INFARCTION; BRAIN INJURY; BRAIN PERFUSION; COMMON CAROTID ARTERY; CONTROLLED STUDY; EXPERIMENTAL MODEL; HYPERTENSION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SPONTANEOUSLY HYPERTENSIVE RAT; TRANSIENT ISCHEMIC ATTACK;

EID: 0030856804     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199710000-00006     Document Type: Article

References (53)

1. 2+/calmodulin-dependent protein kinase II: potential roles in neuronal damage. J Neurochem 58:1743-1753
2. Aronowski J, Waxham MN, Grotta JC (1992b) Neuronal protection and preservation of calcium/calmodulin-dependent protein kinase II and protein kinase C activity by dextrorphan treatment in global ischemia. J Cereb Blood Flow Metab 13:550-557
3. Aronowski J, Ostrow P, Samways E, Strong R, Zivin JA, Grotta JC (1994) A graded bioassay for determination of brain rescue from experimental acute ischemia. Stroke 25:2235-2240
4. Aronowski J, Strong R, Grotta JC (1996) Combined neuroprotection and reperfusion therapy for stroke: the effect of lubeluzole and diaspirin cross-linked hemoglobin in experimental focal ischemia. Stroke 27:1571-1577
5. Brim S, Jacewicz M, Kiessling M, Tanobe J, Pulsinelli W. (1988) Focal brain ischemia in rat: method for reproducible neocortical infarction using tandem occlusion of the distal middle cerebral and ipsilateral common carotid arteries. J Cereb Blood Flow Metab 8: 474-485
6. Buchan MA, Xue D, Slivka A. (1992) A new model of temporary focal neocortical ischemia in the rat. Stroke 23:273-279
7. Cao X, Phillis JW (1994) Alfa-phenyl-tert-butyl-nitrone reduces cortical infarction and edema in rats subjected to focal ischemia. Brain Res 644:267-272
8. Chen ST, Hsu CY, Hogan EL, Maricq H, Balentine JD (1986) A model of focal ischemia stroke in rats: reproducible extensive cortical infarction. Stroke 17:738-743
9. Churn SB, Taft WC, Billingsley MS, Blair RE, DeLorenzo RJ (1990) Temperature modulation of ischemic neuronal death and inhibition of calcium/calmodulin-dependent protein kinase II in gerbils. Stroke 21:1715-1721.
10. Coyle P, Heistad DD (1986) Blood flow through cerebral collateral vessels in hypertensive and normotensive rats. Stroke 8(suppl 2):II-67-II-71
11. Coyle P (1986) Different susceptibilities to cerebral infarction in spontaneously hypertensive (SHR) and normotensive Sprague-Dawley rats. Stroke 17:520-525
12. Coyle P, Heistad DD (1987) Blood flow through cerebral collateral vessels one month after middle cerebral artery occlusion. Stroke 18:407-411.
13. Du C, Hu R, Csernansky CA, Hsu CY, Choi DW (1996) Very delayed infarction after mild focal cerebral ischemia: A role of apoptosis? J Cereb Blood Flow Metab 16:195-201
14. Floyd RA (1990) Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J 4:2587-2597
15. Folbergrova J, Zhao Q, Katsura K-I, Siesjo BK (1995) N-tert-butyl-alpha-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia. Proc Natl Acad Sci USA 92: 5057-5061
16. Garcia JH, Liu K-F, Yashida Y, Chen S, Lian J (1994) Brain microvessels: factors altering their patency after the occlusion of a middle cerebral artery (Wistar rat) Am J Pathol 145:728-740
17. Gaudet RJ, Alam I, Levine L (1980) Accumulation of cyclooxygenase products of arachidonic acid metabolism in gerbil brain during reperfusion after bilateral common carotid artery occlusion. J Neurochem 35:653-658
18. Grabowski M, Nordborg C, Brundin P, Johansson BB (1988) Middle cerebral artery occlusion in the hypertensive and normotensive rats: a study of histhopotology and behavior. J Hypertension 6: 405-411
19. 2+/calmodulin-dependent protein kinase II activity in focal ischemia with reperfusion. Stroke 25:466-473
20. Harper SL, Bohlen HL (1984) Microvascular adaptation in the cerebral cortex of adult spontaneously hypertensive rats. Hypertension 6: 408-419
21. Hiestand DM, Haley BE, Kindy MS (1992) Role of calcium in inactivation of calcium/calmodulin dependent protein kinase II after cerebral ischemia. J Neurol Sci 113:31-37
22. Hossman K-A (1991) Disturbances of cerebral protein synthesis and ischemic cell death. Prog Brain Res 96:161-177
23. Jacewicz M (1992) The hypertensive rat and predisposition to cerebral infarction. Hypertension 19:47-48
24. Jennings RB, Sommers HM, Smyth GA, Flack HA, Linn H (1960) Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog. Pathology 70:68-78
25. Johansson BB (1984) Cerebral vascular bed in hypertension and consequences for the brain. Hypertension 6(suppl III):III81-III86
26. Kaplan B, Brint S, Tanabe J, Jacewicz M, Wand X-J, Pulsinelli W (1991) Temporal threshold of neocortical infarction in rats subjected to reversible focal cerebral ischemia. Stroke 22:1031-1039
