Brain-derived peptides reduce the size of cerebral infarction and loss of MAP2 immunoreactivity after focal ischemia in rats

Journal of Neural Transmission, Supplement

Volumn , Issue 53, 1998, Pages 299-311

  Schwab, M ^a   Antonow Schlorke, I ^a   Zwiener, U ^a   Bauer, R ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CEREBROLYSIN; MICROTUBULE ASSOCIATED PROTEIN 2; AMINO ACID; MICROTUBULE ASSOCIATED PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; HISTOLOGY; IMMUNOHISTOCHEMISTRY; NERVE INJURY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BLOOD GAS ANALYSIS; BRAIN; BRAIN EDEMA; DRUG EFFECT; HEMODYNAMICS; MALE; METABOLISM; PATHOLOGY; RAT STRAIN; TRANSIENT ISCHEMIC ATTACK;

AMINO ACIDS; ANIMALS; BLOOD GAS ANALYSIS; BRAIN; BRAIN EDEMA; CEREBRAL INFARCTION; HEMODYNAMIC PROCESSES; ISCHEMIC ATTACK, TRANSIENT; MALE; MICROTUBULE-ASSOCIATED PROTEINS; RATS; RATS, INBRED STRAINS;

EID: 0031596276     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6467-9_26     Document Type: Article

References (34)