27. Karmazyn M (1991) Ischemic and reperfusion injury in the heart: cellular mechanisms and pharmacological intervention. Can J Physiol Pharmacol 69:719-730
28. Kiessling M, Xie Y, Ullrich B, Thilmann R (1991) Are the neuroprotective effects of protein synthesis inhibitor cycloheximide due to prevention of apoptosis? Stroke 11(suppl 2): S357
29. Kinouchi H, Imaizumi S, Yoshimoto T, Yamamoto H, Motomiya M (1990) Changes of polyphosphoinositides, lysophospholipid, and free fatty acids in transient cerebral ischemia of rat brain. Mol Chem Neuropathol 12:215-228
30. Kiwak KJ, Moskowitz MA, Levin L (1985) Leukotriene production in gerbil brain after ischemic insult, subarachnoid hemorrhage, and concussive injury. J Neurosurg 62:865-869
31. Krause GS, Tiffany BR (1993) Suppression of protein synthesis in the reperfused brain. Stroke 24:747-756
32. Lin T-N, He YY, Wu G, Khan M, Hsu CY (1993) Effect of brain edema on infarct volume in a focal cerebral ischemia model in rat. Stroke 24:117-121
33. Matsumoto K, Lo EH, Pierce AR, Halpern EF, Newcomb R. (1996) Secondary elevation of extracellular neurotransmitter amino acids in the reperfusion phase following focal cerebral ischemia. J Cereb Blood Flow Metab 16:114-124
34. Memezawa H, Smith M-L, Siesjo BK (1992a) Penumbral tissue salvaged by reperfusion following middle cerebral artery occlusion in rat. Stroke 23:552-559
35. Memezawa H, Minamisawa H, Smith M-L, Siesjo BK (1992) Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat. Exp Brain Res 89:67-78
36. Miyajima T, Kotake Y (1995) Spin trapping agent, phenyl n-tert-butyl nitrone, inhibits induction of nitric oxide synthase in endotoxin-induced shock in mice. Biochem Biophys Res Commun 215:114-120.
37. Morimoto K, Yanagihara T (1981) Cerebral ischemia in gerbils: polyribosomal function during progression and recovery. Stroke 12: 105-110
38. The National Institute of Neurological Disorders and Stroke (NINDS) rt-PA Stroke Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333:1581-1587
39. Nordborg C, Fredriksson K, Johansson BB (1985) The morphometry of consecutive segments in cerebral arteries of nonnotensive and spontaneously hypertensive rats. Stroke 2:313-320
40. Okada Y, Copeland BR, Mori E, Tung M-M, Thomas WS, del Zappo GJ (1994) P-selectin and intercellular adhesion molecule-1 expression after focal ischemia and reperfusion. Stroke 25:202-211
41. Orunesu G, Pau A, Sehrbundt Viale E, Turtas S, Viale GL (1980) Amino acid incorporation into polyribosomes of ischemic and reperfused gerbil brain. Acta Neurochir (Wien) 51:247-252
42. Pavlik A, Teisinger J. (1980) Effect of cycloheximide administered to rats in early postnatal life: prolonged of DNA synthesis in the developing brain. Brain Res 192:531-541
43. Phillis JW, Smith-Barbour M, O'Regan MH, Perkins LM (1994) Amino acid and purine release in rat brain following temporary middle cerebral artery occlusion. Neurochem Res 19:1125-1130.
44. Pulsinelli WA, Duffy TA (1983) Regional Energy balance in rat brain after transient forebrain ischemia. J Neurochem 40:1500-1503
45. Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, Sharp FR (1990) A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab 10:290-293
46. Tegtmeier F, Weber C, Heister U, Haker I, Scheller D, Nikolov R, Holler M (1990) Eicosanoids in rat brain during ischemia and reperfusion-correlation to DC depolarization. J Cereb Blood Flow Metab 10:358-364
47. Traystman RJ, Kirsch JR, Koehler RC (1991) Oxygen radical mechanism of brain injury following ischemia and reperfusion. J Appl Physiol 71:1185-1195
48. Uematsu D, Greenberg JH, Reivich M, Karp A (1988) In vivo measurement of cytosolic free calcium during cerebral ischemia and reperfusion. Ann Neurol 24:420-428
49. Waxham NM, Grotta JC, Silva A, Strong R, Aronowski J (1996) Ischemia induced neuronal damage: A role of calcium/calmodulin dependent protein kinase II. J Cereb Blood Flow Metab 16:1-6
50. Yang GY, Betz AL (1994) Reperfusion-induced injury to the blood-brain barrier after middle cerebral artery occlusion in rats. Stroke 25:1658-1665
51. Yue T-L, Gu J-L, Lysko PG, Cheng H-Y, Barone FC, Fauerstein G (1992) Neuroprotective effects of phenyl-t-butyl-nitrone in gerbil global brain ischemia and in cultured rat cerebellar neurons. Brain Res 574:193-197
52. Zhang RL, Chopp M, Jiang N, Tang WX, Prostak J, Manning AM, Anderson DC (1995) Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat. Stroke 26:1438-1442
53. Zhao Q, Phlmark K, Smith M-L, Siesjo BK (1994) Delayed treatment with the spin trap alfa-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats. Acta Physiol Scand 152:349-350