1. Akai F, Hiruma S, Sato T, Iwamoto N, Fujimoto M, Ioku M, Hashimoto S (1992) Neurotrophic factor-like effect of FPF1070 on septal cholinergic neurons after transections of fimbria-fornix in the rat brain. Histol Histopathol 7: 213-221
2. Albrecht E, Hingel S, Crailsheim K, Windisch M (1993) The effects of Cerebrolysin on survial sprouting of neurons from cerebral hemispheres and from the brainstem of chick embryos in vitro. Adv Biosci 87: 341-342
3. Astrup J, Siesjö BK, Symon L (1981) Thresholds in cerebral ischemia. The ischemic penumbra. Stroke 8: 723-725
4. Bartus RT, Dean RL, Cavanaugh K, Eveleth D, Carriero DL, Lynch G (1995) Time-related neuronal changes following middle cerebral artery occlusion: implications for therapeutic intervention and the role of calpain. J Cereb Blood Flow Metab 15: 969-979
5. Bershadsky AD, Vasiliev JM (1989) Cytoskeleton. Plenum Press, New York
6. Boado RJ (1995) Brain-derived peptides regulate the steady state levels and increase stability of the blood-brain barrier GLUT1 glucose transporter mRNA. Neurosci Lett 197: 179-182
7. Chen H, Chopp M, Zhang ZG, Garcia JH (1992) The effect of hypothermia on transient middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 12: 621-628
8. DeGraba TJ, Ostrow PT, Grotta JC (1993) Threshold of calcium disturbances after focal cerebral ischemia in rats. Implications of the window of therapeutic opportunity. Stroke 24: 1212-1216
9. Francis-Turner L, Valouskova V (1996) Nerve growth factor and nootropic drug Cerebrolysin but not fibroblast growth factor can reduce spatial memory impairment elicited by fimbria-fornix transection: short-term study. Neurosci Lett 202: 193-196
10. Ginsberg MD (1997) Injury mechanisms in the ischaemic penumbra: approaches to neuroprotection in acute ischaemic stroke. Cerebrovasc Dis 7 [Suppl]: 7-12
11. Globus MY, Busto R, Martinez E, Valdes I, Dietrich WD, Ginsberg MD (1991) Comparative effect of transient global ischemia on extracellular levels of glutamate, glycine, and gamma-aminobutyric acid in vulnerable and nonvulnerable brain regions in the rat. J Neurochem 57: 470-478
12. Heiss WD, Graf R, Wienhard K, Lottgen J, Saito R, Fujita T, Rosner G, Wagner R (1994) Dynamic penumbra demonstrated by sequential multitracer PET after middle cerebral artery occlusion in cats. J Cereb Blood Flow Metab 14: 892-902
13. Karibe H, Zarow GJ, Graham SH, Weinstein PR (1994) Mild intraischemic hypothermia reduces postischemic hyperperfusion, delayed postischemic hypoperfusion, blood-brain barrier disruption, brain edema, and neuronal damage volume after temporary focal cerebral ischemia in rats. J Cereb Blood Flow Metab 14: 620-627
14. Kempski O, Heimann A, Strecker U (1995) On the number of measurements necessary to assess regional cerebral blood flow by local laser Doppler recordings: a simulation study with data from 45 rabbits. Int J Microcirc Clin Exp 15: 37-42
15. Kitagawa K, Matsumoto M, Niinobe M, Mikoshiba K, Hata R, Ueda H, Handa N, Fukunaga R, Isaka Y, Kimura K, et al (1989) Microtubule-associated protein 2 as a sensitive marker for cerebral ischemic damage - immunohistochemical investigation of dendritic damage. Neuroscience 31: 401-411
16. Nedergaard M (1987) Neuronal injury in the infarct border: a neuropathological study in the rat. Acta Neuropathol 73: 267-274
17. Obrenovitch TP (1995) The ischaemic penumbra: twenty years on. Cerebrovasc Brain Metab Rev 7: 297-323
18. Osborne KA, Shigeno T, Balarsky AM, Ford I, McCulloch J, Teasdale GM, Graham DI (1987) Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia. J Neurol Neurosurg Psychiatr 50: 402-410
19. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. Academic Press, San Diego
20. Saido TC, Yokota M, Nagao S, Yamaura I, Tani E, Tsuchiya T, Suzuki K, Kawashima S (1993) Spatial resolution of fodrin proteolysis in postischemic brain. J Biol Chem 268: 25239-25243
21. Saito R, Graf R, Hubel K, Taguchi J, Rosner G, Fujita T, Heiss WD (1995) Halothane, but not alpha-chloralose, blocks potassium-evoked cortical spreading depression in cats. Brain Res 699: 109-115
22. 14C]antipyrine. Am J Physiol 234: H59-66
23. Satou T, Imano F, Akai F, Hashimoto S, et al (1993) Morphological observation of effects of Cerebrolysin on cultured neural cells. Adv Biosci 87: 195-196
24. Schuier FJ, Hossmann KA (1980) Experimental brain infarcts in cats. II. Ischemic brain edema. Stroke 11: 593-601
25. Schwab M, Schaller R, Bauer R, Zwiener U (1997a) Morphofunctional effects of moderate forebrain ischemia combined with short-term hypoxia in rats - protective effects of Cerebrolysin. Exp Toxic Pathol 49: 29-37
26. Schwab M, Bauer R, Zwiener U (1997b) Physiological effects and brain protection by hypothermia and Cerebrolysin after moderate forebrain ischemia in rats. Exp Toxic Pathol 49: 105-116
27. Schwab M, Antonow-Schlorke I, Bauer R, Zwiener U (1998) MAP2 is an early marker of neuronal dysfunction after focal ischemia in Thomae rats. Brain Res Bull (in press)
28. Shigeno T, Teasdale GM, McCulloch J, Graham DI (1985) Recirculation model following MCA occlusion in rats. Cerebral blood flow, cerebrovascular permeability, and brain edema. J Neurosurg 63: 272-277
29. Slivka A, Murphy E, Horrocks L (1995) Cerebral edema after temporary and permanent middle cerebral artery occlusion in the rat. Stroke 26: 1061-1065
30. Takagi K, Ginsberg MD, Globus MY, Dietrich WD, Martinez E, Kraydieh S, Busto R (1993) Changes in amino acid neurotransmitters and cerebral blood flow in the ischemic penumbral region following middle cerebral artery occlusion in the rat: correlation with histopathology. J Cereb Blood Flow Metab 13: 575-585
31. Verhaegen M, Todd MM, Warner DS (1994) Ischemic depolarization during halothanenitrous oxide and isoflurane-nitrous oxide anesthesia. An examination of cerebral blood flow threshold and times to depolarization. Anesthesiology 81: 965-973
32. Xiong H, Baskys A, Wojtowicz JM (1996) Brain-derived peptides inhibit synaptic transmission via presynaptic GABAB receptors in CA1 area of rat hippocampal slices. Brain Res 737: 188-194
33. Yanagihara T, Brengman JM, Mushynski WE (1990) Differential vulnerability of microtubule components in cerebral ischemia. Acta Neuropathol 80: 499-505
34. Zea Longa E, Weinstein PR, Cummuns RW, Carlson S (1989) A new method of middle cerebral artery oclusion in the rat without craniectomy. Stroke 20: 84-91